公开(公告)号：US08790666B2

公开(公告)日：2014-07-29

申请号：US11429201

申请日：2006-05-05

申请人： Douglas H. Smith

发明人： Douglas H. Smith

IPC分类号： A61K9/00

CPC分类号： A61N1/04 ,  A61N1/05 ,  A61N1/326 ,  A61N1/36103

摘要： The present invention relates to mechanically elongated neurons and provides useful compositions, devices and methods for treating a nerve lesion using such mechanically elongated neurons.

摘要翻译： 本发明涉及机械伸长的神经元，并且提供使用这种机械拉伸的神经元治疗神经损伤的有用的组合物，装置和方法。

公开(公告)号：US06702474B2

公开(公告)日：2004-03-09

申请号：US10195025

申请日：2002-07-11

申请人： Alan Charles Webb ,  Peter Holland ,  Peter Standring ,  Douglas H. Smith ,  Larry L. Bahney

发明人： Alan Charles Webb ,  Peter Holland ,  Peter Standring ,  Douglas H. Smith ,  Larry L. Bahney

IPC分类号： F16C1938

CPC分类号： B60B27/001 ,  B23P11/005 ,  B60B35/18 ,  B60B2310/208 ,  B60B2310/228 ,  B60B2310/306 ,  B60B2310/316 ,  B60B2360/10 ,  B60B2360/102 ,  B60B2380/14 ,  F16C19/386 ,  F16C35/063 ,  F16C2326/02 ,  Y10T29/49533 ,  Y10T29/49535 ,  Y10T29/49536 ,  Y10T29/49682 ,  Y10T29/49696 ,  Y10T29/49776 ,  Y10T29/49918 ,  Y10T29/53065 ,  Y10T29/53104

摘要： A hub (2) includes a spindle (14) which projects through a housing (4) and rotates relative to the housing (4) on a bearing (6) that is located between the spindle (14) and the housing (4). The bearing (6) has two sets of raceways (28,40) that are oblique to the axis x, and in addition rolling elements (36) arranged in two rows between the sets of raceways (28,40). The inner raceways (28) that fit around the spindle (14) and have back faces (32), with the back face (32) for one of the races (26) being against a shoulder (18) from which the spindle (14) projects. Initially, the end of the spindle (14) projects straight beyond the back face (32) of the outer race—indeed, so that the races (26) can be installed over the spindle (14). But once the housing (4) and races (26) are in a position around the spindle (14), the projecting end portion of the spindle (14) is deformed radially and axially in a rotary forming operation such that it transforms into a formed end (20) that lies behind back face (32) of the race (26). With the two races (26) between the formed end (20) and the shoulder (18). During the rotary forming operation the hub (26) rotates, and the end of its spindle (14) is forced against a rotating forming tool and the force is monitored. The housing (4) is restrained and the torque transferred from the rotating hub (2) to the housing (4) is monitored.

公开(公告)号：US06443622B1

公开(公告)日：2002-09-03

申请号：US09446671

申请日：1999-12-23

申请人： Alan Charles Webb ,  Peter Holland ,  Peter Standring ,  Douglas H. Smith ,  Larry L. Bahney

发明人： Alan Charles Webb ,  Peter Holland ,  Peter Standring ,  Douglas H. Smith ,  Larry L. Bahney

IPC分类号： F16C1938

CPC分类号： B23P11/005 ,  B23P11/00 ,  B60B27/001 ,  B60B35/18 ,  B60B2310/208 ,  B60B2310/228 ,  B60B2310/306 ,  B60B2310/316 ,  B60B2360/10 ,  B60B2360/102 ,  B60B2380/14 ,  F16C19/386 ,  F16C35/063 ,  F16C41/007 ,  F16C2326/02 ,  G01P3/443 ,  G01P3/446

