公开(公告)号：US08012919B2

公开(公告)日：2011-09-06

申请号：US12493589

申请日：2009-06-29

Applicant: Bernard Kinker ,  Matthias Fischer ,  Martin Bollinger ,  Robert Cybert ,  Ernst Bielmeier ,  David Cooper ,  Angelika Fischer ,  Melanie Croessmann

Inventor： Bernard Kinker ,  Matthias Fischer ,  Martin Bollinger ,  Robert Cybert ,  Ernst Bielmeier ,  David Cooper ,  Angelika Fischer ,  Melanie Croessmann

IPC: C10M145/14

CPC classification number: C10M149/02 ,  C10M161/00 ,  C10M2205/04 ,  C10M2209/084 ,  C10M2209/086 ,  C10M2217/023 ,  C10M2217/024 ,  C10M2217/028 ,  C10N2220/021 ,  C10N2230/041 ,  C10N2240/102

Abstract: The present invention is directed to a lubricating oil composition, a diesel engine comprising a lubricating oil composition, and a method of lubricating a diesel engine provided with an exhaust gas recirculation system, comprising lubricating said engine with a lubricating oil composition comprising an oil of lubricating viscosity, and a polymeric N-dispersant booster comprising monomer units of: a) 0 to 40 wt. % of one or more ethylenically unsaturated ester compounds of formula (I) wherein R is equal to H or CH3, R1 represents a linear or branched alkyl group with 1 to 5 carbon atoms, R2 and R3 independently represent H or a group of the formula —COOR′, wherein R′ is H or an alkyl group with 1 to 5 carbon atoms, b) 10 to 98 wt. % of one or more ethylenically unsaturated ester compounds of formula (II) wherein R is equal to H or CH3, R4 represents a linear or branched alkyl group with 6 to 15 carbon atoms, R5 and R6 independently represent H or a group of the formula —COOR″, wherein R″ is H or an alkyl group with 6 to 15 carbon atoms, c) 0 to 30 wt. % of one or more ethylenically unsaturated ester compounds of formula (III) wherein R is equal to H or CH3, R7 represents a linear or branched alkyl group with 16 to 30 carbon atoms, R8 and R9 independently represent H or a group of the formula —COOR′″, wherein R′″ is H or an alkyl group with 16 to 30 carbon atoms, d) 0 to 30 wt. % vinyl monomers, e) 7 to 25 wt. % of at least one N— dispersant monomer, wherein a)-e) add up to 100 wt. %.

Abstract translation: 本发明涉及润滑油组合物，包含润滑油组合物的柴油发动机，以及润滑具有废气再循环系统的柴油发动机的方法，包括用润滑油组合物润滑所述发动机，所述润滑油组合物包含润滑油 粘度和聚合N-分散剂增强剂，其包含以下单体单元：a）0至40wt。 ％的一种或多种式（I）的烯属不饱和酯化合物，其中R等于H或CH 3，R 1表示具有1至5个碳原子的直链或支链烷基，R2和R3独立地表示H或式 -COOR'，其中R'是H或具有1至5个碳原子的烷基，b）10至98wt。 ％的一种或多种式（II）的烯键式不饱和酯化合物，其中R等于H或CH 3，R 4表示具有6至15个碳原子的直链或支链烷基，R 5和R 6独立地表示H或式 -COOR“，其中R”为H或具有6至15个碳原子的烷基，c）0至30重量％ ％的一种或多种式（III）的烯键式不饱和酯化合物，其中R等于H或CH 3，R 7表示具有16至30个碳原子的直链或支链烷基，R8和R9独立地表示H或式 -COOR'“，其中R'”为H或具有16至30个碳原子的烷基，d）0至30重量％ ％乙烯基单体，e）7〜25wt。 ％的至少一种N-分散剂单体，其中a）-e）加到100wt。 ％。

