摘要:
New therapeutic use of some heterocyclylpiperazines of formula (I) ##STR1## wherein R represents hydrogen or (C.sub.1 -C.sub.4)alkyl, R.sub.1 represents hydrogen or a methyl group, R.sub.2 represents hydrogen or a halogen atom; X et Y represent each --CH.dbd., or one is --CH.dbd. and the other is --N.dbd., as well as their pharmaceutically acceptable salts for the preparation of a medicament for the treatment or prophylaxis of the pathological conditions which can be improved by 5-HT.sub.3 mediated selective agonism and new compounds deriving from this chemical class.
摘要:
The components of a rotary conveyor (1) for a carousel type capping machine (2) include a center shaft aligned on a main axis (X) coinciding with the main axis of the machine (2), a carrier element (4) coupled to the shaft so that the two rotate as one about the main axis (X), and a set of gripper mechanisms (5) associated operationally with the carrier element (4), distributed circumferentially about the supporting shaft. Each gripper mechanism (5) is switchable between a first configuration, establishing a recess (6) in which to accommodate a respective container (3), a second configuration in which the container (3) is retained within the recess (6) by a predetermined gripping force, and a third configuration in which the container (3) is restrained by a gripping force greater than the force exerted in the second configuration, so as to counteract any unwanted rotation of the container (3) about its longitudinal axis (Y) that might be induced during the course of capping operations.
摘要:
The disclosure relates to (heterocycle-fused piperidine)-(piperazinyl)-1-alkanone derivatives and (heterocycle-fused pyrrolidine)-(piperazinyl)-1-alkanone derivatives of formula (I): wherein A, W, R2 and n are as defined in the disclosure, to the method of preparation thereof and the therapeutic use thereof.
摘要:
The present invention relates to derivatives of ((phenyl)-3,6-dihydropyridin-1-yl)(bridged piperazinyl)-1-alkanone derivatives and ((phenyl)-2,5-dihydropyrrol-1-yl) (bridged piperazinyl)-1-alkanone corresponding to Formula (I): in which the variables are as defined herein, to the preparation thereof and to the therapeutic use thereof.
摘要:
A container supplied to a carousel type filling unit is directed onto a supporting and weighing device (1) that presents a hollow body (12) attached to the carousel and housing a load cell. The hollow body (12) is equipped with a pedestal (19) presenting a platform (20) on which to stand the container, and a connecting element (21) of which a first end (21a) is coupled with the load cell internally of the hollow body (12) and a second end (21b), opposite to the first end (21a), is secured to the platform (20). To advantage, the first end (21a) of the connecting element (21) is seated in a through opening (13) afforded by the underside of the hollow body (12).
摘要:
The present invention relates to derivatives of 4-{2-[phenyl-3,6-dihydropyridin-1-yl]-2-oxoalkyl}-1-piperazin-2-one and 4-{2-[phenyl-2,5-dihydropyrrol-1-yl]-2-oxoalkyl}-1-piperazin-2-one having general formula (I): in which A, B, m, R3 and n are as defined herein. The invention also relates to the preparation thereof and to the therapeutic use thereof.
摘要:
The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independently represent a hydrogen atom or a methyl group; n is 0 or 1; A represents an optionally substituted nitrogenous heterocycle; and to their N-oxides and to their salts or solvates, to the pharmaceutical compositions and the medicaments comprising them, and to a process for their preparation.
摘要翻译:本发明涉及式(I)化合物:其中X表示N或CH; R 1表示氢或卤素原子或CF 3 N 3基团; R 2和R 3独立地表示氢原子或甲基; n为0或1; A表示任选取代的含氮杂环; 以及它们的N-氧化物及其盐或溶剂化物,涉及药物组合物和包含它们的药物及其制备方法。
摘要:
The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
摘要:
The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; W represents a diazoheterocycle; R2 and R3 independently represent a hydrogen atom or a methyl group; n is 0 or 1; A represents a quinoline or an isoquinoline which are optionally substituted.
摘要翻译:本发明涉及式(I)化合物:其中X表示N或CH; R 1表示氢或卤素原子或CF 3 N 3基团; W代表重氮杂环; R 2和R 3独立地表示氢原子或甲基; n为0或1; A代表任选取代的喹啉或异喹啉。
摘要:
The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.