公开(公告)号：US08559598B2

公开(公告)日：2013-10-15

申请号：US12665491

申请日：2008-06-17

Applicant: Johann Kindlein ,  Evert Hendrik Agterhuis ,  Godefridus Hendricus Maria Gubbels ,  Frank Simonis

Inventor： Johann Kindlein ,  Evert Hendrik Agterhuis ,  Godefridus Hendricus Maria Gubbels ,  Frank Simonis

IPC: H01J35/00

CPC classification number: A61N5/1001 ,  H01J35/06 ,  H01J35/14 ,  H01J35/16 ,  H01J2235/062 ,  H01J2235/081 ,  H01J2235/087 ,  H01J2235/164 ,  H01J2235/165 ,  H01J2235/205

Abstract: A miniature X-ray source device for effecting radiation therapy at least comprising a vacuum tube containing a cathode and an anode spaced apart at some distance from each other; emitting means for emitting free electrons from the cathode; electric field generating means for applying during use a high-voltage electric field between the cathode and the anode for accelerating the emitted free electrons towards the anode, as well as an exit window for X-ray radiation being generating at the anode. The present invention provides an improved miniature X-ray source device, that can also properly be used in treating skin cancer and which is easy to handle. The anode is provided with a flat X-ray emitting surface. In particular, the cathode exhibits a concave shaped surface having a center part surrounded by an upright circumferential edge, wherein the center part of the concave shaped surface is provided with an electron emitting material.

Abstract translation: 一种用于进行放射治疗的微型X射线源装置，至少包括一个真空管，该真空管包含彼此间隔一定距离的阴极和阳极; 用于从阴极发射自由电子的发射装置; 电场产生装置，用于在使用期间施加阴极和阳极之间的高电压电场，用于加速向阳极发射的自由电子，以及在阳极处产生X射线辐射的出射窗口。 本发明提供一种改进的微型X射线源装置，其也可以适当地用于治疗皮肤癌，并且易于处理。 阳极设置有平坦的X射线发射表面。 特别地，阴极具有凹形状的表面，其中心部分被直立的周向边缘包围，其中凹形表面的中心部分设置有电子发射材料。

公开(公告)号：US08145290B2

公开(公告)日：2012-03-27

申请号：US11187941

申请日：2005-07-25

Applicant: Johann Kindlein

Inventor： Johann Kindlein

IPC: A61B5/05

CPC classification number: A61N5/1007 ,  A61B2034/2051 ,  A61N5/103 ,  A61N5/1048 ,  A61N2005/1008 ,  A61N2005/1012 ,  A61N2005/1018 ,  A61N2005/1058

Abstract: The invention relates to a method for identifying the location at least one treatment channel from a group of a plurality of treatment channels as wells as a system for effecting radiation treatment on a pre-selected anatomical portion of an animal body.According to the invention the identifying method being characterized by the steps of A selecting at least one of said plurality of treatment channels; B reconstructing the actual location of said selected treatment channel relative to said animal body; and C comparing said reconstructed location said pre-planned plurality of locations. Furthermore the system according to the invention is characterized in that identifying means are present for identifying the location of at least one treatment channel from said group of said plurality of inserted treatment channels and comparing said identified location with one or more of said pre-planned locations present in said treatment plan.

Abstract translation: 本发明涉及一种用于鉴定来自多个治疗通道的组的至少一个治疗通道的位置的方法，作为用于对预先选择的动物体的解剖部分进行辐射治疗的系统。 根据本发明，识别方法的特征在于以下步骤：A选择所述多个治疗通道中的至少一个; B重建所述选择的治疗通道相对于所述动物体的实际位置; 和C比较所述重建位置所述预先计划的多个位置。 此外，根据本发明的系统的特征在于，存在用于识别来自所述多个插入的治疗通道的所述组的至少一个治疗通道的位置的识别装置，并且将所述识别的位置与一个或多个所述预先计划的位置进行比较 出现在治疗计划中。

公开(公告)号：US08133166B2

公开(公告)日：2012-03-13

申请号：US11487303

申请日：2006-07-17

Applicant: Johann Kindlein ,  Arie Visscher ,  Johan Henning ,  Wouter Peter Engels

Inventor： Johann Kindlein ,  Arie Visscher ,  Johan Henning ,  Wouter Peter Engels

