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公开(公告)号：US07020519B2
公开(公告)日：2006-03-28
申请号：US10407916
申请日：2003-04-04
Applicant: Wilson Greatbatch , Jeffrey Deal
Inventor： Wilson Greatbatch , Jeffrey Deal
IPC: A61N1/18
CPC classification number: H01M16/00 , A61N1/378 , H01M6/16 , H01M6/5016 , H01M6/5033 , H01M10/052 , H01M10/0525 , H02J7/0054
Abstract: A hybrid battery power source for implantable medical use provides a generally constant low internal resistance during discharge and avoids voltage delays of the type that develop as a result of run down-induced resistance increase in Li/SVO cells. The hybrid battery power source utilizes two batteries or cells, one being a primary cell of relatively high energy density and the other being a secondary cell of relatively low internal resistance that is rechargeable. The primary and secondary cells are connected in a parallel arrangement via a voltage boost/charge control circuit that is powered by the primary cell and adapted to charge the secondary cell while limiting charge/discharge excursions thereof in a manner that optimizes its output for high energy medical device use. The energy storage capacitors of the medical device in which the hybrid battery power source is situated are driven by the secondary cell. The primary cell is used to as an energy source for recharging the secondary cell.
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公开(公告)号：US4314554A
公开(公告)日：1982-02-09
申请号：US57744
申请日：1979-07-16
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
Abstract: A method and apparatus for providing germicidal and healing treatment of tissue such as bone wherein an electrode of silver or like material is applied to a living tissue site to be healed, initially a direct voltage is applied to the electrode of a polarity driving the electrode as an anode to release silver ions to create a germicidal environment at the site, and thereafter a direct voltage of opposite polarity is applied to the electrode driving it as a cathode to stimulate healing of the tissue at the site. The apparatus is implanted in the body of a patient, and in one embodiment a battery is connected through a switch to the electrode and a reference electrode, the switch initially connecting the electrode as an anode and thereafter changeable by an external operator such as a magnet to connect the electrode as a cathode. In another embodiment, another electrode and an element cooperate with the treating electrode to form a galvanic couple with the treating electrode to create a germicidal environment and a predetermined time thereafter the arrangement changes to a biogalvanic couple with body fluid to cause healing of the tissue. In either embodiment a wave shaping circuit can be operatively associated with the treating electrode to facilitate external monitoring of the apparatus when implanted.
Abstract translation: 一种用于提供诸如骨的组织的杀菌和愈合治疗的方法和装置，其中将银或类似材料的电极施加到待愈合的生物体组织部位，最初将直流电压施加到驱动电极的极性的电极，如 阳极以释放银离子以在该位置产生杀菌环境，之后将极性相反的直流电压施加到驱动其作为阴极的电极上，以刺激该部位组织的愈合。 该装置植入患者体内，在一个实施例中，电池通过开关连接到电极和参考电极，开关最初将电极连接为阳极，然后可由诸如磁体的外部操作者 将电极连接成阴极。 在另一个实施方案中，另一个电极和元件与处理电极配合，以与处理电极形成电偶，以产生杀菌环境，此后，预定时间将布置改变为与体液的生物金属联接，从而引起组织愈合。 在任一实施例中，波形整形电路可以与处理电极可操作地相关联，以便于在植入时对装置进行外部监测。
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公开(公告)号：US4294256A
公开(公告)日：1981-10-13
申请号：US57745
申请日：1979-07-16
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
CPC classification number: A61N1/37211
Abstract: An artificial cardiac pacer including a pulse source of relatively high and constant frequency, such as a quartz crystal oscillator, and a frequency divider for converting the source pulses to a lower frequency suitable for application to pacer electrodes for heart stimulation is provided with a pulse rate controller operatively connected to the frequency converter for inhibiting a predetermined number of pulses in each time interval to change the frequency of pulses applied to the pacer electrodes. An external controller operatively coupled to the pulse rate control generates first and second command signals in response to manual selection which are received by the pulse rate control and cause an increase or decrease in the number of pulses inhibited.
Abstract translation: 提供了包括相对高和恒定频率的脉冲源的人造心脏起搏器，例如石英晶体振荡器和用于将源脉冲转换成适合于用于心脏刺激的起搏电极的较低频率的分频器，脉冲频率 控制器可操作地连接到变频器，用于在每个时间间隔中抑制预定数量的脉冲，以改变施加到起搏器电极的脉冲频率。 可操作地耦合到脉搏速率控制的外部控制器响应于由脉冲速率控制接收的手动选择产生第一和第二命令信号，并且导致抑制的脉冲数量的增加或减少。
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34.发明授权
公开(公告)号：US4135519A
公开(公告)日：1979-01-23
申请号：US853136
申请日：1977-11-21
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
Abstract: A cardiac pacer having an alkali metal-halogen cell comprising an alkali metal anode, preferably lithium, a solid alkali metal-halogen electrolyte and a cathode comprising a mixture of two halogens, for example iodine and bromine, the two halogens providing discharge of the cell at two different levels of cell output voltage. The two halogens are in different proportions by weight of the mixture thereby providing a two step output voltage-time characteristic. The second step or plateau in the output voltage characteristic provides an early warning of pacer battery exhaustion.
