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公开(公告)号：US08378068B2
公开(公告)日：2013-02-19
申请号：US12705094
申请日：2010-02-12
IPC分类号： C07K14/00
CPC分类号： A61K38/1709 , A61K38/16 , C07K14/775
摘要： Provided are peptides, compositions thereof, and methods for treating or preventing dyslipidemia, a cardiovascular disease, endothelial dysfunction, a macrovascular disorder, or a microvascular disorder.
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公开(公告)号：US20120232005A1
公开(公告)日：2012-09-13
申请号：US13367237
申请日：2012-02-06
CPC分类号： A61K38/1709 , A61K38/17 , A61K38/18 , A61K45/00 , A61K47/50 , C07K1/04 , C07K1/042 , C07K14/775 , Y10T428/2982
摘要： The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods.
摘要翻译： 本公开涉及脂蛋白复合物和脂蛋白种群及其在治疗和/或预防血脂异常疾病，病症和/或病症中的用途。 本公开还涉及载脂蛋白的重组表达，载脂蛋白的纯化，以及使用基于热循环的方法产生脂蛋白复合物。
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公开(公告)号：US08206750B2
公开(公告)日：2012-06-26
申请号：US11388135
申请日：2006-03-22
申请人： Jean-Louis Dasseux
发明人： Jean-Louis Dasseux
IPC分类号： A61K38/17 , C07K14/775
CPC分类号： A61K38/1709 , A61K9/0095 , A61K9/127 , A61K9/1275 , A61K31/685 , A61K31/688 , A61K38/00 , A61K49/0008 , C07K14/775
摘要： The present disclosure provides charged lipoprotein complexes that include as one component a negatively charged phospholipid that is expected to impart the complexes with improved therapeutic properties.
摘要翻译： 本公开提供了带电荷的脂蛋白复合物，其包括作为一种组分的带负电荷的磷脂，其预期赋予复合物改善的治疗性质。
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公开(公告)号：US20080293102A1
公开(公告)日：2008-11-27
申请号：US12039385
申请日：2008-02-28
CPC分类号： C07K14/775 , C12N15/746
摘要： The disclosure relates to recombinant nucleic acids, expression vectors comprising the recombinant nucleic acids, and host cells comprising the expression vectors for expressing a protein of interest.
摘要翻译： 本公开涉及重组核酸，包含重组核酸的表达载体和包含用于表达目的蛋白质的表达载体的宿主细胞。
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公开(公告)号：US20070167351A1
公开(公告)日：2007-07-19
申请号：US11683784
申请日：2007-03-08
申请人： Jean-Louis Dasseux
发明人： Jean-Louis Dasseux
IPC分类号： A61K38/16
CPC分类号： A61K9/19 , A61K9/1075 , A61K9/1275 , A61K9/1277 , A61K38/1709 , A61K47/62 , C07K14/775
摘要： The invention relates to the formation of peptide/lipid vesicles and complexes through the co-lyophilization of peptides, preferably that are able to adopt an amphipathic alphahelical conformation, and one or more lipids. A single solution which solubilizes both the peptides and lipids or two separate solutions may be lyophilized.
摘要翻译： 本发明涉及肽/脂质囊泡和复合物的形成，其通过肽的共冻干，优选能够采用两亲性α-螺旋构象，以及一种或多种脂质。 溶解肽和脂质或两种单独溶液的单一溶液可以被冻干。
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36.发明申请KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES 有权酮类化合物和组合物用于胆固醇管理及相关用途公开(公告)号：US20070149615A9
公开(公告)日：2007-06-28
申请号：US10743952
申请日：2003-12-24
申请人： Jean-Louis Dasseux , Daniela Oniciu
发明人： Jean-Louis Dasseux , Daniela Oniciu
IPC分类号： A61K31/275 , A61K31/20 , C07C59/147 , C07C59/185
CPC分类号： C07C49/17 , C07C49/185 , C07C49/215 , C07C49/245 , C07C49/258 , C07C49/507 , C07C49/723 , C07C49/743 , C07C49/747 , C07C49/782 , C07C49/82 , C07C49/86 , C07C50/30 , C07C59/347 , C07C59/353 , C07C59/84 , C07C69/716 , C07C69/738 , C07C261/04 , C07C309/07 , C07C309/24 , C07D233/72 , C07D233/84 , C07D233/86 , C07D257/04 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/12 , C07D309/30 , C07D309/40 , C07D495/04 , C07F9/093 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新颖的酮化合物，包含酮化合物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含酮化合物的组合物。 本发明的化合物，组合物和方法还可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和 阳。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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公开(公告)号：US20060217312A1
公开(公告)日：2006-09-28
申请号：US11388135
申请日：2006-03-22
申请人： Jean-Louis Dasseux
发明人： Jean-Louis Dasseux
IPC分类号： A61K38/17 , C07K14/775
CPC分类号： A61K38/1709 , A61K9/0095 , A61K9/127 , A61K9/1275 , A61K31/685 , A61K31/688 , A61K38/00 , A61K49/0008 , C07K14/775
摘要： The present disclosure provides charged lipoprotein complexes that include as one component a negatively charged phospholipid that is expected to impart the complexes with improved therapeutic properties.