公开(公告)号：US20090270287A1

公开(公告)日：2009-10-29

申请号：US12493589

申请日：2009-06-29

Applicant: Bernard KINKER ,  Matthias Fischer ,  Martin Bollinger ,  Robert Cybert ,  Ernst Bielmeier ,  David Cooper ,  Angelika Fischer ,  Melanie Croessmann

Inventor： Bernard KINKER ,  Matthias Fischer ,  Martin Bollinger ,  Robert Cybert ,  Ernst Bielmeier ,  David Cooper ,  Angelika Fischer ,  Melanie Croessmann

IPC: C10M149/10

CPC classification number: C10M149/02 ,  C10M161/00 ,  C10M2205/04 ,  C10M2209/084 ,  C10M2209/086 ,  C10M2217/023 ,  C10M2217/024 ,  C10M2217/028 ,  C10N2220/021 ,  C10N2230/041 ,  C10N2240/102

Abstract: The present invention is directed to a lubricating oil composition, a diesel engine comprising a lubricating oil composition, and a method of lubricating a diesel engine provided with an exhaust gas recirculation system, comprising lubricating said engine with a lubricating oil composition comprising an oil of lubricating viscosity, and a polymeric N-dispersant booster comprising monomer units of: a) 0 to 40 wt. % of one or more ethylenically unsaturated ester compounds of formula (I) wherein R is equal to H or CH3, R1 represents a linear or branched alkyl group with 1 to 5 carbon atoms, R2 and R3 independently represent H or a group of the formula —COOR′, wherein R′ is H or an alkyl group with 1 to 5 carbon atoms, b) 10 to 98 wt. % of one or more ethylenically unsaturated ester compounds of formula (II) wherein R is equal to H or CH3, R4 represents a linear or branched alkyl group with 6 to 15 carbon atoms, R5 and R6 independently represent H or a group of the formula —COOR″, wherein R″ is H or an alkyl group with 6 to 15 carbon atoms, c) 0 to 30 wt. % of one or more ethylenically unsaturated ester compounds of formula (III) wherein R is equal to H or CH3, R7 represents a linear or branched alkyl group with 16 to 30 carbon atoms, R8 and R9 independently represent H or a group of the formula —COOR′″, wherein R′″ is H or an alkyl group with 16 to 30 carbon atoms, d) 0 to 30 wt. % vinyl monomers, e) 7 to 25 wt. % of at least one N— dispersant monomer, wherein a)-e) add up to 100 wt. %.

Abstract translation: 本发明涉及润滑油组合物，包含润滑油组合物的柴油发动机，以及润滑具有废气再循环系统的柴油发动机的方法，包括用润滑油组合物润滑所述发动机，所述润滑油组合物包含润滑油 粘度和聚合N-分散剂增强剂，其包含以下单体单元：a）0至40wt。 ％的一种或多种式（I）的烯属不饱和酯化合物，其中R等于H或CH 3，R 1表示具有1至5个碳原子的直链或支链烷基，R2和R3独立地表示H或式 -COOR'，其中R'是H或具有1至5个碳原子的烷基，b）10至98wt。 ％的一种或多种式（II）的烯键式不饱和酯化合物，其中R等于H或CH 3，R 4表示具有6至15个碳原子的直链或支链烷基，R 5和R 6独立地表示H或式 -COOR“，其中R”为H或具有6至15个碳原子的烷基，c）0至30重量％ ％的一种或多种式（III）的烯键式不饱和酯化合物，其中R等于H或CH 3，R 7表示具有16至30个碳原子的直链或支链烷基，R8和R9独立地表示H或式 -COOR“'，其中R”'为H或具有16至30个碳原子的烷基，d）0至30重量％ ％乙烯基单体，e）7〜25wt。 ％的至少一种N-分散剂单体，其中a）-e）加到100wt。 ％。