IPC: A61N5/00

CPC classification number: A61N5/1007 ,  A61N5/1075 ,  A61N2005/1008 ,  A61N2005/1012 ,  A61N2005/1094

Abstract: The invention relates to an apparatus for effecting radiation treatment on a pre-selected anatomical portion of an animal body comprising: a group of n hollow treatment channels being inserted at one or more pre-planned positions in said pre-selected anatomical portion; a group of m delivery channels to be connected to a corresponding number m from said group of n hollow treatment channels with m being 2 or more and n being 1 or more; identifying means for identifying which one of said m delivery channels is being connected with which one of said n hollow treatment channels, said identifying means comprising a tracking element accommodated in a tracking channel, said tracking element being intended to be displaced from said tracking channel through each of said interconnected m delivery channels and m treatment channels; storage means for storing k energy emitting sources in a corresponding source-channel, with k≦m; delivery means for temporarily inserting said k energy emitting sources from their source-channels through a corresponding one of said interconnected m delivery channels and m treatment channels towards one of said pre-planned positions in said anatomical portion; coupling means for coupling at least one of said m delivery channels with a corresponding treatment channel.

Abstract translation: 本发明涉及一种用于对动物体的预先选择的解剖部分进行辐射治疗的装置，包括：一组n个中空治疗通道，其插入在所述预先选择的解剖部分中的一个或多个预先计划的位置; 一组m个传送通道，其与m个为2个以上且n为1以上的n个中空处理通道组相对应的m个连接; 识别装置，用于识别所述m个输送通道中的哪一个正在与所述n个中空治疗通道中的一个连接，所述识别装置包括容纳在跟踪通道中的跟踪元件，所述跟踪元件旨在从所述跟踪通道移位通过 每个所述相互连接的输送通道和m个治疗通道; 存储装置，用于在相应的源信道中存储k个能量发射源，其中k＆n; E; m; 递送装置，用于将所述k个能量发射源从其源通道中通过所述互连的m个输送通道和m个治疗通道中的相应一个朝向所述解剖部分中的所述预先计划的位置之一插入; 用于将所述m个输送通道中的至少一个与相应的治疗通道联接的联接装置。

公开(公告)号：US08130384B2

公开(公告)日：2012-03-06

申请号：US12704979

申请日：2010-02-12

Applicant: Johann Kindlein ,  Tim Thurn

Inventor： Johann Kindlein ,  Tim Thurn

IPC: G01B11/30

CPC classification number: A61N5/1049 ,  A61B6/032 ,  A61B6/08 ,  A61B6/548 ,  A61B90/13 ,  A61B2090/366 ,  A61N2005/105 ,  A61N2005/1059

Abstract: The invention is related to an apparatus for the representation of a geometrical figure on the surface of a patient's body that is situated on a support, comprising at least one projection device, by which a given geometrical figure can be projected onto the three-dimensional surface of the patient's body, at least one control device and at least one optical sensor device, by which the geometrical figure projected onto the surface of the patient's body can be acquired and the acquired data can be supplied to the control device, wherein the control device is realized to determine the three-dimensional coordinates of the geometrical figure projected onto the patient's body from the data acquired by the sensor device, and wherein the control device is realized to compare the determined three-dimensional coordinates of the geometrical figure projected onto the patient's body with desired three-dimensional coordinates.

Abstract translation: 本发明涉及一种用于在患者身体的表面上表示位于支撑体上的几何图形的装置，该装置包括至少一个投影装置，通过该装置可以将给定的几何图形投影到三维表面上 患者身体的至少一个控制装置和至少一个光学传感器装置，通过该至少一个光学传感器装置可以获取投影到患者身体表面上的几何图形，并且可以将所获取的数据提供给控制装置，其中控制装置 被实现为根据由传感器装置获取的数据来确定投影到患者身体上的几何图形的三维坐标，并且其中实现控制装置以比较所确定的投影到患者身体上的几何图形的三维坐标 身体具有所需的三维坐标。

公开(公告)号：US07425194B2

公开(公告)日：2008-09-16

申请号：US10462719

申请日：2003-06-17

Applicant: Dimos Baltas ,  Johann Kindlein ,  Oscar Boel ,  Albert Dirk Adrianus Koster ,  Emil Matthijs Buijs

