公开(公告)号：US20100212778A1

公开(公告)日：2010-08-26

申请号：US12671197

申请日：2008-07-22

Applicant: Michael O'Brien

Inventor： Michael O'Brien

IPC: B67C3/26 ,  B67D7/84 ,  B67D7/06 ,  G01F11/00

CPC classification number: A47K5/18 ,  B05B11/0056 ,  B05B11/0086 ,  B05B11/3057 ,  B05B11/3059 ,  B05B15/62 ,  B65D83/267 ,  B67D7/0205

Abstract: A concentrate dispensing system for dispensing a fluid for dilution, comprises a bracket (1) and a bottle (2). The bracket (1) is arranged to releasably hold the bottle (2). The bottle (2) is arranged to dispense a predetermined quantity of the fluid to a first receptacle type, which is freestanding, when the bottle (2) is in a freehand mode and is not held in the bracket (1). The bottle (2) is arranged to dispense a predetermined quantity of the fluid to a second receptacle type (3), which is received and guided by the bracket (1), when the bottle (2) is in a bracket mode and is held in the bracket (1).

Abstract translation: 用于分配用于稀释的流体的浓缩物分配系统包括支架（1）和瓶（2）。 支架（1）布置成可释放地保持瓶子（2）。 瓶子（2）布置成当瓶子（2）处于手写模式并且不保持在支架（1）中时，将预定量的流体分配到独立的第一容器类型。 瓶（2）布置成当瓶（2）处于支架模式并被保持时，将预定量的流体分配到由支架（1）接收和引导的第二插座类型（3） 在支架（1）中。

公开(公告)号：US07645294B2

公开(公告)日：2010-01-12

申请号：US10813904

申请日：2004-03-31

Applicant: Iain H. Kalfas ,  Carl Lauryssen ,  Steven Ludwig ,  Michael O'Brien ,  Thomas Doherty ,  Mark T. Hall ,  Bryan S. Jones ,  David Konieczynski ,  Raymond F. Murphy

Inventor： Iain H. Kalfas ,  Carl Lauryssen ,  Steven Ludwig ,  Michael O'Brien ,  Thomas Doherty ,  Mark T. Hall ,  Bryan S. Jones ,  David Konieczynski ,  Raymond F. Murphy

IPC: A61B17/70

CPC classification number: A61B17/7049 ,  A61B17/7007 ,  A61B17/701 ,  A61B17/7011 ,  A61B17/7032 ,  A61B17/7037 ,  A61B17/7041 ,  A61B17/7071 ,  A61B17/8028

Abstract: A spinal fixation system comprising at least two bone anchors, a rod connecting the bone anchors and a connecting plate extending from a proximal surface of at least one of the bone anchors. A method of fixing vertebrae relative to each other comprising the steps of: implanting bone anchors in two adjacent vertebrae, each bone anchor having a rod receiving portion; placing a rod in the rod receiving portions, thereby connecting the bone anchors; threadably engaging set screws in the rod receiving portions of at least a portion of the bone anchors, thereby fixing the rod to the bone anchors; mating one end of a connecting plate to a proximal bearing surface of at least a portion of the bone anchors; and engaging a cap with at least a portion of the set screws, thereby fixing the connecting plate to the bone anchors.

Abstract translation: 包括至少两个骨锚的脊柱固定系统，连接骨锚的杆和从至少一个骨锚的近端表面延伸的连接板。 一种相对于彼此固定椎骨的方法，包括以下步骤：将骨锚植入两个相邻的椎骨中，每个骨锚具有杆接收部分; 将棒放置在杆接收部分中，从而连接骨锚; 在至少一部分骨锚固件的杆接收部分中将固定螺钉螺纹接合，从而将杆固定到骨锚固件上; 将连接板的一端配合到所述骨锚的至少一部分的近侧支承表面; 并且将盖与至少一部分固定螺钉接合，从而将连接板固定到骨锚上。

公开(公告)号：US20090289678A1

公开(公告)日：2009-11-26

申请号：US12440663

申请日：2006-09-11

Applicant: Patrick Pratt ,  Denis Dineen ,  Michael O'Brien

Inventor： Patrick Pratt ,  Denis Dineen ,  Michael O'Brien

IPC: H03K5/12

CPC classification number: H03G3/3047 ,  H03F1/0261 ,  H03F3/189 ,  H03F3/24 ,  H03F2200/207

Abstract: A control loop has a control slope associated therewith. The control loop is provided to control a unit under control. A method of regulating the control slope comprises the step of measuring the control slope of the control loop and modifying a parameter associated with the unit under control in order to maintain the control slope within a desired range. Lock of the control loop is therefore maintained.

