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70 条记录 (耗时 0.035 秒)

    COMPOSITIONS AND METHODS FOR DETECTION, PREVENTION, AND TREATMENT OF ANTHRAX AND OTHER INFECTIOUS DISEASES
    31.
    发明申请
    COMPOSITIONS AND METHODS FOR DETECTION, PREVENTION, AND TREATMENT OF ANTHRAX AND OTHER INFECTIOUS DISEASES 有权
    用于检测，预防和治疗其他感染性疾病的组合物和方法

    公开(公告)号：US20100291092A1

    公开(公告)日：2010-11-18

    申请号：US12701149

    申请日：2010-02-05

    申请人： Thomas Kozel ,  William Murphy ,  Suzanne Brandt ,  Bruce R. Blazar ,  Julie A. Lovchik ,  Peter Thorkildson ,  Ann Percival ,  C. Richard Lyons

    发明人： Thomas Kozel ,  William Murphy ,  Suzanne Brandt ,  Bruce R. Blazar ,  Julie A. Lovchik ,  Peter Thorkildson ,  Ann Percival ,  C. Richard Lyons

    IPC分类号： A61K39/395 ,  C07K16/28 ,  G01N33/53 ,  A61P31/04

    CPC分类号： G01N33/56911 ,  G01N33/68 ,  G01N2333/32

    摘要： Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods for immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused by Bacillus anthracis or other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.

    摘要翻译： 用于检测，预防或治疗炭疽或其他传染病的组合物和方法。 一方面，本发明提供了用于免疫人或动物针对炭疽芽孢杆菌或其他包裹的病原体的方法。 所述方法包括向人或动物施用目的病原体的荚膜多肽和CD40激动剂。 荚膜多肽或CD40激动剂以可以在人或动物中针对感兴趣的病原体引起免疫保护反应的量或频率施用。 另一方面，本发明提供了使用被动免疫与抗荚膜多肽抗体来预防或治疗由炭疽芽孢杆菌或其他病原体引起的感染的方法。 另一方面，本发明提供了通过检测血清或其他生物样品中的荚膜多肽来诊断炭疽的方法。

    In-situ generation of peroxides in petroleum streams
    33.
    发明申请
    In-situ generation of peroxides in petroleum streams 审中-公开
    在石油流中原位生成过氧化物

    公开(公告)号：US20070140950A1

    公开(公告)日：2007-06-21

    申请号：US11303539

    申请日：2005-12-16

    申请人： Thomas Palmer ,  William Murphy ,  Christ Wright

    发明人： Thomas Palmer ,  William Murphy ,  Christ Wright

    IPC分类号： C01B15/00

    CPC分类号： C10G27/04 ,  C10G27/12

    摘要： This invention relates to a method for generating peroxides in petroleum streams. More particularly, peroxides are generated in-situ by combining the petroleum stream with a high neutralization number (HNN) crude and adding an oxygen-containing stream. HNN crudes contain molecules sufficient for peroxide generation.

    摘要翻译： 本发明涉及在石油流中产生过氧化物的方法。 更具体地说，通过将石油流与高中和数（HNN）原油混合并加入含氧流原位产生过氧化物。 HNN原油含有足够的过氧化物产生的分子。

    Selective ring opening by oxidation process
    34.
    发明申请
    Selective ring opening by oxidation process 审中-公开
    通过氧化工艺选择性开环

    公开(公告)号：US20070138054A1

    公开(公告)日：2007-06-21

    申请号：US11303511

    申请日：2005-12-16

    申请人： Thomas Palmer ,  William Murphy

    发明人： Thomas Palmer ,  William Murphy

    IPC分类号： C10G73/06 ,  C10G47/24 ,  C10G47/02

    CPC分类号： C10G27/10 ,  C10G27/04 ,  C10G53/14 ,  C10G67/12

    摘要： This invention relates to the selective ring opening of naphthenic and aromatic rings, and more particularly, to any petroleum or hydrocarbon streams derived from crudes containing naphthene and aromatic species. The rings may be selectively ring opened using an oxidation catalyst in the presence of an oxygen

