公开(公告)号：US08664221B2

公开(公告)日：2014-03-04

申请号：US13063186

申请日：2009-09-11

申请人： Masatomo Kato ,  Miwa Takai ,  Takahiro Matsuyama ,  Tatsuji Kurose ,  Yumi Hagiwara ,  Kenji Oki ,  Mamoru Matsuda ,  Toshiyuki Mori

发明人： Masatomo Kato ,  Miwa Takai ,  Takahiro Matsuyama ,  Tatsuji Kurose ,  Yumi Hagiwara ,  Kenji Oki ,  Mamoru Matsuda ,  Toshiyuki Mori

IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/495 ,  A61K31/50 ,  C07D241/36

CPC分类号： C07D295/135 ,  A61K31/498 ,  A61K31/5377 ,  C07D241/44 ,  C07D409/12

摘要： The object aims to find a novel pharmacological activity of a novel 1,2,3,4-tetrahydroquinoxaline derivative which contains, as a substituent, a phenyl group having a sulfonic acid ester structure introduced therein. A compound represented by general formula (1) or a salt thereof is useful as a glucocorticoid receptor agonist, particularly as a therapeutic agent for diseases against which a glucocorticoid receptor agonist (e.g., a steroid) is believed to be effective, such as inflammatory bone/joint diseases, inflammatory ophthalmic diseases (inflammatory ophthalmic diseases in the anterior or posterior segment of an eye). R1 represents a group represented by general formula (2a), (3a), (4a) or (5a); R2 represents a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, or the like; R3 represents a lower alkyl group; R4, R5, R6 or R7 represent a halogen atom, a lower alkyl group which may have a substituent, a hydroxy group, a lower alkoxy group which may have a substituent, or the like; and m, n, p or q represents a number of 0, 1 or 2.

摘要翻译： 本发明的目的在于找到引入其中具有磺酸酯结构的苯基作为取代基的新的1,2,3,4-四氢喹喔啉衍生物的新药理活性。 由通式（1）表示的化合物或其盐可用作糖皮质激素受体激动剂，特别是作为糖皮质激素受体激动剂（例如类固醇）被认为有效的疾病的治疗剂，例如炎性骨 /关节疾病，炎症性眼部疾病（眼睛前部或后部的炎症性眼部疾病）。 R1表示通式（2a），（3a），（4a）或（5a）表示的基团。 R 2表示可以具有取代基的低级烷基，可以具有取代基的低级环烷基等。 R3表示低级烷基; R4，R5，R6或R7表示卤素原子，可以具有取代基的低级烷基，羟基，可以具有取代基的低级烷氧基等; m，n，p或q表示0,1或2的数。

公开(公告)号：US08293512B2

公开(公告)日：2012-10-23

申请号：US13180209

申请日：2011-07-11

申请人： Shigeyuki Yokoyama ,  Kensaku Sakamoto ,  Kenji Oki ,  Takahito Mukai

发明人： Shigeyuki Yokoyama ,  Kensaku Sakamoto ,  Kenji Oki ,  Takahito Mukai

IPC分类号： C12N9/00 ,  C07H21/04

CPC分类号： C12N9/93

摘要： A polypeptide according to the present invention includes: an altered polypeptide obtained by altering an ArgRS, a CysRS, a MetRS, a GlnRS, a GluRS, a LysRS, a TyrRS, or a TrpRS so that an unnatural amino acid is recognized; and an editing polypeptide derived from a PheRS, a LeuRS, an IleRS, a ValRS, an AlaRS, a ProRS, or a ThrRS, the editing polypeptide having been either inserted between a Rossman-fold N domain and a Rossman-fold C domain that exist in the altered polypeptide, or bound to an N terminal of the altered polypeptide. Thus provided are a new aaRS that exhibits high substrate specificity to an unnatural amino acid and a technique that involves the use of such an aaRS.

