Ultrasensitive bioanalytical assays based on the use of high-gain catalytic chemical amplification
    31.
    发明申请
    Ultrasensitive bioanalytical assays based on the use of high-gain catalytic chemical amplification 有权
    基于高增益催化化学扩增的超灵敏生物分析测定

    公开(公告)号:US20070128679A1

    公开(公告)日:2007-06-07

    申请号:US11292585

    申请日:2005-12-02

    IPC分类号: G01N33/00

    CPC分类号: G01N33/58 G01N2458/30

    摘要: The invention relates to ultrasensitive bioanalytical assays based on the use of high-gain catalytic chemical amplification methods. The ultrasensitive bioanalytical assays of the invention utilize high gain catalytic chemical amplification methods to detect the presence and to quantify the concentrations of target analytes labeled with specific binding reagents or biomarkers comprising a catalyst or a catalyst precursor.

    摘要翻译: 本发明涉及基于使用高增益催化化学扩增方法的超敏感生物分析测定法。 本发明的超灵敏生物分析测定法利用高增益催化化学扩增方法来检测用包含催化剂或催化剂前体的特异性结合试剂或生物标志物标记的靶分析物的存在和定量。

    METHOD OF PATTERNING AN ELECTROCONDUCTIVE LAYER ON A SUPPORT
    32.
    发明申请
    METHOD OF PATTERNING AN ELECTROCONDUCTIVE LAYER ON A SUPPORT 有权
    在支持下绘制电磁层的方法

    公开(公告)号:US20050048406A1

    公开(公告)日:2005-03-03

    申请号:US10648421

    申请日:2003-08-26

    摘要: An element for making patterns on an electroconductive substrate, the element comprising a support, on which is disposed: a) a conductive layer containing an electrically conductive polymer, a polyanion and a conductivity enhancing agent; and b) a mixing layer containing a thermally mobile material; wherein, upon imagewise heating the mixing layer, the thermally mobile material mixes with the conductive layer, thereby causing the initial surface resistivity (SR) of the conductive layer to imagewise increase from an initial value SRi, which is lower than 105 Ω/square, to SRiΔ, Δ being at least 102.

    摘要翻译: 一种用于在导电衬底上制作图案的元件,所述元件包括支撑件,其上设置有:a)包含导电聚合物,聚阴离子和导电性增强剂的导电层; 和b)含有热移动材料的混合层; 其中,在对混合层进行成像加热时,热移动材料与导电层混合,由此导致导电层的初始表面电阻率(SR)从初始值SRi成像,其初始值SRi低于10Ω /平方,至SRiDelta,Delta至少为10 2。

    Chemically sensitized aqueous-based photothermographic emulsions and materials and methods of using same
    33.
    发明授权
    Chemically sensitized aqueous-based photothermographic emulsions and materials and methods of using same 失效
    化学敏化水性光热敏成像乳剂及其使用方法

    公开(公告)号:US06733959B2

    公开(公告)日:2004-05-11

    申请号:US09923039

    申请日:2001-08-06

    IPC分类号: G03C1498

    摘要: Photothermographic materials prepared using aqueous formulations include silver halides that are chemically sensitized using certain tellurium-containing compounds. Such tellurium-containing chemical sensitizing compounds are generally provided in aqueous solution or in an aqueous solid particulate dispersion and can be represented by the following Structure I, II, or III: Te(L)m(X1)n  (II) Pd(X2)2[Te(R′)2]2  (III) wherein X represents the same or different COR, CSR, CNRRa, CR, PRRa, or P(OR)2 groups, R and Ra are independently alkyl, alkenyl, or aryl groups, L is a ligand derived from a neutral Lewis base, X1 and X2 independently represent a halo, OCN, SCN, S2CNRRa, S2COR, S2CSR S2P(OR)2, S2PRRa, SeCN, TeCN, CN, SR, OR, alkyl, aryl, N3, or O2CR group, R′ is an alkyl or aryl group, p is 2 or 4, m is 0, 1, 2, or 4, and n is 2 or 4 provided that when m is 0 or 2, n is 2 or 4, and when m is 1 or 4, n is 2.

