公开(公告)号：US10408601B2

公开(公告)日：2019-09-10

申请号：US15808070

申请日：2017-11-09

Applicant: Novartis AG

Inventor： Hugang Ren ,  Lingfeng Yu

IPC: G01B9/02 ,  A61B3/10 ,  A61B3/14 ,  A61B3/00 ,  A61B3/15 ,  G01J9/02

Abstract: The present disclosure provides a visualization system for performing optimized optical coherence tomography (OCT) by determining the absolute distance between the OCT source and a sample. The present disclosure also provides a method for optimizing OCT, which includes determining an absolute distance between the OCT source and a sample using data relating to the focal length or position of an autofocus imager lens.

公开(公告)号：US20190183335A1

公开(公告)日：2019-06-20

申请号：US16216497

申请日：2018-12-11

Applicant: Novartis AG

Inventor： Lingfeng Yu ,  Valentina Doushkina

IPC: A61B3/13 ,  G02B21/00 ,  G02B5/04

CPC classification number: A61B3/13 ,  G02B5/04 ,  G02B13/26 ,  G02B17/026 ,  G02B17/045 ,  G02B21/0012

Abstract: The present disclosure relates to an ophthalmic surgical microscope including a magnifying lens positioned in an optical path, a reflection inverter positioned in the optical path, and an ocular lens or eyepiece positioned in the optical path. The reflection inverter may include A Schmidt-Pechan prism or a pair of inverting lenses and a reduction lens.

公开(公告)号：US10285584B2

公开(公告)日：2019-05-14

申请号：US15695608

申请日：2017-09-05

Applicant: NOVARTIS AG

Inventor： Steven T. Charles ,  Lingfeng Yu ,  Hugang Ren

IPC: G06K9/00 ,  A61B3/10 ,  G06T7/11 ,  A61B3/00 ,  A61B3/13 ,  G06T7/00 ,  G06T11/60 ,  A61B3/12 ,  G06T5/50 ,  G06T11/00

Abstract: En face or 3D volumetric OCT imaging during ophthalmic surgery may be performed with an OCT scanning controller that interfaces to an OCT scanner used with a surgical microscope. The OCT scanner may generate en face images before and after surgical operations, such as retinal membrane peeling, are performed. Using digital subtraction on the en face images, an overlay image indicative of the changes from the surgical operations to the eye may be generated and overlaid onto an optical image displayed to a user of the surgical microscope.

公开(公告)号：US20180368678A1

公开(公告)日：2018-12-27

申请号：US16012010

申请日：2018-06-19

Applicant: Novartis AG

Inventor： Valentina Doushkina ,  Lingfeng Yu

IPC: A61B3/13 ,  G02B27/10 ,  G02B13/06 ,  G02B9/04

Abstract: Systems and methods for high-resolution, wide-angle viewing of a retina of an eye using an ophthalmic microscope that can view a high-resolution image of a retina formed using a wide field of view optical system. A wide field of view optical system can involve a first lens having a diffractive surface on at least one surface and a second lens housing in a shared housing. A wide field of view optical system can involve one or more lens formed from an optical grade polymer and manufactured at a cost that allows the lens to be disposable.

公开(公告)号：US09844319B2

公开(公告)日：2017-12-19

申请号：US14837341

申请日：2015-08-27

Applicant: NOVARTIS AG

Inventor： Michael J. Papac ,  Hugang Ren ,  Lingfeng Yu

IPC: A61B3/14 ,  A61B3/00 ,  A61B3/10 ,  A61B90/00 ,  A61B3/12 ,  A61B3/13 ,  A61F9/007 ,  G02B27/01 ,  A61F9/008

CPC classification number: A61B3/102 ,  A61B3/0025 ,  A61B3/0058 ,  A61B3/12 ,  A61B3/1225 ,  A61B3/13 ,  A61B3/145 ,  A61B90/06 ,  A61B90/37 ,  A61F9/00736 ,  A61F2009/00851 ,  A61F2009/00863 ,  G02B27/0101 ,  G02B2027/0141

Abstract: An epiretinal membrane (ERM) visualization system includes an OCT system operable to generate an OCT image of a region of a patient's eye, the region of the patient's eye including an ERM. The ERM visualization system further includes an image processing unit operable to process the OCT image to identify the ERM by differentiating the ERM from other structures within the region of the patient's eye and generate an ERM map depicting one or more characteristics (including at least a location of a portion of the ERM within the region of the patient's eye) of the identified ERM. The ERM visualization system further includes a display operable to display the ERM map.

公开(公告)号：US09826900B2

公开(公告)日：2017-11-28

申请号：US14827473

申请日：2015-08-17

Applicant: NOVARTIS AG

Inventor： Tammo Heeren ,  Hugang Ren ,  Vadim Shofman ,  Lingfeng Yu

IPC: A61B3/13 ,  A61B3/12 ,  A61B3/00 ,  A61B3/10

CPC classification number: A61B3/132 ,  A61B3/0025 ,  A61B3/10 ,  A61B3/102 ,  A61B3/12

Abstract: An ophthalmic surgical microscope includes a beam coupler positioned along an optical path of the surgical microscope between a first eyepiece and magnifying/focusing optics, the beam coupler operable to direct the OCT imaging beam along a first portion of the optical path of the surgical microscope between the beam coupler and a patient's eye (an OCT image being generated based on a reflected portion of the OCT imaging beam). The surgical microscope additionally includes a real-time data projection unit operable to project the OCT image generated by the OCT system and a beam splitter positioned along the optical path of the surgical microscope between a second eyepiece and the magnifying/focusing optics. The beam splitter is operable to direct the projected OCT image along a second portion of the optical path of the surgical microscope between the beam splitter and the second eyepiece such that the projected OCT image is viewable through the second eyepiece.

