公开(公告)号：US06642493B1

公开(公告)日：2003-11-04

申请号：US10071515

申请日：2002-02-08

申请人： Fernando J Barbosa ,  Stanislaw Majewski ,  Juan J. Vaquero

发明人： Fernando J Barbosa ,  Stanislaw Majewski ,  Juan J. Vaquero

IPC分类号： H01J4014

CPC分类号： H01J43/30 ,  H01J43/045

摘要： A modular base for a position sensitive Photo-Multiplier Tube (PS-PMT) that can be connected to other similar modular bases to form arrays of PS-PMTs. X and Y resistor chains are provided within the base to connect all X and Y coordinate anodes from the PS-PMT, respectively. An amplifier is provided at each end of each resistor chain to amplify output signals when the base is used alone; not connected to other bases. Jumpers associated with each amplifier are provided to include the amplifier in the output signal path or bypass the amplifier and connect to jumpers of other bases. When a base is used alone, the jumpers, which provide either an X or Y output signal, are set to include the amplifier in the output signal path. When two bases are connected together, the jumpers are set to bypass their associated amplifiers and connect the respective X or Y resistor chains of the two bases. The present method advantageously maintains the number of required amplifiers for each X or Y coordinate at two, no matter how many bases are used in the a row or column.

摘要翻译： 用于位置敏感的光电倍增管（PS-PMT）的模块化基座，可连接到其他类似的模块化基座，以形成PS-PMT阵列。 X和Y电阻链设在基座内，分别连接PS-PMT的所有X和Y坐标阳极。 在每个电阻链的两端设置一个放大器，用于在单独使用基极时放大输出信号; 没有连接到其他基地。 提供与每个放大器相关联的跳线，以将放大器包括在输出信号路径中或者绕过放大器并连接到其他基座的跳线。 当单独使用基极时，提供X或Y输出信号的跳线被设置为在输出信号路径中包括放大器。 当两个基座连接在一起时，跳线被设置为绕过其相关的放大器并连接两个基座的相应的X或Y电阻器链。 本方法有利地将每个X或Y坐标的所需放大器的数量保持在两个，无论在一行或多列中使用多少个基底。

公开(公告)号：US06597940B2

公开(公告)日：2003-07-22

申请号：US09996602

申请日：2001-11-30

申请人： Harry Bishop ,  Stanislaw Majewski ,  Marc M. Umeno

发明人： Harry Bishop ,  Stanislaw Majewski ,  Marc M. Umeno

IPC分类号： A61B600

CPC分类号： G01T1/1644 ,  A61B5/02755 ,  A61B6/4258 ,  A61B6/507

摘要： One aspect of the present invention relates to screening patients for an early stage of coronary artery disease. According to this method, a patient is screened based on the time-activity curve for a radioactive tracer passing through a left ventricle region of the patient's body. According to another aspect of the invention, an array of gamma particle detectors is employed to obtain data for a region of interest that is larger than and encompasses a left ventricle region of the patient's body. An analysis of the data identifies the subset of the region of interest that corresponds to the left ventricle region. According to a further aspect of the present invention, a second technique is employed to locate the left ventricle region. A still further aspect of the present invention relates to obtaining images of a patient's heart using a high temporal resolution gamma camera.

公开(公告)号：US06452185B1

公开(公告)日：2002-09-17

申请号：US09465165

申请日：1999-12-16

申请人： Andrew G. Weisenberger ,  Stanislaw Majewski

发明人： Andrew G. Weisenberger ,  Stanislaw Majewski

IPC分类号： G01T124

CPC分类号： G01T1/208 ,  G01T1/202

摘要： A system for improving the resolution of nuclear medicine gamma cameras. A pixellated crystal scintillator is optically connected to position sensitive photomultiplier tubes. Photons incident on the crystal scintillator travel a distance through the crystal that is directly proportional to the energy level of the photon before converting to photoelectrons. The system uses this depth of interaction information to classify the received photons according to their energy levels. Images may then be displayed using information from only those photons that are within the selected energy class.

摘要翻译： 一个改善核医学伽玛照相机分辨率的系统。 像素化晶体闪烁体与位置敏感的光电倍增管光学连接。 入射到晶体闪烁体上的光子在转换成光电子之前通过与晶体的能级成正比的晶体行进一段距离。 该系统使用这种深度的交互信息来根据它们的能级对所接收的光子进行分类。 然后可以使用仅来自所选能量类别内的那些光子的信息来显示图像。

