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1.
公开(公告)号:US07943302B2
公开(公告)日:2011-05-17
申请号:US10592171
申请日:2005-03-10
申请人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
IPC分类号: C12Q1/68 , G01N33/53 , C07H21/04 , C07K14/435
CPC分类号: G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要: Human C20ORF23 genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of C20ORF23 are provided.
摘要翻译: 人类C20ORF23基因被鉴定为IGFR途径的调节剂,因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法,包括筛选调节C20ORF23活性的试剂。
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2.
公开(公告)号:US20090202563A1
公开(公告)日:2009-08-13
申请号:US10592171
申请日:2005-03-10
申请人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
IPC分类号: A61K39/395 , G01N33/68 , G01N33/00 , C12Q1/02 , C12Q1/68 , G01N33/566 , A01K67/027 , C12N5/06
CPC分类号: G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要: Human C20ORF23 genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of C20ORF23 are provided.
摘要翻译: 人类C20ORF23基因被鉴定为IGFR途径的调节剂,因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法,包括筛选调节C20ORF23活性的试剂。
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公开(公告)号:US07888047B2
公开(公告)日:2011-02-15
申请号:US10592605
申请日:2005-03-10
申请人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号: G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要: Human PDE genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of PDE are provided.
摘要翻译: 人PDE基因被鉴定为IGFR途径的调节剂,因此是与缺陷IGFR功能相关的病症的治疗靶标。提供了鉴定IGFR调节剂的方法,包括筛选调节PDE活性的药剂。
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公开(公告)号:US20090013416A1
公开(公告)日:2009-01-08
申请号:US10592605
申请日:2005-03-10
申请人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号: G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要: Human PDE genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of PDE are provided
摘要翻译: 人类PDE基因被鉴定为IGFR途径的调节剂,因此是与缺陷IGFR功能相关的病症的治疗靶标。提供了鉴定IGFR调节剂的方法,包括筛选调节PDE活性的药剂
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公开(公告)号:US20090142272A1
公开(公告)日:2009-06-04
申请号:US11628557
申请日:2005-06-20
申请人: Lori S. Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Lori S. Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号: C12Q1/485 , A61K49/0008 , C12N9/0071 , C12Q1/26 , C12Q1/68 , C12Q1/6886 , C12Y114/11002 , G01N33/574 , G01N33/74 , G01N2500/00 , Y10T436/143333
摘要: Human PFK genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of PFK are provided.
摘要翻译: 人PFK基因被鉴定为IGFR途径的调节剂,因此是与缺陷型IGFR功能相关的病症的治疗靶标。 提供了鉴定IGFR调节剂的方法,包括筛选调节PFK活性的试剂。
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公开(公告)号:US20090028844A1
公开(公告)日:2009-01-29
申请号:US11628560
申请日:2005-06-20
申请人: Lori S. Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Timothy S. Heuer , Lynn Margaret Bjerke
发明人: Lori S. Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Timothy S. Heuer , Lynn Margaret Bjerke
IPC分类号: A61K39/395 , G01N33/00 , C12Q1/02 , C12Q1/68 , C12Q1/48 , A61P31/00 , A61K31/7088 , G01N33/566 , A01K67/027 , C12N5/06
CPC分类号: C12Q1/485 , A61K49/0008 , C12N9/0071 , C12Q1/26 , C12Q1/68 , C12Q1/6886 , C12Y114/11002 , G01N33/574 , G01N33/74 , G01N2500/00 , Y10T436/143333
摘要: Human MIGFR genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of MIGFR are provided.
摘要翻译: 人MIGFR基因被鉴定为IGFR途径的调节剂,因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法,包括筛选调节MIGFR活性的药剂。
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公开(公告)号:US07888048B2
公开(公告)日:2011-02-15
申请号:US11628561
申请日:2005-06-20
申请人: Lori S. Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Timothy S. Heuer , Lynn Margaret Bjerke
发明人: Lori S. Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Timothy S. Heuer , Lynn Margaret Bjerke
CPC分类号: C12Q1/485 , A61K49/0008 , C12N9/0071 , C12Q1/26 , C12Q1/68 , C12Q1/6886 , C12Y114/11002 , G01N33/574 , G01N33/74 , G01N2500/00 , Y10T436/143333
摘要: Human P4HA genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of P4HA are provided.
摘要翻译: 人类P4HA基因被鉴定为IGFR途径的调节剂,因此是与缺陷性IGFR功能相关的疾病的治疗靶点。 提供了鉴定IGFR调节剂的方法,包括筛选调节P4HA活性的药剂。
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公开(公告)号:US20090025096A1
公开(公告)日:2009-01-22
申请号:US11628561
申请日:2005-06-20
申请人: Lori S. Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Timothy S. Heuer , Lynn Margaret Bjerke
发明人: Lori S. Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Timothy S. Heuer , Lynn Margaret Bjerke
CPC分类号: C12Q1/485 , A61K49/0008 , C12N9/0071 , C12Q1/26 , C12Q1/68 , C12Q1/6886 , C12Y114/11002 , G01N33/574 , G01N33/74 , G01N2500/00 , Y10T436/143333
摘要: Human P4HA genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of P4HA are provided.
摘要翻译: 人类P4HA基因被鉴定为IGFR途径的调节剂,因此是与缺陷性IGFR功能相关的疾病的治疗靶点。 提供了鉴定IGFR调节剂的方法,包括筛选调节P4HA活性的药剂。
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公开(公告)号:US07785805B2
公开(公告)日:2010-08-31
申请号:US10587253
申请日:2005-01-27
申请人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , HaiGuang Zhang , Timothy S. Heuer
发明人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , HaiGuang Zhang , Timothy S. Heuer
IPC分类号: G01N33/53
CPC分类号: C12Q1/34 , G01N2500/00
摘要: Human MAN2A genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of MAN2A are provided.
摘要翻译: 人类MAN2A基因被鉴定为IGFR途径的调节剂,因此是与缺陷IGFR功能相关的病症的治疗靶标。提供了鉴定IGFR调节剂的方法,包括筛选调节MAN2A活性的药剂。
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10.
公开(公告)号:US08632962B2
公开(公告)日:2014-01-21
申请号:US10580131
申请日:2004-11-23
申请人: Helen Francis-Lang , Christopher G. Winter , Richard Benn Abegania Ventura , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Helen Francis-Lang , Christopher G. Winter , Richard Benn Abegania Ventura , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号: C12Q1/485 , G01N33/573 , G01N33/57496 , G01N2500/00 , G01N2510/00
摘要: Human PLK genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of PLK are provided.
摘要翻译: 人PLK基因被鉴定为β连环蛋白途径的调节剂,因此是与β-连环蛋白失活功能相关的病症的治疗靶点。 提供了鉴定β连环蛋白调节剂的方法,包括筛选调节PLK活性的试剂。
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