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    THERAPY OPTIMIZATION VIA MULTI-DIMENSIONAL MAPPING
    32.
    发明申请
    THERAPY OPTIMIZATION VIA MULTI-DIMENSIONAL MAPPING 有权
    通过多维映射进行治疗优化

    公开(公告)号：US20100268059A1

    公开(公告)日：2010-10-21

    申请号：US12755366

    申请日：2010-04-06

    申请人： Kyungmoo Ryu ,  Stuart Rosenberg ,  Allen Keel ,  Wenbo Hou ,  Thao Thu Nguyen ,  Steve Koh ,  Kjell Noren ,  Michael Yang

    发明人： Kyungmoo Ryu ,  Stuart Rosenberg ,  Allen Keel ,  Wenbo Hou ,  Thao Thu Nguyen ,  Steve Koh ,  Kjell Noren ,  Michael Yang

    IPC分类号： A61B5/05

    CPC分类号： A61B5/042 ,  A61B5/7203 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/37258 ,  A61N1/37264

    摘要： An exemplary method includes accessing cardiac information acquired via a catheter located at various positions in a venous network of a heart of a patient where the cardiac information comprises position information, electrical information and mechanical information; mapping local electrical activation times to anatomic positions to generate an electrical activation time map; mapping local mechanical activation times to anatomic positions to generate a mechanical activation time map; generating an electromechanical delay map by subtracting local electrical activation times from corresponding local mechanical activation times; and rendering at least the electromechanical delay map to a display. Various other methods, devices, systems, etc., are also disclosed.

    摘要翻译： 一种示例性方法包括访问位于患者心脏的静脉网络中的各个位置处的导管获取的心脏信息，其中所述心脏信息包括位置信息，电信息和机械信息; 将局部电激活时间映射到解剖位置以产生电激活时间图; 将局部机械激活时间映射到解剖位置以产生机械激活时间图; 通过从相应的局部机械激活时间减去局部电激活时间来产生机电延迟图; 并将至少机电延迟图呈现给显示器。 还公开了各种其它方法，装置，系统等。

    Closed-loop systems and methods for controlling neurostimulation based on far-field cardiac signals sensed by a spinal cord stimulation device
    35.
    发明授权
    Closed-loop systems and methods for controlling neurostimulation based on far-field cardiac signals sensed by a spinal cord stimulation device 有权
    基于由脊髓刺激装置感测到的远场心脏信号的闭环系统和用于控制神经刺激的方法

    公开(公告)号：US08983604B2

    公开(公告)日：2015-03-17

    申请号：US13838305

    申请日：2013-03-15

    申请人： Allen Keel ,  Stuart Rosenberg ,  Rupinder Bharmi ,  Kyungmoo Ryu ,  Edward Karst ,  Fujian Qu ,  Xiaoyi Min ,  Yelena Nabutovsky

    发明人： Allen Keel ,  Stuart Rosenberg ,  Rupinder Bharmi ,  Kyungmoo Ryu ,  Edward Karst ,  Fujian Qu ,  Xiaoyi Min ,  Yelena Nabutovsky

    IPC分类号： A61N1/365 ,  A61N1/36

    CPC分类号： A61N1/36114 ,  A61N1/36139

    摘要： Techniques are provided for controlling spinal cord stimulation (SCS) or other forms of neurostimulation. Far-field cardiac electrical signals are sensed using a lead of the SCS device and neurostimulation is selectively delivering using a set of adjustable SCS control parameters. Parameters representative of cardiac rhythm are derived from the far-field cardiac electrical signals. The parameters representative of cardiac rhythm are correlated with SCS control parameters to thereby map neurostimulation control settings to cardiac rhythm parameters. The delivery of further neurostimulation is then controlled based on the mapping of neurostimulation control settings to cardiac rhythm parameters to, for example, address any cardiovascular disorders detected based on the far-field cardiac signals. In this manner, a closed loop control system is provided to automatically adjust SCS control parameters to respond to changes in cardiac rhythm such as changes associated with ischemia, arrhythmia or heart failure.

