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    Therapy delivery and monitoring using a gene of interest-reporter fusion protein and optical imaging
    31.
    发明授权
    Therapy delivery and monitoring using a gene of interest-reporter fusion protein and optical imaging 有权
    使用感兴趣的基因 - 报告融合蛋白和光学成像的治疗传播和监测

    公开(公告)号：US09528113B2

    公开(公告)日：2016-12-27

    申请号：US12993109

    申请日：2009-05-14

    申请人： Nevenka Dimitrova ,  Chetan Mittal

    发明人： Nevenka Dimitrova ,  Chetan Mittal

    IPC分类号： G01N33/00 ,  C12N15/62 ,  C07K14/435 ,  C07K14/71 ,  C12Q1/68

    CPC分类号： C12N15/62 ,  C07K14/43595 ,  C07K14/71 ,  C07K2319/60 ,  C12Q1/6897 ,  C12Q2537/164 ,  C12Q2525/207 ,  C12Q2525/143

    摘要： The present invention relates to a method of non-invasively monitoring the expression of a gene of interest in a cell when contacting said cell with a compound influencing the expression of said gene of interest. The present invention is also concerned with different isolated nucleic acid molecules comprising a coding sequence. Said coding sequence comprises a gene of interest-sequence encoding a gene of interest-polypeptide fused to a reporter sequence encoding a fluorescent reporter polypeptide and is operatively coupled to a promoter sequence. The present invention is also concerned with the use of a method and a nucleic acid molecule of the invention for delivering a compound influencing the expression of a gene of interest in a cell, monitoring the delivery of said compound as well as monitoring the influence on the expression of said gene of interest induced by said compound at the same time.

    摘要翻译： 本发明涉及当使所述细胞与影响目标基因表达的化合物接触时非侵入性地监测细胞中目的基因的表达的方法。 本发明还涉及包含编码序列的不同分离的核酸分子。 所述编码序列包含编​​码与编码荧光报道多肽的报告基因融合的感兴趣基因多肽的目标基因序列，并且可操作地偶联至启动子序列。 本发明还涉及本发明的方法和核酸分子用于递送影响细胞中目的基因表达的化合物，监测所述化合物的递送以及监测对所述化合物的影响 所述化合物同时诱导的所述感兴趣的基因的表达。

    Method and device for automatic generation of summary of a plurality of images
    33.
    发明授权
    Method and device for automatic generation of summary of a plurality of images 失效
    用于自动生成多个图像的概要的方法和装置

    公开(公告)号：US08204317B2

    公开(公告)日：2012-06-19

    申请号：US12281005

    申请日：2007-02-27

    申请人： Mauro Barbieri ,  Lalitha Agnihotri ,  Nevenka Dimitrova

    发明人： Mauro Barbieri ,  Lalitha Agnihotri ,  Nevenka Dimitrova

    IPC分类号： G06K9/62 ,  H04N9/80

    CPC分类号： G06F17/30843 ,  G06K9/00751

    摘要： Method and device for providing a summary of a plurality of images, e.g. a video sequence. The method includes dividing the video sequence into a plurality of segments. The segments are analyzed with respect to content and a set of content descriptors are associated to the segments. Preferably, additional textual information about the segments, screenplay etc., is used to determine the content descriptors. A graph representing relations between the segments is constructed indicating relations between segments. Weights are associated to the relations so as to represent a measure of relation, e.g. a logical correlation, between segments. The weights are based on the calculated content descriptors. A relevance measure for a segment is determined based on all weights associated with relations to said segment. Finally, a summary is generated by selecting the most relevant segments. The method can create an automatic summary of a film that preserves all the logical plot of the original but is shorter in duration (e.g. 70% of the original film) while the original playback rate is preserved.