Inventor： Dimos Baltas ,  Johann Kindlein ,  Oscar Boel ,  Albert Dirk Adrianus Koster ,  Emil Matthijs Buijs

IPC: A61N5/00

CPC classification number: A61N5/1007 ,  A61B2017/3411 ,  A61N2005/1012

Abstract: A template-assembly for effecting radiation treatment within an animal body by implanting one or more hollow needles at a desired location within the animal body includes a template frame being mountable to a stepping device of a radiation treatment device. The template frame has a needle guiding component having a plurality of guiding apertures for guiding the one or more hollow implant needles towards the desired location within the animal body. The template-assembly has a needle fixation component for fixating one or more of the implanted needles relative to the animal body, wherein the needle fixation component can be sutured to the skin of the animal body.

Abstract translation: 用于通过将一个或多个中空针植入动物体内的期望位置来在动物体内进行放射治疗的模板组件包括可安装到放射线治疗装置的步进装置的模板框架。 模板框架具有针引导部件，该引导部件具有多个引导孔，用于将一个或多个中空注射针朝向动物体内的期望位置引导。 模板组件具有用于相对于动物体固定一个或多个植入针的针固定部件，其中针固定部件可被缝合到动物体的皮肤上。

公开(公告)号：US07217235B2

公开(公告)日：2007-05-15

申请号：US10811938

申请日：2004-03-30

Applicant: Johann Kindlein ,  Rudolf Leonard Josef Scholte

Inventor： Johann Kindlein ,  Rudolf Leonard Josef Scholte

IPC: A61N5/00

CPC classification number: A61N5/1001 ,  H01J35/065 ,  H01J35/32 ,  H01J2235/186 ,  H01J2235/205

Abstract: The invention relates to a solid state brachytherapy applicator for performing radiation therapy treatment in an animal body, said applicator at least comprising an X-ray emitting surface composed of: a vacuum cavity containing a cathode and an anode spaced apart at some distance from each other; emitting means for emitting free electrons from the cathode; electric field means for applying during use a high-voltage electric field between said cathode and said anode for accelerating said emitted free electrons towards said anode; wherein said vacuum cavity being at least partly transparent to X-ray radiation emitted by said anode.The invention furthermore relates to a radiation therapy treatment system for performing radiation therapy treatment in an animal body and to a method for performing radiation therapy treatment in an animal body using a solid state brachytherapy applicator according to the invention.According to the invention said vacuum cavity is bound by first and second plate-shaped elements spaced some distance from each other, said first plate-shaped element serving as cathode and said second plate-shaped element serving as anode.

Abstract translation: 本发明涉及用于在动物体内进行放射治疗治疗的固态近距离放射疗法施加器，所述施用器至少包括由X射线发射表面组成的真空腔，所述真空腔包含彼此间隔一定距离的阴极和阳极 ; 用于从阴极发射自由电子的发射装置; 电场装置，用于在所述阴极和所述阳极之间施加高电压电场，用于将所述发射的自由电子加速到所述阳极; 其中所述真空腔对于由所述阳极发射的X射线辐射至少部分透明。 本发明还涉及一种用于在动物体内进行放射治疗治疗的放射线治疗治疗系统和使用根据本发明的固态近距离放射疗法施加器在动物体内进行放射治疗治疗的方法。 根据本发明，所述真空腔由彼此隔开一定距离的第一和第二板状元件结合，所述第一板状元件用作阴极，所述第二板状元件用作阳极。

公开(公告)号：US20070078327A1

公开(公告)日：2007-04-05

申请号：US11187941

申请日：2005-07-25

Applicant: Johann Kindlein

Inventor： Johann Kindlein

IPC: A61B5/05

CPC classification number: A61N5/1007 ,  A61B2034/2051 ,  A61N5/103 ,  A61N5/1048 ,  A61N2005/1008 ,  A61N2005/1012 ,  A61N2005/1018 ,  A61N2005/1058

Abstract: The invention relates to a method for identifying the location at least one treatment channel from a group of a plurality of treatment channels as wells as a system for effecting radiation treatment on a pre-selected anatomical portion of an animal body. According to the invention the identifying method being characterized by the steps of A selecting at least one of said plurality of treatment channels; B reconstructing the actual location of said selected treatment channel relative to said animal body; and C comparing said reconstructed location said pre-planned plurality of locations. Furthermore the system according to the invention is characterized in that identifying means are present for identifying the location of at least one treatment channel from said group of said plurality of inserted treatment channels and comparing said identified location with one or more of said pre-planned locations present in said treatment plan.