摘要： A hub (2) includes a spindle (14) which projects through a housing (4) and rotates relative to the housing (4) on a bearing (6) that is located between the spindle (14) and the housing (4). The bearing (6) has two sets of raceways (28, 40) that are oblique to the axis x, and in addition rolling elements (36) arranged in two rows between the sets of raceways (28, 40). The inner raceways (28) that fit around the spindle (14) and have back faces (32), with the back face (32) for one of the races (26) being against a shoulder (18) from which the spindle (14) projects. Initially, the end of the spindle (14) projects straight beyond the back face (32) of the outer race—indeed, so that the races (26) can be installed over the spindle (14). But once the housing (4) and races (26) are in a position around the spindle (14), the projecting end portion of the spindle (14) is deformed radially and axially in a rotary forming operation such that it transforms into a formed end (20) that lies behind back face (32) of the race (26). With the two races (26) between the formed end (20) and the shoulder (18). During the rotary forming operation the hub (26) rotates, and the end of its spindle (14) is forced against a rotating forming tool and the force is monitored. The housing (4) is restrained and the torque transferred from the rotating hub (2) to the housing (4) is monitored.

摘要翻译： 轮毂（2）包括主轴（14），该主轴突出通过壳体（4）并且相对于壳体（4）在位于主轴（14）和壳体（4）之间的轴承（6）上旋转。 轴承（6）具有与轴线x倾斜的两组滚道（28,40），另外还有两组排列在滚道组（28,40）之间的滚动元件（36）。 安装在主轴（14）周围并且具有后表面（32）的内滚道（28），其中一个座圈（26）的后表面（32）抵靠在肩部（18）上，主轴 ）项目。 最初，主轴（14）的端部直接突出超过外圈的背面（32），实际上，使得座圈（26）可以安装在主轴（14）上。 但是，一旦壳体（4）和座圈（26）处于围绕心轴（14）的位置，则主轴（14）的突出端部在旋转成形操作中径向和轴向地变形，使得其转变成形成 端部（20）位于座圈（26）的背面（32）之后。 通过形成的端部（20）和肩部（18）之间的两个座圈（26）。 在旋转成形操作期间，毂（26）旋转，并且其主轴（14）的端部被迫抵抗旋转成形工具，并且该力被监测。 对壳体（4）进行限制，并且监测从旋转轮毂（2）传递到壳体（4）的扭矩。

公开(公告)号：US5951015A

公开(公告)日：1999-09-14

申请号：US90023

申请日：1998-06-10

申请人： Douglas H. Smith ,  James E. Stoneham ,  William P. Fricke ,  Anthony L. Creed ,  Peter N. Skillman ,  Johnson K. Chow

发明人： Douglas H. Smith ,  James E. Stoneham ,  William P. Fricke ,  Anthony L. Creed ,  Peter N. Skillman ,  Johnson K. Chow

IPC分类号： F41N9/14

CPC分类号： F41J5/052 ,  A63B24/0006 ,  A63B24/0075 ,  A63B63/00 ,  A63B69/002 ,  A63B71/0605 ,  F41J5/24 ,  A63B2071/0694 ,  A63B2220/40 ,  A63B2220/805 ,  A63B2220/806 ,  A63B2220/807 ,  A63B2220/833 ,  A63B2225/50 ,  A63B24/0084 ,  A63B69/36

摘要： An interactive game apparatus in which players throw projectiles, such as soft balls, against a display panel on which a target image is projected and contact sensitive elements aligned with target areas in the projected image are activated by a hit from the thrown projectile to initiate a change in the projected image uniquely associated with the target area hit and the player who threw the projectile. An embodiment in the context of a tic-tac-toe game is described. A number of embodiments for identifying specific projectiles with a player responsible for throwing the projectile are described.