Abstract translation: 一种具有碱金属卤素电池的心脏起搏器，其包含碱金属阳极，优选锂，固体碱金属 - 卤素电解质和包含两种卤素如碘和溴的混合物的阴极，所述两种卤素提供电池的放电 在两个不同级别的电池输出电压。 两种卤素按混合物的重量不同，由此提供两步输出电压 - 时间特性。 输出电压特性的第二步或平台提供了电池耗尽的预警。
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公开(公告)号：US07047074B2
公开(公告)日：2006-05-16
申请号：US10077988
申请日：2002-02-19
Applicant: Patrick R. Connelly , Michael L. Weiner , Stuart G. MacDonald , Thomas H. Foster , Wilson Greatbatch , Victor Miller
Inventor： Patrick R. Connelly , Michael L. Weiner , Stuart G. MacDonald , Thomas H. Foster , Wilson Greatbatch , Victor Miller
IPC: A61N1/362
CPC classification number: G01R33/285 , A61N1/056 , A61N1/086 , A61N1/3718 , A61N1/375 , G01R33/288
Abstract: An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.
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Patent Agency Ranking
公开(公告)号：US5580761A
公开(公告)日：1996-12-03
申请号：US217210
申请日：1994-03-23
Applicant: Wilson Greatbatch , John C. Sanford
Inventor： Wilson Greatbatch , John C. Sanford
IPC: A61K48/00 , C07K14/15 , C07K14/155 , C12N15/113 , C12N15/867 , C12N15/11 , C07H21/02 , C07H21/04 , C12N5/10
CPC classification number: C12N15/1131 , C07K14/005 , C12N15/1132 , C12N15/86 , A61K48/00 , C12N2740/13022 , C12N2740/15022 , C12N2740/16043
Abstract: In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes including retroviral replication and assembly into infective viral particles. The method involves introducing a vector into a host cell, wherein the vector comprises a polynucleotide which directs transcription, within the host cell, of RNA which is a) complementary or corresponding, depending on the target region, to a nucleic acid sequence within one or more regions of the genome of the retrovirus; and b) is effective in inhibiting one or more steps in the retroviral infection process by interfering with retroviral replication, reverse transcription, translation, or assembly into viral particles when the host cell is infected. Also disclosed is a method of treatment using the nucleic acid constructs, or cells upon which resistance to infection has been conferred.
Abstract translation: 根据本发明，所公开的方法是通过干扰一种或多种包括逆转录病毒复制和组装在感染性病毒颗粒中的感染过程来赋予宿主细胞抗逆转录病毒感染的方法。 所述方法包括将载体导入宿主细胞，其中所述载体包含多核苷酸，其指导宿主细胞内的RNA，所述RNA是a）互补或相应的（取决于靶区域）的核酸序列与一个或多个 逆转录病毒基因组的更多区域; 和b）当宿主细胞被感染时，通过干扰逆转录病毒复制，逆转录，翻译或组装成病毒颗粒来有效抑制逆转录病毒感染过程中的一个或多个步骤。 还公开了使用核酸构建体或其赋予抗感染性的细胞的治疗方法。
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公开(公告)号：US4291125A
公开(公告)日：1981-09-22
申请号：US112704
申请日：1980-01-16
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
CPC classification number: A01N59/16 , A61L2/035 , C02F1/4606 , Y10S435/80 , Y10S47/01
Abstract: A method and apparatus for killing plant and animal bacteria and plant viroids by electrically generated silver ions. The silver ions serve as germicidal agents in infection control and are generated by very slow electrical anodic corrosion of a silver wire located closely adjacent the infection site. In particular, a silver anode and a cathode of non-corroding metal are located in an electrolytic nutrient medium with the silver anode being within five millimeters of the infection site, and a direct voltage is applied to the anode and cathode in a manner passing a positive current in the microampere range into the silver anode causing it to corrode slightly and give off silver ions which produce a germicidal environment about the infection site.