Abstract translation: 控制回路具有与其相关联的控制斜率。 提供控制回路以控制受控的单元。 调节控制斜率的方法包括测量控制回路的控制斜率并修改与控制单元相关联的参数以便将控制斜率保持在所需范围内的步骤。 因此保持控制回路的锁定。

公开(公告)号：US20090216272A1

公开(公告)日：2009-08-27

申请号：US12035684

申请日：2008-02-22

Applicant: Bradford L. Currier ,  Carl Lauryssen ,  Michael O'Brien ,  Gerald M. Towns

Inventor： Bradford L. Currier ,  Carl Lauryssen ,  Michael O'Brien ,  Gerald M. Towns

IPC: A61B17/70 ,  A61B19/00 ,  A61B17/04

CPC classification number: A61B17/7035 ,  A61B17/7002 ,  A61B17/7032 ,  A61B17/704 ,  A61B2017/564

Abstract: A method of providing spinal stabilization is provided herein. More specifically, the method includes positioning a plurality of fixation assemblies within a plurality of vertebrae in a trans-lamina orientation wherein each fixation assembly includes a proximal portion configured to securely receive a stabilization element (e.g., a stabilization rod). The proximal portions of the various fixation assemblies can be aligned so as to secure at least one stabilization element in a desired position (e.g., along and above a midline of the patient's spine, adjacent and parallel to the midline). A system for providing spinal stabilization is also provided which utilizes trans-lamina delivery and positioning of fixation assemblies within target vertebrae thereby providing stronger fixation and a significant reduction in associated tissue damage.

Abstract translation: 本文提供了一种提供脊柱稳定的方法。 更具体地，该方法包括将多个固定组件定位在跨椎板取向中的多个椎骨内，其中每个固定组件包括被配置为牢固地容纳稳定元件（例如稳定杆）的近端部分。 各个固定组件的近端部分可以对准，以便将至少一个稳定元件固定在期望的位置（例如，沿着和靠近患者脊柱的中线，邻近并平行于中线）。 还提供了一种用于提供脊柱稳定的系统，其利用跨椎板递送并将固定组件定位在目标椎骨内，从而提供更强的固定和相关组织损伤的显着减少。

公开(公告)号：US07378455B2

公开(公告)日：2008-05-27

申请号：US11172308

申请日：2005-06-30

Applicant: Qiwei Lu ,  Michael O'Brien ,  Michael Vallance

Inventor： Qiwei Lu ,  Michael O'Brien ,  Michael Vallance

IPC: C08F2/50 ,  B29C41/00 ,  B29C39/00

CPC classification number: C08G59/68 ,  H01L2224/32245 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/48257 ,  H01L2224/73265 ,  Y10T428/31511 ,  H01L2924/00014 ,  H01L2924/00

Abstract: A curable method useful for encapsulating solid state devices includes (A) an epoxy resin; (B) an effective amount of a cure catalyst comprising (B1) a first latent cationic cure catalyst comprising a diaryl iodonium hexafluoroantimonate salt; (B2) a second latent cationic cure catalyst comprising (B2a) a diaryl iodonium cation, and (B2b) an anion selected from perchlorate, imidodisulfurylfluoride anion, unsubstituted and substituted (C1-C12)-hydrocarbylsulfonates, (C2-C12)-perfluoroalkanoates, tetrafluoroborate, unsubstituted and substituted tetra-(C1-C12)-hydrocarbylborates, hexafluorophosphate, hexafluoroarsenate, tris(trifluoromethylsulfonyl)methyl anion, bis(trifluoromethylsulfonyl)methyl anion, bis(trifluoromethylsulfuryl)imide anion, and combinations thereof; and (B3) a cure co-catalyst selected from free-radical generating aromatic compounds, peroxy compounds, copper (II) salts of aliphatic carboxylic acids, copper (II) salts of aromatic carboxylic acids, copper (II) acetylacetonate, and combinations thereof; and (C) about 70 to about 95 weight percent of an inorganic filler, based on the total weight of the curable composition. The composition's cure catalyst allows the use of increased filler loadings, which in turn reduces moisture absorption and thermal expansion of the cured composition.

