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    Antibodies And Methods For Generating Genetically Altered Antibodies With High Affinity
    33.
    发明申请
    Antibodies And Methods For Generating Genetically Altered Antibodies With High Affinity 有权
    用于产生具有高亲和力的遗传改变的抗体的抗体和方法

    公开(公告)号：US20070244302A1

    公开(公告)日：2007-10-18

    申请号：US11746868

    申请日：2007-05-10

    申请人： Nicholas Nicolaides ,  Luigi Grasso ,  Philip Sass

    发明人： Nicholas Nicolaides ,  Luigi Grasso ,  Philip Sass

    IPC分类号： C12P21/00 ,  C12P21/08

    CPC分类号： C12N15/01 ,  C07K16/00 ,  C07K16/4291 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/92 ,  C12N15/1024

    摘要： Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within immunoglobulin genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. The invention also provides methods for increasing the affinity of monoclonal antibodies and monoclonal antibodies with increased affinity.

    摘要翻译： 人类错配修复基因的主要阴性等位基因可用于产生超可变细胞和生物体。 通过将这些基因引入细胞和转基因动物，可以比通过依赖于突变的自然速率更有效地制备具有新颖和有用性质的新细胞系和动物品种。 这些方法可用于在针对感兴趣的抗原的免疫球蛋白基因内产生遗传多样性，以产生具有增强的生化活性的改变的抗体。 此外，这些方法可用于产生具有增加的抗体产生水平的产生抗体的细胞。 本发明还提供了增加亲和力的单克隆抗体和单克隆抗体的亲和力的方法。

    Polynucleotides encoding anti-GD2 antibodies
    38.
    发明授权
    Polynucleotides encoding anti-GD2 antibodies 失效
    编码抗GD2抗体的多核苷酸

    公开(公告)号：US08278065B2

    公开(公告)日：2012-10-02

    申请号：US12494631

    申请日：2009-06-30

    申请人： Nicholas C. Nicolaides ,  Philip M. Sass ,  Luigi Grasso ,  Wolfgang Ebel ,  Yuhong Zhou

    发明人： Nicholas C. Nicolaides ,  Philip M. Sass ,  Luigi Grasso ,  Wolfgang Ebel ,  Yuhong Zhou

    IPC分类号： C12N15/09 ,  C12P21/08

    CPC分类号： C07K16/3084 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： Described herein are antibodies that specifically bind ganglioside GD2. Also described are nucleotides encoding such antibodies, cells expressing such antibodies, methods of use for such antibodies, and methods for using the antibodies to treat diseases associated with ganglioside GD2. In addition, tissue culture media supplements are described as are methods of use for the supplements. Described herein are albumin-ganglioside conjugates and corresponding methods for producing such conjugates. Methods of purifying or isolating antibodies are also described.

    摘要翻译： 本文描述了特异性结合神经节苷脂GD2的抗体。 还描述了编码这种抗体的核苷酸，表达这种抗体的细胞，这种抗体的使用方法，以及使用该抗体治疗与神经节苷脂GD2相关的疾病的方法。 此外，组织培养基补充剂被描述为补充剂的使用方法。 本文描述的是白蛋白 - 神经节苷脂缀合物和用于产生这种缀合物的相应方法。 还描述了纯化或分离抗体的方法。