摘要翻译： 根据本发明的多肽包括：通过改变ArgRS，CysRS，MetRS，GlnRS，GluRS，LysRS，TyrRS或TrpRS获得的改变的多肽，使得识别出非天然氨基酸; 和衍生自PheRS，LeuRS，IleRS，ValRS，AlaRS，ProRS或ThrRS的编辑多肽，所述编辑多肽已插入Rossman折叠N结构域和Rossman折叠C结构域之间， 存在于改变的多肽中，或者与改变的多肽的N末端结合。 因此提供了对非天然氨基酸表现出高底物特异性的新aaRS和涉及使用这种aaRS的技术。

公开(公告)号：US07745203B2

公开(公告)日：2010-06-29

申请号：US11045646

申请日：2005-01-31

申请人： Sadato Hongo ,  Minoru Ishikawa ,  Takiji Ishimura ,  Shigeru Wakayama ,  Shinji Yanaga ,  Kenji Oki ,  Jun Okada

发明人： Sadato Hongo ,  Minoru Ishikawa ,  Takiji Ishimura ,  Shigeru Wakayama ,  Shinji Yanaga ,  Kenji Oki ,  Jun Okada

IPC分类号： C12M1/00 ,  C12M1/34 ,  C12M3/00

CPC分类号： G01N33/5438

摘要： A base sequence detection apparatus is provided with a channel formed on a base sequence detection chip. Working electrodes are formed along the channel and include a probe immobilized thereon, counter electrodes are formed on the inner surface of the channel and, reference electrodes are formed on the inner surface of the channel. An introduction port introduces solution or air from the upstream side of the channel, a delivery port delivers the solution or air in the channel, and the sample is injected into the channel through a sample injection port.

摘要翻译： 碱基序列检测装置具有形成在基序列检测芯片上的信道。 沿通道形成工作电极，并且包括固定在其上的探针，在通道的内表面上形成相对电极，并且在通道的内表面上形成参考电极。 引入端口从通道的上游侧引入溶液或空气，输送口将溶液或空气输送到通道中，并且样品通过样品注入口注入通道。

公开(公告)号：US07194985B2

公开(公告)日：2007-03-27

申请号：US11227893

申请日：2005-09-15

申请人： Karou Wachigai ,  Kenji Oki

发明人： Karou Wachigai ,  Kenji Oki

IPC分类号： F01P7/14 ,  F01P5/10 ,  F02B67/00

CPC分类号： F01P11/04 ,  F01P5/10 ,  F01P7/16 ,  F01P2050/16

摘要： An engine cooling structure for a water cooled engine includes water pump and a thermostat. The water pump pumps coolant to a water jacket of the engine. The water pump and thermostat are provided on a cover member installed on an outside of a crankcase of the engine, and a coolant passage, which communicates with the water jacket through the water pump from the thermostat, is integrally formed in the cover member, so as to obtain arrangement of the cooling structure that is efficient in terms of space. The engine cooling structure increases the degree of freedom of layout around a cylinder head by keeping the projection amount on a side of the cylinder head small, simplifies the piping construction, and reduces the number of assembly steps.

摘要翻译： 水冷发动机的发动机冷却结构包括水泵和恒温器。 水泵将冷却剂泵送到发动机的水套。 水泵和恒温器设置在安装在发动机曲轴箱外侧的盖构件上，并且通过水泵从恒温器与水套连通的冷却剂通道一体形成在盖构件中，因此 以获得在空间方面有效的冷却结构的布置。 发动机冷却结构通过将气缸盖一侧的突出量保持在较小的状态来增加气缸盖周围的布置自由度，简化了管道结构，并且减少了组装步骤的数量。

公开(公告)号：US07175101B2

公开(公告)日：2007-02-13

申请号：US10796039

申请日：2004-03-10

申请人： Ryuji Moriyama ,  Koji Kobayashi ,  Toyoyuki Yogo ,  Kenji Oki

发明人： Ryuji Moriyama ,  Koji Kobayashi ,  Toyoyuki Yogo ,  Kenji Oki

IPC分类号： G05D23/00 ,  F01P7/14 ,  F01P1/04

CPC分类号： G05D23/1333 ,  F01P7/16 ,  F01P2070/00

摘要： A thermostat mounting structure capable of reliably positioning an embedded thermostat and ensuring high sealability. A coolant channel is formed in a casing. An embedding hole is formed in the casing across the coolant channel. A thermostat includes a cylindrical valve body with a surrounding wall having an entry aperture and an exit aperture. A valving element for advancing and retracting to open and close the entry aperture and the exit aperture. The thermostat is inserted into the embedding hole so that both apertures face the coolant channel. A cover member for covering the embedding hole via a circular rubber seal seated in a groove of the cover member and for fixing the thermostat. A positioning structure for positioning the thermostat to a side of the cover member.