    摘要翻译： 提供了用于控制脊髓刺激（SCS）或其他形式的神经刺激的技术。 使用SCS装置的引线感测远场心电信号，并且神经刺激使用一组可调节的SCS控制参数选择性地递送。 代表心律的参数来源于远场心电信号。 代表心律的参数与SCS控制参数相关，从而将神经刺激控制设置映射到心律参数。 然后基于神经刺激控制设置对心律参数的映射来控制进一步的神经刺激的传递，以例如解决基于远场心脏信号检测的任何心血管疾病。 以这种方式，提供闭环控制系统以自动调整SCS控制参数以响应心律的变化，例如与缺血，心律失常或心力衰竭相关的变化。

    Cardiac resynchronization therapy optimization using vector measurements obtained from realtime electrode position tracking
    36.
    发明授权
    Cardiac resynchronization therapy optimization using vector measurements obtained from realtime electrode position tracking 有权
    使用从实时电极位置跟踪获得的矢量测量的心脏再同步治疗优化

    公开(公告)号：US08527049B2

    公开(公告)日：2013-09-03

    申请号：US12621373

    申请日：2009-11-18

    申请人： Steve Koh ,  Stuart Rosenberg ,  Kyungmoo Ryu ,  Michael Yang ,  Allen Keel

    发明人： Steve Koh ,  Stuart Rosenberg ,  Kyungmoo Ryu ,  Michael Yang ,  Allen Keel

    IPC分类号： A61N1/365 ,  A61B5/05

    CPC分类号： A61N1/3627 ,  A61B5/0422 ,  A61B5/0452 ,  A61N1/36585 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3686

    摘要： An exemplary method includes selecting multiple electrodes located in a patient; acquiring position information during one or more cardiac cycles for the multiple electrodes where the acquiring includes using each of the electrodes for measuring one or more electrical potentials in an electrical localization field established in the patient; calculating one or more vector metrics based on the acquired position information for one or more vectors, each vector defined by two of the multiple electrodes; and analyzing the one or more vector metrics to assess cardiac performance during the one or more cardiac cycles. Various other methods, devices, systems, etc., are also disclosed.

    摘要翻译： 一种示例性方法包括选择位于患者体内的多个电极; 在所述多个电极的一个或多个心动周期期间获取位置信息，其中所述获取包括使用每个所述电极来测量在所述患者中建立的电定位场中的一个或多个电位; 基于所获取的一个或多个向量的位置信息来计算一个或多个矢量度量，每个矢量由所述多个电极中的两个限定; 以及分析所述一个或多个矢量度量以评估所述一个或多个心动周期期间的心脏性能。 还公开了各种其它方法，装置，系统等。

    Electrode and lead stability indexes and stability maps based on localization system data
    38.
    发明授权
    Electrode and lead stability indexes and stability maps based on localization system data 有权
    基于定位系统数据的电极和铅稳定性指标和稳定性图

    公开(公告)号：US08401645B2

    公开(公告)日：2013-03-19

    申请号：US12562003

    申请日：2009-09-17

    申请人： Stuart Rosenberg ,  Thao Thu Nguyen ,  Kyungmoo Ryu ,  Kjell Norén ,  Allen Keel ,  Wenbo Hou ,  Michael Yang

    发明人： Stuart Rosenberg ,  Thao Thu Nguyen ,  Kyungmoo Ryu ,  Kjell Norén ,  Allen Keel ,  Wenbo Hou ,  Michael Yang

    IPC分类号： A61N1/00 ,  A61B5/04

    CPC分类号： A61N1/3702 ,  A61B5/042 ,  A61B5/0424 ,  A61B2560/0276 ,  A61N1/368 ,  A61N1/371

    摘要： A method includes selecting an electrode located in a patient; acquiring position information with respect to time for the electrode where the acquiring uses the electrode for repeatedly measuring electrical potentials in an electrical localization field established in the patient; calculating a stability metric for the electrode based on the acquired position information with respect to time; and deciding if the selected electrode, as located in the patient, has a stable location for sensing biological electrical activity, for delivering electrical energy or for sensing biological electrical activity and delivering electrical energy. Position information may be acquired during one or both of intrinsic or paced activation of a heart and respective stability indexes calculated for each activation type.