Abstract translation: 本发明涉及一种用于鉴定来自多个治疗通道的组的至少一个治疗通道的位置的方法，作为用于对预先选择的动物体的解剖部分进行辐射治疗的系统。 根据本发明，识别方法的特征在于以下步骤：A选择所述多个治疗通道中的至少一个; B重建所述选择的治疗通道相对于所述动物体的实际位置; 和C比较所述重建位置所述预先计划的多个位置。 此外，根据本发明的系统的特征在于，存在用于识别来自所述多个插入的治疗通道的所述组的至少一个治疗通道的位置的识别装置，并且将所述识别的位置与一个或多个所述预先计划的位置进行比较 出现在治疗计划中。

公开(公告)号：US20060014997A1

公开(公告)日：2006-01-19

申请号：US11167166

申请日：2005-06-28

Applicant: Johann Kindlein ,  Frits Van Krieken

Inventor： Johann Kindlein ,  Frits Van Krieken

IPC: A61N5/00

CPC classification number: A61N5/1015

Abstract: The invention relates to a device for radiation treatment of proliferative tissue surrounding a cavity in an animal body comprising at least an inflatable balloon system having a balloon wall for placement in said cavity; a supportive probe having an elongated body with a distal end connected with said inflatable balloon system and a proximal end remaining outside said cavity; inflation means for inflating and deflating said balloon system with a pressurized medium; radiation delivering means for placing at least one energy emitting source within said cavity for performing said radiation treatment. It is an object of the invention to provide a device for radiation treatment of proliferative tissue surrounding a cavity in an animal patient body according to the above preamble capable in controlling the real, actual status of the inflated balloon system present inside said body cavity, especially when said device is utilized with an after loading apparatus. The device is according to the invention characterized in that said device comprises monitoring means for monitoring the inflation status of the inflatable balloon system. Hence with the device according to the invention the actual inflation status of the inflated balloon system can be determined, providing accurate information about the operational conditions of the device during radiation treatments being performed in an animal body. Any malfunction can be easily detected thereby obviating the risk of any misadministration of a radiation dose to the patient.

Abstract translation: 本发明涉及一种用于放射治疗包围动物体腔内的增生组织的装置，该装置包括至少一个具有用于放置在所述空腔中的球囊壁的可膨胀球囊系统; 支撑探针，其具有细长体，其远端与所述可充气球囊系统连接，并且近端保持在所述空腔外; 膨胀装置用于用加压介质对所述球囊系统进行充气和放气; 辐射传送装置，用于将至少一个能量发射源放置在所述空腔内用于进行所述辐射处理。 本发明的一个目的是提供一种用于根据上述前序能够对动物患者体内空腔周围的增生组织进行放射治疗的装置，其能够控制存在于所述体腔内的充气球囊系统的实际状态，特别是 当所述装置与后装载装置一起使用时。 根据本发明的装置，其特征在于，所述装置包括用于监测可充气球囊系统的充气状态的监视装置。 因此，根据本发明的装置，可以确定充气球囊系统的实际充气状态，在动物体内执行放射治疗期间提供关于装置的操作条件的准确信息。 可以容易地检测到任何故障，从而避免了向患者施加辐射剂量的任何错误的风险。

公开(公告)号：US20050101823A1

公开(公告)日：2005-05-12

申请号：US10669359

申请日：2003-09-25

Applicant: Luis Linares ,  Johann Kindlein

Inventor： Luis Linares ,  Johann Kindlein

IPC: A61N5/10 ,  A61M36/04

CPC classification number: A61N5/1015 ,  A61N2005/1018

Abstract: The invention relates to a device for radiation treatment of proliferative tissue surrounding a cavity in an animal body comprising: at least a first inflatable chamber having a wall for placement in said cavity; a supportive probe having an elongated body with a distal end connected with said at least first inflatable chamber and a proximal end remaining outside said cavity; inflation means for inflating and deflating said at least first chamber; radiation delivering means for placing at least one energy emitting source within said cavity for performing said radiation treatment. The invention aims to provide a device according the above preamble, wherein it is possible to temporarily position a solid energy emitting source in a reproducible manner at different locations within the inflated chamber, such that subsequent identical radiation treatment sessions can be performed, whereas the comfort of the patient is maxim and an out hospitalization treatment is possible. According to the invention said radiation delivering means comprises at least one hollow, flexible tunnel channel having at least one fixation point to said wall of said first inflatable chamber and a proximal end remaining outside said cavity; wherein said at least one hollow, flexible tunnel channel serves to guide said at least one radiation emitting source inside said cavity.

