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    Affinity support and method for trapping substance using the same
    32.
    发明授权
    Affinity support and method for trapping substance using the same 有权

    公开(公告)号：US10968263B2

    公开(公告)日：2021-04-06

    申请号：US14414329

    申请日：2013-06-03

    申请人： Daniel J. Capon

    发明人： Daniel J. Capon

    IPC分类号： C07K14/47 ,  G01N33/543 ,  B01J20/289 ,  B01D15/38 ,  B01J20/32 ,  G01N33/68 ,  H01J49/00 ,  H01J49/16 ,  B01D15/34

    摘要： Problems to be Solved
    The present invention provides an affinity support capable of trapping a substance by cooperative binding that is less likely to cause dissociation even when the substance is a molecule other than an antibody, and a trapping method using the same.
    Means to Solve the Problems
    A method of trapping a substance comprising the step of contacting an objective to be trapped with an affinity support comprising a support, a spacer bound to the support and an affinity substance bound to the spacer, so as to bind the objective to be trapped to the affinity substance, wherein each one of the objective to be trapped has a plural of affinity sites and the affinity substance binds to at least two of the affinity sites simultaneously.

    AFFINITY SUPPORT AND METHOD FOR TRAPPING SUBSTANCE USING THE SAME
    33.
    发明申请
    AFFINITY SUPPORT AND METHOD FOR TRAPPING SUBSTANCE USING THE SAME 审中-公开
    使用该物质的物质支持和方法来追踪物质

    公开(公告)号：US20150197549A1

    公开(公告)日：2015-07-16

    申请号：US14414329

    申请日：2013-06-03

    申请人： Daniel J. CAPON

    发明人： Daniel J. Capon

    IPC分类号： C07K14/47 ,  B01D15/38 ,  B01D15/34

    CPC分类号： C07K14/4711 ,  B01D15/34 ,  B01D15/3804 ,  B01D15/3809 ,  B01D15/3847 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3274 ,  G01N33/54353 ,  G01N33/6896 ,  G01N2333/4703 ,  H01J49/0027 ,  H01J49/164

    摘要： Problems to be SolvedThe present invention provides an affinity support capable of trapping a substance by cooperative binding that is less likely to cause dissociation even when the substance is a molecule other than an antibody, and a trapping method using the same.Means to Solve the ProblemsA method of trapping a substance comprising the step of contacting an objective to be trapped with an affinity support comprising a support, a spacer bound to the support and an affinity substance bound to the spacer, so as to bind the objective to be trapped to the affinity substance, wherein each one of the objective to be trapped has a plural of affinity sites and the affinity substance binds to at least two of the affinity sites simultaneously.

    摘要翻译： 待解决的问题本发明提供能够通过协同结合捕获物质的亲和载体，即使该物质是除抗体以外的分子也不太可能导致解离的亲和载体，以及使用其的捕获方法。 解决问题的手段捕获物质的方法包括使要捕获的目标与亲和载体接触的步骤，所述亲和载体包括载体，与载体结合的间隔基和与间隔基结合的亲和性物质，以便结合物镜 被捕获到亲和物质，其中待捕获的每个目标具有多个亲和位点，并且亲和物质同时与至少两个亲和位点结合。

    PEPTIDE-HINGE-FREE FLEXIBLE ANTIBODY-LIKE MOLECULE
    34.
    发明申请
    PEPTIDE-HINGE-FREE FLEXIBLE ANTIBODY-LIKE MOLECULE 审中-公开
    肽无铰链抗体类似分子

    公开(公告)号：US20150183858A1

    公开(公告)日：2015-07-02

    申请号：US14569070

    申请日：2014-12-12

    申请人： Daniel J. Capon

    发明人： Daniel J. Capon

    IPC分类号： C07K16/18 ,  C07K7/06 ,  C07K14/47

    CPC分类号： C07K16/18 ,  C07K7/06 ,  C07K7/08 ,  C07K14/4711 ,  C07K2317/53 ,  C07K2319/02 ,  C07K2319/30

    摘要： The present invention provides an antibody that can bind to targets with greater affinity. A flexible antibody-like molecule having a nonpeptide hinge part comprising: a group having a nonpeptide hinge part represented by a general formula (I): XY-Asp-Lys-Thr-His-Thr (SEQ ID No. 1)—wherein X represents an amino acid or a peptide composed of 2 to 50 amino acid residues, and Y represents for a group having an alkyleneoxide; and an antibody Fc fragment bound to the group having a nonpeptide hinge part.

