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31.发明授权Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders 有权用于递送用于治疗鼻窦炎和其他疾病的治疗物质的装置和方法公开(公告)号：US07410480B2
公开(公告)日：2008-08-12
申请号：US11234395
申请日：2005-09-23
申请人： Ketan P. Muni , Hung V. Ha , Joshua Makower , John H. Morriss , John Y. Chang , William M. Facteau , Amrish Jayprakash Walke
发明人： Ketan P. Muni , Hung V. Ha , Joshua Makower , John H. Morriss , John Y. Chang , William M. Facteau , Amrish Jayprakash Walke
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61B5/064 , A61B5/411 , A61B5/416 , A61B17/24 , A61B17/320725 , A61B17/320758 , A61B17/320783 , A61B17/3478 , A61B34/20 , A61B90/361 , A61B2017/22061 , A61B2034/105 , A61B2034/107 , A61B2034/2048 , A61B2034/2051 , A61B2090/365 , A61F2/18 , A61F2/82 , A61F2/92 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2250/0039 , A61M25/007 , A61M25/10 , A61M31/00 , A61M2025/004 , A61M2025/1052
摘要： Devices and methods for delivering drugs and other therapeutic or diagnostic substances to desired locations within the bodies of human or non-human animal subjects. An implantable delivery device comprising a reservoir is initianlly attached to a deliver catheter or delivery tool and is introduced into the body and positioned at a desired site. A therapeutic or diagnostic substance is then introduced into the reservoir and the delivery catheter or deliver tool is then removed, leaving the implantable delivery device implanted within the body. The substance is then delivered from the reservoir at a rate that causes the desire diagnostic or therapeutic effect. Also provided are substance eluting stents that elute substance from a selected surface of the stent (e.g., the outer surface) but not from another surface of the stent (e.g., the inner surface).
摘要翻译： 将药物和其他治疗或诊断物质递送到人类或非人类动物受试者体内所需位置的装置和方法。 包括储存器的可植入递送装置初始地附接到递送导管或递送工具，并且被引入体内并且定位在期望的位置。 然后将治疗或诊断物质引入储存器中，然后移出输送导管或递送工具，使植入式输送装置植入体内。 然后将物质以引起期望诊断或治疗效果的速率从储存器输送。 还提供了从支架的选定表面（例如外表面）洗脱物质而不从支架的另一表面（例如，内表面）洗脱物质的物质洗脱支架。
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公开(公告)号：US20090181074A1
公开(公告)日：2009-07-16
申请号：US12341315
申请日：2008-12-22
申请人： Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
发明人： Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
CPC分类号： A61L26/0023 , A61F13/00017 , A61F2013/00357 , A61K9/006 , A61L15/42 , A61L15/44 , A61L15/58 , A61L15/64 , A61L26/0061 , A61L26/0066 , A61L26/009 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/608 , Y10T156/10
摘要： A method and apparatus for reducing or eliminating pain after surgical procedures related to mucosal tissue, including tonsillectomy, adenoidectomy, or other pharyngeal operations. Certain embodiments provide a biodegradable film or covering that serves as a mechanical barrier to reduce pain caused, for example, by friction between solid food and healing tissue in the first few days after surgery. Some embodiments may include one or more therapeutic substances for locally reducing pain, facilitating healing and/or otherwise treating mucosal tissue at or near a tonsil bed.
摘要翻译： 用于减少或消除与粘膜组织相关的外科手术后疼痛的方法和装置，包括扁桃体切除术，腺样体切除术或其他咽部手术。 某些实施方案提供用作机械屏障的可生物降解的膜或覆盖物，以减少例如在手术后的头几天固体食物与愈合组织之间的摩擦所引起的疼痛。 一些实施方案可以包括一种或多种用于局部减轻疼痛，促进愈合和/或以其他方式治疗扁桃体床处或附近的治疗物质。
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公开(公告)号：US20100152730A1
公开(公告)日：2010-06-17
申请号：US12643788
申请日：2009-12-21
申请人： Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
发明人： Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
CPC分类号： A61L26/0023 , A61F13/00017 , A61F2013/00357 , A61K9/006 , A61L15/42 , A61L15/44 , A61L15/58 , A61L15/64 , A61L26/0061 , A61L26/0066 , A61L26/009 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/608 , Y10T156/10
摘要： A method and apparatus for reducing or eliminating pain after surgical procedures related to mucosal tissue, including tonsillectomy, adenoidectomy, or other pharyngeal operations. Certain embodiments provide a biodegradable film or covering that serves as a mechanical barrier to reduce pain caused, for example, by friction between solid food and healing tissue in the first few days after surgery. Some embodiments include a method for increasing the adhesion between tissue and the film or covering.