Abstract translation: 一种用于通过电产生的银离子杀死植物和动物细菌并植入类病毒的方法和装置。 银离子在感染控制中用作杀菌剂，并且通过位于紧邻感染部位的银丝的非常缓慢的电阳极腐蚀产生。 特别地，非腐蚀金属的银阳极和阴极位于电解营养介质中，银阳极在感染部位的5毫米内，并且以通过一个方式的方式向阳极和阴极施加直流电压 在阳极范围内的正电流进入银阳极，导致其轻微腐蚀，并释放产生关于感染部位的杀菌环境的银离子。
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公开(公告)号：US4132836A
公开(公告)日：1979-01-02
申请号：US853108
申请日：1977-11-21
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
Abstract: An alkali metal-halogen cell comprising an alkali metal anode, preferably lithium, a solid alkali metal-halogen electrolyte and a cathode comprising a mixture of two halogens, for example iodine and bromine, the two halogens providing discharge of the cell at two different levels of cell output voltage. The two halogens are in different proportions by weight of the mixture thereby providing a two step output voltage-time characteristic. The cell advantageously can be employed in a battery for an artificial cardiac pacer.
Abstract translation: 包含碱金属卤素电池，其包含碱金属阳极，优选锂，固体碱金属 - 卤素电解质和包含两种卤素（例如碘和溴）的混合物的阴极，所述两种卤素提供电池在两个不同水平的放电 的电池输出电压。 两种卤素按混合物的重量不同，由此提供两步输出电压 - 时间特性。 该细胞有利地可用于人造心脏起搏器的电池。
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公开(公告)号：US08059779B2
公开(公告)日：2011-11-15
申请号：US10998188
申请日：2004-11-27
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
IPC: G21B1/02
Abstract: An improved 3He nuclear reactor with provision for direct electric conversion of a relativistic proton stream into useable electric power at a voltage level compatible with the national power grid (one million V DC). Various embodiments include multiple collector cages for extracting relativistic protons of various energy levels, diverter wires for deflecting high-energy proton streams to either side of lower energy cages to avoid unwanted impact. Other embodiments include arrangements for dividing multi-megavolt voltages down to a useable one megavolt level compatible with the national power grid. Further embodiments comprise guiding the proton stream by the cusps of magnetron cavities to permit conversion of the relativistic proton energies into microwave power. A proposal is also made for harvesting 3He from the Moon to supply earth-bound and space-bound reactors. A solution to the problem of charging a potential well-forming anode in an electrostatic fusion reactor without electrical arcing is further disclosed.
Abstract translation: 一个改进的3He核反应堆，提供相对论质子流直接电转换为与国家电网（一百万V DC）兼容的电压电平的可用电力。 各种实施例包括用于提取各种能级的相对论质子的多个收集器笼，用于将高能质子流偏转到较低能量笼的任一侧的分流线，以避免不必要的冲击。 其他实施例包括将多兆伏特电压分解为与国家电网兼容的可用的一兆瓦级的布置。 另外的实施例包括通过磁控管腔的尖端引导质子流，以允许相对论质子能量转换成微波功率。 还提出了从月球收获3He以提供地球和空间有限的反应堆的建议。 进一步公开了在没有电弧放电的静电聚变反应器中对潜在的成井阳极进行充电的问题的解决方案。
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公开(公告)号：US20060129192A1
公开(公告)日：2006-06-15
申请号：US11274926
申请日：2005-11-15
Applicant: Wilson Greatbatch , Jeffrey Deal , Glenn Thomas
Inventor： Wilson Greatbatch , Jeffrey Deal , Glenn Thomas
IPC: A61N1/39
CPC classification number: A61N1/378 , A61N1/375 , A61N1/3956
Abstract: A high energy battery power source suitable for use in an implantable medical device includes an input, an output, and two or more battery modules each comprising two or more battery cells. The battery cells are of relatively low voltage and permanently configured within each battery module in an electrically parallel arrangement in order to provide a desired current discharge level needed to achieve high-energy output. A switching system configures the battery modules between a first configuration wherein the battery modules are electrically connected in parallel to each other and to the input in order to receive charging energy at the relatively low voltage, and a second configuration wherein the battery modules are electrically connected in series to each other in order to provide to the output a relatively high voltage corresponding to the number of battery modules at a current level corresponding to the number of battery cells in a single battery module. An alternate embodiment permanently connects the battery modules in series so that no switching system is need for discharging and charging. A technique that provides for the control of discharge voltages on a pulse-to-pulse basis is also disclosed.
Abstract translation: 适用于可植入医疗装置的高能量电池电源包括输入端，输出端和两个或更多个电池模块，每个电池模块包括两个或多个电池单元。 电池单元具有相对低的电压并且以电并联的方式永久地配置在每个电池模块内，以便提供实现高能量输出所需的期望的电流放电水平。 交换系统将电池模块配置在第一配置之间，其中电池模块彼此并联电连接到输入端，以便在相对低的电压下接收充电能量;以及第二配置，其中电池模块电连接 彼此串联，以向输出提供对应于在单个电池模块中与电池单元的数量相对应的当前电平的电池模块的数量的相对高的电压。 一个替代实施例将串联的电池模块永久连接，使得不需要用于放电和充电的开关系统。 还公开了一种提供脉冲对脉冲的放电电压控制的技术。
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