    摘要翻译： 用于提供多个图像的概要的方法和装置，例如， 视频序列。 该方法包括将视频序列划分成多个段。 关于内容分析段，并且一组内容描述符与段相关联。 优选地，使用关于段，剧本等的附加文本信息来确定内容描述符。 构建表示段之间的关系的图形，指示段之间的关系。 权重与关系相关联，以便表示关系的度量，例如。 段之间的逻辑关联。 权重基于计算的内容描述符。 基于与与所述段的关系相关联的所有权重来确定段的相关性度量。 最后，通过选择最相关的段来生成摘要。 该方法可以创建电影的自动摘要，其保留原始的所有逻辑图，但是在保持原始回放速率的同时，持续时间更短（例如原始电影的70％）。

    SYSTEMS AND METHODS FOR DNA COMPUTING USING METHYLATION
    36.
    发明申请
    SYSTEMS AND METHODS FOR DNA COMPUTING USING METHYLATION 审中-公开
    使用甲基DNA计算的系统和方法

    公开(公告)号：US20090017547A1

    公开(公告)日：2009-01-15

    申请号：US12279874

    申请日：2007-02-06

    申请人： Nevenka Dimitrova ,  Susannah Gal

    发明人： Nevenka Dimitrova ,  Susannah Gal

    IPC分类号： G01N33/48 ,  G06N3/12

    CPC分类号： G06N3/123 ,  B82Y10/00 ,  Y10T436/143333

    摘要： The present disclosure is directed to new methods and systems performing flexible and reversible modification of DNA in order to establish the logical value of true or false for a set of clauses. It combines both the biological meaning and experimental procedure with the logical implementation of the basic Boolean operators: OR, AND, and NOT. A feature of methylation logic is the use of the reversibility of DNA methylation of cytosine and adenine. Logic variables can be negated by reversing the DNA methylation status. Four implementation scenarios are described: three of them use methyl-sensitive restriction enzymes and the fourth uses methyl-binding proteins. Encoding can use either single or double stranded DNA. In addition, the disclosure allows for solving a multi-variable SAT problems by implementing a logic circuit.

    摘要翻译： 本公开涉及对DNA进行灵活和可逆修饰的新方法和系统，以便为一组条款建立true或false的逻辑值。 它将生物学意义和实验过程与基本布尔运算符的逻辑实现相结合：OR，AND和NOT。 甲基化逻辑的特征是使用胞嘧啶和腺嘌呤的DNA甲基化的可逆性。 通过逆转DNA甲基化状态可以消除逻辑变量。 描述了四种实施方案：其中三种使用甲基敏感限制酶，第四种使用甲基结合蛋白。 编码可以使用单链或双链DNA。 此外，该公开允许通过实现逻辑电路来解决多变量SAT问题。

    Synthesis of Composite News Stories
    37.
    发明申请
    Synthesis of Composite News Stories 审中-公开
    综合新闻故事综述

    公开(公告)号：US20080193101A1

    公开(公告)日：2008-08-14

    申请号：US11909653

    申请日：2006-03-29

    申请人： Lalitha Agnihotri ,  Nevenka Dimitrova ,  Mauro Barbieri ,  Alan Hanjalic

    发明人： Lalitha Agnihotri ,  Nevenka Dimitrova ,  Mauro Barbieri ,  Alan Hanjalic

    IPC分类号： G11B27/00

    CPC分类号： G11B27/28 ,  G06F16/735

    摘要： A method and system characterizes (220) individual news stories and identifies (230) a common news story among a variety of stories based on this characterization. A composite story is created (240-280) for the common news story, preferably using a structure that is based on a common structure of the different versions of the story. The selection of video segments (110) from the different versions of the story for inclusion in the composite story is based on determined rankings (260, 270) of the video and audio content of the video segments (110).

    摘要翻译： 一种方法和系统表征（220）个人新闻故事，并根据这种表征识别（230）各种故事中的常见新闻故事。 创建一个综合故事（240 - 280）为共同的新闻故事，最好使用基于不同版本的故事的共同结构的结构。 从故事的不同版本中选择视频段（110）以包含在复合故事中是基于视频片段（110）的视频和音频内容的确定的排名（260,270）。

    Intelligent information delivery system
    38.
    发明授权
    Intelligent information delivery system 有权
    智能信息传递系统