摘要翻译： 恒温器安装结构，能够可靠地定位嵌入式恒温器并确保高密封性。 冷却剂通道形成在壳体中。 在套管中形成一个嵌入孔穿过冷却剂通道。 恒温器包括具有带入口孔和出口孔的周围壁的圆柱形阀体。 用于前进和后退以打开和关闭入口孔和出口孔的阀元件。 恒温器插入到嵌入孔中，使得两个孔面对冷却剂通道。 盖构件，用于通过位于盖构件的凹槽中的环形橡胶密封件覆盖嵌入孔并固定恒温器。 一种定位结构，用于将恒温器定位在盖构件的一侧。

公开(公告)号：US20060007588A1

公开(公告)日：2006-01-12

申请号：US11013080

申请日：2004-12-15

申请人： Kenji Oki

发明人： Kenji Oki

IPC分类号： G11B21/02

CPC分类号： G11B5/59633 ,  G11B5/59666

摘要： A two-step self-servowriting process first writes an intermediate pattern based on a reference pattern, and then writes a final pattern based on the intermediate pattern, wherein the reference pattern can be a printed media or a spiral pattern. Such an approach can be utilized to reduce the noise/runout, eliminate timing eccentricity, and increase the sample rate of the final pattern. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

公开(公告)号：US20050109321A1

公开(公告)日：2005-05-26

申请号：US10970858

申请日：2004-09-27

申请人： Kenichiro Ikeda ,  Kenji Oki ,  Nobuhiro Shimada

发明人： Kenichiro Ikeda ,  Kenji Oki ,  Nobuhiro Shimada

IPC分类号： B62J9/00 ,  B60K13/02 ,  B62J99/00 ,  B62M7/02 ,  F02B15/00 ,  F02F1/42 ,  F02M35/10 ,  F02M35/16 ,  F02M69/00 ,  F02M69/04

CPC分类号： F02M35/10216 ,  F02M35/162 ,  F02M69/044

摘要： A fuel injection device is installed in a cylinder head of an internal combustion engine in such a manner that a fuel injection port thereof faces a curved intake passage formed in the cylinder head. Fuel is injected from the fuel injection device directly toward a wall surface of the intake passage without aiming at an intake port.

摘要翻译： 燃料喷射装置安装在内燃机的气缸盖中，使得其燃料喷射口面对形成在气缸盖中的弯曲的进气通道。 燃料从燃料喷射装置直接朝向进气通道的壁面喷射，而不瞄准进气口。

公开(公告)号：US4714056A

公开(公告)日：1987-12-22

申请号：US760306

申请日：1985-07-29

申请人： Takumi Tottori ,  Kenji Oki ,  Kazuo Ooyama ,  Toshio Mizushima

发明人： Takumi Tottori ,  Kenji Oki ,  Kazuo Ooyama ,  Toshio Mizushima

IPC分类号： F02B27/06 ,  F02B75/02

CPC分类号： F02B27/06 ,  F02B2075/025 ,  Y02T10/146

摘要： A two-cycle engine includes a cylinder block having at least one pair of first and second cylinders, the first and second cylinders having a pair of first and second exhaust ports, respectively. A pair of first and second pistons are received respectively in the first and second cylinders for reciprocal movement therealong, each of the exhaust ports being selectively closed and opened by a respective one of the pistons during the movement thereof along a respective one of the cylinders. The first and second pistons are operatively connected to a crankshaft in such a manner that the first and second pistons are reciprocable 180.degree. out of phase along the respective cylinders. A final portion of the duration of opening of one of the exhaust ports overlaps an initial portion of the duration of opening of the other. An exhaust passage has a communicating portion communicating the first and second exhaust ports with each other adjacent thereto.

摘要翻译： 双冲程发动机包括具有至少一对第一和第二气缸的气缸体，第一和第二气缸分别具有一对第一和第二排气口。 一对第一和第二活塞分别容纳在第一和第二气缸中，用于在其上往复运动，每个排气口在相应的一个活塞的运动期间由相应的一个活塞选择性地关闭和打开。 第一和第二活塞以这样的方式可操作地连接到曲轴，使得第一和第二活塞沿相应的气缸往复运动180°异相。 一个排气口的打开持续时间的最后部分与另一个排气口的打开持续时间的初始部分重叠。 排气通道具有使第一和第二排气口彼此相邻连通的连通部。