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1.发明申请公开(公告)号：US20100183583A1
公开(公告)日：2010-07-22
申请号：US11993191
申请日：2006-06-20
申请人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
发明人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
IPC分类号： A61K39/395 , G01N33/53 , C12Q1/68 , A01K67/00 , C12N5/02
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human GALK1 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of GALK1 are provided.
摘要翻译： 人GALK1基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的疾病的治疗靶点。 提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节GALK1活性的试剂。
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公开(公告)号：US20070141664A1
公开(公告)日：2007-06-21
申请号：US10535445
申请日：2003-11-24
申请人： Lisa Kadyk , George Francis , Lynn Bjerke
发明人： Lisa Kadyk , George Francis , Lynn Bjerke
CPC分类号： G01N33/6842 , C12N9/1205 , C12Q1/485
摘要： Human CSNK genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of CSNK are provided.
摘要翻译： 人类CSNK基因被鉴定为RAC途径的调节剂，因此是与缺陷型RAC功能相关的疾病的治疗靶点。 提供用于鉴定RAC调节剂的方法，包括筛选调节CSNK活性的试剂。
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3.发明申请公开(公告)号：US20100122354A1
公开(公告)日：2010-05-13
申请号：US11993122
申请日：2006-06-20
申请人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
发明人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human CDC6 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of CDC6 are provided.
摘要翻译： 人CDC6基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的病症的治疗靶点。 提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节CDC6活性的试剂。
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公开(公告)号：US20080095763A1
公开(公告)日：2008-04-24
申请号：US11628636
申请日：2005-06-20
申请人： Mark Maxwell , Michael Ollmann , Timothy Heuer , Lynn Bjerke
发明人： Mark Maxwell , Michael Ollmann , Timothy Heuer , Lynn Bjerke
IPC分类号： C12N5/06 , A01K67/00 , A61K31/70 , C12Q1/02 , C12Q1/68 , G01N33/53 , C12Q1/48 , A61K39/395 , A61P43/00
CPC分类号： G01N33/573 , C12Q1/485 , C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , G01N33/57438 , G01N33/6872 , G01N2500/00 , Y10T436/143333
摘要： Human CDK9 genes are identified as modulators of the IGF pathway, and thus are therapeutic targets for disorders associated with defective IGF function. Methods for identifying modulators of IGF, comprising screening for agents that modulate the activity of CDK9 are provided.
摘要翻译： 人CDK9基因被鉴定为IGF途径的调节剂，因此是与缺陷性IGF功能相关的病症的治疗靶点。 提供了用于鉴定IGF调节剂的方法，包括筛选调节CDK9活性的试剂。
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公开(公告)号：US20070142271A1
公开(公告)日：2007-06-21
申请号：US10535446
申请日：2003-11-24
申请人： Lisa Kadyk , George Francis , Lynn Bjerke , Kim Lickteig
发明人： Lisa Kadyk , George Francis , Lynn Bjerke , Kim Lickteig
IPC分类号： A61K38/17
CPC分类号： G01N33/68 , G01N33/6842 , G01N2333/90 , G01N2500/04
摘要： Human MRAC genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of MRAC are provided.
摘要翻译： 人类MRAC基因被鉴定为RAC途径的调节剂，因此是与缺陷型RAC功能相关的病症的治疗靶点。 提供了鉴定RAC调节剂的方法，包括筛选调节MRAC活性的试剂。
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6.发明申请公开(公告)号：US20070274914A1
公开(公告)日：2007-11-29
申请号：US10556630
申请日：2004-05-13
申请人： Chunyan Song , Michael Ollmann , Kim Lickteig , HaiGuang Zhang , Lynn Bjerke
发明人： Chunyan Song , Michael Ollmann , Kim Lickteig , HaiGuang Zhang , Lynn Bjerke
IPC分类号： A61K49/00 , A61P5/00 , C12N5/02 , C12Q1/42 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/574
CPC分类号： G01N33/5011 , A01K67/0339 , A01K2227/706 , A01K2267/03 , C07K14/47 , C12Q1/42 , G01N33/5008 , G01N33/5041 , G01N33/507 , G01N33/566 , G01N33/74 , G01N2500/10 , G01N2500/20 , G01N2510/00
摘要： Human MPTEN genes are identified as modulators of the PTEN/IGF pathway, and thus are therapeutic targets for disorders associated with defective PTEN/IGF function. Methods for identifying modulators of PTEN/IGF, comprising screening for agents that modulate the activity of MPTEN are provided.