公开(公告)号：US20170156588A1

公开(公告)日：2017-06-08

申请号：US14957306

申请日：2015-12-02

Applicant: Novartis AG

Inventor： Hugang Ren ,  Lingfeng Yu

IPC: A61B3/10 ,  A61B34/20 ,  A61B3/14 ,  A61B3/13 ,  A61B3/00

CPC classification number: A61B3/102 ,  A61B3/0025 ,  A61B3/0058 ,  A61B3/13 ,  A61B3/14 ,  A61B3/18 ,  A61B34/20 ,  A61B2034/2055 ,  G02B21/0012

Abstract: An ophthalmic visualization system can include a computing device in communication with an OCT system configured to scan a surgical field to generate an OCT image. The computing device can be configured to determine locations within the surgical field corresponding to locations within the OCT image. The ophthalmic visualization system can also include an indicator mechanism in communication with the computing device and a surgical microscope configured to image the surgical field. The indicator mechanism can be configured to cause a location indicator to be positioned within a field of view of the surgical microscope. The location indicator can graphically represent the locations within the surgical field corresponding to the locations within the OCT image.

公开(公告)号：US20170045728A1

公开(公告)日：2017-02-16

申请号：US14825224

申请日：2015-08-13

Applicant: Novartis AG

Inventor： Mauricio Jochinsen ,  Vadim Shofman ,  Lingfeng Yu

IPC: G02B21/36 ,  G02B21/00

CPC classification number: G02B21/364 ,  G02B21/0012 ,  G02B21/22 ,  G02B21/361 ,  G02B21/362

Abstract: An optical system configured to display a composite image includes a projection system that overlays a projected image onto a projected image plane. The optical system further includes at least two eyepieces through which the composite image is viewable to a user and a lens system having a subject image plane viewable through the at least two eyepieces. The subject image plane includes a subject image. The projection system causes the projected image to appear on a projected image plane, viewable through the at least two eyepieces, to include the projected image and the subject image in the composite image. The projection system further includes an adjustable optical component that is adjustable to position the projected image plane relative to the subject image plane.

Abstract translation: 配置为显示合成图像的光学系统包括将投影图像重叠到投影图像平面上的投影系统。 光学系统还包括至少两个目镜，合成图像可通过该目镜观看到用户，透镜系统具有可通过至少两个目镜观看的被摄体图像平面。 被摄体像平面包括被摄体图像。 投影系统使得投影图像出现在投影图像平面上，可通过至少两个目镜观看，以将投影图像和被摄体图像包括在合成图像中。 投影系统还包括可调节的光学部件，其可调节以相对于被摄体像平面定位投影图像平面。

公开(公告)号：US20160278983A1

公开(公告)日：2016-09-29

申请号：US15050903

申请日：2016-02-23

Applicant: NOVARTIS AG

Inventor： Michael John Claus ,  Robert Sanchez ,  Tammo Heeren ,  Argelio Michael Olivera ,  Michael Papac ,  Lingfeng Yu ,  Hugang Ren

IPC: A61F9/008

CPC classification number: A61F9/00821 ,  A61B34/10 ,  A61F9/008 ,  A61F2009/00846 ,  A61F2009/00851 ,  A61F2009/00863 ,  A61F2009/00878 ,  A61F2009/00897

Abstract: Apparatuses, systems, and methods for treating tissue abnormalities are disclosed. The tissue may be visualized for determining a presence of one or more abnormalities contained therein. Imaging data obtained by visualization may be used to determine the presence of one or more abnormalities. Each of the detected abnormalities may be identified and a treatment plan developed for treating the abnormalities. Treatment may be delivered to the abnormalities according to the treatment plan.

Abstract translation: 公开了用于治疗组织异常的装置，系统和方法。 可以将组织可视化以确定其中包含的一种或多种异常的存在。 通过可视化获得的成像数据可用于确定一个或多个异常的存在。 可以识别每个检测到的异常，并且开发用于治疗异常的治疗计划。 根据治疗计划，治疗可能会发生异常。

公开(公告)号：US09392936B1

公开(公告)日：2016-07-19

申请号：US14623317

申请日：2015-02-16

Applicant: NOVARTIS AG

Inventor： Lingfeng Yu ,  Hugang Ren

IPC: A61B3/14 ,  A61B3/00 ,  A61B3/10 ,  A61B3/12

CPC classification number: A61B3/0025 ,  A61B3/0058 ,  A61B3/102 ,  A61B3/12 ,  A61B3/14 ,  G06T5/50 ,  G06T2207/10101 ,  G06T2207/30041

Abstract: A system and method for using optical coherence tomography (OCT) to image both the vitreous and the retina in the eye. The image of both tissues may be created sequentially, simultaneously, or near-simultaneously from at least one OCT image.

Abstract translation: 一种使用光学相干断层扫描（OCT）来对眼睛中的玻璃体和视网膜进行成像的系统和方法。 可以从至少一个OCT图像顺序地，同时地或几乎同时地创建两个组织的图像。