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    PROCESS FOR PRODUCING A HUMAN T-CELL POPULATION HAVING BOTH CYTOTOXIC AND IMMUNOSUPPRESSIVE ACTIVITIES
    32.
    发明申请
    PROCESS FOR PRODUCING A HUMAN T-CELL POPULATION HAVING BOTH CYTOTOXIC AND IMMUNOSUPPRESSIVE ACTIVITIES 有权
    生产具有两种细胞因子和免疫抑制活性的人类T细胞群体的方法

    公开(公告)号：US20120040454A1

    公开(公告)日：2012-02-16

    申请号：US13265942

    申请日：2010-04-15

    Applicant: Takeshi Otani ,  Makoto Takeuchi ,  Shuji Nakamura ,  Fumiyuki Yamasaki

    Inventor： Takeshi Otani ,  Makoto Takeuchi ,  Shuji Nakamura ,  Fumiyuki Yamasaki

    IPC: C12N5/0783

    CPC classification number: C12N5/0638 ,  A61K2035/122 ,  A61K2035/124 ,  A61K2039/5158 ,  A61K2039/57 ,  C12N5/0637 ,  C12N2502/1394

    Abstract: The present invention has an object to provide a method for efficiently producing a human T cell population which has both cytotoxic and immunosuppressive activities, and solves the above object by providing a method for producing a human T cell population which has both cytotoxic and immunosuppressive activities, comprising the following steps (1) to (4):(1) fractionating mononuclear cells collected from a human umbilical cord blood into CD14-positive (CD14+) cells and CD14-negative (CD14−) cells, and then fractionating the CD14-negative (CD14−) cells into CD2-positive CD14-negative (CD2+CD14−) cells, and CD2-negative CD14-negative (CD2−CD14−) cells;(2) co-culturing the CD2-positive CD14-negative (CD2+CD14−) cells obtained in step (1) with stromal cells to generate blast cells;(3) adding the blast cells obtained in step (2) to the co-culture of the CD14-positive (CD14+) cells obtained in step (1) with stromal cells to allow the blast cells to proliferate; and(4) allowing the blast cells obtained in step (3) to further proliferate by co-culturing with stromal cells in the presence of interleukin-2 (IL-2) to generate a human T cell population which has both cytotoxic and immunosuppressive activities.

    Abstract translation: 本发明的目的是提供一种有效地制备具有细胞毒性和免疫抑制活性的人T细胞群的方法，通过提供具有细胞毒性和免疫抑制活性的人T细胞群的制备方法来解决上述目的， 包括以下步骤（1）至（4）：（1）将从人脐带血中收集的单核细胞分离成CD14阳性（CD14 +）细胞和CD14阴性（CD14-）细胞，然后将CD14阴性 （CD14-）细胞进入CD2阳性CD14阴性（CD2 + CD14-）细胞和CD2阴性CD14阴性（CD2-CD14-）细胞; （2）在步骤（1）中获得的CD2阳性CD14-阴性（CD2 + CD14-）细胞与基质细胞共培养以产生胚细胞; （3）将步骤（2）中获得的胚细胞添加到步骤（1）中获得的CD14阳性（CD14 +）细胞与基质细胞的共培养物中，以使胚细胞增殖; 和（4）通过在白细胞介素-2（IL-2）存在下与基质细胞共培养使得步骤（3）中获得的胚细胞进一步增殖以产生具有细胞毒性和免疫抑制活性的人T细胞群 。

    Torque fluctuation absorbing apparatus
    33.
    发明授权
    Torque fluctuation absorbing apparatus 有权
    扭矩波动吸收装置

    公开(公告)号：US07927219B2

    公开(公告)日：2011-04-19

    申请号：US12731181

    申请日：2010-03-25

    Applicant: Tomohiro Saeki ,  Satoshi Nakagaito ,  Makoto Takeuchi ,  Masanori Suzuki ,  Masaru Ebata

    Inventor： Tomohiro Saeki ,  Satoshi Nakagaito ,  Makoto Takeuchi ,  Masanori Suzuki ,  Masaru Ebata

    IPC: F16D7/02

    CPC classification number: F16D7/025 ,  F16F15/129

    Abstract: A torque fluctuation absorbing apparatus provided between a driving source and a transmission and transmitting torque from the driving source to the transmission, the apparatus absorbing fluctuations in the torque and limiting a maximum value of the torque, the apparatus includes a flywheel, a supporting member, a first plate having a sliding surface, a second plate having a sliding surface, a disc spring supported by the supporting member and biasing one of the first and second plates towards the other one thereof, a friction material sandwiched tightly between the sliding surface of the first plate and the sliding surface of the second plate, a damper mechanism connected to the friction material and transmitting the torque from the driving source to an input shaft of the transmission, and a cover member demarcating the sliding surfaces of the first and second plates from an exterior of the torque fluctuation absorbing apparatus.