摘要翻译： 一种交互式游戏装置，其中玩家将诸如软球的抛射物投射到其上投射有目标图像的显示面板上并且与投影图像中的目标区域对准的接触敏感元件被来自抛出的射弹的命中激活以启动 改变与目标区域击中唯一相关联的投影图像和投掷射弹的玩家。 描述了在tic-tac-toe游戏的上下文中的一个实施例。 描述了用负责投掷弹药的玩家识别特定射弹的多个实施例。

公开(公告)号：US08400636B2

公开(公告)日：2013-03-19

申请号：US12383777

申请日：2009-03-27

申请人： Douglas H. Smith ,  Shu Yang ,  D. Kacy Cullen

发明人： Douglas H. Smith ,  Shu Yang ,  D. Kacy Cullen

IPC分类号： G01J3/46 ,  G01B11/30

CPC分类号： G01P15/06

摘要： A method for detecting blast induced pressure changes includes exposing a material, a contained solution, a membrane-bound solution, or a photonic crystal material, having a first optical property, to a pressure wave having a blast level. A change in the first optical property to a second optical property of the exposed material, contained solution, membrane-bound solution, or photonic crystal material is determined, and the extent of change corresponds to the blast level.

摘要翻译： 用于检测炸药诱发的压力变化的方法包括将具有第一光学特性的材料，所含溶液，膜结合溶液或光子晶体材料暴露于具有爆炸级别的压力波。 确定曝光材料，包含溶液，膜结合溶液或光子晶体材料的第一光学特性与第二光学特性的变化，并且变化程度对应于爆破级别。

公开(公告)号：US07972367B2

公开(公告)日：2011-07-05

申请号：US12194693

申请日：2008-08-20

申请人： Douglas H. Smith ,  Bryan Pfister ,  David F. Meaney

发明人： Douglas H. Smith ,  Bryan Pfister ,  David F. Meaney

IPC分类号： A61N1/00

CPC分类号： A61N1/04 ,  A61N1/05 ,  A61N1/326 ,  A61N1/36103

摘要： The present invention provides a device of integrated neuronal cells interfaced with an electronic device and a method of producing the same.

摘要翻译： 本发明提供了与电子设备接口的集成神经细胞的装置及其制造方法。

公开(公告)号：US20110097719A1

公开(公告)日：2011-04-28

申请号：US12808097

申请日：2008-12-10

申请人： Douglas H. Smith ,  William Stewart ,  Vicrtoria E. Johnson

发明人： Douglas H. Smith ,  William Stewart ,  Vicrtoria E. Johnson

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： The invention relates to methods of diagnosing risk of amyloid β deposition following traumatic brain injury. More particularly, the invention relates to the discovery of a specific single nucleotide polymorphism in the neprilysin gene that is linked to an increased risk of amyloid β deposition after traumatic brain injury

摘要翻译： 本发明涉及诊断淀粉样蛋白和风险的方法。 创伤性脑损伤后的沉积。 更具体地，本发明涉及发现与升高的淀粉样蛋白和bgr的风险相关的neprilysin基因中的特定单核苷酸多态性; 创伤性脑损伤后沉积

公开(公告)号：US06640438B2

公开(公告)日：2003-11-04

申请号：US09854060

申请日：2001-05-11

申请人： Alan Charles Webb ,  Peter Holland ,  Peter Standring ,  Douglas H. Smith ,  Larry L. Bahney

发明人： Alan Charles Webb ,  Peter Holland ,  Peter Standring ,  Douglas H. Smith ,  Larry L. Bahney

IPC分类号： B21D5310

CPC分类号： B60B27/001 ,  B23P11/005 ,  B60B35/18 ,  B60B2310/208 ,  B60B2310/228 ,  B60B2310/306 ,  B60B2310/316 ,  B60B2360/10 ,  B60B2360/102 ,  B60B2380/14 ,  F16C19/386 ,  F16C35/063 ,  F16C2326/02 ,  Y10T29/49533 ,  Y10T29/49535 ,  Y10T29/49536 ,  Y10T29/49682 ,  Y10T29/49696 ,  Y10T29/49776 ,  Y10T29/49918 ,  Y10T29/53065 ,  Y10T29/53104