摘要翻译： 用于减少或消除与粘膜组织相关的外科手术后疼痛的方法和装置，包括扁桃体切除术，腺样体切除术或其他咽部手术。 某些实施方案提供用作机械屏障的可生物降解的膜或覆盖物，以减少例如在手术后的头几天固体食物与愈合组织之间的摩擦所引起的疼痛。 一些实施例包括用于增加组织和膜或覆盖物之间的粘附的方法。
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34.发明申请Ethmoidotomy System and Implantable Spacer Devices Having Therapeutic Substance Delivery Capability for Treatment of Paranasal Sinusitis 有权具有用于治疗鼻旁窦炎的治疗物质输送能力的乙状腺切开术和可植入间隔装置公开(公告)号：US20080287908A1
公开(公告)日：2008-11-20
申请号：US12100361
申请日：2008-04-09
申请人： Ketan P. Muni , Hung V. Ha , John Y. Chang , Randy S. Chan , Nga K. Van , Joshua Makower , William M. Facteau , Howard L. Levine
发明人： Ketan P. Muni , Hung V. Ha , John Y. Chang , Randy S. Chan , Nga K. Van , Joshua Makower , William M. Facteau , Howard L. Levine
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61B17/24 , A61B17/3415 , A61B17/3417 , A61B17/3421 , A61B2090/062 , A61F11/004 , A61M25/0075 , A61M25/0084 , A61M25/04 , A61M29/02 , A61M31/00 , A61M2025/0681 , A61M2025/105
摘要： Substance delivering spacer devices may comprise expandable reservoirs that are implantable in paranasal sinuses and other cavities, openings and passageways of the body to maintain patency and to provide sustained local delivery of a therapeutic or diagnostic substance. Also provided are sinus penetrator devices and systems for performing ethmoidotomy procedures or for creating other openings in the walls of paranasal sinuses or other anatomical structures.
摘要翻译： 输送间隔物的物质可以包括可植入鼻旁窦和身体的其它空腔，开口和通道的可扩张的储存器，以维持通畅并提供治疗或诊断物质的持续的局部递送。 还提供了用于执行筛管手术或用于在鼻旁窦或其他解剖结构的壁中产生其他开口的窦穿刺装置和系统。
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公开(公告)号：US08894614B2
公开(公告)日：2014-11-25
申请号：US11355512
申请日：2006-02-16
CPC分类号： A61B17/24 , A61B18/12 , A61B2017/22061 , A61B2018/00577 , A61B2018/00601 , A61M25/0041 , A61M25/0108 , A61M25/09 , A61M25/10 , A61M25/1002 , A61M29/02 , A61M31/005 , A61M2025/1086 , A61M2029/025 , A61M2210/0618 , A61M2210/0681 , A61M2230/005
摘要： Devices, systems and methods wherein a dilator, such as a balloon or other expandable member, is positionable within the frontal sinus ostium and adjacent frontal recess and useable to dilate the frontal sinus ostium and substantially all of the frontal sinus recess without requiring repositioning and repeated re-expansion of the dilator. One balloon catheter device of the invention comprises a catheter body that is less than about 50 cm in length (and in some embodiments less than 25 cm in length and a semi-compliant or non-compliant balloon on the catheter body. The balloon may have a working length of about 12 mm to about 30 mm and a width at its widest point when fully inflated of about 2 mm to about 7 mm. Such balloon may be constructed to withstand inflation pressures of about 12 atmospheres. In some embodiments, the dilator is advanced through or over a guide (e.g., guidewire or guide catheter) that has a preformed shape.