Abstract translation: 用于封装固态器件的可固化方法包括（A）环氧树脂; （B）有效量的固化催化剂，其包含（B1）包含二芳基碘鎓六氟锑酸盐的第一潜阳离子固化催化剂; （B2）包含（B2a）二芳基碘鎓阳离子的第二潜在阳离子固化催化剂和（B2b）选自高氯酸盐，亚氨基二硫基氟化物阴离子，未取代和取代的（C 1 -C 12） 全氟链烷酸酯，四氟硼酸酯，未取代和取代的四 - （C 1 -C 12 - ）烷基磺酸酯，（C 2 -C 12 -C 12 - 六氟磷酸盐，六氟砷酸盐，三（三氟甲基磺酰基）甲基阴离子，双（三氟甲基磺酰基）甲基阴离子，双（三氟甲基磺酰基）亚胺阴离子及其组合; 和（B3）选自自由基产生芳族化合物，过氧化合物，脂族羧酸的铜（II）盐，芳族羧酸的铜（II）盐，乙酰丙酮化的铜（II）及其组合）的固化助催化剂 ; 和（C）约70至约95重量％的无机填料，基于可固化组合物的总重量。 组合物的固化催化剂允许使用增加的填料负载，这进而降低固化的组合物的吸湿和热膨胀。

公开(公告)号：US07337373B2

公开(公告)日：2008-02-26

申请号：US11489032

申请日：2006-07-18

Applicant: Michael O'Brien ,  Peter Gravestock

Inventor： Michael O'Brien ,  Peter Gravestock

IPC: G06F11/00

CPC classification number: G06F11/0709 ,  G06F11/0793

Abstract: Many computing system environments require continuous availability and high operational readiness. The ability to find, diagnose, and correct actual faults and potential faults in these systems is a high priority. By combining a continually updated database of computing system performance with the ability to analyze that information to detect faults and then communicating that fault information to correct the fault or provide appropriate notification of the fault results in achieving the goals of high availability and operational readiness. FIG. (1) shows how the data collectors, fault detectors and policy actions are combined to meet those goals.

Abstract translation: 许多计算系统环境需要连续可用性和高操作准备。 在这些系统中查找，诊断和纠正实际故障和潜在故障的能力是高度重视的。 通过将不断更新的计算系统性能数据库与分析该信息以检测故障的能力相结合，然后传达故障信息以纠正故障或提供故障的适当通知，从而实现高可用性和运行准备的目标。 图。 （1）显示了如何组合数据采集器，故障检测器和策略动作来实现这些目标。

公开(公告)号：US20070259871A1

公开(公告)日：2007-11-08

申请号：US11680830

申请日：2007-03-01

Applicant: Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead ,  Alison Woolford

Inventor： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead ,  Alison Woolford

IPC: A61K31/4035 ,  A61K31/47 ,  A61K31/496 ,  A61K31/5377 ,  A61P35/00 ,  C07D209/04 ,  C07D215/00 ,  C07D217/00 ,  C07D227/00 ,  C07D241/00 ,  C07D265/30 ,  C07D401/02 ,  C07D471/00

CPC classification number: C07D401/12 ,  C07C65/21 ,  C07D209/08 ,  C07D209/44 ,  C07D215/08 ,  C07D217/06 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D491/08 ,  C07D491/10

Abstract: The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.

