公开(公告)号：US3930851A

公开(公告)日：1976-01-06

申请号：US455797

申请日：1974-03-28

申请人： Hisatake Ono ,  Syu Watarai ,  Harumi Katsuyama

发明人： Hisatake Ono ,  Syu Watarai ,  Harumi Katsuyama

IPC分类号： G03G5/06 ,  G03G5/07 ,  G03G13/22

CPC分类号： G03G5/0661 ,  G03G5/065 ,  G03G5/071 ,  Y10S430/163

摘要： An electrophotographic member comprising a resin binder and an organic photoconductive composition and a process using the electrophotographic member, the composition consisting essentially of a compound of the formula (A), its dimeric compound or its polymeric compound: ##SPC1##Whereim R.sub.1 is hydrogen atom, halogen atom, alkyl group having 1 to 4 carbon atoms, alkoxy group having 1 to 4 carbon atoms, alkoxycarbonyl group having alkyl group 1 to 4 carbon atoms, nitro group, alkylene group having 1 to 3 carbon atoms which is capable of forming a bis-compound, or a bond which is capable of forming a bis-compound, R.sub.2 is hydrogen atom, hydroxyl group, alkoxycarbonyl group having alkyl group of 1 to 4 carbon atoms, cyano or phenyl group, R is substituted phenyl group (where substituted group is hydrogen atom, halogen atom, alkyl group having 1 to 4 carbon atoms, or alkoxy group having 1 to 4 carbon atoms), alkylene group having 1 to 3 carbon atoms which is capable of forming a bis-compound, phenylene group which is capable of forming a bis-compound, or a bond which is capable of forming a bis-compound, and m is an integer from 1 to 4.

公开(公告)号：US5508173A

公开(公告)日：1996-04-16

申请号：US373885

申请日：1995-01-17

申请人： Yoshikazu Amano ,  Kazuya Kawasaki ,  Harumi Katsuyama

发明人： Yoshikazu Amano ,  Kazuya Kawasaki ,  Harumi Katsuyama

IPC分类号： G01N31/22 ,  C12Q1/00 ,  G01N33/52 ,  C12Q1/28 ,  C12Q1/26 ,  C12Q1/52

CPC分类号： G01N33/525 ,  G01N33/526

摘要： A multilayer analytical element for measuring enzyme activity in a liquid sample such as a body fluid which is less affected by intrinsic pyruvic acid contained in the liquid sample is disclosed. The analytical element comprises a support, a reagent layer, an optionally provided other layer, and a porous spreading layer. The reagent layer and/or the optionally provided other layer contain pyruvic acid oxidase. The characteristic feature of the analytical element lies in that the spreading layer has a specific void volume in the range of 3-15 .mu.l/cm.sup.2.

摘要翻译： 公开了一种用于测量液体样品中的酶活性的多层分析元件，所述液体样品例如体液中较少受到液体样品中所含的固有丙酮酸的影响。 分析元件包括载体，试剂层，任选提供的其它层和多孔扩散层。 试剂层和/或任选提供的其它层含有丙酮酸氧化酶。 分析元件的特征在于扩散层具有在3-15μml/ cm 2范围内的特定空隙体积。

公开(公告)号：US5183741A

公开(公告)日：1993-02-02

申请号：US603243

申请日：1990-10-22

申请人： Fuminori Arai ,  Harumi Katsuyama

发明人： Fuminori Arai ,  Harumi Katsuyama

IPC分类号： C12Q1/26

CPC分类号： C12Q1/26 ,  Y10S435/805

摘要： An integral multilayer element for chemical analysis utilizing an oxidase enzyme reaction system is prepared having in the following order:(a) a porous spreading layer;(b) an oxygen-permeable, protein-impermeable light-blocking layer;(c) an oxidase-containing layer;(d) an indicator layer containing peroxidase and a hydrogen peroxide indicator showing detectable change in the presence of peroxidase and hydrogen peroxide; and(e) a water-impermeable, light-transmissive support. The oxidase in the oxidase-containing layer is preferably glucose oxidase to provide a multilayer element for glucose determination. This multilayer element shortens the analytical time, widens the measurable concentration range of the analyte and improves accuracy.

