公开(公告)号：US20190085388A1

公开(公告)日：2019-03-21

申请号：US16208379

申请日：2018-12-03

Applicant: Jingyue Ju ,  Huanyan Cao ,  Zengmin Li ,  Qinglin Meng ,  Jia Guo ,  Shenglong Zhang ,  Lin Yu

Inventor： Jingyue Ju ,  Huanyan Cao ,  Zengmin Li ,  Qinglin Meng ,  Jia Guo ,  Shenglong Zhang ,  Lin Yu

IPC: C12Q1/6869 ,  C07H19/20 ,  C07H19/10 ,  C07H19/14 ,  C07H19/06 ,  C07H19/16

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

公开(公告)号：US20180327828A1

公开(公告)日：2018-11-15

申请号：US15777416

申请日：2016-11-18

Applicant: Jingyue Ju ,  Xiaoxu Li ,  Zengmin Li ,  Shiv Kumar ,  Xin Chen ,  Cheng Guo ,  Shundi Shi ,  Jianyi Ren ,  Chuanjuan Tao ,  Minchen Chien ,  James J. Russo ,  Lin Yu

Inventor： Jingyue Ju ,  Xiaoxu Li ,  Zengmin Li ,  Shiv Kumar ,  Xin Chen ,  Cheng Guo ,  Shundi Shi ,  Jianyi Ren ,  Chuanjuan Tao ,  Minchen Chien ,  James J. Russo ,  Lin Yu

IPC: C12Q1/6869

CPC classification number: C12Q1/6869 ,  C07H19/10 ,  C07H19/20 ,  C12Q2525/101 ,  C12Q2527/119 ,  C12Q2565/607

Abstract: This disclosure is related to a method for determining the identity of a nucleotide residue of a single-stranded DNA or RNA, or sequencing DNA or RNA, in a solution using an ion-sensing field effect transistor and reversible nucleotide terminators.

公开(公告)号：US07693845B2

公开(公告)日：2010-04-06

申请号：US09942787

申请日：2001-08-29

Applicant: Henry Scanzano ,  Lin Yu ,  Alaaeldin A. Aly ,  Sameh Yamany

Inventor： Henry Scanzano ,  Lin Yu ,  Alaaeldin A. Aly ,  Sameh Yamany

IPC: G06F7/00 ,  G06F17/00

CPC classification number: G06F17/30595

Abstract: Database systems, methods and/or computer program products provide for multiple but exclusive relationships between tables in a relational database. The multiple but exclusive relationship may be enforced based on a type associated with a record in a relating table. The multiple but exclusive relationship may be a one-to-many or a many-to-many relationship. A foreign key value of a record in a relating table may be selectively associated with a specific one of a plurality of related tables based on at least one attribute of the record containing the foreign key in the relating table. In particular embodiments of the present invention, the foreign key values of a record in the relating table are selectively associated with one of the plurality of related tables by defining a foreign key of records of the relating table and defining a plurality of types of foreign key associations, each of the types corresponding to a respective one of the plurality of related tables. One of the related tables having a type corresponding to a type value associated with a record of the relating table is selected and a record in the selected related table identified based on a foreign key value of the foreign key of the record in the relating table.

Abstract translation: 数据库系统，方法和/或计算机程序产品提供关系数据库中的表之间的多个但是排他的关系。 可以基于与相关表中的记录相关联的类型来强制执行多个但是排他的关系。 多重但唯一的关系可能是一对多或多对多的关系。 基于在相关表中包含外键的记录的至少一个属性，相关表中的记录的外键值可以与多个相关表中的特定的一个有选择地相关联。 在本发明的特定实施例中，通过定义相关表的记录的外键并定义多种类型的外键，相关表中的记录的外键值选择性地与多个相关表之一相关联 关联，每个类型对应于多个相关表中的相应一个。 选择对应于与相关表的记录相关联的类型值的类型的相关表中的一个，并且基于相关表中记录的外键的外键值标识所选择的相关表中的记录。

公开(公告)号：US20080293643A1

公开(公告)日：2008-11-27

申请号：US12097321

申请日：2006-08-28

Applicant: Hui Kang ,  Jinhua Zhao ,  Guanghui Yao ,  Weizhen Zeng ,  Milai Yin ,  Yong Li ,  Cunfang Wang ,  Lijuan Zhang ,  Dan Zhu ,  Hong Chen ,  Chuangui Huang ,  Yu Man ,  Jing Li ,  Hanlin Feng ,  Lin Yu