公开(公告)号：US5453609A

公开(公告)日：1995-09-26

申请号：US141331

申请日：1993-10-22

申请人： Javier Gomez ,  Stanislaw Majewski ,  Andrew G. Weisenberger

发明人： Javier Gomez ,  Stanislaw Majewski ,  Andrew G. Weisenberger

IPC分类号： H01J43/18 ,  H01J43/24 ,  G01J3/50 ,  H01J3/38

CPC分类号： H01J43/246 ,  H01J43/18

摘要： An improved multi-channel electron multiplier is provided that exhibits zero cross-talk and high rate operation. Resistive material input and output masks are employed to control divergence of electrons. Electron multiplication takes place in closed channels. Several embodiments are provided for these channels including a continuous resistive emissive multiplier and a discrete resistive multiplier with discrete dynode chains interspaced with resistive layers-masks. Both basic embodiments provide high gain multiplication of electrons without accumulating surface charges while containing electrons to their proper channels to eliminate cross-talk. The invention can be for example applied to improve the performance of ion mass spectrometers, positron emission tomography devices, in DNA sequencing and other beta radiography applications and in many applications in particle physics.

摘要翻译： 提供了一种改进的多通道电子倍增器，其呈现零串扰和高速率操作。 采用电阻材料输入和输出掩模来控制电子的发散。 电子倍增发生在闭合通道中。 为这些通道提供了几个实施例，包括连续的电阻发射乘法器和具有与电阻层掩模间隔开的离散倍增极链的离散电阻乘法器。 两个基本实施例提供电子的高增益倍数而不累积表面电荷，同时将电子包含到其适当的通道以消除串扰。 本发明可以例如应用于提高离子质谱仪，正电子发射断层摄影装置，DNA测序和其他β射线照相应用中以及在粒子物理学中的许多应用中的性能。

公开(公告)号：US10568560B2

公开(公告)日：2020-02-25

申请号：US13826574

申请日：2013-03-14

申请人： Osama Mukdadi ,  Mohamad W. Salkini ,  Stanislaw Majewski ,  James Proffitt

发明人： Osama Mukdadi ,  Mohamad W. Salkini ,  Stanislaw Majewski ,  James Proffitt

IPC分类号： A61B5/00 ,  A61B8/00 ,  A61B6/00 ,  A61B8/12 ,  A61B6/03

摘要： A dual modality probe is disclosed having both a positron emission tomography sensor and a ultrasound sensor. A dual imaging system is provided having the probe and at least one external positron emission tomography detector and a data acquisition computer system for collecting data simultaneously from the positron emission sensor and the ultrasound sensor of the probe and the positron emission tomography detector. A method for evaluating a target organ of a patient utilizing the probe and imaging system, and performing a biopsy of the organ is disclosed.

公开(公告)号：US20140276019A1

公开(公告)日：2014-09-18

申请号：US13827084

申请日：2013-03-14

申请人： Stanislaw Majewski ,  Alexander Stolin

发明人： Stanislaw Majewski ,  Alexander Stolin

IPC分类号： A61B6/03

CPC分类号： A61B6/037 ,  A61B6/4405 ,  A61B6/583 ,  A61B10/0233 ,  G01T1/161 ,  G01T1/2985

摘要： A probe is disclosed having a positron emission tomography sensor. An imaging system is provided having the probe and at least one external positron emission tomography detector and a data acquisition computer system for collecting data simultaneously from said positron emission sensor of said probe and said positron emission tomography detector. A method for evaluating a target organ of a patient utilizing the probe and imaging system, and performing a biopsy of the organ is disclosed.

摘要翻译： 公开了一种具有正电子发射断层摄影传感器的探针。 提供一种具有探针和至少一个外部正电子发射断层摄影检测器和用于从所述探针和所述正电子发射断层摄影检测器的所述正电子发射传感器同时收集数据的数据采集计算机系统的成像系统。 公开了一种利用探针和成像系统评估患者的靶器官并进行器官的活组织检查的方法。

公开(公告)号：US20140276018A1

公开(公告)日：2014-09-18

申请号：US13826574

申请日：2013-03-14

申请人： Osama Mukdadi ,  Mohamad W. Salkini ,  Stanislaw Majewski ,  James Proffitt

发明人： Osama Mukdadi ,  Mohamad W. Salkini ,  Stanislaw Majewski ,  James Proffitt

IPC分类号： A61B5/00 ,  A61B8/00 ,  A61B6/04

摘要： A dual modality probe is disclosed having both a positron emission tomography sensor and a ultrasound sensor. A dual imaging system is provided having the probe and at least one external positron emission tomography detector and a data acquisition computer system for collecting data simultaneously from said positron emission sensor and said ultrasound sensor of said probe and said positron emission tomography detector. A method for evaluating a target organ of a patient utilizing the probe and imaging system, and performing a biopsy of the organ is disclosed.