摘要翻译： 按照以下顺序制备用于利用氧化酶反应体系的化学分析的整体多层元件：（a）多孔扩散层; （b）透氧的蛋白质不透过的遮光层; （c）含氧化酶层; （d）包含过氧化物酶和过氧化氢指示剂的指示剂层，显示过氧化物酶和过氧化氢存在下可检测的变化; 和（e）不透水的透光支架。 氧化酶层中的氧化酶优选为葡萄糖氧化酶，以提供用于葡萄糖测定的多层元件。 该多层元件缩短了分析时间，扩大了分析物的可测量浓度范围，提高了精度。

公开(公告)号：US5006458A

公开(公告)日：1991-04-09

申请号：US135670

申请日：1987-12-21

申请人： Keiko Kato ,  Shigeki Kageyama ,  Yoshikazu Amano ,  Fuminori Arai ,  Harumi Katsuyama

发明人： Keiko Kato ,  Shigeki Kageyama ,  Yoshikazu Amano ,  Fuminori Arai ,  Harumi Katsuyama

IPC分类号： G01N31/22 ,  C12Q1/00 ,  C12Q1/32 ,  G01N33/52

CPC分类号： G01N33/525 ,  Y10S435/805 ,  Y10S436/81 ,  Y10S436/904

摘要： A dry-type analytical element suitable for measuring enzyme activity of in a liquid sample, characterized by incorporating a polyacrylamide, polymethacrylamide or their derivatives into at least one water-permeable layer. The background concentration of the dry-type analytical element exhibits minimal increase even under a fluorescent light, and allows an accurate measured value to be easily obtained.

公开(公告)号：USH622H

公开(公告)日：1989-04-04

申请号：US195238

申请日：1988-05-18

申请人： Shigeki Kageyama ,  Kazuya Kawasaki ,  Harumi Katsuyama

发明人： Shigeki Kageyama ,  Kazuya Kawasaki ,  Harumi Katsuyama

IPC分类号： C12Q1/50

CPC分类号： C12Q1/50

摘要： In a dry analytical element for the determination of creatine kinase enzymatic activity is disclosed, comprising at least one porous medium and at least one water permeable layer having a liquid contact relation with the porous medium, the porous medium or the water permeable layer contains creatine phosphoric acid, ADP, a thiol compound as a creatine kinase activation agent, glucose, hexokinase, G6PDH, NAD.sup.+, an electron transmission agent and a formazane dye forming tetrazolium salt, the improvement wherein at least one water permeable layer having a liquid contact relation with the porous medium contains a formazane dye forming tetrazolium salt and not more than 16 g/m.sup.2 of gelatin.

公开(公告)号：US4786595A

公开(公告)日：1988-11-22

申请号：US858545

申请日：1986-04-29

申请人： Fuminori Arai ,  Takushi Miyazako ,  Harumi Katsuyama

发明人： Fuminori Arai ,  Takushi Miyazako ,  Harumi Katsuyama

IPC分类号： C12Q1/26 ,  C12Q1/40 ,  C12Q1/60 ,  G01N31/22 ,  G01N33/52 ,  G01N21/77 ,  G01N33/546

CPC分类号： C12Q1/26 ,  C12Q1/40 ,  C12Q1/60 ,  G01N31/22 ,  G01N33/525 ,  Y10S436/805

摘要： An analytical element for quantitative analysis of analyte contained in a body fluid or the like, which has at least one reagent layer comprising a reactive reagent and a binder, characterized in that a portion or whole of the binder is a polycarboxylic acid carrying a nonionic surface active agent attached through ester linkage to at least a portion of the carboxyl groups contained therein.

摘要翻译： 用于定量分析包含在体液等中的分析物的分析元件，其具有至少一个包含反应性试剂和粘合剂的试剂层，其特征在于，所述粘合剂的一部分或全部是携带非离子表面的多元羧酸 活性剂通过酯键连接至其中所含羧基的至少一部分。

公开(公告)号：US4721670A

公开(公告)日：1988-01-26

申请号：US745914

申请日：1985-06-18

申请人： Chiaki Osada ,  Harumi Katsuyama

发明人： Chiaki Osada ,  Harumi Katsuyama

IPC分类号： G01N33/52 ,  C12Q1/28 ,  G01N31/22 ,  G01N33/48 ,  C07D403/00 ,  G01N33/00

CPC分类号： C12Q1/28 ,  C12Q2326/00 ,  Y10S435/805 ,  Y10S435/81 ,  Y10T436/206664

摘要： A novel imidazole derivative type reagent for analysis of hydrogen peroxide, a method of analysis of hydrogen peroxide using the same, a method of analysis of peroxidase using the same, and a multilayer chemicalanalytical element containing the same are disclosed.The imidazole derivative has the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 represent an aryl group or a substituted aryl group, and R.sup.1 and R.sup.2 are identical with or different from each other, and R.sup.3 represents 2- or 3-pyrrolyl group, a substituted 2- or 3-pyrrolyl group, 2- or 3-indolyl group, or a substituted 2- or 3-indolyl group.