    摘要翻译: 使用水性制剂制备的光热照相材料包括使用某些含碲化合物化学增感的卤化银。 这种含碲的化学增感化合物通常提供在水溶液或水性固体颗粒分散体中,并且可以由以下结构I,II或III表示:其中X表示相同或不同的COR,CSR,CNRRa,CR, PRRa或P(OR)2基团,R和Ra独立地是烷基,烯基或芳基,L是衍生自中性路易斯碱的配体,X 1和X 2独立地表示卤素,OCN, SCN,S2CNRRa,S2COR,S2CSR S2P(OR)2,S2PRRa,SeCN,TeCN,CN,SR,OR,烷基,芳基,N 3或O 2 CR基团,R'为烷基或芳基,p为2或4, m为0,1,2或4,n为2或4,条件是当m为0或2时,n为2或4,当m为1或4时,n为2。

    Thermographic imaging elements and processes for their use

    公开(公告)号:US06509296B1

    公开(公告)日:2003-01-21

    申请号:US09536181

    申请日:2000-03-27

    IPC分类号: B41M530

    CPC分类号: B41M5/32 B41M5/30

    摘要: A thermally imageable element can be imaged using heat alone without the need for photosensitivity or post-imaging processing. The element contains image-forming chemistry that comprises i) image precursor chemistry and ii) a catalyst or a catalyst precursor that upon imagewise heating is capable of promoting thermally induced image formation with the image precursor chemistry. The image-forming chemistry i) and ii) components are in reactive association and uniformly dispersed or dissolved within a binder in one or more layers of the element. Thus, the element is capable of being thermally addressed to provide a visible image as a result of thermally induced catalytic transformation of the image-forming chemistry.

    Ferroelectric imaging member and methods of use
    35.
    发明授权
    Ferroelectric imaging member and methods of use 失效
    铁电成像构件及使用方法

    公开(公告)号:US5927206A

    公开(公告)日:1999-07-27

    申请号:US995311

    申请日:1997-12-22

    IPC分类号: G03G5/02 B41N1/00 B41N1/14

    CPC分类号: B41N1/006

    摘要: An imagewise polarizable imaging member can be used to print the same or different images with an electrically responsive marking media. The imaging member includes a matrix-addressable microelectronic layer in proximate relationship with an imagewise polarizable ferroelectric layer. Imaging is accomplished by forming an imagewise electrical pattern in the ferroelectric layer using signals from the matrix-addressable microelectronic layer, and applying the electrically responsive marking media to the electrically polarized ferroelectric layer, creating thereon an identifiable image pattern. The marking media can then be transferred to a suitable receiver material to form the desired printed image.

    摘要翻译: 可以使用成像极化成像构件用电响应标记介质打印相同或不同的图像。 成像构件包括与成像可极化铁电层成近邻关系的矩阵寻址微电子层。 通过使用来自矩阵寻址微电子层的信号在铁电层中形成图像电图案,并将电响应标记介质施加到电极化铁电层,从而在其上产生可识别的图像图案来实现成像。 然后可以将标记介质转移到合适的接收器材料以形成所需的打印图像。

    Dye-forming electrothermographic material and process
    37.
    发明授权
    Dye-forming electrothermographic material and process 失效
    染料电热成像材料及工艺

    公开(公告)号:US4752547A

    公开(公告)日:1988-06-21

    申请号:US870572

    申请日:1986-06-04

    CPC分类号: G03G5/00 G03C1/67 G03C7/46

    摘要: A dye-forming electrothermographic element comprises an electrically activatable recording layer comprising (a) a reducing agent or reducing agent precursor capable of being activated by a Lewis base; (b) a cobalt(III) Lewis base complex; and (c) at least one of (i) a reducible dye-forming compound that has an oxidation state above that of the conjugate dye, (ii) a dye capable of changing its wavelength of absorption by reaction with a Lewis base, and (iii) a dye-forming coupler capable of reacting with the oxidized form of the reducing agent in (a) to form a dye. A negative or positive dye image is formed in such a dye-forming electrothermographic element by applying an electrical potential imagewise to the element of a magnitude and for a time sufficient to produce in the image areas a charge density sufficient to produce a latent image; and, then, heating the element to a temperature and for a time sufficient to form a dye image in the element. The dye-forming electrothermographic element can be a multicolor, multilayer electrothermographic element.

    摘要翻译: 染料形成电热成像元件包括电可活化记录层,其包含(a)能够被路易斯碱活化的还原剂或还原剂前体; (b)一种钴(III)路易斯碱络合物; 和(c)至少一种(i)具有高于该共轭染料的氧化态的可还原的形成染料的化合物,(ii)能够通过与路易斯碱反应来改变其吸收波长的染料和( iii)能够在(a)中与氧化形式的还原剂反应形成染料的染料形成成色剂。 在这种染料形成的电热成像元件中,通过将图像上的电位成像到该元件的大小和时间足以在图像区域中产生足以产生潜像的电荷密度来形成负或正的染料图像; 然后,将元件加热到足以在元件中形成染料图像的温度和时间。 染料形成电热元件可以是多色多层电热元件。

    Polymeric electrically active conductive layer (EAC) for electrically
activatable recording element and process
    38.
    发明授权
    Polymeric electrically active conductive layer (EAC) for electrically activatable recording element and process 失效
    用于电可激活记录元件和工艺的聚合物电活性导电层(EAC)

