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1.
公开(公告)号:US07943302B2
公开(公告)日:2011-05-17
申请号:US10592171
申请日:2005-03-10
申请人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
IPC分类号: C12Q1/68 , G01N33/53 , C07H21/04 , C07K14/435
CPC分类号: G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要: Human C20ORF23 genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of C20ORF23 are provided.
摘要翻译: 人类C20ORF23基因被鉴定为IGFR途径的调节剂,因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法,包括筛选调节C20ORF23活性的试剂。
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2.
公开(公告)号:US20090202563A1
公开(公告)日:2009-08-13
申请号:US10592171
申请日:2005-03-10
申请人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
IPC分类号: A61K39/395 , G01N33/68 , G01N33/00 , C12Q1/02 , C12Q1/68 , G01N33/566 , A01K67/027 , C12N5/06
CPC分类号: G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要: Human C20ORF23 genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of C20ORF23 are provided.
摘要翻译: 人类C20ORF23基因被鉴定为IGFR途径的调节剂,因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法,包括筛选调节C20ORF23活性的试剂。
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公开(公告)号:US07888047B2
公开(公告)日:2011-02-15
申请号:US10592605
申请日:2005-03-10
申请人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号: G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要: Human PDE genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of PDE are provided.
摘要翻译: 人PDE基因被鉴定为IGFR途径的调节剂,因此是与缺陷IGFR功能相关的病症的治疗靶标。提供了鉴定IGFR调节剂的方法,包括筛选调节PDE活性的药剂。
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公开(公告)号:US20090013416A1
公开(公告)日:2009-01-08
申请号:US10592605
申请日:2005-03-10
申请人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号: G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要: Human PDE genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of PDE are provided
摘要翻译: 人类PDE基因被鉴定为IGFR途径的调节剂,因此是与缺陷IGFR功能相关的病症的治疗靶标。提供了鉴定IGFR调节剂的方法,包括筛选调节PDE活性的药剂
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公开(公告)号:US07785805B2
公开(公告)日:2010-08-31
申请号:US10587253
申请日:2005-01-27
申请人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , HaiGuang Zhang , Timothy S. Heuer
发明人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , HaiGuang Zhang , Timothy S. Heuer
IPC分类号: G01N33/53
CPC分类号: C12Q1/34 , G01N2500/00
摘要: Human MAN2A genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of MAN2A are provided.
摘要翻译: 人类MAN2A基因被鉴定为IGFR途径的调节剂,因此是与缺陷IGFR功能相关的病症的治疗靶标。提供了鉴定IGFR调节剂的方法,包括筛选调节MAN2A活性的药剂。
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公开(公告)号:US20100159470A1
公开(公告)日:2010-06-24
申请号:US12714257
申请日:2010-02-26
IPC分类号: C12Q1/68
CPC分类号: G01N33/5011 , C12Q1/485 , C12Q1/527 , G01N33/5017 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/90212 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/10 , G01N2510/00
摘要: Human SCD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SCD are provided.
摘要翻译: 人类SCD基因被鉴定为p53途径的调节剂,因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法,包括筛选调节SCD活性的药剂。
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公开(公告)号:US08771942B2
公开(公告)日:2014-07-08
申请号:US12714257
申请日:2010-02-26
IPC分类号: C12Q1/68
CPC分类号: G01N33/5011 , C12Q1/485 , C12Q1/527 , G01N33/5017 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/90212 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/10 , G01N2510/00
摘要: Human SCD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SCD are provided.
摘要翻译: 人类SCD基因被鉴定为p53途径的调节剂,因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法,包括筛选调节SCD活性的药剂。
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公开(公告)号:US08426147B2
公开(公告)日:2013-04-23
申请号:US12325914
申请日:2008-12-01
IPC分类号: G01N33/53
CPC分类号: G01N33/57484 , A01K2267/0331 , C07K14/4702 , C12Q1/6886 , C12Q2600/136 , G01N33/566 , G01N33/57407 , G01N2333/4704 , G01N2333/70567 , G01N2333/9121 , G01N2500/10
摘要: Human ROR genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of ROR are provided.
摘要翻译: 人类ROR基因被鉴定为p21途径的调节剂,因此是与缺陷型p21功能相关的疾病的治疗靶点。 提供了用于鉴定p21调节剂的方法,包括筛选调节ROR活性的药剂。
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公开(公告)号:US07993829B2
公开(公告)日:2011-08-09
申请号:US11627831
申请日:2007-01-26
申请人: Lori Friedman , Gregory D. Plowman , Tak Hung , Helen Francis-Lang , Danix Li , Roel P. Funke , Michael Costa
发明人: Lori Friedman , Gregory D. Plowman , Tak Hung , Helen Francis-Lang , Danix Li , Roel P. Funke , Michael Costa
IPC分类号: C12Q1/68
CPC分类号: G01N33/57449 , C12Q1/485 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5091 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/68 , G01N33/6842 , G01N33/6875 , G01N2500/00 , G01N2510/00
摘要: Human hPRP4 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of hPRP4 are provided.
摘要翻译: 人hPRP4基因被鉴定为p53途径的调节剂,因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法,包括筛选调节hPRP4活性的试剂。
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公开(公告)号:US20090149413A1
公开(公告)日:2009-06-11
申请号:US12325914
申请日:2008-12-01
IPC分类号: A61K31/7105 , C12Q1/68
CPC分类号: G01N33/57484 , A01K2267/0331 , C07K14/4702 , C12Q1/6886 , C12Q2600/136 , G01N33/566 , G01N33/57407 , G01N2333/4704 , G01N2333/70567 , G01N2333/9121 , G01N2500/10
摘要: Human ROR genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of ROR are provided.
摘要翻译: 人类ROR基因被鉴定为p21途径的调节剂,因此是与缺陷型p21功能相关的疾病的治疗靶点。 提供了用于鉴定p21调节剂的方法,包括筛选调节ROR活性的药剂。
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