公开(公告)号：US20090037030A1

公开(公告)日：2009-02-05

申请号：US12251304

申请日：2008-10-14

Applicant: Avinash Chidambaram ,  Richard Francis Penn ,  David Cooper

Inventor： Avinash Chidambaram ,  Richard Francis Penn ,  David Cooper

IPC: G06F17/00 ,  G06F3/048

CPC classification number: H02J13/001 ,  Y04S10/40 ,  Y10T307/484 ,  Y10T307/685 ,  Y10T307/702

Abstract: Information for configuring control apparatus for a power system including a plurality of controlled power supplies is produced using a graphical interface which displays the topology and sequencing of the power supplies in the power system. A database is used to select power supplies to add in determining the power system topology. Sequencing is represented by displacing icons representing the power supplies along lines representing their input and output voltages, and arrows representing startup sequence dependencies. A processor produces the configuration information, consistent with the displayed topology and sequencing, using information for the selected power supplies from the database, for downloading to the control apparatus.

Abstract translation: 用于配置包括多个受控电源的电力系统的控制装置的信息使用显示电力系统中的电源的拓扑和排序的图形界面来产生。 数据库用于选择电源以添加以确定电力系统拓扑。 排序通过沿表示其输入和输出电压的线代替电源的图标和表示启动顺序依赖性的箭头来表示。 处理器使用来自数据库的所选电源的信息来产生与显示的拓扑和排序一致的配置信息，以便下载到控制设备。

公开(公告)号：US07458028B2

公开(公告)日：2008-11-25

申请号：US10621414

申请日：2003-07-18

Applicant: Avinash Chidambaram ,  Richard Francis Penn ,  David Cooper

Inventor： Avinash Chidambaram ,  Richard Francis Penn ,  David Cooper

IPC: G06F15/177 ,  G06F15/18

CPC classification number: H02J13/001 ,  Y04S10/40 ,  Y10T307/484 ,  Y10T307/685 ,  Y10T307/702

Abstract: Information for configuring control apparatus for a power system including a plurality of controlled power supplies is produced using a graphical interface which displays the topology and sequencing of the power supplies in the power system. A database is used to select power supplies to add in determining the power system topology. Sequencing is represented by displacing icons representing the power supplies along lines representing their input and output voltages, and arrows representing startup sequence dependencies. A processor produces the configuration information, consistent with the displayed topology and sequencing, using information for the selected power supplies from the database, for downloading to the control apparatus.

Abstract translation: 用于配置包括多个受控电源的电力系统的控制装置的信息使用显示电力系统中的电源的拓扑和排序的图形界面来产生。 数据库用于选择电源以添加以确定电力系统拓扑。 排序通过沿表示其输入和输出电压的线代替电源的图标和表示启动顺序依赖性的箭头来表示。 处理器使用来自数据库的所选电源的信息来产生与显示的拓扑和排序一致的配置信息，以便下载到控制设备。

公开(公告)号：US20080175976A1

公开(公告)日：2008-07-24

申请号：US11624328

申请日：2007-01-18

Applicant: Peter M. Bernegger ,  David Cooper

Inventor： Peter M. Bernegger ,  David Cooper

IPC: A23L1/325

CPC classification number: A23J1/04 ,  A23L29/284

Abstract: Process for the preparation of gelatin from fish parts includes the steps of washing the fish parts with an aqueous solution of a calcium hydroxide hydrate and ice to remove blood from the fish parts, treating the washed skins with an acid, and extracting gelatin from the fish skins at a temperature approximately between 100 Fahrenheit to 170 Fahrenheit and at an acidic pH approximately between pH 1.5 to pH 5.5.