摘要翻译： 公开了一种具有正电子发射断层摄影传感器和超声波传感器的双模式探头。 提供了具有探针和至少一个外部正电子发射断层摄影检测器和用于从所述正电子发射传感器和所述探针和所述正电子发射断层摄影检测器的所述超声传感器同时收集数据的数据采集计算机系统的双成像系统。 公开了一种利用探针和成像系统评估患者的靶器官并进行器官的活组织检查的方法。

公开(公告)号：US20130334408A1

公开(公告)日：2013-12-19

申请号：US13904183

申请日：2013-05-29

申请人： Alexander Stolin ,  Stanislaw Majewski ,  Raymond Raylman

发明人： Alexander Stolin ,  Stanislaw Majewski ,  Raymond Raylman

IPC分类号： H01L31/024

CPC分类号： H01L31/024 ,  G01J1/0252 ,  G01J1/0425 ,  G01T1/2018

摘要： A cooled optical light guide is provided having a conduit having a translucent top and a translucent bottom wherein at least a portion of the translucent top of the conduit is in alignment above at least a portion of the translucent bottom of the conduit. A fluid medium that is preferably cooled flows through the conduit. The optical light guide is placed between a scintillator array and an array detector. The temperature of the light that is emitted by the scintillator array is stabilized, and preferably cooled, as it passes through the translucent bottom of the conduit and through the translucent top of the conduit for detection by the array detector. A method of temperature stabilization for photomultiplier based detectors is disclosed.

摘要翻译： 提供了一种冷却的光学光导，其具有具有半透明顶部和半透明底部的导管，其中导管的半透明顶部的至少一部分在导管的半透明底部的至少一部分上方对准。 优选冷却的流体介质流过导管。 光学光导被放置在闪烁体阵列和阵列检测器之间。 由闪烁体阵列发射的光的温度稳定，并且优选地冷却，因为它通过导管的半透明底部并且通过导管的半透明顶部，由阵列检测器检测。 公开了一种基于光电倍增管的检测器的温度稳定方法。

公开(公告)号：USRE43499E1

公开(公告)日：2012-07-03

申请号：US12913372

申请日：2010-10-27

申请人： Douglas Arthur Kieper ,  Stanislaw Majewski ,  Benjamin L. Welch

发明人： Douglas Arthur Kieper ,  Stanislaw Majewski ,  Benjamin L. Welch

IPC分类号： G06K9/00 ,  A61B6/04

CPC分类号： A61B6/4258 ,  A61B6/502 ,  A61B6/583 ,  G01T1/1642 ,  G01T1/1644

摘要： An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

摘要翻译： 一种用于增强经历双头闪烁物理检查的乳房的背景和病变区域之间的对比度的改进方法，包括：1）从一对小的FOV或迷你伽马照相机获取一对数字图像，以从相对侧压缩检查的乳房; 2）反转一对图像中的一个以对准或共同对准另一个图像，以获得共同注册的像素值; 3）通过将两个获取的图像和共同注册的图像中的每一个的像素值除以相应检测器的整个乳房区域中的每个像素的平均计数来逐像素地归一化该对图像; 以及4）将每个像素中的计数数乘以步骤3中获得的值，以产生归一化增强二维对比图。 这种增强（增强的对比度）对比图增强了背景下活动的局部增加（摄取）的可见性，因此改善了病变检测灵敏度，特别是小病变的敏感性。

公开(公告)号：US08183530B2

公开(公告)日：2012-05-22

申请号：US12319649

申请日：2009-01-09

申请人： Steven W. Falen ,  Richard A. Hoefer ,  Stanislaw Majewski ,  John McKisson ,  Brian Kross ,  James Proffitt ,  Alexander Stolin ,  Andrew G. Weisenberger

发明人： Steven W. Falen ,  Richard A. Hoefer ,  Stanislaw Majewski ,  John McKisson ,  Brian Kross ,  James Proffitt ,  Alexander Stolin ,  Andrew G. Weisenberger

IPC分类号： G01T1/166

CPC分类号： G01T1/2985 ,  A61B6/037 ,  G01N23/046 ,  G01N2223/419 ,  G01T1/1603

摘要： A mobile compact imaging system that combines both PET imaging and optical imaging into a single system which can be located in the operating room (OR) and provides faster feedback to determine if a tumor has been fully resected and if there are adequate surgical margins. While final confirmation is obtained from the pathology lab, such a device can reduce the total time necessary for the procedure and the number of iterations required to achieve satisfactory resection of a tumor with good margins.

摘要翻译： 一种移动紧凑型成像系统，将PET成像和光学成像结合到可以位于手术室（OR）中的单个系统中，并提供更快的反馈，以确定肿瘤是否已被完全切除，以及是否有足够的手术切缘。 虽然从病理实验室获得最终确认，但是这样的装置可以减少手术所需的总时间以及实现令人满意地切除具有良好边缘的肿瘤所需的迭代次数。