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43 条记录 (耗时 0.033 秒)

    Method and apparatus for coating skin piercing microprojections
    31.
    发明授权
    Method and apparatus for coating skin piercing microprojections 有权
    皮肤穿刺微粒涂层的方法和装置

    公开(公告)号：US06855372B2

    公开(公告)日：2005-02-15

    申请号：US10099604

    申请日：2002-03-15

    申请人： Joseph C. Trautman ,  Cedric T. Wright ,  Michel J. N. Cormier

    发明人： Joseph C. Trautman ,  Cedric T. Wright ,  Michel J. N. Cormier

    IPC分类号： A61B17/20 ,  B05D1/18 ,  B05D1/28 ,  B05D5/00

    CPC分类号： A61K9/0021 ,  A61B17/205 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0053 ,  B05D1/18 ,  B05D1/28

    摘要： An apparatus and method are provided for selectively applying an agent-containing liquid coating to extremely tiny skin piercing microprojections (10). The coating solution is applied to the skin piercing microprojections (10) using a coating technique which selectively coats only the skin piercing microprojections (10) and not the substrate (12) from which the microprojections (10) extend, and then dried. The coating method includes providing an agent-containing coating liquid and conveying the liquid to a liquid holding surface having a coating transfer region. The depth of the coating liquid at the coating transfer region is precisely controlled. The microprojections are then immersed to a predetermined level in the coating liquid. The liquid that coats the microprojections (10) is then dried to form a solid agent-containing coating on the microprojections (10).

    摘要翻译： 提供了一种用于选择性地将含药剂的液体涂层施加到极微小的皮肤刺穿微突出物（10）上的装置和方法。 使用涂覆技术将涂布溶液施加到皮肤刺穿微突出物（10）上，涂覆技术仅选择性地涂覆皮肤刺穿微突出物（10）而不是微突出物（10）延伸的基底（12），然后干燥。 涂布方法包括提供含药剂的涂布液体并将液体输送到具有涂覆转移区域的液体保持表面。 涂层转移区域的涂布液的深度被精确地控制。 然后将微注入物浸入涂布液中的预定水平。 然后将涂覆微喷射体（10）的液体干燥，以在微喷射体（10）上形成含固体剂的涂层。

    Method for transdermal nucleic acid sampling
    32.
    发明授权
    Method for transdermal nucleic acid sampling 有权
    透皮核酸取样方法

    公开(公告)号：US06749575B2

    公开(公告)日：2004-06-15

    申请号：US09933647

    申请日：2001-08-20

    申请人： James A. Matriano ,  Michel J. N. Cormier

    发明人： James A. Matriano ,  Michel J. N. Cormier

    IPC分类号： A61B1000

    CPC分类号： A61B17/205 ,  A61B10/0045 ,  A61B2010/008

    摘要： A minimally invasive transdermal nucleic acid sampling method comprises piercing through the outermost layer of the skin and into the underlying epidermis with a plurality of microprojections. Living skin cells in the underlying epidermis are disrupted, causing them to release their contents including their nucleic acids (i.e., DNA, RNA, fragments thereof or other polynucleic acid material found in the nucleii and/or mitochondria of cells). The nucleic acid is collected on the surfaces of the microprojections and/or in a separate nucleic acid collection reservoir. The collected nucleic acid is then analyzed using standard polymerase chain reaction (PCR) techniques. Optionally a suction device applies a partial vacuum through openings in the microprojection member to the microcuts in the skin for enhanced efflux of intracellular and extracellular (i.e., body) fluids containing the nucleic acid.

    摘要翻译： 微创透皮核酸取样方法包括用多个微突出物穿透皮肤的最外层并进入下面的表皮。 底层表皮中的活细胞被破坏，导致它们释放出其核酸（即DNA，RNA，其片段或细胞核和/或线粒体中发现的其他多核酸物质）的内容物。 将核酸收集在微突出物表面和/或在单独的核酸采集储存器中。 然后使用标准聚合酶链反应（PCR）技术分析所收集的核酸。 任选地，抽吸装置通过微突出物构件中的开口将局部真空施加到皮肤中的微切口，以增强含有核酸的细胞内和细胞外（即，体）流体的流出。

    Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition
    34.
    发明授权
    Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition 有权

    公开(公告)号：US07761147B2

    公开(公告)日：2010-07-20

    申请号：US11084628

    申请日：2005-03-18

    申请人： Wendy A. Young ,  Michel J. N. Cormier

    发明人： Wendy A. Young ,  Michel J. N. Cormier

    IPC分类号： A61N1/30 ,  A61K9/22

    CPC分类号： A61N1/30

    摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

    Method and apparatus for coating skin piercing microprojections
    35.
    发明申请
    Method and apparatus for coating skin piercing microprojections 审中-公开
    皮肤穿刺微粒涂层的方法和装置

    公开(公告)号：US20090183673A1

    公开(公告)日：2009-07-23

    申请号：US12285703

    申请日：2008-10-08

    申请人： Joseph C. Trautman ,  Cedric T. Wright ,  Michel J. N. Cormier

    发明人： Joseph C. Trautman ,  Cedric T. Wright ,  Michel J. N. Cormier

    IPC分类号： B05C3/02

    CPC分类号： A61K9/0021 ,  A61B17/205 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0053 ,  B05D1/18 ,  B05D1/28

    摘要： An Apparatus and method are provided for selectively applying an agent-containing liquid coating to extremely tiny skin piercing microprojections (10). The coating solution is applied to the skin piercing microprojections (10) using a coating technique which selectively coats only the skin piercing microprojections (10) and not to substrate (12) from which the microprojections (10) extend, and the dried. The coating method includes providing an agent-containing coating liquid and conveying the liquid to a liquid holding surface having a coating transfer region. The depth of the coating liquid at the coating transfer region is precisely controlled. The microprojections are then immersed to a predetermined level in the coating liquid. The liquid that coats the microprojections (10) is then dried to form a solid agent-containing coating on the microprojections (10).

