公开(公告)号：US20200331959A1

公开(公告)日：2020-10-22

申请号：US16923154

申请日：2020-07-08

Applicant: Pfizer Inc.

Inventor： Mingming Han ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad

IPC: C07K1/107 ,  C07K14/34 ,  C07K14/22 ,  C07K14/315 ,  A61K39/095 ,  A61K39/09 ,  A61K47/64 ,  C07H3/06

Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US10668164B2

公开(公告)日：2020-06-02

申请号：US15118038

申请日：2015-02-06

Applicant: PFIZER INC.

Inventor： Jianxin Gu ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad ,  Yu-Ying Yang

IPC: A61K47/64 ,  A61K39/09 ,  A61K39/00

Abstract: The present invention relates generally to glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a spacer containing ((2-oxoethyl)thio)). In an aspect the invention provides oxo-eT linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a ((2-oxoethyl)thio) spacer having the formula (I): (I) wherein: A is a group (C═X)m wherein X is S or O and m is 0 or 1; B is a bond, O, or CH2; and when m is 0, B can also be (C═O); R is a C2-C16 alkylene, C2-C16 heteroalkylene, NH—C(═O)—C2-C16 alkylene, or NH—C(═O)—C2-C16 heteroalkylene, wherein said alkylene and heteroalkylene are optionally substituted by 1, 2 or 3 groups independently selected from COOR′ where R′ is selected from H, methyl, ethyl or propyl. The invention further relates to immunogenic compositions comprising such glycoconjugates, and to methods for the preparation and use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US20190330265A1

公开(公告)日：2019-10-31

申请号：US16505757

申请日：2019-07-09

Applicant: Pfizer Inc.

Inventor： Mingming Han ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad

IPC: C07K1/107 ,  A61K39/09 ,  C07H3/06 ,  A61K47/64 ,  C07K14/34 ,  A61K39/095 ,  C07K14/315 ,  C07K14/22

Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US20180099039A1

公开(公告)日：2018-04-12

申请号：US15286696

申请日：2016-10-06

Applicant: Pfizer Inc.

Inventor： Emilio Anthony Emini ,  Wendy Jo Watson ,  Avvari Krishna Prasad ,  Mingming Han ,  Jin-Hwan Kim ,  Jianxin Gu ,  Yu-ying Yang ,  Rajesh Kumar Kainthan ,  David Cooper ,  Michael William Pride ,  Kathrin Ute Jansen

IPC: A61K39/09 ,  A61K9/19

CPC classification number: A61K39/092 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70 ,  Y02A50/466

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.

公开(公告)号：US20170182151A1

公开(公告)日：2017-06-29

申请号：US15385611

申请日：2016-12-20

Applicant: Pfizer Inc.

Inventor： Ye Che ,  Philip Ralph Dormitzer ,  Alexey Vyacheslavovich Gribenko ,  Luke David Handke ,  Avvari Krishna Prasad ,  Xiayang Qiu ,  Mark Edward Ruppen ,  Xi Song ,  Kena Anne Swanson ,  Srinivas Kodali ,  Xin Xu ,  KariAnn Sweeney Efferen ,  Ping Cai ,  Kristin Rachael Tompkins ,  Lorna del Pilar Nunez

IPC: A61K39/155 ,  C07K14/005 ,  C12N7/00

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K2039/575 ,  C07K14/005 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/40 ,  C07K2319/70 ,  C07K2319/735 ,  C12N7/00 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18571

Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.

公开(公告)号：US11872274B2

公开(公告)日：2024-01-16

申请号：US17194224

申请日：2021-03-06

Applicant: Pfizer Inc.

Inventor： Emilio Anthony Emini ,  Wendy Jo Watson ,  Avvari Krishna Prasad ,  Mingming Han ,  Jin-Hwan Kim ,  Jianxin Gu ,  Yu-Ying Yang ,  Rajesh Kumar Kainthan ,  David Cooper ,  Michael William Pride ,  Kathrin Ute Jansen

IPC: A61K39/00 ,  A61K39/09 ,  A61K47/64

CPC classification number: A61K39/092 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70 ,  Y02A50/30

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

公开(公告)号：US20230355735A1

公开(公告)日：2023-11-09

申请号：US18338961

申请日：2023-06-21

Applicant: PFIZER INC.

Inventor： Jianxin Gu ,  Jin-hwan Kim ,  Avvari Krishna Prasad ,  Yu-ying Yang

IPC: A61K39/095 ,  A61K47/64 ,  A61K39/09 ,  A61K45/06

CPC classification number: A61K39/095 ,  A61K47/646 ,  A61K47/64 ,  A61K39/092 ,  A61K45/06 ,  A61K47/6415 ,  A61K2039/6068

Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US20230203091A1

公开(公告)日：2023-06-29

申请号：US18176631

申请日：2023-03-01

Applicant: Pfizer Inc.

Inventor： Mingming Han ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad

IPC: C07K1/107 ,  C07K14/34 ,  C07K14/22 ,  C07K14/315 ,  A61K39/095 ,  A61K39/09 ,  A61K47/64 ,  C07H3/06

CPC classification number: C07K1/1077 ,  C07K14/34 ,  C07K14/22 ,  C07K14/315 ,  A61K39/095 ,  A61K39/092 ,  A61K47/646 ,  A61K47/6415 ,  A61K39/09 ,  C07H3/06 ,  A61K2039/6037

Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US11426456B2

公开(公告)日：2022-08-30

申请号：US17060337

申请日：2020-10-01

Applicant: Pfizer Inc.

Inventor： Jianxin Gu ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad ,  Yu-Ying Yang

IPC: A61K39/09 ,  A61K39/385 ,  A61K39/39 ,  A61K39/00

Abstract: The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation. The invention also relates to immunogenic conjugates comprising Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides covalently linked to a carrier protein, processes for their preparation and immunogenic compositions and vaccines comprising them.

公开(公告)号：US11110160B2

公开(公告)日：2021-09-07

申请号：US16774309

申请日：2020-01-28

Applicant: PFIZER INC.

Inventor： Jianxin Gu ,  Jin-hwan Kim ,  Avvari Krishna Prasad ,  Yu-ying Yang

IPC: A61K39/095 ,  A61K47/64 ,  A61K39/09 ,  A61K45/06 ,  A61K39/00

Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.