Abstract translation: 用于从鱼部分制备明胶的方法包括用氢氧化钙水合物和冰水溶液洗涤鱼部分以从鱼部分去除血液，用酸处理洗涤的皮肤并从鱼中提取明胶的步骤 在约华氏温度至170华氏度的温度下，pH约为1.5至pH5.5的酸性pH皮肤。

公开(公告)号：US20070116548A1

公开(公告)日：2007-05-24

申请号：US11281139

申请日：2005-11-18

Applicant: David Cooper

Inventor： David Cooper

IPC: B66F9/18

CPC classification number: B62B3/06 ,  B62B2203/24 ,  B66F9/122 ,  B66F9/142

Abstract: A fork-type pallet-lifting device having frame means with a steering wheel-mounting mechanism and fork-supporting means a steering wheel unit mounted to the steering wheel-mounting mechanism, a fork unit with opposing first and second fork elements mounted to the fork-supporting means, fork-displacing means structured to selectively and separately allow lateral displacement of the first and second fork elements relative to each other, hydraulic means with supporting wheel means, a hydraulic motor, and a linkage arrangement structured to suspend the first and second fork elements at a selected elevation above an underlying supporting surface, and control means including a hydraulic motor, and a main handle and a release mechanism for controlling the hydraulic motor.

Abstract translation: 一种具有方向盘安装机构和叉支撑装置的框架装置的叉式托盘提升装置，安装在方向盘安装机构上的方向盘单元，具有安装到叉子上的相对的第一和第二叉形元件的叉形单元 支撑装置，构造成选择性地和分开地允许第一和第二叉形元件相对于彼此的横向移位的叉移动装置，具有支撑轮装置的液压装置，液压马达和连接装置，其被构造成悬挂第一和第二叉形元件 在下面的支撑表面上方的选定的高度处的叉形元件，以及包括液压马达的控制装置，以及用于控制液压马达的主手柄和释放机构。

公开(公告)号：US20060166210A1

公开(公告)日：2006-07-27

申请号：US10535013

申请日：2003-11-04

Applicant: Linda Fryklund ,  Mark Lewis ,  David Cooper

Inventor： Linda Fryklund ,  Mark Lewis ,  David Cooper

IPC: C12Q1/68 ,  C12Q1/37

CPC classification number: C07K16/40 ,  A61K38/00 ,  C07K14/61 ,  C12Q1/37 ,  C12Q2600/156 ,  G01N33/6803

Abstract: The invention relates to a method for determining the effect of a polymorphism or mutation on the structural properties of a protein wherein the method relies on the structural properties of the protein and so its cleavage during proteolysis.

Abstract translation: 本发明涉及一种用于确定多态性或突变对蛋白质结构特性的影响的方法，其中所述方法依赖于蛋白质的结构性质，因此其在蛋白水解期间的切割。

公开(公告)号：US20050233417A1

公开(公告)日：2005-10-20

申请号：US10495235

申请日：2002-11-12

Applicant: David Cooper ,  Ann Procter ,  John Gregory ,  David Millar ,  Mark Lewis ,  Angeles Ulied

Inventor： David Cooper ,  Ann Procter ,  John Gregory ,  David Millar ,  Mark Lewis ,  Angeles Ulied

IPC: G01N33/53 ,  A61K48/00 ,  A61P19/00 ,  A61P43/00 ,  C07K14/61 ,  C07K16/26 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/00 ,  C12Q1/68 ,  C07H21/04

CPC classification number: C07K14/61 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates to naturally-occurring growth hormone mutations; to a method for detecting them and their use in screening patients for growth hormone irregularities or for producing variant proteins suitable for treating such irregularities. In one aspect there is disclosed variants of GH1, selected from the group consisting of: (a) (i) +480 C→T; (ii) +446 C→T; (iii) +1491 C→G; (iv) −60 G→A; (v) −40 to −39 GG→CT; (vi) −360 A→G; and (vii) +748 A→G (where figures relate to GH1 nucleotide position number, counting from TSS); (b) a sequence substantially homologous to or that hybridises to sequence (a) under stringent conditions; (c) a sequence substantially homologous to or that hybridises to the sequences (a) or (b) but for degeneracy of the genetic code; and (d) an oligonucleotide specific for any of the sequences (a), (b) or (c) above.