    摘要翻译： 提供了一种用于选择性地将含药剂的液体涂层施加到极微小的皮肤刺穿微突出物（10）的装置和方法。 使用涂覆技术将涂布溶液施加到皮肤刺穿微突出物（10）上，涂覆技术仅选择性地仅涂覆皮肤穿刺微突出物（10）而不是微弹（10）延伸的基底（12），并干燥。 涂布方法包括提供含药剂的涂布液体并将液体输送到具有涂覆转移区域的液体保持表面。 涂层转移区域的涂布液的深度被精确地控制。 然后将微注入物浸入涂布液中的预定水平。 然后将涂覆微喷射体（10）的液体干燥，以在微喷射体（10）上形成含固体剂的涂层。

    Formulations for the administration of fluoxetine
    38.
    发明授权
    Formulations for the administration of fluoxetine 失效
    氟西汀治疗剂型

    公开(公告)号：US06512010B1

    公开(公告)日：2003-01-28

    申请号：US08892118

    申请日：1997-07-14

    申请人： Robert M. Gale ,  Melinda K. Nelson ,  Michel J. N. Cormier ,  Suneel K. Gupta ,  Patricia S. Campbell

    发明人： Robert M. Gale ,  Melinda K. Nelson ,  Michel J. N. Cormier ,  Suneel K. Gupta ,  Patricia S. Campbell

    IPC分类号： A61K3135

    CPC分类号： A61K9/7084 ,  A61K31/135 ,  A61K31/138 ,  A61K31/57 ,  A61K2300/00

    摘要： Composition of matter for application to a body surface or membrane to administer fluoxetine by permeation through the body surface or membrane, the composition comprising fluoxetine to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. A preferred embodiment is directed to the transdermal administration of fluoxetine at reduced skin irritation levels wherein fluoxetine, preferably provided as fluoxetine acetate, is coadministered with a corticosteroid such as hydrocortisone. Also disclosed are drug delivery devices containing the fluoxetine or fluoxetine and enhancer composition and methods for the transdermal administration of the fluoxetine and fluoxetine/enhancer composition.

    摘要翻译： 用于通过穿过身体表面或膜透过体外表面或膜施用氟西汀的物质的组成，所述组合物包含单独或与渗透促进剂或混合物组合的待施用氟西汀。 优选的实施方案涉及在减少的皮肤刺激水平下透皮给药氟西汀，其中氟西汀，优选以醋酸氟西汀提供，与皮质类固醇如氢化可的松共同施用。 还公开了含有氟西汀或氟西汀和增强剂组合物的药物递送装置和用于透皮给药氟西汀和氟西汀/增强剂组合物的方法。

    Transdermal electrotransport delivery device including a cathodic reservoir containing a compatible antimicrobial agent
    39.
    发明授权
    Transdermal electrotransport delivery device including a cathodic reservoir containing a compatible antimicrobial agent 有权
    透皮电运输装置包括含有相容的抗微生物剂的阴极储存器

    公开(公告)号：US06181963B2

    公开(公告)日：2001-01-30

    申请号：US09433615

    申请日：1999-11-02

    申请人： Ivan W. Chin ,  Thomas O. Murdock ,  Michel J. N. Cormier

    发明人： Ivan W. Chin ,  Thomas O. Murdock ,  Michel J. N. Cormier

    IPC分类号： A61N130

    CPC分类号： A61N1/30

    摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. The cathode includes a cathodic electrode and a cathodic reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes i) a drug or an electrolyte salt or a mixture thereof and ii) a cetylpyridinium salt in an amount sufficient to inhibit microbial growth in the aqueous medium. The polymeric material is compatible with the cetylpyridinium salt. A process is also provided wherein when electric current flows from the source of electrical power so that the drug is transdermally delivered to the patient by electrotransport from the anodic reservoir, the cetylpyridinium salt is not transdermally delivered to the patient by electrotransport from the cathodic reservoir. A process for preparing a transdermal electrotransport drug delivery device is also provided.

    摘要翻译： 具有电连接到阳极和阴极的阳极，阴极和电源的透皮电运输药物递送装置。 阴极包括阴极电极和阴极储存器，阴极蓄电池包括由聚合物材料和与壳体接触的水性介质构成的壳体。 水性介质包括i）药物或电解质盐或其混合物，和ii）足以抑制水性介质中微生物生长的量的十六烷基吡啶鎓盐。 聚合物材料与十六烷基吡啶鎓盐相容。 还提供了一种方法，其中当电流从电源流出时，使得药物通过从阳极储存器的电转运经皮递送给患者，所以十六烷基吡啶鎓盐不会通过从阴极储存器的电转运经皮递送给患者。 还提供了一种制备透皮电转运药物递送装置的方法。