摘要： A hub (2) includes a spindle (14) which projects through a housing (4) and rotates relative to the housing (4) on a bearing (6) that is located between the spindle (14) and the housing (4). The bearing (6) has two sets of raceways (28,40) that are oblique to the axis x, and in addition rolling elements (36) arranged in two rows between the sets of raceways (28,40). The inner raceways (28) that fit around the spindle (14) and have back faces (32), with the back face (32) for one of the races (26) being against a shoulder (18) from which the spindle (14) projects. Initially, the end of the spindle (14) projects straight beyond the back face (32) of the outer race—indeed, so that the races (26) can be installed over the spindle (14). But once the housing (4) and races (26) are in a position around the spindle (14), the projecting end portion of the spindle (14) is deformed radially and axially in a rotary forming operation such that it transforms into a formed end (20) that lies behind back face (32) of the race (26). With the two races (26) between the formed end (20) and the shoulder (18). During the rotary forming operation the hub (26) rotates, and the end of its spindle (14) is forced against a rotating forming tool and the force is monitored. The housing (4) is restrained and the torque transferred from the rotating hub (2) to the housing (4) is monitored.

摘要翻译： 轮毂（2）包括主轴（14），该主轴突出通过壳体（4）并且相对于壳体（4）在位于主轴（14）和壳体（4）之间的轴承（6）上旋转。 轴承（6）具有与轴线x倾斜的两组滚道（28,40），以及在滚道组（28,40）之间布置成两排的滚动元件（36）。 安装在主轴（14）周围并且具有后表面（32）的内滚道（28），其中一个座圈（26）的后表面（32）抵靠在肩部（18）上，主轴 ）项目。 最初，主轴（14）的端部直接突出超过外圈的背面（32），实际上，使得座圈（26）可以安装在主轴（14）上。 但是，一旦壳体（4）和座圈（26）处于围绕心轴（14）的位置，则主轴（14）的突出端部在旋转成形操作中径向和轴向地变形，使得其转变成形成 端部（20）位于座圈（26）的背面（32）之后。 通过形成的端部（20）和肩部（18）之间的两个座圈（26）。 在旋转成形操作期间，毂（26）旋转，并且其主轴（14）的端部被迫抵抗旋转成形工具，并且该力被监测。 对壳体（4）进行限制，并且监测从旋转轮毂（2）传递到壳体（4）的扭矩。

公开(公告)号：US06264944B1

公开(公告)日：2001-07-24

申请号：US09630461

申请日：2000-08-02

申请人： Douglas H. Smith

发明人： Douglas H. Smith

IPC分类号： A01N6300

CPC分类号： C12N5/0618 ,  A61K35/12 ,  C12M35/04 ,  C12N5/0619

摘要： Mechanically elongated neuronal cells and methods of mechanically producing elongated cells are provided. Also provided are methods for transplanting elongated neuronal cells into an animal for treatment of spinal cord injuries and other nerve injuries.

摘要翻译： 提供机械拉长的神经元细胞和机械地生产细长细胞的方法。 还提供了将细长的神经元细胞移植到用于治疗脊髓损伤和其它神经损伤的动物中的方法。

公开(公告)号：US08401635B2

公开(公告)日：2013-03-19

申请号：US13156927

申请日：2011-06-09

申请人： Douglas H. Smith ,  Bryan Pfister ,  David F. Meaney

发明人： Douglas H. Smith ,  Bryan Pfister ,  David F. Meaney

IPC分类号： A61N1/00

CPC分类号： A61N1/04 ,  A61N1/05 ,  A61N1/326 ,  A61N1/36103

摘要： The present invention provides a device of integrated neuronal cells interfaced with an electronic device and a method of producing the same.

摘要翻译： 本发明提供了与电子设备接口的集成神经细胞的装置及其制造方法。