摘要翻译： 装置，系统和方法，其中扩张器，例如气囊或其他可扩张构件，可定位在额窦口和相邻的前额槽内，并且可用于扩张额窦口和基本上所有的额叶窦腔，而不需要重新定位并重复 扩张器重新扩张。 本发明的一个气囊导管装置包括导管主体，其长度小于约50cm（并且在一些实施例中小于25cm长，导管主体上具有半顺应性或非顺应性气囊），球囊可具有 约12毫米至约30毫米的工作长度，当完全膨胀约2毫米至约7毫米时，其最宽点处的宽度可以构造成可承受大约12个大气压的充气压力在一些实施例中，扩张器 通过或超过具有预成形形状的引导件（例如，导丝或引导导管）。
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36.发明授权Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis 有权具有用于治疗鼻旁窦炎的治疗物质递送能力的乙状腺切开术系统和可植入间隔装置公开(公告)号：US08864787B2
公开(公告)日：2014-10-21
申请号：US12100361
申请日：2008-04-09
申请人： Ketan P. Muni , Hung V. Ha , John Y. Chang , Randy S. Chan , Nga K. Van , Joshua Makower , William M. Facteau , Howard L. Levine
发明人： Ketan P. Muni , Hung V. Ha , John Y. Chang , Randy S. Chan , Nga K. Van , Joshua Makower , William M. Facteau , Howard L. Levine
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61B17/24 , A61B17/3415 , A61B17/3417 , A61B17/3421 , A61B2090/062 , A61F11/004 , A61M25/0075 , A61M25/0084 , A61M25/04 , A61M29/02 , A61M31/00 , A61M2025/0681 , A61M2025/105
摘要： Substance delivering spacer devices may comprise expandable reservoirs that are implantable in paranasal sinuses and other cavities, openings and passageways of the body to maintain patency and to provide sustained local delivery of a therapeutic or diagnostic substance. Also provided are sinus penetrator devices and systems for performing ethmoidotomy procedures or for creating other openings in the walls of paranasal sinuses or other anatomical structures.
摘要翻译： 输送间隔物的物质可以包括可植入鼻旁窦和身体的其它空腔，开口和通道的可扩张的储存器，以维持通畅并提供治疗或诊断物质的持续的局部递送。 还提供了用于执行筛管手术或用于在鼻旁窦或其他解剖结构的壁中产生其他开口的窦穿刺装置和系统。
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公开(公告)号：US08795713B2
公开(公告)日：2014-08-05
申请号：US12341315
申请日：2008-12-22
申请人： Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
发明人： Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
CPC分类号： A61L26/0023 , A61F13/00017 , A61F2013/00357 , A61K9/006 , A61L15/42 , A61L15/44 , A61L15/58 , A61L15/64 , A61L26/0061 , A61L26/0066 , A61L26/009 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/608 , Y10T156/10
摘要： A method and apparatus for reducing or eliminating pain after surgical procedures related to mucosal tissue, including tonsillectomy, adenoidectomy, or other pharyngeal operations. Certain embodiments provide a biodegradable film or covering that serves as a mechanical barrier to reduce pain caused, for example, by friction between solid food and healing tissue in the first few days after surgery. Some embodiments may include one or more therapeutic substances for locally reducing pain, facilitating healing and/or otherwise treating mucosal tissue at or near a tonsil bed.
摘要翻译： 用于减少或消除与粘膜组织相关的外科手术后疼痛的方法和装置，包括扁桃体切除术，腺样体切除术或其他咽部手术。 某些实施方案提供用作机械屏障的可生物降解的膜或覆盖物，以减少例如在手术后的头几天固体食物与愈合组织之间的摩擦所引起的疼痛。 一些实施方案可以包括一种或多种用于局部减轻疼痛，促进愈合和/或以其他方式治疗扁桃体床处或附近的治疗物质。
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38.发明申请IMPLANTABLE DEVICES AND METHODS FOR TREATING SINUSITIS AND OTHER DISORDERS 审中-公开可治疗装置和治疗神经病和其他疾病的方法公开(公告)号：US20130245608A1
公开(公告)日：2013-09-19
申请号：US13784293
申请日：2013-03-04
申请人： Ketan P. Muni , Hung V. Ha , John H. Morriss , William E. Bolger , Joshua Makower , John Y. Chang , Randy S. Chan , Nga K. Van , Anton G. Clifford
发明人： Ketan P. Muni , Hung V. Ha , John H. Morriss , William E. Bolger , Joshua Makower , John Y. Chang , Randy S. Chan , Nga K. Van , Anton G. Clifford
IPC分类号： A61M29/02
CPC分类号： A61M29/02 , A61B17/1204 , A61B17/12104 , A61B17/12136 , A61B17/24 , A61B17/3417 , A61B17/3421 , A61B17/3478 , A61F11/004 , A61M25/0075 , A61M25/0084 , A61M25/04 , A61M25/10 , A61M2025/105 , A61M2025/1052 , A61M2025/1086 , A61M2210/0618
摘要： Devices, systems and methods for stenting, spacing, draining, ventilating and/or delivering drugs and other therapeutic or diagnostic substances to desired locations within the bodies of human or non-human animal subjects, including methods and systems for treating paranasal sinusitis and ethmoid disease.