Abstract translation: 本发明提供式（I）的化合物：或其盐，互变异构体，溶剂合物和N-氧化物; 其中R 1是羟基或氢; R 2是羟基; 甲氧基或氢; 条件是R 1和R 2中的至少一个是羟基; R 3选自氢; 卤素; 氰基; 任选取代的C 1-5烃基和任选取代的C 1-5 - 烃氧基; R 4选自氢; 其中n为0或1且R 7为任选取代的无环C 1 - （O）N - ， - -5个烃基或具有3〜7个环成员的单环碳环或杂环基; 卤素; 氰基; 羟基; 氨基; 和任选取代的单或二-C 1-5烃基 - 氨基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且NR 5 R 6形成具有8至12个环成员的任选取代的双环杂环基，其中多达5个环成员是选自氧，氮和硫的杂原子。 该化合物具有作为Hsp90抑制剂的活性。

公开(公告)号：US20070004872A1

公开(公告)日：2007-01-04

申请号：US11172300

申请日：2005-06-30

Applicant: Qiwei Lu ,  Michael O'Brien ,  Gerardo Rocha-Galicia ,  Prameela Susarla

Inventor： Qiwei Lu ,  Michael O'Brien ,  Gerardo Rocha-Galicia ,  Prameela Susarla

IPC: C08L63/00 ,  C08L71/02

CPC classification number: C08G59/621 ,  C08L63/00 ,  C08L71/123 ,  H01L2224/32245 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/73265 ,  Y10T428/31511 ,  C08L2666/22 ,  H01L2924/00014 ,  H01L2924/00

Abstract: A molding composition suitable for encapsulating solid state devices includes an epoxy resin, a hardener, a poly(arylene ether) resin comprising less than 5 weight percent of particles greater than 100 micrometers, and about 70 to about 95 weight percent of a silica filler, based on the total weight of the composition. After curing, the composition exhibits improved increased copper adhesion and reduced shrinkage compared to conventional molding compositions.

Abstract translation: 适用于封装固态器件的模塑组合物包括环氧树脂，硬化剂，包含小于5重量％的大于100微米的颗粒的聚（亚芳基醚）树脂和约70至约95重量％的二氧化硅填料， 基于组合物的总重量。 固化后，与常规模塑组合物相比，该组合物显示出改进的增加的铜附着力和减小的收缩率。

公开(公告)号：US20060221489A1

公开(公告)日：2006-10-05

申请号：US11099214

申请日：2005-04-05

Applicant: Jason Christianson ,  Michael O'Brien ,  Cameron Rabe ,  Carl Elliott

Inventor： Jason Christianson ,  Michael O'Brien ,  Cameron Rabe ,  Carl Elliott

IPC: G11B21/02

CPC classification number: G11B5/40

Abstract: An apparatus and method for providing electrostatic discharge protection for a disc drive read head. A pair of depletion mode MOSFETS, and a fuse associated with each are disposed between the read head output terminals. The MOSFETS are controlled to an “off” state for testing the preamplifier prior to assembly of the read head. After assembly of the head, a second pair of MOSFETS is gated to an “on” state to open the fuses and thus permit normal operation of the read head.

公开(公告)号：US20060194843A1

公开(公告)日：2006-08-31

申请号：US11336599

申请日：2006-01-20

Applicant: Valerio Berdini ,  Michael O'Brien ,  Maria Carr ,  Theresa Early ,  Adrian Gill ,  Gary Trewartha ,  Alison Woolford ,  Andrew Woodhead ,  Paul Wyatt

Inventor： Valerio Berdini ,  Michael O'Brien ,  Maria Carr ,  Theresa Early ,  Adrian Gill ,  Gary Trewartha ,  Alison Woolford ,  Andrew Woodhead ,  Paul Wyatt

IPC: A61K31/454 ,  A61K31/416 ,  A61K31/4152 ,  C07D403/02

CPC classification number: C07D231/38 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C04B35/632 ,  C07D231/14 ,  C07D231/40 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D453/02 ,  C07D471/04

Abstract: The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. In formula (0): X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C═O, NRg(C═O) or O(C═O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).