Abstract translation: 本发明涉及天然存在的生长激素突变; 检测它们的方法及其在筛选患者生长激素不规则或用于产生适于治疗这种不规则的变体蛋白质的用途。 一方面，公开了GH1的变体，其选自：（a）（i）+480C-> T; （ii）+446 C-> T; （iii）+1491 C-> G; （iv）-60 G-> A; （v）-40至-39 GG-> CT; （vi）-360 A-> G; 和（vii）+748 A-> G（其中数字涉及GH1核苷酸位置号，从TSS计数）; （b）在严格条件下与序列（a）基本同源或杂交的序列; （c）与序列（a）或（b）基本上同源或杂交的序列，但是遗传密码的简并性; 和（d）对上述（a），（b）或（c）中任一项的特异性寡核苷酸。

公开(公告)号：US20050205630A1

公开(公告)日：2005-09-22

申请号：US10802283

申请日：2004-03-16

Applicant: David Cooper ,  Robert Nugent

Inventor： David Cooper ,  Robert Nugent

IPC: B60R9/00 ,  B60R9/06 ,  B60R9/12 ,  B60R11/00

CPC classification number: B60R9/06 ,  B60R9/12

Abstract: A hitch-mountable, vehicle load carrying apparatus and method is herein disclosed. The device includes a base load-carrying platform, and a vertical support structure connected to a horizontal crossbar structure that is adjustable in height. The device further includes several transverse bars that are also adjustable for secure fitting to the equipment that is to be transported. An exemplary embodiment includes wheels connected to the load-carrying platform for convenient stowage of equipment without physical removal from the device.

Abstract translation: 本文公开了一种可搭载的车辆载重装置和方法。 该装置包括基座承载平台和连接到高度可调节的水平横梁结构的垂直支撑结构。 该装置还包括若干横向杆，其也可调节，用于与要运输的设备的安全配合。 示例性实施例包括连接到承载平台的轮子，用于方便地装载设备而不从设备物理移除。

公开(公告)号：US20050085461A1

公开(公告)日：2005-04-21

申请号：US10504110

申请日：2003-02-13

Applicant: David Cooper ,  Ian Forbes ,  Andrew Gribble ,  Andrew Lightfoot

Inventor： David Cooper ,  Ian Forbes ,  Andrew Gribble ,  Andrew Lightfoot

IPC: C07D217/02 ,  A61K31/395 ,  A61K31/4035 ,  A61K31/47 ,  A61K31/472 ,  A61K31/55 ,  A61P1/00 ,  A61P1/08 ,  A61P3/04 ,  A61P15/02 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07C307/00 ,  C07D209/44 ,  C07D217/22 ,  C07D223/16 ,  C07D405/12 ,  C07D409/12

CPC classification number: C07D223/16 ,  C07D217/02

Abstract: The invention provides compounds of formula (I) wherein A and B represent the groups CH2)m— and CH2)n— respectively; R1 represents hydrogen or C1-4alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pC3-6cycloalkyloxy, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S-C1-6alkyl, —CO2C1-6alkyl, —CO2NR7R8, —SO2NR7R8, —(CH2)pNR7R8, —(CH2)pNR7COR8, optionally substituted aryl, optionally substituted heteroaryl or a fused bicyclic heterocyclic ring system; R3 represents hydrogen or C1-6alkyl; R4 represents halogen, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, —(CH2)pC3-6cycloalkyl or —(CH2)pC3-6cycloalkyloxy; R5 and R6 each independently represent hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pC3-6cycloalkyloxy, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR7R8, —SO2NR7R8, —(CH2)pNR7R8, —(CH2)pNR7COR8, optionally substituted aryl, optionally substituted heteroaryl or a fused bicyclic heterocyclic ring system; R7 and R8 each independently represent hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that the compounds 4-methyl-N-(1,2,3,4-tetrahydroisoquinolin-6-yl)-benzenesulfonamide, 7-(4-chlorophenyl)sulfonamido-1,2,3,4-tetrahydroisoquinoline hydrochloride and N-(2-ethyl-5-isoindolinyl)-p-toluenesulfonamide are excluded. The compounds are useful in therapy, in particular as antipsychotic agents.