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31.发明授权公开(公告)号：US06261562B1
公开(公告)日：2001-07-17
申请号：US09020956
申请日：1998-02-09
申请人： Jiangchun Xu , Davin C. Dillon
发明人： Jiangchun Xu , Davin C. Dillon
IPC分类号： A61K3900
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/705 , C07K2319/00 , C12N9/90
摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
摘要翻译： 提供了治疗前列腺癌的化合物和方法。 本发明化合物包括含有前列腺肿瘤蛋白质的至少一部分的多肽。 包含此类多肽的前列腺癌的免疫治疗用疫苗和药物组合物或编码此类多肽的DNA分子也与制备本发明多肽的DNA分子一起提供。
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32.发明授权公开(公告)号：US07008772B1
公开(公告)日：2006-03-07
申请号：US09116134
申请日：1998-07-14
申请人： Jiangchun Xu , Davin C. Dillon
发明人： Jiangchun Xu , Davin C. Dillon
IPC分类号： G01N33/53
CPC分类号： G01N33/57434
摘要： Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
摘要翻译： 提供了用于诊断前列腺癌的化合物和方法。 本发明化合物包括含有前列腺肿瘤蛋白质的至少一部分的多肽。 本发明的多肽可用于产生可用于诊断和监测前列腺癌的抗体。 还提供了用于制备探针，引物和多肽的核酸序列。
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33.发明授权公开(公告)号：US06887660B2
公开(公告)日：2005-05-03
申请号：US09030606
申请日：1998-02-25
申请人： Jiangchun Xu , Davin C. Dillon
发明人： Jiangchun Xu , Davin C. Dillon
IPC分类号： C07K16/30 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/574 , G01N33/577
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/158
摘要： Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
摘要翻译： 提供了用于诊断前列腺癌的化合物和方法。 本发明化合物包括含有前列腺肿瘤蛋白质的至少一部分的多肽。 本发明的多肽可用于产生可用于诊断和监测前列腺癌的抗体。 还提供了用于制备探针，引物和多肽的核酸序列。
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公开(公告)号：US06657056B2
公开(公告)日：2003-12-02
申请号：US09115453
申请日：1998-07-14
申请人： Jiangchun Xu , Davin C. Dillon
发明人： Jiangchun Xu , Davin C. Dillon
IPC分类号： C07H2104
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5156 , C07K14/705 , C07K2319/00
摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
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35.发明授权公开(公告)号：US06465611B1
公开(公告)日：2002-10-15
申请号：US09232149
申请日：1999-01-15
IPC分类号： A61K3800
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5156 , C07K14/705 , C07K2319/00
摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
摘要翻译： 提供了治疗前列腺癌的化合物和方法。 本发明化合物包括含有前列腺肿瘤蛋白质的至少一部分的多肽。 包含此类多肽的前列腺癌的免疫治疗用疫苗和药物组合物或编码此类多肽的DNA分子也与制备本发明多肽的DNA分子一起提供。
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36.发明申请公开(公告)号：US20110150919A1
公开(公告)日：2011-06-23
申请号：US11929831
申请日：2007-10-30
IPC分类号： A61K39/00 , C07K2/00 , C07H21/04 , A61P35/00 , G01N33/68 , C12N5/0783 , A61K35/12 , A61P37/04
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/53 , C07K14/4748 , C07K14/82 , C07K16/3015 , C07K2317/21 , C07K2317/34 , C07K2319/00 , C12Q1/6886
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。
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37.发明授权公开(公告)号：US07270980B2
公开(公告)日：2007-09-18
申请号：US09232880
申请日：1999-01-15
IPC分类号： C12P19/34 , C12Q1/00 , C12Q1/68 , G01N33/567 , G01N33/574 , G01N33/53 , G01N33/537 , A61K38/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K2/00 , C07K4/00 , C07K5/00
CPC分类号： C07K14/4748 , A61K39/00 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158 , Y10T436/25
摘要： Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
摘要翻译： 提供了用于诊断前列腺癌的化合物和方法。 本发明化合物包括含有前列腺肿瘤蛋白质的至少一部分的多肽。 本发明的多肽可用于产生可用于诊断和监测前列腺癌的抗体。 还提供了用于制备探针，引物和多肽的核酸序列。
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38.发明授权Compounds for immunotherapy and diagnosis of breast cancer and methods for their use 失效乳腺癌免疫治疗和诊断用化合物及其使用方法公开(公告)号：US06410507B1
公开(公告)日：2002-06-25
申请号：US09346327
申请日：1999-07-02
申请人： Steven G. Reed , Jiangchun Xu , Davin C. Dillon
发明人： Steven G. Reed , Jiangchun Xu , Davin C. Dillon
IPC分类号： A61K3818
CPC分类号： C12N9/0077 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/47 , C07K14/82 , C07K2319/00
摘要： Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided, together with polynucleotides for preparing the inventive polypeptides.
摘要翻译： 提供了用于治疗和诊断乳腺癌的化合物和方法。 本发明化合物包括含有至少一部分乳腺肿瘤蛋白质的多肽。 包含此类多肽的乳腺癌的免疫治疗用疫苗和药物组合物，或编码此类多肽的多核苷酸也与制备本发明多肽的多核苷酸一起提供。
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公开(公告)号：US06262245B1
公开(公告)日：2001-07-17
申请号：US09030607
申请日：1998-02-25
申请人： Jiangchun Xu , Davin C. Dillon
发明人： Jiangchun Xu , Davin C. Dillon
IPC分类号： C07H100
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N9/90
摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
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公开(公告)号：US20080311109A1
公开(公告)日：2008-12-18
申请号：US11929835
申请日：2007-10-30
IPC分类号： A61K35/12 , C07H21/04 , C12N15/63 , C12N5/06 , C07K16/00 , C07K2/00 , G01N33/53 , C12Q1/68 , A61P35/00 , C07K14/00 , C12N5/08 , A61K38/02 , A61K31/711 , A61K39/395 , A61K38/16
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/53 , C07K14/4748 , C07K14/82 , C07K16/3015 , C07K2317/21 , C07K2317/34 , C07K2319/00 , C12Q1/6886
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
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