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公开(公告)号：US08460361B2
公开(公告)日：2013-06-11
申请号：US11180165
申请日：2005-07-13
IPC分类号： A61F2/06
CPC分类号： C23C14/34 , A61F2/82 , A61F2210/0014 , A61F2240/001 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61F2310/00071 , A61F2310/00089 , A61F2310/00095 , A61F2310/00113 , A61F2310/00131 , A61F2310/00149 , A61F2310/00155 , A61L31/022 , C23C14/0005 , C23C14/562
摘要： A method of forming a medical device, the method including the steps of providing a substrate, depositing a metallic layer on the substrate by a vapor deposition process, and removing the metallic layer from the substrate. The metallic layer thus removed is the medical device or serves as a basis for forming the medical device. In another aspect, the present invention includes a medical device formed by the process of the present invention.
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32.发明申请PROCESS FOR PRODUCING A HUMAN T-CELL POPULATION HAVING BOTH CYTOTOXIC AND IMMUNOSUPPRESSIVE ACTIVITIES 有权生产具有两种细胞因子和免疫抑制活性的人类T细胞群体的方法公开(公告)号：US20120040454A1
公开(公告)日：2012-02-16
申请号：US13265942
申请日：2010-04-15
IPC分类号： C12N5/0783
CPC分类号： C12N5/0638 , A61K2035/122 , A61K2035/124 , A61K2039/5158 , A61K2039/57 , C12N5/0637 , C12N2502/1394
摘要： The present invention has an object to provide a method for efficiently producing a human T cell population which has both cytotoxic and immunosuppressive activities, and solves the above object by providing a method for producing a human T cell population which has both cytotoxic and immunosuppressive activities, comprising the following steps (1) to (4):(1) fractionating mononuclear cells collected from a human umbilical cord blood into CD14-positive (CD14+) cells and CD14-negative (CD14−) cells, and then fractionating the CD14-negative (CD14−) cells into CD2-positive CD14-negative (CD2+CD14−) cells, and CD2-negative CD14-negative (CD2−CD14−) cells;(2) co-culturing the CD2-positive CD14-negative (CD2+CD14−) cells obtained in step (1) with stromal cells to generate blast cells;(3) adding the blast cells obtained in step (2) to the co-culture of the CD14-positive (CD14+) cells obtained in step (1) with stromal cells to allow the blast cells to proliferate; and(4) allowing the blast cells obtained in step (3) to further proliferate by co-culturing with stromal cells in the presence of interleukin-2 (IL-2) to generate a human T cell population which has both cytotoxic and immunosuppressive activities.
摘要翻译： 本发明的目的是提供一种有效地制备具有细胞毒性和免疫抑制活性的人T细胞群的方法，通过提供具有细胞毒性和免疫抑制活性的人T细胞群的制备方法来解决上述目的， 包括以下步骤（1）至（4）：（1）将从人脐带血中收集的单核细胞分离成CD14阳性（CD14 +）细胞和CD14阴性（CD14-）细胞，然后将CD14阴性 （CD14-）细胞进入CD2阳性CD14阴性（CD2 + CD14-）细胞和CD2阴性CD14阴性（CD2-CD14-）细胞; （2）在步骤（1）中获得的CD2阳性CD14-阴性（CD2 + CD14-）细胞与基质细胞共培养以产生胚细胞; （3）将步骤（2）中获得的胚细胞添加到步骤（1）中获得的CD14阳性（CD14 +）细胞与基质细胞的共培养物中，以使胚细胞增殖; 和（4）通过在白细胞介素-2（IL-2）存在下与基质细胞共培养使得步骤（3）中获得的胚细胞进一步增殖以产生具有细胞毒性和免疫抑制活性的人T细胞群 。
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公开(公告)号：US07927219B2
公开(公告)日：2011-04-19
申请号：US12731181
申请日：2010-03-25
IPC分类号： F16D7/02
CPC分类号： F16D7/025 , F16F15/129
摘要： A torque fluctuation absorbing apparatus provided between a driving source and a transmission and transmitting torque from the driving source to the transmission, the apparatus absorbing fluctuations in the torque and limiting a maximum value of the torque, the apparatus includes a flywheel, a supporting member, a first plate having a sliding surface, a second plate having a sliding surface, a disc spring supported by the supporting member and biasing one of the first and second plates towards the other one thereof, a friction material sandwiched tightly between the sliding surface of the first plate and the sliding surface of the second plate, a damper mechanism connected to the friction material and transmitting the torque from the driving source to an input shaft of the transmission, and a cover member demarcating the sliding surfaces of the first and second plates from an exterior of the torque fluctuation absorbing apparatus.