摘要翻译： 公开了一种用于分析过氧化氢的新型咪唑衍生物试剂，使用该过氧化氢的过氧化氢的分析方法，使用该过氧化物酶的分析方法和含有该过氧化物的多层化学分析元素。 咪唑衍生物具有式（I）：其中R 1和R 2表示芳基或取代的芳基，并且R 1和R 2彼此相同或不同，并且R 3表示2-或3 吡咯基，取代的2-或3-吡咯基，2-或3-吲哚基，或取代的2-或3-吲哚基。

公开(公告)号：US4452887A

公开(公告)日：1984-06-05

申请号：US389344

申请日：1982-06-17

申请人： Masao Kitajima ,  Fuminori Arai ,  Harumi Katsuyama

发明人： Masao Kitajima ,  Fuminori Arai ,  Harumi Katsuyama

IPC分类号： C12Q1/26 ,  C12Q1/00 ,  C12Q1/28 ,  C12Q1/54 ,  G01N33/52 ,  G01N33/66

CPC分类号： C12Q1/54 ,  G01N33/526 ,  Y10S435/805

摘要： In a dry-type multilayer liquid analysis material for glucose determination composed of a transparent water-impermeable support having formed thereon in sequence at least a reagent layer containing a reactive component forming a detectable material by the action of hydrogen peroxide, a non-porous light-shielding layer, and a porous spreading layer, the coloring efficiency for colorimetry using the liquid analysis material is improved by incorporating a glucose oxidase enzyme in at least one layer disposed above the reagent layer.

摘要翻译： 在用于葡萄糖测定的干式多层液体分析材料中，其由透明的不透水支持体组成，其中至少在其上形成有通过过氧化氢的作用形成可检测材料的反应性成分的试剂层，非多孔光 并且多孔扩散层，通过在设置在试剂层上方的至少一层中并入葡萄糖氧化酶来提高使用液体分析材料的比色法的着色效率。

公开(公告)号：US4435362A

公开(公告)日：1984-03-06

申请号：US441062

申请日：1982-11-12

申请人： Harumi Katsuyama ,  Masaaki Terashima

发明人： Harumi Katsuyama ,  Masaaki Terashima

IPC分类号： G01N33/52 ,  G01N33/68 ,  G01N21/78

CPC分类号： G01N33/526 ,  G01N33/6833

摘要： An improved integral multilayer analytical element for the assay of total protein contained in liquid sample. The element comprises a transparent support on which a reagent layer and a spreading layer are superposed. The feature of the element exists in the reagent layer comprising potassium sodium tartarate, a cupric salt, a basic compound providing a pH in excess of about 12.0 in the element under conditions of use thereof, an alkali-proof polymer and an alkali metal ion complexing agent.

摘要翻译： 改进的整体多层分析元素，用于测定液体样品中所含的总蛋白质。 该元件包括其上叠加有试剂层和扩散层的透明载体。 该元件的特征存在于包含钾酒石酸钠，铜盐，在使用条件下元素中超过约12.0的pH的碱性化合物的试剂层，耐碱聚合物和碱金属离子络合 代理商

公开(公告)号：US4343948A

公开(公告)日：1982-08-10

申请号：US135030

申请日：1980-03-28

申请人： Kouichi Kawamura ,  Harumi Katsuyama ,  Hideo Sato

发明人： Kouichi Kawamura ,  Harumi Katsuyama ,  Hideo Sato

IPC分类号： C07D309/34 ,  C07D335/02 ,  C07D333/08 ,  C07D333/32 ,  C07D333/34

CPC分类号： C07D335/02 ,  C07D309/34

摘要： 2,6-Di-tert-butyl-4-methyl thiopyrylium salt of the formula (I): ##STR1## wherein Z.sup..crclbar. is an anionic function and certain intermediates encountered in its synthesis.

摘要翻译： 式（I）的2,6-二叔丁基-4-甲基硫代吡喃盐：其中Z（ - ）是阴离子官能团，在合成中遇到某些中间体。