    摘要翻译： 本发明涉及环烷和芳环的选择性开环，更具体地说，涉及衍生自含有环烷烃和芳族物质的原油的任何石油或烃流。 可以在氧的存在下使用氧化催化剂选择性地环开环

    Method and system for delivering nucleic acid into a target cell
    35.
    发明申请
    Method and system for delivering nucleic acid into a target cell 有权
    将核酸输送到靶细胞的方法和系统

    公开(公告)号：US20070092906A1

    公开(公告)日：2007-04-26

    申请号：US11583223

    申请日：2006-10-19

    申请人： William Murphy ,  Siyoung Choi

    发明人： William Murphy ,  Siyoung Choi

    IPC分类号： C12Q1/68 ,  C12M3/00 ,  C12N5/08

    CPC分类号： C12N15/64 ,  B82Y30/00 ,  C12N15/87

    摘要： Controlled delivery of nucleic acid into adhered of cells is achieved by immobilizing the nucleic acid and the cells to a substrate. Improved control over delivery is achieved by immobilizing the nucleic acid to the substrate via complimentary DNA binding interactions with an oligonucleotide linker.

    摘要翻译： 通过将核酸和细胞固定在底物上来实现将核酸控制递送到细胞粘附中。 通过经由与寡核苷酸接头的互补DNA结合相互作用将核酸固定到底物来实现改善对递送的控制。

    In-line filter for tubing
    38.
    发明授权
    In-line filter for tubing 失效
    管道过滤器

    公开(公告)号：US5545242A

    公开(公告)日：1996-08-13

    申请号：US277071

    申请日：1994-07-19

    申请人： Michael Whitlock ,  William Murphy

    发明人： Michael Whitlock ,  William Murphy

    IPC分类号： B01D46/00 ,  B01D46/10 ,  B01D46/52 ,  F16L55/24 ,  B01D35/02

    CPC分类号： B01D46/0012 ,  B01D46/10 ,  F16L55/24 ,  B01D2201/34 ,  B01D2271/022

    摘要： An in-line filter includes a filter element sandwiched between two gaskets. A sealing portion is disposed between the gaskets to forming a seal around a periphery of the filter element. The filter can be disposed inside a standard type of tubing connector, and a seal can be formed between the gaskets and opposing sealing surfaces of the tubing connector. The gaskets may directly contact the sealing surfaces of the tubing connector, or sealing members may be disposed between the gaskets and the sealing surfaces.

    摘要翻译： 在线过滤器包括夹在两个衬垫之间的过滤元件。 密封部分设置在垫圈之间以围绕过滤元件的周边形成密封。 过滤器可以设置在标准类型的管连接器内，并且可以在垫圈和管连接器的相对的密封表面之间形成密封。 垫圈可以直接接触管连接器的密封表面，或者密封构件可以设置在垫圈和密封表面之间。

    Horseshoe full pad
    40.
    发明授权
    Horseshoe full pad 失效
    马蹄全垫

    公开(公告)号：US4513825A

    公开(公告)日：1985-04-30

    申请号：US573063

    申请日：1984-01-23

    申请人： William Murphy

    发明人： William Murphy

    IPC分类号： A01L7/02

    CPC分类号： A01L7/02

    摘要： A horseshoe full pad to be interposed between a metal horseshoe and the hoof is made of an energy absorbing microcellular urethane foam having a tough outer skin. The pad is characterized by having a central layer or sheet which covers and can be trimmed to the hoof. Stabilizer bars and heel shock reducers are molded into the turf side of the pad and rise to about the level of the horseshoe so that they along with the shoe take up and absorb some of the shock. A frog pad may be molded into the hoof side of the pad to further protect and/or stimulate it.

    摘要翻译： 夹在金属马蹄和蹄之间的马掌全垫由具有坚韧外皮的能量吸收微孔聚氨酯泡沫制成。 垫的特征在于具有覆盖并可以修剪到蹄的中心层或片。 稳定杆和脚跟减震器被模制到垫的草皮侧，并且上升到马蹄形的高度，使得它们与鞋一起吸收并吸收一些冲击。 青蛙垫可以模制到垫的蹄侧以进一步保护和/或刺激它。