    摘要翻译： 本发明提供能够以更高亲和力结合靶的抗体。 具有非肽铰链部分的柔性抗体样分子，其包含：具有由通式（I）表示的非肽铰链部分的基团：XY-Asp-Lys-Thr-His-Thr（SEQ ID No.1），其中X 表示2〜50个氨基酸残基的氨基酸或肽，Y表示具有环氧烷的基团。 和与具有非肽铰链部分的基团结合的抗体Fc片段。

    Adheson variants
    35.
    发明授权
    Adheson variants 失效
    粘合剂变体

    公开(公告)号：US06710169B2

    公开(公告)日：2004-03-23

    申请号：US10157408

    申请日：2002-05-28

    申请人： Daniel J. Capon ,  Timothy J. Gregory

    发明人： Daniel J. Capon ,  Timothy J. Gregory

    IPC分类号： C07K14705

    CPC分类号： C07K14/34 ,  A61K38/00 ,  A61K47/6425 ,  C07K14/70514 ,  C07K16/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/55 ,  G01N33/6854

    摘要： Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics, in particular, CD4 variants are therapeutically useful in the treatment of HIV infections.

    摘要翻译： 提供了与免疫球蛋白超家族（粘合剂）同源的细胞表面蛋白质的新型衍生物。 将氨基酸序列变异引入到粘连中，其中最值得注意的是跨膜和优选细胞质结构域在功能上无活性，其中粘附细胞外结构域替代免疫球蛋白可变区的那些。 这些变体在治疗或诊断中是有用的，特别是CD4变体在治疗HIV感染中是治疗上有用的。

    Non-human animal interferons
    36.
    发明授权
    Non-human animal interferons 失效
    非人动物干扰素

    公开(公告)号：US06432677B1

    公开(公告)日：2002-08-13

    申请号：US07949327

    申请日：1992-09-21

    申请人： Daniel J. Capon ,  David V. Goeddel

    发明人： Daniel J. Capon ,  David V. Goeddel

    IPC分类号： C12P2104

    CPC分类号： C07K14/555 ,  A61K38/00 ,  C12N15/71 ,  C12N15/81

    摘要： Distinct &agr;-, &bgr;- and &ggr;-interferon genes from various animal species have been identified, cloned and expressed to produce the corresponding non-human animal interferon proteins. Specifically disclosed are interferons of bovine, porcine, feline and rabbit origin.

    摘要翻译： 已经鉴定，克隆和表达来自各种动物物种的不同的α-，β-和γ-干扰素基因以产生相应的非人动物干扰素蛋白质。 具体公开的是牛，猪，猫和兔来源的干扰素。

    Multispecific chimeric receptors
    37.
    发明授权
    Multispecific chimeric receptors 失效
    多特异性嵌合受体

    公开(公告)号：US6103521A

    公开(公告)日：2000-08-15

    申请号：US454098

    申请日：1995-05-30

    申请人： Daniel J. Capon ,  Douglas H. Smith ,  Huan Tian ,  Genine A. Winslow ,  Miriam Siekevitz

    发明人： Daniel J. Capon ,  Douglas H. Smith ,  Huan Tian ,  Genine A. Winslow ,  Miriam Siekevitz

    IPC分类号： A61K35/14 ,  A61K35/17 ,  A61K39/00 ,  C07K14/16 ,  C07K14/725 ,  C07K14/73 ,  C07K16/10 ,  C12N15/12 ,  C12N15/62 ,  C07K14/705

    CPC分类号： C07K14/005 ,  A61K35/17 ,  C07K14/7051 ,  C07K14/70514 ,  C07K16/1063 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/02 ,  C12N2740/10043 ,  C12N2740/16122

    摘要： Novel multispecific chimeric receptor DNA sequences, expression cassettes and vectors containing these sequences as well as cells containing the chimeric DNA and novel chimeric receptor proteins expressed from the sequences are provided in the present invention. The novel multispecific chimeric receptor DNA and amino acid sequences comprise at least three domains that do not naturally exist together: (1) a multispecific binding domain comprising at least two extracellular inducer-responsive clustering domains which serves to bind at least one specific inducer molecule, (2) a transmembrane domain, which crosses the plasma membrane, and (3) either a proliferation signaling domain that signals the cell to divide, or an effector function signaling domain which directs a host cell to perform its specialized function. Optionally, all the multispecific chimeric receptors may contain one or more intracellular inducer-responsive clustering domains attached to one or more of the cytoplasmic signaling domains or the transmembrane domain. The present invention also relates to novel hybrid multispecific chimeric receptors comprising at least one proliferation signaling domain and at least one effector function signaling domain together on the multispecific receptor molecule. The present invention further relates to therapeutic methods and strategies that employ the cells expressing these novel chimeric receptors for the treatment of cancer, infectious disease and autoimmune disease which may have greater therapeutic benefit over a combination of drug therapies.