    Abstract translation: 一种扭矩波动吸收装置，其设置在驱动源和变速器之间，并且将扭矩从驱动源传递到变速器，该装置吸收扭矩的波动并限制扭矩的最大值，该装置包括飞轮，支撑构件， 具有滑动表面的第一板，具有滑动表面的第二板，由所述支撑构件支撑并将所述第一板和第二板中的一个朝向其另一个支撑的盘簧，紧密地夹在所述第一板的滑动表面之间的摩擦材料 第一板和第二板的滑动表面，阻尼机构，连接到摩擦材料并将来自驱动源的扭矩传递到变速器的输入轴;以及盖构件，其将第一和第二板的滑动表面从 转矩波动吸收装置的外部。

    TORQUE FLUCTUATION ABSORBING APPARATUS
    34.
    发明申请
    TORQUE FLUCTUATION ABSORBING APPARATUS 有权
    扭矩波动吸收装置

    公开(公告)号：US20100175963A1

    公开(公告)日：2010-07-15

    申请号：US12731181

    申请日：2010-03-25

    Applicant: Tomohiro Saeki ,  Satoshi Nakagaito ,  Makoto Takeuchi ,  Masanori Suzuki ,  Masaru Ebata

    Inventor： Tomohiro Saeki ,  Satoshi Nakagaito ,  Makoto Takeuchi ,  Masanori Suzuki ,  Masaru Ebata

    IPC: F16F15/123

    CPC classification number: F16D7/025 ,  F16F15/129

    Abstract: A torque fluctuation absorbing apparatus provided between a driving source and a transmission and transmitting torque from the driving source to the transmission, the apparatus absorbing fluctuations in the torque and limiting a maximum value of the torque, the apparatus includes a flywheel, a supporting member, a first plate having a sliding surface, a second plate having a sliding surface, a disc spring supported by the supporting member and biasing one of the first and second plates towards the other one thereof, a friction material sandwiched tightly between the sliding surface of the first plate and the sliding surface of the second plate, a damper mechanism connected to the friction material and transmitting the torque from the driving source to an input shaft of the transmission, and a cover member demarcating the sliding surfaces of the first and second plates from an exterior of the torque fluctuation absorbing apparatus.

    Abstract translation: 一种扭矩波动吸收装置，其设置在驱动源和变速器之间，并且将扭矩从驱动源传递到变速器，该装置吸收扭矩的波动并限制扭矩的最大值，该装置包括飞轮，支撑构件， 具有滑动表面的第一板，具有滑动表面的第二板，由所述支撑构件支撑并将所述第一板和第二板中的一个朝向其另一个支撑的盘簧，紧密地夹在所述第一板的滑动表面之间的摩擦材料 第一板和第二板的滑动表面，阻尼机构，连接到摩擦材料并将来自驱动源的扭矩传递到变速器的输入轴;以及盖构件，其将第一和第二板的滑动表面从 转矩波动吸收装置的外部。

    Pharmaceutical composition for therapy of interstitial cystitis
    36.
    发明申请
    Pharmaceutical composition for therapy of interstitial cystitis 审中-公开
    用于间质性膀胱炎治疗的药物组合物

    公开(公告)号：US20090105298A1

    公开(公告)日：2009-04-23

    申请号：US12003908

    申请日：2008-01-03

    Applicant: Ken Ikeda ,  Makoto Takeuchi

    Inventor： Ken Ikeda ,  Makoto Takeuchi

    IPC: A61K31/4748

    CPC classification number: A61K31/439

    Abstract: A depressant of capsaicin-sensitive sensory nerve, containing quinuclidin-3′-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate or a salt thereof as an active ingredient, specifically a therapeutic drug of interstitial cystitis, hypersensitive disorder of the lower urinary tract, and/or abacterial prostatitis.