Abstract translation: 本发明涉及一种用于放射治疗包围动物体腔内的增生组织的装置，包括：至少第一充气室，其具有用于放置在所述空腔中的壁; 支撑探针，其具有细长体，远端与所述至少第一可充气室连接，远端保持在所述空腔外; 膨胀装置用于使所述至少第一室充气和放气; 辐射传送装置，用于将至少一个能量发射源放置在所述空腔内用于进行所述辐射处理。 本发明旨在提供一种根据上述前序部分的装置，其中可以将可再生能量的固体能量发射源临时定位在充气室内的不同位置，使得可以执行后续相同的辐射治疗会话，而舒适度 的患者是最大的，可以进行住院治疗。 根据本发明，所述辐射递送装置包括至少一个中空的柔性隧道通道，其具有至少一个固定点到所述第一可充气室的所述壁，以及保持在所述空腔外部的近端; 其中所述至少一个中空柔性隧道通道用于在所述空腔内引导所述至少一个辐射发射源。

公开(公告)号：US20050031083A1

公开(公告)日：2005-02-10

申请号：US10878160

申请日：2004-06-29

Applicant: Johann Kindlein

Inventor： Johann Kindlein

IPC: A61N5/10 ,  H01J35/06 ,  H01J35/16 ,  H01J35/20 ,  H01J35/32 ,  H01J29/50

CPC classification number: A61N5/1001 ,  H01J35/20 ,  H01J35/32 ,  H01J2235/205

Abstract: The invention relates to a miniature X-ray source device connected to a distal end of a guiding wire for insertion towards a desired location within an animal body for effecting radiation therapy, said X-ray source device at least comprising a vacuum tube containing a cathode and an anode spaced apart at some distance from each other; emitting means for emitting free electrons from the cathode; electric field generating means for applying during use a high-voltage electric field between said cathode and said anode for accelerating said emitted free electrons towards said anode; a getter material located in a high-voltage electric field free region in said vacuum tube; wherein said vacuum tube being at least partly transparent to X-ray radiation emitted by said anode. It is necessary to locate the getter material inside the vacuum tube at a location, where no electric field between the anode and cathode exits. An essentially electric field free location of the getter material is required as therefore the getter would not present any internal electrical problems associated with surface arcing or breakdown. To this end, in order to benefit from the use of a getter material inside the vacuum tube for improving the vacuum level inside as well as avoiding any electrical problems as mentioned above and to obtain an improved miniature X-ray tube source device having reduced constructional dimensions according to the invention said cathode is arranged for shielding said getter material from said high-voltage electric field.

Abstract translation: 本发明涉及连接到导丝线的远端的微型X射线源装置，用于插入到动物体内的所需位置以进行放射治疗，所述X射线源装置至少包括含有阴极的真空管 以及在彼此间隔一定距离的阳极; 用于从阴极发射自由电子的发射装置; 电场产生装置，用于在使用期间施加所述阴极和所述阳极之间的高压电场，用于将所述发射的自由电子加速到所述阳极; 位于所述真空管中的高压无电场区域中的吸气剂材料; 其中所述真空管对于由所述阳极发射的X射线辐射至少部分透明。 必须将吸气剂材料定位在真空管内的阳极和阴极之间没有电场的位置。 因此，吸气剂材料基本上无电场的位置是必需的，因此吸气剂不会呈现与表面起弧或击穿相关的任何内部电气问题。 为此，为了在真空管内部使用吸气材料以改善内部的真空度以及避免如上所述的任何电气问题，并且获得具有减小的结构的改进的微型X射线管源装置 根据本发明的尺寸，所述阴极被布置用于从所述高压电场屏蔽所述吸气材料。