-
公开(公告)号：US09607820B2
公开(公告)日：2017-03-28
申请号：US12306162
申请日：2007-06-25
CPC分类号： H01J49/429 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A mass spectrometer includes an ion mobility spectrometer or separator arranged upstream of a collision or fragmentation cell. Ions are separated according to their ion mobility within the ion mobility spectrometer or separator. The kinetic energy of the ions exiting the ion mobility spectrometer or separator is increased substantially linearly with time in order to optimize the fragmentation energy of ions as they enter the collision or fragmentation cell. During the time that the potential of the ion mobility spectrometer or separator is being varied, the potential of ion-optical components upstream of the ion mobility spectrometer or separator such as an ion source, ion guide, quadrupole mass filter, optional second collision or fragmentation cell and an ion trapping device are kept constant.
-
公开(公告)号：US09281171B2
公开(公告)日：2016-03-08
申请号：US11721260
申请日：2005-12-08
申请人： Robert Harold Bateman , Kevin Giles , Jeffery Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Jeffery Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
CPC分类号： H01J49/062 , H01J49/004
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyzer arranged upstream of an ion guide. Ions are scanned out of the mass selective ion trap or mass analyzer and are received in one or more axial potential wells created or formed within the ion guide. One or more transient DC voltages or potentials are preferably applied to the ion guide in order to create a plurality of axial potential wells which are translated along the length of the ion guide. Ions are released in packets from the exit of the ion guide and are orthogonally acceleration into a drift or flight region of an orthogonal acceleration Time of Flight mass analyzer with a relatively high duty cycle.
摘要翻译： 公开了一种质谱仪，其包括布置在离子导向器上游的质量选择性离子阱或质量分析器。 离子从质量选择性离子阱或质量分析器扫描出来，并被接收在一个或多个在离子导向器内产生或形成的轴向势阱中。 优选地将一个或多个瞬态DC电压或电位施加到离子导向器，以便产生沿离子导向件的长度平移的多个轴向势阱。 离子从离子导向器的出口释放出来的离子，并且正交加速到相对较高占空比的正交加速时间飞行质量分析器的漂移或飞行区域。
-
公开(公告)号：US08519331B2
公开(公告)日：2013-08-27
申请号：US12528173
申请日：2008-02-21
CPC分类号： H01J49/0095 , H01J49/423 , H01J49/424
摘要： A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods to allow ions to be ejected radially from the ion trap. The 3D ion trap comprises a central ring electrode which is radially segmented and wherein a slot is provided in each radial segment to allow ions to be ejected radially from the ion trap. Ions having different mass to charge ratios and/or opposite polarities may be simultaneously ejected from the ion trap via different exit pathways.
摘要翻译： 公开了包括2D或3D离子阱的质谱仪。 2D离子阱包括四极杆组离子阱，其中在每个棒中设置有槽，以允许离子从离子阱径向喷射。 3D离子阱包括径向分段的中心环电极，并且其中在每个径向段中设置狭槽以允许离子从离子阱径向喷射。 具有不同质荷比和/或相反极性的离子可以通过不同的出口通道从离子阱同时喷出。
-
公开(公告)号：US08164052B2
公开(公告)日：2012-04-24
申请号：US12593006
申请日：2008-03-26
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell (1). Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell (1). The cell comprises a plurality of ring electrodes (1) which form a spherical trapping volume. Ions experience negligible RF heating over the majority, of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell (1) having an enhanced sensitivity is thereby provided. Fragment ions created within the cell (1) may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译： 公开了包含电子转移离解电池（1）的质谱仪。 当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子（1）。 电池包括形成球形捕获体积的多个环形电极（1）。 离子经验可忽略大部分的RF加热，捕集体积使分析物和试剂离子的动能降低到高于热温度。 由此提供了具有增强的灵敏度的电子转移解离单元（1）。 在细胞（1）内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，能够显着提高质量分析仪的分辨率。
-
公开(公告)号：US20100252730A1
公开(公告)日：2010-10-07
申请号：US12668813
申请日：2008-07-14
CPC分类号： H01J49/4205 , H01J49/02 , H01J49/4225
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion trap (2, 3) wherein a potential field is created at the exit of the ion trap (4, 5) which decreases with increasing radius in one radial direction. Ions within the ion trap (2, 3) are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap (2, 3).