摘要翻译： 人MPTEN基因被鉴定为PTEN / IGF途径的调节剂，因此是与缺陷性PTEN / IGF功能相关的病症的治疗靶点。 提供了用于鉴定PTEN / IGF调节剂的方法，包括筛选调节MPTEN活性的试剂。
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7.发明申请公开(公告)号：US20070269378A1
公开(公告)日：2007-11-22
申请号：US10556440
申请日：2004-06-18
申请人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yinsheng Jin , Lynn Bjerke , Timothy Heuer
发明人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yinsheng Jin , Lynn Bjerke , Timothy Heuer
CPC分类号： G01N33/574 , A01K67/0275 , A01K2217/058 , A01K2227/40 , A01K2267/03 , A61K49/0008 , C12N9/1205 , C12Q1/485 , G01N33/5008 , G01N33/5011 , G01N33/5041
摘要： Human NADK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morpho-genesis, comprising screening for agents that modulate the activity of NADK are provided.
摘要翻译： 人NADK基因被鉴定为分支形态发生的调节剂，因此是与缺陷支链形态发生功能相关的病症的治疗靶点。 提供用于鉴定分支形态发生的调节剂的方法，包括筛选调节NADK活性的试剂。
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8.发明申请公开(公告)号：US20110135629A1
公开(公告)日：2011-06-09
申请号：US11993130
申请日：2006-06-20
申请人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
发明人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
IPC分类号： A61K39/395 , A61K31/7088 , A61P35/00 , C12Q1/68 , C12N5/00 , C12Q1/48 , G01N33/53
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human MPTENAKT genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of MPTENAKT are provided.
摘要翻译： 人类MPTENAKT基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷性PTEN / AKT功能相关的病症的治疗靶点。 提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节MPTENAKT活性的试剂。
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公开(公告)号：US20070292349A1
公开(公告)日：2007-12-20
申请号：US10587683
申请日：2005-01-27
申请人： Lori Friedman , Helen Francis-Lang , Annette Parks , Kenneth Shaw , Lynn Bjerke , Timothy Heuer
发明人： Lori Friedman , Helen Francis-Lang , Annette Parks , Kenneth Shaw , Lynn Bjerke , Timothy Heuer
CPC分类号： C12Q1/34 , G01N2500/00
摘要： Human MIGFR genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of MIGFR are provided.
摘要翻译： 人MIGFR基因被鉴定为IGFR途径的调节剂，因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法，包括筛选调节MIGFR活性的药剂。
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10.发明申请Loc169505 as modifiers of the apc and axin pathways and methods of use 审中-公开Loc169505作为apc和axin途径的修饰剂和使用方法公开(公告)号：US20070141649A1
公开(公告)日：2007-06-21
申请号：US10535444
申请日：2003-11-24
申请人： Steven Gendreau , Eva Mora-Blanco , Lynn Bjerke
发明人： Steven Gendreau , Eva Mora-Blanco , Lynn Bjerke
IPC分类号： G01N33/574
CPC分类号： G01N33/5041 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N33/574 , G01N33/57438 , G01N33/57449 , G01N2333/4704
摘要： Human LOC169505 genes are identified as modulators of the APC and axin pathways, and thus are therapeutic targets for disorders associated with defective APC and axin function. Methods for identifying modulators of APC and axin, comprising screening for agents that modulate the activity of LOC169505 are provided.
摘要翻译： 人类LOC169505基因被鉴定为APC和axin途径的调节剂，因此是与APC和axin功能缺陷相关的疾病的治疗靶点。 提供了用于鉴定APC和轴的调节剂的方法，包括筛选调节LOC169505活性的试剂。
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