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公开(公告)号：US06900177B1
公开(公告)日：2005-05-31
申请号：US09465718
申请日：1999-12-17
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , A61K48/00 , A61P3/06 , A61P9/00 , A61P9/10 , C07K14/00 , C07K14/775 , A61K38/10 , C07K7/08
CPC分类号： A61K38/1709 , A61K48/00 , C07K7/08 , C07K14/001 , C07K14/775
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
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39.发明申请Hydroxyl compounds and compositions for cholesterol management and related uses 有权用于胆固醇管理和相关用途的羟基化合物和组合物公开(公告)号：US20050043278A1
公开(公告)日：2005-02-24
申请号：US10743470
申请日：2003-12-23
申请人： Jean-Louis Dasseux , Carmen Oniciu
发明人： Jean-Louis Dasseux , Carmen Oniciu
IPC分类号： A61P3/10 , C07C31/20 , C07C31/22 , C07C31/24 , C07C59/11 , C07C59/245 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C62/02 , C07C62/06 , C07C65/17 , C07C69/757 , C07D213/80 , C07D309/10 , C07D309/12 , C07D405/12 , C07F9/09 , C07F9/117 , C07F9/24 , C07F9/44 , A61K31/66 , C07D305/12 , C07F9/02 , A61K31/366 , A61K31/365 , A61K31/19 , A61K31/185
CPC分类号： C07C31/27 , A61K31/191 , A61K31/194 , A61K31/20 , A61K31/23 , C07C31/20 , C07C31/22 , C07C31/24 , C07C33/26 , C07C47/19 , C07C47/34 , C07C59/01 , C07C59/105 , C07C59/11 , C07C59/245 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C61/12 , C07C62/02 , C07C62/06 , C07C65/17 , C07C69/003 , C07C69/017 , C07C69/675 , C07C69/757 , C07C255/00 , C07C309/08 , C07C309/24 , C07C309/25 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/80 , C07D257/04 , C07D261/08 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/10 , C07D309/12 , C07D309/30 , C07D405/12 , C07D495/04 , C07F9/093 , C07F9/094 , C07F9/11 , C07F9/117 , C07F9/12 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新的羟基化合物，包含羟基化合物的组合物和可用于治疗和预防各种疾病和病症例如但不限于老化，阿尔茨海默氏病，癌症，心血管疾病，糖尿病性肾病，糖尿病性视网膜病变， 葡萄糖代谢异常，血脂异常，脂蛋白血症，高血压，阳ence，炎症，胰岛素抵抗，胆汁中的脂质清除，肥胖，胆汁中的氧固醇消除，胰腺炎，胰腺炎，帕金森病，过氧化物酶体增殖物激活受体相关病症，磷脂消除 胆汁，肾脏疾病，败血症，代谢综合症（如X综合症），血栓形成障碍。 本发明的化合物和方法也可用于调节C反应蛋白或增强患者的胆汁产生。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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公开(公告)号：US06376464B1
公开(公告)日：2002-04-23
申请号：US09453838
申请日：1999-12-01
申请人： Jean-Louis Dasseux , Renate Sekul , Klaus Büttner , Isabelle Cornut , Günther Metz , Jean Dufourcq
发明人： Jean-Louis Dasseux , Renate Sekul , Klaus Büttner , Isabelle Cornut , Günther Metz , Jean Dufourcq
IPC分类号： A61K3800
CPC分类号： C07K14/775 , A61K38/1709 , C07K7/08
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
摘要翻译： 本发明提供模拟人ApoA-I的结构和药理学性质的肽和肽类似物。 肽和肽类似物可用于治疗与血脂异常相关的各种障碍。
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