摘要翻译： 用于支架，间隔，排泄，通气和/或递送药物和其他治疗或诊断物质到人或非人类动物受试者体内所需位置的装置，系统和方法，包括用于治疗鼻旁窦炎和筛窦疾病的方法和系统 。
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公开(公告)号：US08747389B2
公开(公告)日：2014-06-10
申请号：US11789704
申请日：2007-04-24
申请人： Eric Goldfarb , John Y. Chang , William M. Facteau , Sivette Lam , Hung V. Ha , Isaac J. Kim , Ketan P. Muni
发明人： Eric Goldfarb , John Y. Chang , William M. Facteau , Sivette Lam , Hung V. Ha , Isaac J. Kim , Ketan P. Muni
IPC分类号： A61K9/22
CPC分类号： A61M29/02 , A61M25/0041 , A61M25/0045 , A61M25/0662 , A61M25/09 , A61M25/10 , A61M25/1002 , A61M2025/0046 , A61M2025/0681 , A61M2025/1086 , A61M2029/025 , A61M2210/0618 , A61M2210/0681 , A61M2230/005
摘要： Devices, systems and methods useable for dilating the ostia of paranasal sinuses and/or other passageways within the ear, nose or throat. A dilation catheter device and system is constructed in a manner that facilitates ease of use by the operator and, in at least some cases, allows the dilation procedure to be performed by a single operator. Additionally, the dilation catheter device and system may be useable in conjunction with an endoscope and/or a fluoroscope to provide for easy manipulation and positioning of the devices and real time visualization of the entire procedure or selected portions thereof. In some embodiments, an optional handle may be used to facilitate grasping or supporting a device of the present invention as well as another device (e.g., an endoscope) with a single hand.
摘要翻译： 可用于扩张鼻窦口和/或耳，鼻或咽喉内其他通道的口腔的装置，系统和方法。 膨胀导管装置和系统以促进操作者易于使用的方式构造，并且在至少一些情况下允许扩张程序由单个操作者执行。 此外，扩张导管装置和系统可以与内窥镜和/或荧光镜结合使用，以提供装置的容易操作和定位以及整个程序或其选定部分的实时可视化。 在一些实施例中，可以使用可选的手柄来便于用单手抓握或支撑本发明的装置以及另一装置（例如，内窥镜）。
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40.发明申请Systems and methods for transnasal dilation of passageways in the ear, nose and throat 有权鼻，鼻和喉部通道经鼻扩张的系统和方法公开(公告)号：US20080195041A1
公开(公告)日：2008-08-14
申请号：US11789704
申请日：2007-04-24
申请人： Eric Goldfarb , John Y. Chang , William M. Facteau , Sivette Lam , Hung V. Ha , Isaac J. Kim , Ketan P. Muni
发明人： Eric Goldfarb , John Y. Chang , William M. Facteau , Sivette Lam , Hung V. Ha , Isaac J. Kim , Ketan P. Muni
IPC分类号： A61M29/02
CPC分类号： A61M29/02 , A61M25/0041 , A61M25/0045 , A61M25/0662 , A61M25/09 , A61M25/10 , A61M25/1002 , A61M2025/0046 , A61M2025/0681 , A61M2025/1086 , A61M2029/025 , A61M2210/0618 , A61M2210/0681 , A61M2230/005
摘要： Devices, systems and methods useable for dilating the ostia of paranasal sinuses and/or other passageways within the ear, nose or throat. A dilation catheter device and system is constructed in a manner that facilitates ease of use by the operator and, in at least some cases, allows the dilation procedure to be performed by a single operator. Additionally, the dilation catheter device and system may be useable in conjunction with an endoscope and/or a fluoroscope to provide for easy manipulation and positioning of the devices and real time visualization of the entire procedure or selected portions thereof. In some embodiments, an optional handle may be used to facilitate grasping or supporting a device of the present invention as well as another device (e.g., an endoscope) with a single hand.
摘要翻译： 可用于扩张鼻窦口和/或耳，鼻或咽喉内其他通道的口腔的装置，系统和方法。 膨胀导管装置和系统以促进操作者易于使用的方式构造，并且在至少一些情况下允许扩张程序由单个操作者执行。 此外，扩张导管装置和系统可以与内窥镜和/或荧光镜结合使用，以提供装置的简单操作和定位以及整个程序或其选定部分的实时可视化。 在一些实施例中，可以使用可选的手柄来便于用单手抓握或支撑本发明的装置以及另一装置（例如，内窥镜）。
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