    摘要翻译： 一种方法包括选择位于患者体内的电极; 获取相对于所述电极的时间的位置信息，其中所述电极在所述患者中建立的电定位场中使用所述电极重复测量电位; 基于获取的相对于时间的位置信息计算电极的稳定性度量; 并且确定位于患者体内的所选择的电极是否具有用于感测生物电活动的稳定位置，用于传递电能或用于感测生物电活动和递送电能。 位置信息可以在心脏的固有或起搏激活和对于每种激活类型计算的各个稳定性指标的一个或两个期间获取。

    METHODS AND SYSTEMS FOR DETERMINING PACING PARAMETERS BASED ON REPOLARIZATION INDEX
    39.
    发明申请
    METHODS AND SYSTEMS FOR DETERMINING PACING PARAMETERS BASED ON REPOLARIZATION INDEX 审中-公开
    基于复合指数确定PAC参数的方法和系统

    公开(公告)号：US20130035738A1

    公开(公告)日：2013-02-07

    申请号：US13197665

    申请日：2011-08-03

    申请人： Edward Karst ,  Kyungmoo Ryu ,  Stuart Rosenberg ,  Allen Keel

    发明人： Edward Karst ,  Kyungmoo Ryu ,  Stuart Rosenberg ,  Allen Keel

    IPC分类号： A61N1/368

    CPC分类号： A61N1/3684 ,  A61N1/36507

    摘要： Methods and systems are provided for determining pacing parameters for an implantable medical device (IMD). The methods and systems provide electrodes in the right atrium (RA), right ventricle (RV) and left ventricle (LV). The methods and systems sense RV cardiac signals and LV cardiac signals at an RV electrode and an LV electrode, respectively, over multiple cardiac cycles, to collect global activation information. The methods and systems identify a T-wave in the LV cardiac signal. The methods and systems calculate a repolarization index based at least in part on a timing of the T-wave identified in the LV cardiac signal. The methods and systems set at least one pacing parameter based on the repolarization index, wherein the at least one pacing parameter that is set represents at least one of an AV delay, an inter-ventricular interval and an intra-ventricular interval. Optionally, the methods and systems may deliver an RV pacing stimulus at the RV electrode such that the LV cardiac signal sensed thereafter includes the RV pacing stimulus followed by a T-wave. The methods and systems determine a waveform metric such as at least one of a QT interval, T-wave duration, and T-wave amplitude, and utilize the waveform metric to determine as the repolarization index.

    摘要翻译： 提供了用于确定可植入医疗装置（IMD）的起搏参数的方法和系统。 方法和系统在右心房（RA），右心室（RV）和左心室（LV）中提供电极。 方法和系统分别在多个心动周期上检测RV电极和LV电极上的RV心脏信号和LV心脏信号，以收集全局激活信息。 方法和系统识别LV心脏信号中的T波。 所述方法和系统至少部分地基于在LV心脏信号中识别的T波的定时来计算复极化指数。 方法和系统基于复极度指数设置至少一个起搏参数，其中设置的至少一个起搏参数表示AV延迟，心室间间隔和心室间间隔中的至少一个。 任选地，方法和系统可以在RV电极处递送RV起搏刺激，使得之后感测的LV心脏信号包括后跟T波的RV起搏刺激。 方法和系统确定诸如QT间期，T波持续时间和T波幅度中的至少一个的波形度量，并且利用波形度量来确定复极化指数。