    Abstract translation: 含有奎宁环-3'-基1-苯基-1,2,3,4-四氢异喹啉-2-羧酸钠或其盐作为活性成分的具有辣椒素敏感性感觉神经抑制剂，特别是间质性膀胱炎的治疗药物， 下尿路过敏性疾病和/或非细菌性前列腺炎。

    Solifenacin Succinate-Containing Composition
    37.
    发明申请
    Solifenacin Succinate-Containing Composition 审中-公开
    索非那新琥珀酸酯组合物

    公开(公告)号：US20080287680A1

    公开(公告)日：2008-11-20

    申请号：US10588857

    申请日：2005-02-07

    Applicant: Yusuke Ishii ,  Kouji Takaoka ,  Masatoshi Inakoshi ,  Shuichi Nakagawa ,  Koji Nagata ,  Naoki Yorimoto ,  Makoto Takeuchi ,  Yasuhiro Yonetoku

    Inventor： Yusuke Ishii ,  Kouji Takaoka ,  Masatoshi Inakoshi ,  Shuichi Nakagawa ,  Koji Nagata ,  Naoki Yorimoto ,  Makoto Takeuchi ,  Yasuhiro Yonetoku

    IPC: C07D453/02

    CPC classification number: C07D453/02

    Abstract: A solifenacin succinate-containing composition with less impurities which can be used as a bulk for pharmaceutical is provided.The solifenacin succinate-containing composition of the present invention has a reduced content of especially its optical isomers in comparison with the known compositions containing an acid addition salt of solifenacin, so that it can be used for production of a therapeutic agent containing solifenacin succinate. In addition, the above-described solifenacin succinate-containing composition can be easily produced in accordance with the production method of the present invention.

    Abstract translation: 提供了可用作药物的体积较少的杂质的具有较少杂质的索非那新琥珀酸盐组合物。 与含有solifenacin的酸加成盐的已知组合物相比，本发明的索非那新琥珀酸盐组合物特别是其光学异构体的含量降低，因此可用于制备含有索非那新的琥珀酸solifenacin的治疗剂。 此外，根据本发明的制造方法，可以容易地制造上述的solifenacin succinate组合物。

    Torque fluctuation absorber
    39.
    发明申请
    Torque fluctuation absorber 有权
    扭矩波动吸收器

    公开(公告)号：US20070191120A1

    公开(公告)日：2007-08-16

    申请号：US11701508

    申请日：2007-02-02

    Applicant: Tomohiro Saeki ,  Satoshi Nakagaito ,  Makoto Takeuchi ,  Masanori Suzuki ,  Masaru Ebata

    Inventor： Tomohiro Saeki ,  Satoshi Nakagaito ,  Makoto Takeuchi ,  Masanori Suzuki ,  Masaru Ebata

    IPC: F16F15/121

    CPC classification number: F16F15/129

    Abstract: A torque fluctuation absorber includes a disc fixed to a flywheel, a hub fixed to a transmission, first and second side plates fixed to the disc, a damper member, first and second control plates provided at axial both sides of the hub, the first and second control plates being riveted by a stopper pin, a first hysteresis mechanism including first and second low friction members and generating a small hysteresis, and a second hysteresis mechanism including first and second high friction members and generating a large hysteresis. The hub includes a flange portion having a through-hole into which the stopper pin is inserted. A relative rotational angle between the control plates and the hub is defined by a clearance formed between the through-hole and the hub. The first hysteresis mechanism is activated when the relative rotational angle is defined within the clearance.

    Abstract translation: 扭矩波动吸收器包括固定到飞轮的盘，固定到变速器的轮毂，固定到盘的第一和第二侧板，阻尼器构件，设置在轮毂的轴向两侧的第一和第二控制板，第一和第二侧板 第二控制板由止动销铆接，包括第一和第二低摩擦构件并产生小滞后的第一滞后机构，以及包括第一和第二高摩擦构件并产生大的滞后的第二滞后机构。 轮毂包括具有止动销插入其中的通孔的凸缘部分。 控制板和轮毂之间的相对旋转角度由形成在通孔和轮毂之间的间隙限定。 当相对旋转角度在间隙内限定时，第一个滞后机构被激活。

    Method of removing residual active oxy-hydrogens
    40.
    发明授权
    Method of removing residual active oxy-hydrogens 有权

    公开(公告)号：US07141230B2

    公开(公告)日：2006-11-28

    申请号：US10165211

    申请日：2002-06-06

    Applicant: Makoto Takeuchi

    Inventor： Makoto Takeuchi

    IPC: H01G9/058 ,  C01B31/02

    CPC classification number: H01G9/155 ,  C01B32/05 ,  C01B32/30 ,  Y02E60/13

    Abstract: A method of efficiently removing active oxy-hydrogens (e.g., existing as hetero element-containing functional groups such as COOH, CHO, and OH) present in a carbon material at a relative low temperature. The invention also provides a carbon-activating material adapted for use in a polarizable electrode typically used in an electrical double-layer capacitor. The method of removing residual active oxy-hydrogens in the carbon material starts with mixing the carbon material and a transition metal or a transition metal compound. The resulting mixture is thermally processed within a stream of a reducing gas. Preferably, the transition metal or transition metal compound is removed from the thermally processed mixture.

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