摘要:
The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a polycationic complexing agent which is complexed with a therapeutic, prophylactic or diagnostic agent or any combination thereof having a charge capable of complexing with the polycationic complexing agent upon association with the bioactive agent. The particles can further comprise a pharmaceutically acceptable carrier. The amount of polycationic complexing agent present in the particles is an amount sufficient to sustain the release of diagnostic, therapeutic or prophylactic agent from the particles. For example, the amount of complexing agent present can be at about 5% weight/weight (w/w) or more of the total weight of the complexing agent and therapeutic, diagnostic or prophylactic agent. Release of the agent from the administered particles occurs in a sustained fashion.
摘要:
The techniques and mechanisms described herein are directed to a system for stylizing video, such as interactively transforming video to a cartoon-like style. Briefly stated, the techniques include determining a set of volumetric objects within a video, each volumetric object being a segment. Mean shift video segmentation may be used for this step. With that segmentation information, the technique further includes indicating on a limited number of keyframes of the video how segments should be merged into a semantic region. Finally, a contiguous volume is created by interpolating between keyframes by a mean shift constrained interpolation technique to propagate the semantic regions between keyframes.
摘要:
Particles incorporating a surfactant and/or a hydrophilic or hydrophobic complex of a positively or negatively charged therapeutic agent and a charged molecule of opposite charge for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 &mgr;m and 30 &mgr;m, which together yield an aerodynamic diameter of the particles of between approximately one and three microns. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of poly(lactic acid) or poly(glycolic acid) or copolymers thereof. Alternatively, the particles may be formed solely of a therapeutic or diagnostic agent and a surfactant. Surfactants can be incorporated on the particle surface for example by coating the particle after particle formation, or by incorporating the surfactant in the material forming the particle prior to formation of the particle. Exemplary surfactants include phosphoglycerides such as dipalmitoyl phosphatidylcholine (DPPC). The particles can be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide a variety of therapeutic agents. Formation of complexes of positively or negatively charged therapeutic agents with molecules of opposite charge can allow control of the release rate of the agents into the blood stream following administration.
摘要:
An apparatus for sensing an input current through an inductor includes an RC circuit connected in parallel with the inductor across first and second input pins of an integrated circuit. A voltage monitoring circuit monitors a first voltage at the first input pin of the integrated circuit and monitors a second voltage at the second input pin of the integrated circuit. An op-amp compares the first voltage with the second voltage and generates a control output responsive to the comparison. A current sink circuit responsive to the indication controls the first voltage to substantially equal the second voltage.
摘要:
A method for activating network storage includes: a message processing server receives a network storage request from a client; the message processing server establishes a session with a history function (HF) according to the network storage request, and sends the content from the session in which the client participates to the HF through the session with the HF. A system for activating network storage, a message processing server, and a client are also provided. With the present invention, the network storage is implemented more conveniently, and the user experience is improved.
摘要:
A method for rapidly measuring melatonin adulteration of Chinese patent medicines and healthcare foods comprises: (1) extracting melatonin added to a Chinese patent medicine or healthcare food by using ethyl acetate; and (2) adding p-dimethylaminocinnamaldehyde to the extracted solution, and observing color. The method is rapid, simple and convenient, has strong specificity, high accuracy, reaction sensitivity, and a wide application range, and is applicable to on-site detection of melatonin adulteration of a Chinese patent medicine or healthcare food.
摘要:
Methods and apparatus for robust video stabilization. A video stabilization technique applies a feature tracking technique to an input video sequence to generate feature trajectories. The technique applies a video partitioning technique to segment the input video sequence into factorization windows and transition windows. The technique smoothes the trajectories in each of the windows, in sequence. For factorization windows, a subspace-based optimization technique may be used. For transition windows, a direct track optimization technique that uses a similarity motion model may be used. The technique then determines and applies warping models to the frames in the video sequence. In at least some embodiments, the warping models may include a content-preserving warping model, a homography model, a similarity transform model, and a whole-frame translation model. The warped frames may then be cropped according to a cropping technique.
摘要:
A method for transferring a file in a conference system is provided, which includes the following steps. A file sending UE sends a conference identification of the conference to the file receiving UE through a conference server; and sends the file to the file receiving UE through the conference server. A conference server, and a file sending and receiving UE are also provided. In the present invention, when a user sends a file to another user in a conference, a conference identification of the conference, together with the file, is sent to the file receiving user, so that the file receiving user can get to know the conference associated with the file when receiving the file, thereby enhancing the experience enjoyed by the file receiving user.
摘要:
Methods, apparatus, and computer-readable storage media for dynamic color flow modeling. A dynamic color flow model that incorporates motion estimation in a probabilistic fashion is described. By automatically and adaptively changing model parameters based on the inferred local motion uncertainty, the dynamic color flow model accurately and reliably models the object appearance, and improves the foreground color probability estimation when compared to conventional methods. The dynamic color flow model may, for example, be applied to both foreground and background layers (or to additional layers) for video object segmentation, obtaining significantly improved results when compared to conventional methods.
摘要:
Methods and apparatus for robust video stabilization. A video stabilization technique applies a feature tracking technique to an input video sequence to generate feature trajectories. The technique applies a video partitioning technique to segment the input video sequence into factorization windows and transition windows. The technique smoothes the trajectories in each of the windows, in sequence. For factorization windows, a subspace-based optimization technique may be used. For transition windows, a direct track optimization technique that uses a similarity motion model may be used. The technique then determines and applies warping models to the frames in the video sequence. In at least some embodiments, the warping models may include a content-preserving warping model, a homography model, a similarity transform model, and a whole-frame translation model. The warped frames may then be cropped according to a cropping technique.