    公开(公告)号:US4410614A

    公开(公告)日:1983-10-18

    申请号:US388376

    申请日:1982-06-14

    CPC分类号: G03G5/026 G03G5/153

    摘要: In an electrically activatable recording element and process comprising a polymeric electrically active conductive layer improvements are provided wherein the polymeric electrically active conductive layer comprises a polymer that has recurring units represented by the structure: ##STR1## wherein R is hydrogen or alkyl containing 1 to 20 carbon atoms;R.sup.1 and R.sup.3 are individually hydrogen or methyl;R.sup.2 is alkyl containing 2 to 20 carbon atoms;x is 0 or 1;y is 0 to 4;R.sup.4 is C.sub.6 H.sub.5-z X.sub.z ; wherein z is 1 to 5;X is chlorine, bromine or iodine;n is 40 to 100 weight percent;and the polymer has a glass transition temperature within the range of 20.degree. C. to 40.degree. C.Such a polymeric electrically active conductive layer is useful in, for example, an electrically activatable recording element comprising an electrically conductive support having thereon, in sequence:(a) a polymeric electrically active conductive layer, as described,(b) an electrically activatable recording layer comprising:(A) a dye-forming coupler, and(B) an oxidation-reduction combination comprising:(i) an organic silver salt oxidizing agent consisting essentially of a silver salt of a 1,2,4-mercaptotriazole derivative with(ii) a reducing agent which, in its oxidized form, forms a dye with said dye-forming coupler,(c) a photoconductive layer separated from (b) by an air gap of up to 20 microns or separated from (b) by an electrically conductive interlayer, and(d) an electrically conductive layer.The recording element is light handleable and provides a dye image and silver image by dry development processing.

    摘要翻译: 在可激活的记录元件和包含聚合物电活性导电层的方法中,提供了改进的改进,其中聚合物电活性导电层包含具有由以下结构表示的重复单元的聚合物:其中R是氢或含有1至20个 碳原子 R1和R3分别是氢或甲基; R2是含有2-20个碳原子的烷基; x为0或1; y为0〜4; R4为C6H5-zXz; 其中z为1至5; X是氯,溴或碘; n为40〜100重量% 并且聚合物的玻璃化转变温度在20℃至40℃的范围内。这种聚合物电活性导电层可用于例如依次具有其上的导电载体的可电激活的记录元件 (a)聚合物电活性导电层,如上所述,(b)可电致活化的记录层,包括:(A)染料形成成色剂,和(B)氧化还原组合,其包含:(i)有机银 基本上由1,2,4-巯基三唑衍生物的银盐组成的盐氧化剂,和(ii)以氧化形式与所述成色剂形成染料的还原剂,(c)分离的光电导层 从(b)到达20微米的气隙或者由(b)由导电中间层分离,和(d)导电层。 记录元件可轻易处理,并通过干式显影处理提供染料图像和银色图像。

    Polymeric electrically active conductive layer for electrically
activatable recording element and process
    39.
    发明授权
    Polymeric electrically active conductive layer for electrically activatable recording element and process 失效
    用于电可激活记录元件和工艺的聚合物电活性导电层

    公开(公告)号:US4332875A

    公开(公告)日:1982-06-01

    申请号:US229701

    申请日:1981-01-29

    摘要: In an electrically activatable recording element, such as one comprising an electrically conductive support having thereon, in sequence: (a) a polymeric electrically active conductive (EAC) layer, (b) an electrically activatable recording layer comprising (A) a dye-forming coupler, and (B) an oxidation-reduction combination comprising (i) an organic silver salt oxidizing agent consisting essentially of a silver salt of a 1,2,4-mercaptotriazole derivative, with (ii) a reducing agent which, in its oxidized form, forms a dye with the dye-forming coupler, (c) a photoconductive layer separated from (b) by an air gap of up to 20 microns, and (d) an electrically conductive layer; improvements are provided by means of a polymeric EAC layer (a) consisting essentially of a vinyl addition polymer, such as poly(methyl acrylate-co-vinylidene chloride). The recording element is room light handleable and provides a dye image and silver image by dry development processing.

    摘要翻译: 在可激活的记录元件中,例如包括其上的导电载体的顺序:(a)聚合物电活性导电(EAC)层,(b)可电激活的记录层,其包含(A)成染染色剂 成色剂和(B)氧化还原组合,其包含(i)基本上由1,2,4-巯基三唑衍生物的银盐组成的有机银盐氧化剂与(ii)还原剂,其在其氧化 形成染料,与染料形成成色剂形成染料,(c)通过高达20微米的气隙与(b)分离的光电导层,和(d)导电层; 通过基本上由乙烯基加成聚合物如聚(丙烯酸甲酯 - 共 - 偏二氯乙烯)组成的聚合物EAC层(a)提供改进。 记录元件是室内光线处理,通过干式显影处理提供染色图像和银色图像。