    摘要翻译： 在本发明中提供了新的多特异性嵌合受体DNA序列，表达盒和含有这些序列的载体以及含有嵌合DNA的细胞和由序列表达的新型嵌合受体蛋白。 新颖的多特异性嵌合受体DNA和氨基酸序列包含至少三个不天然存在的结构域：（1）多特异性结合结构域，其包含至少两个用于结合至少一个特异性诱导物分子的细胞外诱导物反应性聚簇结构域， （2）穿越质膜的跨膜结构域，和（3）信号细胞分裂的增殖信号转导域或引导宿主细胞执行其特异功能的效应子功能信号结构域。 任选地，所有多特异性嵌合受体可以含有连接至一个或多个胞质信号结构域或跨膜结构域的一个或多个细胞内诱导物反应性聚簇结构域。 本发明还涉及在多特异性受体分子上包含至少一个增殖信号结构域和至少一个效应子功能信号结构域的新型杂合多特异性嵌合受体。 本发明还涉及使用表达这些新型嵌合受体的细胞治疗癌症，感染性疾病和自身免疫疾病的治疗方法和策略，其可以比药物疗法的组合具有更大的治疗益处。

    DNA encoding an intracellular chimeric receptor comprising Janus kinase
    38.
    发明授权
    DNA encoding an intracellular chimeric receptor comprising Janus kinase 失效
    编码包含Janus激酶的细胞内嵌合受体的DNA

    公开(公告)号：US6077947A

    公开(公告)日：2000-06-20

    申请号：US485598

    申请日：1995-06-07

    申请人： Daniel J. Capon ,  Huan Tian ,  Douglas H. Smith ,  Genine A. Winslow ,  Miriam Siekevitz

    发明人： Daniel J. Capon ,  Huan Tian ,  Douglas H. Smith ,  Genine A. Winslow ,  Miriam Siekevitz

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/715 ,  C07K14/73 ,  C12N9/12 ,  C12N15/12 ,  C12N15/62 ,  C12N5/10 ,  C12N15/52 ,  C12N15/63

    CPC分类号： C12N9/1205 ,  C07K14/705 ,  C07K14/70514 ,  C07K14/7155 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention is directed to novel chimeric proliferation receptor proteins and DNA sequences encoding these proteins where the chimeric proteins are characterized in three general categories. In one category, the novel chimeric proteins comprise at least three domains, namely, an extracellular inducer-responsive clustering domain capable of binding an extracellular inducer that transmits a signal to a proliferation signaling domain, a transmembrane domain and a proliferation signaling domain that signals a host cell to divide. In the second category, the novel chimeric proteins comprise at least two domains, namely, an intracellular inducer-responsive clustering domain capable of binding an intracellular inducer and a proliferation signaling domain that signals the cell to divide. In yet a third category, a novel hybrid chimeric protein receptor is contemplated that contains an intracellular or extracellular inducer domain, a transmembrane domain, a proliferation signaling domain and an effector signaling domain in a single chain molecule. Whether the binding domain is intracellular or extracellular, the binding of inducer to these novel chimeric receptor proteins induces the clustering of the binding domains to each other and further signals the cell to proliferate, and optionally, signal an effector function. The present invention further relates to expression vectors containing the nucleic acids encoding the novel chimeric receptors, cells expressing the novel chimeric receptors and therapeutic methods of using cells expressing these novel receptors for the treatment of cancer, infectious disease and autoimmune diseases, for example.

    摘要翻译： 本发明涉及嵌合增殖受体蛋白和编码这些蛋白的DNA序列，其中嵌合蛋白的特征在于三个一般类别。 在一个类别中，新型嵌合蛋白质包含至少三个结构域，即能够结合将信号传递给增殖信号转导域的细胞外诱导物 - 响应性聚簇结构域，跨膜结构域和增殖信号转导域， 宿主细胞分裂。 在第二类中，新的嵌合蛋白包含至少两个结构域，即能够结合细胞内诱导物的细胞内诱导物 - 响应聚簇结构域和信号细胞分裂的增殖信号转导域。 在三分之一类别中，预期在单链分子中含有细胞内或细胞外诱导物结构域，跨膜结构域，增殖信号结构域和效应子信号结构域的新型杂合嵌合蛋白受体。 结合结构域是细胞内还是细胞外，诱导物与这些新型嵌合受体蛋白的结合诱导结合结构域彼此聚集，并进一步使细胞信号增殖，并且任选地发送效应子功能。 本发明还涉及含有编码新型嵌合受体的核酸，表达新型嵌合受体的细胞和使用表达这些新受体的细胞治疗癌症，感染性疾病和自身免疫疾病的治疗方法的表达载体。