Inventor： Hui Kang ,  Jinhua Zhao ,  Guanghui Yao ,  Weizhen Zeng ,  Milai Yin ,  Yong Li ,  Cunfang Wang ,  Lijuan Zhang ,  Dan Zhu ,  Hong Chen ,  Chuangui Huang ,  Yu Man ,  Jing Li ,  Hanlin Feng ,  Lin Yu

IPC: A61K31/7048 ,  C07G3/00 ,  A61P43/00

CPC classification number: C07H15/20

Abstract: The present invention relates to a novel crystalline form of a Compound 3,4′,5-trihydroxy-stilbene-3-β-D-glucoside (polydatin) and a method of preparation and use thereof, and to a pharmaceutical composition containing crystalline form I of 3,4′,5-trihydroxy-stilbene-3-β-D-glucoside. Crystalline form I of 3,4′,5-trihydroxy-stilbene-3-β-D-glucoside of the present invention has a stable crystalline morphology, a definite melting point and a good chemical stability. Such a novel form of 3,4′,5-trihydroxy-stilbene-3-β-D-glucoside possesses the properties required for the preparation of solid formulations and is easily tabletable and readily formable when formulated, which allows for substantial decrease in raw materials costs, more facile operations in production and easier control over quality in industrial drug production, and moreover, better convenience in storage.

Abstract translation: 本发明涉及化合物3,4'，5-三羟基 - 二苯乙烯-3-β-D-葡萄糖苷（多聚糖）的新结晶形式及其制备和应用的方法，以及含有结晶形式的药物组合物 I的3,4'，5-三羟基 - 二苯乙烯-3-β-D-葡萄糖苷。 本发明的3,4'，5-三羟基 - 二苯乙烯-3-β-D-葡萄糖苷的结晶形式I具有稳定的晶体形态，确定的熔点和良好的化学稳定性。 这种新型形式的3,4'，5-三羟基 - 二苯乙烯-3-β-D-葡萄糖苷具有制备固体制剂所需的性质，并且在配制时易于制成并容易形成，这允许原料 材料成本较高，生产操作更加容易，工业药品生产质量更易于控制，而且储存更方便。

公开(公告)号：US20050220785A1

公开(公告)日：2005-10-06

申请号：US11144155

申请日：2005-06-02

Applicant: Steven Engle ,  Richard Jack ,  David Jones ,  Lin Yu

Inventor： Steven Engle ,  Richard Jack ,  David Jones ,  Lin Yu

IPC: A61K39/395 ,  A61K47/48

CPC classification number: A61K47/61 ,  A61K47/54 ,  A61K47/59 ,  A61K47/595 ,  A61K47/60

Abstract: The invention provides methods for reducing circulating levels of antibodies, particularly disease-associated antibodies. The methods entail administering effective amounts of epitope-presenting carriers to an individual. In other embodiments, ex vivo methods for reducing circulating levels of antibodies are provided which employ epitope-presenting carriers.

Abstract translation: 本发明提供降低抗体循环水平，特别是疾病相关抗体的方法。 该方法需要向个体施用有效量的表位呈递载体。 在其它实施方案中，提供用于降低抗体循环水平的离体方法，其使用表位呈递载体。

公开(公告)号：US20050208613A1

公开(公告)日：2005-09-22

申请号：US11118016

申请日：2005-04-29

Applicant: Yong Qin ,  Lin Yu ,  Mark Hansen ,  Eduard Sergienko ,  Bonnie Bertolaet ,  Daniel Sem

Inventor： Yong Qin ,  Lin Yu ,  Mark Hansen ,  Eduard Sergienko ,  Bonnie Bertolaet ,  Daniel Sem

IPC: C12N9/02 ,  G01N33/566 ,  C12Q1/26 ,  C07H19/207

CPC classification number: C12N9/001 ,  C12Y103/01026 ,  G01N33/566 ,  G01N2333/90209 ,  G01N2500/02

Abstract: The present invention provides compositions containing a common ligand linked to a detectable moiety and provides methods for the preparation of such compositions. The present invention also provides methods for screening candidate ligands for binding to a NAD binding receptor, which include contacting a receptor with a candidate ligand and a composition of the invention followed by evaluation of receptor binding. The screening method of the present invention has broad applicability and can be used to screen large numbers of a wide variety of ligands. The present invention further provides methods for detecting the binding activity of a putative receptor, which include combining the putative receptor with a composition of the invention and evaluating the level of detectable moiety. The invention also provides kits useful for detection of receptors having NAD binding activity and for screening of candidate ligands that bind to a NAD binding receptor.