摘要翻译： 公开了一种质谱仪，其包括四极杆组离子阱（2,3），其中在离子阱（4,5）的出口产生一个电势场，该离子阱在一个径向方向上随着半径的增加而减小。 离子阱（2,3）内的离子质量选择性地沿径向激发。 已经在径向方向被激发的离子经历了不再将离子轴向限定在离子阱内的势场，而是作用于提取离子并因此导致离子从离子阱（2,3）轴向地排出， 。
-
公开(公告)号：US20100148056A1
公开(公告)日：2010-06-17
申请号：US12516610
申请日：2007-12-14
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： A mass spectrometer is disclosed comprising an orthogonal acceleration Time of Flight mass analyser. A pulse or packet of ions is released either from an ion trap (7) or alternatively from a travelling wave ion guide arranged upstream of an orthogonal acceleration electrode (2) which forms part of the Time of Flight mass analyser. Ions in the pulse or packet of ions which is released become temporally dispersed and the orthogonal acceleration electrode (2) is energised multiple times prior the release of a subsequent pulse or packet of ions.
摘要翻译： 公开了一种质谱仪，其包括正交加速时间飞行质量分析器。 从离子阱（7）或替代地从布置在作为飞行时间质量分析器的一部分的正交加速电极（2）的上游的行波离子导向器释放脉冲或包离子。 释放的脉冲或离子束中的离子变得暂时分散，并且在随后的脉冲或包离子的释放之前，正交加速电极（2）被多次通电。
-
公开(公告)号：US20100038530A1
公开(公告)日：2010-02-18
申请号：US11813221
申请日：2006-01-17
申请人： Kevin Giles , Martin Green , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Green , Jason Lee Wildgoose
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap (1) is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap (1) by the application of an AC or RF voltage to the electrodes. A static potential well is maintained along at least a portion of the axial length of the ion guide or ion trap (1). A time varying homogeneous electric field is applied along at least a portion of the axial length of the ion guide or ion trap (1). The combination of the static axial potential well and the time varying axial homogeneous electric field causes ions to be ejected from the ion guide or ion trap (1) in a substantially non-resonant manner.
摘要翻译： 公开了一种离子导向器或离子阱（1），其包括分段线性离子导向器或离子阱。 通过向电极施加AC或RF电压，离子在径向上被限制在离子导向器或离子阱（1）内。 沿离子导向器或离子阱（1）的轴向长度的至少一部分保持静电势阱。 沿离子导向器或离子阱（1）的轴向长度的至少一部分施加时变均匀电场。 静态轴向势阱和随时间变化的轴向均匀电场的组合导致离子以基本上非共振的方式从离子导向器或离子阱（1）喷出。
-
公开(公告)号：US20100032561A1
公开(公告)日：2010-02-11
申请号：US12518291
申请日：2007-12-12
IPC分类号： H01J49/26
CPC分类号： G01N27/622 , G01N27/624 , H01J49/062 , H01J49/4235
摘要： A mass spectrometer is disclosed comprising a device (2) which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device (2) is also operable in a second mode of operation wherein ions are separated temporally according to the their mass to charge ratio by pulsing an applied axial electric field ON and OFF.
摘要翻译： 公开了一种质谱仪，其包括可在第一操作模式中操作的装置（2），其通过施加连续轴向电场根据其离子迁移率暂时分离离子。 装置（2）还可在第二操作模式中操作，其中通过脉冲施加的轴向电场ON和OFF，离子根据其质荷比逐时分离。
-
公开(公告)号：US09281172B2
公开(公告)日：2016-03-08
申请号：US12094561
申请日：2006-12-07
CPC分类号： G01N27/622 , H01J49/062
摘要： A closed-loop ion guide is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. Ions are injected into the closed-loop ion guide and may make several circuits of the closed-loop ion guide before being ejected from the ion guide. In a mode of operation the ion guide may be arranged to separate ions temporally according to their ion mobility.
摘要翻译： 公开了一种闭环离子导向器，其包括具有孔的多个电极，在使用中通过该孔具有离子。 离子被注入到闭环离子导向器中，并且可以在从离子导向器喷射之前使闭环离子导向器的几个电路。 在一种操作模式中，离子导向器可以根据其离子迁移率临时分离离子。
-
公开(公告)号：US08952323B2
公开(公告)日：2015-02-10
申请号：US12092601
申请日：2006-11-10
CPC分类号： H01J49/004 , G01N27/622 , H01J49/0031 , H01J49/42
摘要： A mass spectrometer is disclosed comprising a first ion trap or ion guide (2), a single ion mobility spectrometer or separator stage (3) and a second ion trap or ion guide (4) arranged downstream of the ion mobility spectrometer or separator (3). In a mode of operation ions from the second ion trap or ion guide (4) are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator (3).
摘要翻译： 公开了一种质谱仪，其包括第一离子阱或离子导向器（2），单离子迁移谱仪或分离器级（3）和设置在离子迁移谱仪或分离器（3）的下游的第二离子阱或离子导向器 ）。 在操作模式中，来自第二离子阱或离子导向器（4）的离子从第二离子阱或离子导向器返回到离子迁移谱仪或分离器（3）的上游。
-
-
-
-
-
-
-
-
-
搜索结果
105 条记录 (耗时 0.04 秒)