摘要翻译： 一种扭矩波动吸收装置，其设置在驱动源和变速器之间，并且将扭矩从驱动源传递到变速器，该装置吸收扭矩的波动并限制扭矩的最大值，该装置包括飞轮，支撑构件， 具有滑动表面的第一板，具有滑动表面的第二板，由所述支撑构件支撑并将所述第一板和第二板中的一个朝向其另一个支撑的盘簧，紧密地夹在所述第一板的滑动表面之间的摩擦材料 第一板和第二板的滑动表面，阻尼机构，连接到摩擦材料并将来自驱动源的扭矩传递到变速器的输入轴;以及盖构件，其将第一和第二板的滑动表面从 转矩波动吸收装置的外部。
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公开(公告)号：US20100175963A1
公开(公告)日：2010-07-15
申请号：US12731181
申请日：2010-03-25
IPC分类号： F16F15/123
CPC分类号： F16D7/025 , F16F15/129
摘要： A torque fluctuation absorbing apparatus provided between a driving source and a transmission and transmitting torque from the driving source to the transmission, the apparatus absorbing fluctuations in the torque and limiting a maximum value of the torque, the apparatus includes a flywheel, a supporting member, a first plate having a sliding surface, a second plate having a sliding surface, a disc spring supported by the supporting member and biasing one of the first and second plates towards the other one thereof, a friction material sandwiched tightly between the sliding surface of the first plate and the sliding surface of the second plate, a damper mechanism connected to the friction material and transmitting the torque from the driving source to an input shaft of the transmission, and a cover member demarcating the sliding surfaces of the first and second plates from an exterior of the torque fluctuation absorbing apparatus.
摘要翻译： 一种扭矩波动吸收装置，其设置在驱动源和变速器之间，并且将扭矩从驱动源传递到变速器，该装置吸收扭矩的波动并限制扭矩的最大值，该装置包括飞轮，支撑构件， 具有滑动表面的第一板，具有滑动表面的第二板，由所述支撑构件支撑并将所述第一板和第二板中的一个朝向其另一个支撑的盘簧，紧密地夹在所述第一板的滑动表面之间的摩擦材料 第一板和第二板的滑动表面，阻尼机构，连接到摩擦材料并将来自驱动源的扭矩传递到变速器的输入轴;以及盖构件，其将第一和第二板的滑动表面从 转矩波动吸收装置的外部。
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公开(公告)号：US20100021328A1
公开(公告)日：2010-01-28
申请号：US12442002
申请日：2007-11-29
申请人： Hiroshi Yamazaki , Makoto Takeuchi , Takahide Ito , Takamitsu Himeno , Tetsuzou Ukai , Kazuhide Watanabe , Katsuhiro Fujita , Tomohisa Moro
发明人： Hiroshi Yamazaki , Makoto Takeuchi , Takahide Ito , Takamitsu Himeno , Tetsuzou Ukai , Kazuhide Watanabe , Katsuhiro Fujita , Tomohisa Moro
IPC分类号： F04C18/02
CPC分类号： F04C18/0215 , F01C17/063 , F04C2270/12 , F04C2270/16
摘要： In a scroll compressor, a center of a turning scroll body is shifted with respect to a drive central axis so that a distance between a gravity center and the drive central axis in a turning scroll becomes smaller than a predetermined allowable value set based on theoretical displacement and mass of the turning scroll. A moment force about the drive central axis acting on the turning scroll is reduced during revolving, and an alternating force acting on an autorotation preventing pin in the turning scroll is reduced to an allowable level.
摘要翻译： 在涡旋压缩机中，转动涡旋体的中心相对于驱动中心轴移动，使得转向涡卷中的重心与驱动中心轴之间的距离小于基于理论位移设定的预定容许值 和转动卷轴的质量。 作用在转动涡卷上的驱动中心轴的力矩在旋转期间减小，并且作用在转动涡卷中的自动防止销的交替力减小到可允许的水平。
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公开(公告)号：US20090105298A1
公开(公告)日：2009-04-23
申请号：US12003908
申请日：2008-01-03
申请人： Ken Ikeda , Makoto Takeuchi
发明人： Ken Ikeda , Makoto Takeuchi
IPC分类号： A61K31/4748
CPC分类号： A61K31/439
摘要： A depressant of capsaicin-sensitive sensory nerve, containing quinuclidin-3′-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate or a salt thereof as an active ingredient, specifically a therapeutic drug of interstitial cystitis, hypersensitive disorder of the lower urinary tract, and/or abacterial prostatitis.
