-
公开(公告)号：US07943302B2
公开(公告)日：2011-05-17
申请号：US10592171
申请日：2005-03-10
申请人： Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人： Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C07K14/435
CPC分类号： G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要： Human C20ORF23 genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of C20ORF23 are provided.
摘要翻译： 人类C20ORF23基因被鉴定为IGFR途径的调节剂，因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法，包括筛选调节C20ORF23活性的试剂。
-
公开(公告)号：US20090202563A1
公开(公告)日：2009-08-13
申请号：US10592171
申请日：2005-03-10
申请人： Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人： Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
IPC分类号： A61K39/395 , G01N33/68 , G01N33/00 , C12Q1/02 , C12Q1/68 , G01N33/566 , A01K67/027 , C12N5/06
CPC分类号： G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要： Human C20ORF23 genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of C20ORF23 are provided.
摘要翻译： 人类C20ORF23基因被鉴定为IGFR途径的调节剂，因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法，包括筛选调节C20ORF23活性的试剂。
-
公开(公告)号：US20090149413A1
公开(公告)日：2009-06-11
申请号：US12325914
申请日：2008-12-01
IPC分类号： A61K31/7105 , C12Q1/68
CPC分类号： G01N33/57484 , A01K2267/0331 , C07K14/4702 , C12Q1/6886 , C12Q2600/136 , G01N33/566 , G01N33/57407 , G01N2333/4704 , G01N2333/70567 , G01N2333/9121 , G01N2500/10
摘要： Human ROR genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of ROR are provided.
摘要翻译： 人类ROR基因被鉴定为p21途径的调节剂，因此是与缺陷型p21功能相关的疾病的治疗靶点。 提供了用于鉴定p21调节剂的方法，包括筛选调节ROR活性的药剂。
-
公开(公告)号：US20070264268A1
公开(公告)日：2007-11-15
申请号：US10587253
申请日：2005-01-27
申请人： Lori Friedman , Helen Francis-Lang , Annette Parks , Kenneth Shaw , HaiGuang Zhang , Timothy Heuer
发明人： Lori Friedman , Helen Francis-Lang , Annette Parks , Kenneth Shaw , HaiGuang Zhang , Timothy Heuer
IPC分类号： A61K39/00 , A61P35/00 , C12N5/06 , C12Q1/02 , C12Q1/34 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/574
CPC分类号： C12Q1/34 , G01N2500/00
摘要： Human MIGFR genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of MIGFR are provided.
摘要翻译： 人MIGFR基因被鉴定为IGFR途径的调节剂，因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法，包括筛选调节MIGFR活性的药剂。
-
公开(公告)号：US20060101530A1
公开(公告)日：2006-05-11
申请号：US10528032
申请日：2003-09-15
IPC分类号： A01K67/027 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/57484 , A01K2267/0331 , C07K14/4702 , C12Q1/6886 , C12Q2600/136 , G01N33/566 , G01N33/57407 , G01N2333/4704 , G01N2333/70567 , G01N2333/9121 , G01N2500/10
摘要： Human ROR genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of ROR are provided.
摘要翻译： 人类ROR基因被鉴定为p21途径的调节剂，因此是与缺陷型p21功能相关的疾病的治疗靶点。 提供了用于鉴定p21调节剂的方法，包括筛选调节ROR活性的药剂。
-
36.发明申请COMBINATIONS OF PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND CHEMOTHERAPEUTIC AGENTS, AND METHODS OF USE 有权磷酸三辛酯抑制剂化合物和化学治疗剂的组合及使用方法公开(公告)号：US20110223619A1
公开(公告)日：2011-09-15
申请号：US13109670
申请日：2011-05-17
申请人： Marcia Belvin , Lori Friedman , Klaus Hoeflich , Deepak Sampath , Ulka Vijapurkar , Jeffrey Wallin , Leisa Johnson , Mallika Singh , Sonal Patel
发明人： Marcia Belvin , Lori Friedman , Klaus Hoeflich , Deepak Sampath , Ulka Vijapurkar , Jeffrey Wallin , Leisa Johnson , Mallika Singh , Sonal Patel
IPC分类号： G01N33/574 , C12Q1/02
CPC分类号： A61K31/5377 , A61K31/4523 , A61K31/505
摘要： Combinations of PI3K inhibitor compounds having Formulas I and II and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 具有式I和II的PI3K抑制剂化合物的组合和化学治疗剂，包括立体异构体，几何异构体，互变异构体，代谢物及其药学上可接受的盐，可用于治疗过度增殖性疾病如癌症。 公开了将这些组合用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理条件中的这种疾病的方法。
-
公开(公告)号：US07888047B2
公开(公告)日：2011-02-15
申请号：US10592605
申请日：2005-03-10
申请人： Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人： Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号： G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要： Human PDE genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of PDE are provided.
摘要翻译： 人PDE基因被鉴定为IGFR途径的调节剂，因此是与缺陷IGFR功能相关的病症的治疗靶标。提供了鉴定IGFR调节剂的方法，包括筛选调节PDE活性的药剂。
-
公开(公告)号：US20090013416A1
公开(公告)日：2009-01-08
申请号：US10592605
申请日：2005-03-10
申请人： Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人： Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号： G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要： Human PDE genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of PDE are provided
摘要翻译： 人类PDE基因被鉴定为IGFR途径的调节剂，因此是与缺陷IGFR功能相关的病症的治疗靶标。提供了鉴定IGFR调节剂的方法，包括筛选调节PDE活性的药剂
-
公开(公告)号：US20070292349A1
公开(公告)日：2007-12-20
申请号：US10587683
申请日：2005-01-27
申请人： Lori Friedman , Helen Francis-Lang , Annette Parks , Kenneth Shaw , Lynn Bjerke , Timothy Heuer
发明人： Lori Friedman , Helen Francis-Lang , Annette Parks , Kenneth Shaw , Lynn Bjerke , Timothy Heuer
CPC分类号： C12Q1/34 , G01N2500/00
摘要： Human MIGFR genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of MIGFR are provided.
摘要翻译： 人MIGFR基因被鉴定为IGFR途径的调节剂，因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法，包括筛选调节MIGFR活性的药剂。
-
公开(公告)号：US20110086837A1
公开(公告)日：2011-04-14
申请号：US12902062
申请日：2010-10-11
申请人： Marcia Belvin , Iris T. Chan , Lori Friedman , Klaus P. Hoeflich , John Prescott , Jeffrey Wallin
发明人： Marcia Belvin , Iris T. Chan , Lori Friedman , Klaus P. Hoeflich , John Prescott , Jeffrey Wallin
IPC分类号： A61K31/5377 , A61P35/02
CPC分类号： A61K31/5377 , A61K31/4523
摘要： The invention relates methods of treating a patient with locally advanced or metastatic solid tumors with a combination of an inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase or PI3K) and an inhibitor of mitogen activated protein kinase (MEK) described herein.
摘要翻译： 本发明涉及用本文所述的磷脂酰肌醇3-激酶（PI3-激酶或PI3K）抑制剂和丝裂原活化蛋白激酶（MEK）抑制剂的组合治疗患有局部晚期或转移性实体瘤的患者的方法。
-
-
-
-
-
-
-
-
-
搜索结果
52 条记录 (耗时 0.205 秒)