Abstract translation: 本发明提供含有与可检测部分连接的共同配体的组合物，并提供制备这种组合物的方法。 本发明还提供了筛选用于结合NAD结合受体的候选配体的方法，其包括使受体与候选配体和本发明的组合物接触，然后评估受体结合。 本发明的筛选方法具有广泛的适用性，可用于筛选大量各种配体。 本发明还提供了用于检测推定受体的结合活性的方法，其包括将推定的受体与本发明的组合物结合并评估可检测部分的水平。 本发明还提供了可用于检测具有NAD结合活性的受体并用于筛选结合NAD结合受体的候选配体的试剂盒。

公开(公告)号：US20050208480A1

公开(公告)日：2005-09-22

申请号：US10846079

申请日：2004-05-13

Applicant: Edward Victoria ,  David Marquis ,  David Jones ,  Lin Yu

Inventor： Edward Victoria ,  David Marquis ,  David Jones ,  Lin Yu

IPC: A61K38/00 ,  A61K39/00 ,  C07C323/12 ,  C07K14/00 ,  C07K14/47 ,  C07K16/18 ,  C07K16/42 ,  C12Q1/70 ,  G01N33/53 ,  G01N33/543 ,  G01N33/564 ,  G01N33/68 ,  G01N33/92

CPC classification number: G01N33/92 ,  A61K38/00 ,  A61K39/0008 ,  A61K2039/6093 ,  A61K2039/645 ,  C07C323/12 ,  C07K14/001 ,  C07K14/4713 ,  C07K16/18 ,  C07K2317/34 ,  G01N33/54353 ,  G01N33/564 ,  G01N33/6878

Abstract: aPL analogs that (a) bind specifically to B cells to which an aPL epitope binds and are disclosed. Optimized analogs lack T cell epitope(s) are useful as conjugates for treating aPL antibody-mediated diseases. Conjugates comprising aPL analogs and nonimmunogenic valency platform molecules are provides as are novel nonimmunogenic valency platform molecules and linkers. Methods of preparing and identifying said analogs, methods of treatment using said analogs, methods and compositions for preparing conjugates of said analogs and diagnostic immunoassays for aPL antibodies are disclosed.

Abstract translation: （a）特异性结合aPL表位结合并公开的B细胞的aPL类似物。 优化的类似物缺乏T细胞表位可用作治疗aPL抗体介导的疾病的缀合物。 提供包含aPL类似物和非免疫原性价态平台分子的缀合物是新的非免疫原性价态平台分子和接头。 公开了制备和鉴定所述类似物的方法，使用所述类似物的治疗方法，用于制备所述类似物的缀合物的方法和组合物以及用于aPL抗体的诊断免疫测定。

公开(公告)号：US20050042674A9

公开(公告)日：2005-02-24

申请号：US10081989

申请日：2002-02-21

Applicant: Lin Yu ,  Qing Dong ,  Fabrice Pierre ,  Edcon Chang ,  Hengyuan Lang ,  Yong Qin ,  Yunfeng Fang ,  Mark Hansen ,  Maurizio Pellecchia

Inventor： Lin Yu ,  Qing Dong ,  Fabrice Pierre ,  Edcon Chang ,  Hengyuan Lang ,  Yong Qin ,  Yunfeng Fang ,  Mark Hansen ,  Maurizio Pellecchia

IPC: C07B61/00 ,  C07D417/06 ,  C07D417/14 ,  C07D521/00 ,  G01N33/53 ,  C07D413/02 ,  C07K5/06 ,  G01N33/543

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D417/06 ,  C07D417/14 ,  C40B40/00

Abstract: The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affinity and/or selectivity of ligand binding to a receptor or receptor family through the synergistic action of the common ligand mimic and specificity ligand which compose the bi-ligand. The present invention also provides combinatorial libraries containing the common ligand mimics and bi-ligands of the invention. Further, the present invention provides methods for manufacturing the common ligand mimics and bi-ligands of the invention and methods for assaying the combinatorial libraries of the invention.

Abstract translation: 本发明提供了作为受体家族的共同配体的常见配体模拟物。 本发明还提供含有这些共同配体模拟物的双配体。 本发明的双配体通过构成双配体的共同配体模拟物和特异性配体的协同作用，提供配体与受体或受体家族结合的增强的亲和力和/或选择性。 本发明还提供了包含本发明的共同配体模拟物和双配位体的组合文库。 此外，本发明提供了制备本发明的共同配体模拟物和双配位体的方法以及用于测定本发明的组合文库的方法。

公开(公告)号：USD856160S1

公开(公告)日：2019-08-13

申请号：US29603949

申请日：2017-05-15

Applicant: Lin Yu

Designer： Lin Yu

公开(公告)号：USD848893S1

公开(公告)日：2019-05-21

申请号：US29610215

申请日：2017-07-10

Applicant: Lin Yu

Designer： Lin Yu