摘要翻译： 含有奎宁环-3'-基1-苯基-1,2,3,4-四氢异喹啉-2-羧酸钠或其盐作为活性成分的具有辣椒素敏感性感觉神经抑制剂，特别是间质性膀胱炎的治疗药物， 下尿路过敏性疾病和/或非细菌性前列腺炎。
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公开(公告)号：US20080287680A1
公开(公告)日：2008-11-20
申请号：US10588857
申请日：2005-02-07
申请人： Yusuke Ishii , Kouji Takaoka , Masatoshi Inakoshi , Shuichi Nakagawa , Koji Nagata , Naoki Yorimoto , Makoto Takeuchi , Yasuhiro Yonetoku
发明人： Yusuke Ishii , Kouji Takaoka , Masatoshi Inakoshi , Shuichi Nakagawa , Koji Nagata , Naoki Yorimoto , Makoto Takeuchi , Yasuhiro Yonetoku
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： A solifenacin succinate-containing composition with less impurities which can be used as a bulk for pharmaceutical is provided.The solifenacin succinate-containing composition of the present invention has a reduced content of especially its optical isomers in comparison with the known compositions containing an acid addition salt of solifenacin, so that it can be used for production of a therapeutic agent containing solifenacin succinate. In addition, the above-described solifenacin succinate-containing composition can be easily produced in accordance with the production method of the present invention.
摘要翻译： 提供了可用作药物的体积较少的杂质的具有较少杂质的索非那新琥珀酸盐组合物。 与含有solifenacin的酸加成盐的已知组合物相比，本发明的索非那新琥珀酸盐组合物特别是其光学异构体的含量降低，因此可用于制备含有索非那新的琥珀酸solifenacin的治疗剂。 此外，根据本发明的制造方法，可以容易地制造上述的solifenacin succinate组合物。
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公开(公告)号：US07449456B2
公开(公告)日：2008-11-11
申请号：US10518043
申请日：2003-06-26
申请人： Shinya Nagashima , Hiroshi Nagata , Masahiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
发明人： Shinya Nagashima , Hiroshi Nagata , Masahiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D403/12 , C07D239/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D453/02 , C07D471/10 , C07D487/08
摘要： A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.
摘要翻译： 提供了可用于预防或治疗其中涉及STAT6的呼吸系统疾病的化合物，特别是哮喘，慢性阻塞性肺病等。 具有可以被特定取代基取代的芳基氨基或芳基乙氨基的嘧啶衍生物或其盐在2-位被苄基取代的氨基或4-位上的氨基甲酰基和氨基甲酰基， 可以在5位被提供。
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公开(公告)号：US20070191120A1
公开(公告)日：2007-08-16
申请号：US11701508
申请日：2007-02-02
IPC分类号： F16F15/121
CPC分类号： F16F15/129
摘要： A torque fluctuation absorber includes a disc fixed to a flywheel, a hub fixed to a transmission, first and second side plates fixed to the disc, a damper member, first and second control plates provided at axial both sides of the hub, the first and second control plates being riveted by a stopper pin, a first hysteresis mechanism including first and second low friction members and generating a small hysteresis, and a second hysteresis mechanism including first and second high friction members and generating a large hysteresis. The hub includes a flange portion having a through-hole into which the stopper pin is inserted. A relative rotational angle between the control plates and the hub is defined by a clearance formed between the through-hole and the hub. The first hysteresis mechanism is activated when the relative rotational angle is defined within the clearance.
摘要翻译： 扭矩波动吸收器包括固定到飞轮的盘，固定到变速器的轮毂，固定到盘的第一和第二侧板，阻尼器构件，设置在轮毂的轴向两侧的第一和第二控制板，第一和第二侧板 第二控制板由止动销铆接，包括第一和第二低摩擦构件并产生小滞后的第一滞后机构，以及包括第一和第二高摩擦构件并产生大的滞后的第二滞后机构。 轮毂包括具有止动销插入其中的通孔的凸缘部分。 控制板和轮毂之间的相对旋转角度由形成在通孔和轮毂之间的间隙限定。 当相对旋转角度在间隙内限定时，第一个滞后机构被激活。
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公开(公告)号：US07141230B2
公开(公告)日：2006-11-28
申请号：US10165211
申请日：2002-06-06
申请人： Makoto Takeuchi
发明人： Makoto Takeuchi
摘要： A method of efficiently removing active oxy-hydrogens (e.g., existing as hetero element-containing functional groups such as COOH, CHO, and OH) present in a carbon material at a relative low temperature. The invention also provides a carbon-activating material adapted for use in a polarizable electrode typically used in an electrical double-layer capacitor. The method of removing residual active oxy-hydrogens in the carbon material starts with mixing the carbon material and a transition metal or a transition metal compound. The resulting mixture is thermally processed within a stream of a reducing gas. Preferably, the transition metal or transition metal compound is removed from the thermally processed mixture.
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