    公开(公告)号：US06912517B2

    公开(公告)日：2005-06-28

    申请号：US09998057

    申请日：2001-11-29

    申请人： Lalitha Agnihotri ,  John Zimmerman ,  Nevenka Dimitrova

    发明人： Lalitha Agnihotri ,  John Zimmerman ,  Nevenka Dimitrova

    IPC分类号： G06F13/00 ,  G06F17/30 ,  G06F17/00 ,  H04Q7/20

    CPC分类号： G06F17/3087 ,  G06F17/30867

    摘要： A system and method for delivering relevant information to recipients in a timely manner. Information from a plurality of sources is received through interface devices that permit a central processor to evaluate each information stream in light of the dynamic profiles that are stored in a subscriber database. A plurality of location sensors track and report the location of the various recipients. The processor determines the content that will be provided to the recipient and the delivery mode to be used for delivering the selected information to the subscriber.

    摘要翻译： 及时向收件人提供相关信息的系统和方法。 通过接口设备接收来自多个源的信息，该接口设备允许中央处理器根据存储在用户数据库中的动态简档来评估每个信息流。 多个位置传感器跟踪和报告各种接收者的位置。 处理器确定将提供给接收者的内容和用于将所选择的信息递送给用户的传送模式。

    Apparatus and method for program selection utilizing exclusive and inclusive metadata searches
    39.
    发明授权
    Apparatus and method for program selection utilizing exclusive and inclusive metadata searches 有权
    使用排他性和包容性元数据搜索的程序选择的装置和方法

    公开(公告)号：US06859803B2

    公开(公告)日：2005-02-22

    申请号：US10014178

    申请日：2001-11-13

    申请人： Serhan Dagtas ,  Radu S. Jasinschi ,  Nevenka Dimitrova

    发明人： Serhan Dagtas ,  Radu S. Jasinschi ,  Nevenka Dimitrova

    IPC分类号： G06F17/30 ,  H04N5/76

    CPC分类号： G06F17/30817 ,  G06F17/30746 ,  G06F17/30796 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99935 ,  Y10S707/99936

    摘要： An apparatus and method for conducting exclusive and inclusive metadata searches to identify and select multimedia programs. The apparatus of the invention including a metadata search controller that compares user specified search words with metadata words to find programs that meet user specified search criteria. The metadata search controller executes an inclusive metadata search to search for matches between a user specified search word and a metadata word that is related to the user specified search word in a word pair contained within a word pair database. The metadata search controller calculates a rank value for each program that is found by a metadata search and creates a ranked list of such programs.

    摘要翻译： 用于进行排他性和包容性元数据搜索以识别和选择多媒体节目的装置和方法。 本发明的装置包括将用户指定的搜索词与元数据字进行比较的元数据搜索控制器，以找到满足用户指定搜索条件的程序。 元数据搜索控制器执行包含的元数据搜索以搜索用户指定的搜索词和与包含在单词对数据库中的单词对中的用户指定的搜索词相关的元数据词之间的匹配。 元数据搜索控制器计算由元数据搜索找到的每个节目的等级值，并创建这样的节目的排名列表。

    Smart picture-in-picture
    40.
    发明授权
    Smart picture-in-picture 失效
    智能画中画

    公开(公告)号：US06697124B2

    公开(公告)日：2004-02-24

    申请号：US09822456

    申请日：2001-03-30

    申请人： Nevenka Dimitrova ,  Angel Janevski

    发明人： Nevenka Dimitrova ,  Angel Janevski

    IPC分类号： H04N545

    CPC分类号： H04N5/45 ,  H04N21/4316 ,  H04N21/44008 ,  H04N21/4622

    摘要： In a television receiver having Picture-In-Picture (PIP), a controller analyzes the content of a video signal forming a main picture, and automatically adjusts the size and position of a PIP image to correspond to regions of the main picture exhibiting the least amount of motion, texture, and/or a repeating texture. The controller also prevents the PIP image from being positioned over text or faces or other important objects in the main picture.

    摘要翻译： 在具有画中画（PIP）的电视接收机中，控制器分析形成主图像的视频信号的内容，并且自动调整PIP图像的尺寸和位置以对应于显示最少的主图像的区域 运动量，纹理和/或重复纹理。 控制器还防止PIP图像被放置在主图像中的文本或面部或其他重要对象上。