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    Coated implantable medical device method
    31.
    发明授权
    Coated implantable medical device method 有权
    涂层可植入医疗器械方法

    公开(公告)号：US07867275B2

    公开(公告)日：2011-01-11

    申请号：US11515395

    申请日：2006-09-01

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  William D. Voorhees, III ,  Thomas G. Kozma

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  William D. Voorhees, III ,  Thomas G. Kozma

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/24 ,  A61F2/82 ,  A61F2/885 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

    Coated implantable medical device
    32.
    发明授权
    Coated implantable medical device 有权
    涂层可植入医疗器械

    公开(公告)号：US07862605B2

    公开(公告)日：2011-01-04

    申请号：US11604539

    申请日：2006-11-27

    申请人： Anthony O. Ragheb ,  Brian L. Bates ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III

    发明人： Anthony O. Ragheb ,  Brian L. Bates ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III

    IPC分类号： A61F2/06

    CPC分类号： A61K51/1282 ,  A61F2/24 ,  A61F2/82 ,  A61F2250/0068 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of a bioactive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of bioactive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of bioactive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a stent graft. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12，以及至少一个位于结构的至少一个表面上的生物活性剂层18 任选地，装置10可以包括位于生物活性剂层18上方的至少一个多孔的，优选的聚合物层20，并且还可以包括至少一个被涂覆在结构12的一个表面上的涂层16， 至少一层生物活性剂层依次放置在涂层16的至少一部分上。多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。结构12是 优选构造为支架移植物。 多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。 特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。

    VARIABLE STIFFNESS WIRE GUIDE
    34.
    发明申请
    VARIABLE STIFFNESS WIRE GUIDE 有权
    可变硬线指南

    公开(公告)号：US20090082851A1

    公开(公告)日：2009-03-26

    申请号：US11860837

    申请日：2007-09-25

    申请人： John A. Brumleve ,  Brian L. Bates

    发明人： John A. Brumleve ,  Brian L. Bates

    IPC分类号： A61F2/06

    CPC分类号： A61M25/09025 ,  A61M2025/0915

    摘要： The present invention provides a wire guide having a variable stiffness region that may be selectively adjusted to vary the stiffness along a portion of the wire guide. The wire guide generally comprises an outer core member and an inner core member, wherein the inner core member is disposed for longitudinal movement with respect to the outer core member. The outer core member is attached to a proximal end of a coiled member, while the inner core member is attached to the coiled member at an attachment region between proximal and distal ends of the coiled member. In operation, distal advancement of the outer core member with respect to the inner core member causes the coiled member to compress at a location between the proximal end of the coiled member and the attachment region, thereby selectively increasing the stiffness along a portion of the length of the wire guide.

    摘要翻译： 本发明提供了具有可变刚度区域的导线器，其可以被选择性地调节以沿着导线器的一部分改变刚度。 线导向器通常包括外芯部件和内芯部件，其中内芯部件设置成相对于外芯部件纵向移动。 外芯构件附接到线圈构件的近端，而内芯构件在线圈构件的近端和远端之间的附接区附接到线圈构件。 在操作中，外芯构件相对于内芯构件的远端前进使得线圈构件在线圈构件的近端和附接区域之间的位置处被压缩，从而沿着长度的一部分选择性地增加刚度 的导线。

    COATED IMPLANTABLE MEDICAL DEVICE
    36.
    发明申请
    COATED IMPLANTABLE MEDICAL DEVICE 有权
    涂层可植入医疗器械

    公开(公告)号：US20080145399A1

    公开(公告)日：2008-06-19

    申请号：US11932113

    申请日：2007-10-31

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees

    IPC分类号： A61F2/02 ,  A61P37/06

    CPC分类号： A61K51/1282 ,  A61F2/24 ,  A61F2/82 ,  A61F2250/0068 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppressive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食管，气管，结肠，胆管或尿道中的结构12，以及至少一个位于结构的至少一个表面上的免疫抑制剂层18 12。 任选地，装置10可以包括位于免疫抑制剂的层18上的至少一个多孔的，优选的聚合物层20，并且可以可选地或另外包括位于结构12的一个表面上的至少一个涂层16，至少一个 免疫抑制剂的层18再次依次涂覆在涂层16的至少一部分上。 多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。 结构12优选构造为冠状动脉支架。 多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。

    COATED IMPLANTABLE MEDICAL DEVICE
    37.
    发明申请
    COATED IMPLANTABLE MEDICAL DEVICE 有权
    涂层可植入医疗器械

    公开(公告)号：US20080145398A1

    公开(公告)日：2008-06-19

    申请号：US11932078

    申请日：2007-10-31

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees

    IPC分类号： A61F2/02 ,  A61P37/06

    CPC分类号： A61K51/1282 ,  A61F2/24 ,  A61F2/82 ,  A61F2250/0068 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppessive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食管，气管，结肠，胆管或尿道中的结构12，以及至少一个位于结构的至少一个表面上的免疫抑制剂层18 12。 任选地，装置10可以包括位于免疫抑制剂的层18上的至少一个多孔的，优选的聚合物层20，并且可以可选地或另外包括位于结构12的一个表面上的至少一个涂层16，至少一个 免疫抑制剂层18又依次放置在涂层16的至少一部分上。 多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。 结构12优选构造为冠状动脉支架。 多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。 特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。

    Graft material, stent graft and method
    38.
    发明授权
    Graft material, stent graft and method 有权
    移植材料，支架移植和方法

    公开(公告)号：US07244444B2

    公开(公告)日：2007-07-17

    申请号：US11093759

    申请日：2005-03-30

    申请人： Brian L. Bates

    发明人： Brian L. Bates

    IPC分类号： A61K31/74 ,  A61K9/70

    CPC分类号： A61L31/146 ,  A61F2/06 ,  A61F2/07 ,  A61F2/89 ,  A61F2/91 ,  A61F2002/075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3679 ,  A61L27/48 ,  A61L27/56 ,  A61L31/005 ,  A61L31/128 ,  A61L31/129

    摘要： This invention is directed to graft materials for implanting, transplanting, replacing, or repairing a part of a patient and to methods of making the graft materials. The present invention is also directed to stent grafts and endoluminal prostheses formed of the graft materials. More specifically, the present invention is a graft material which includes polymeric sheet comprising holes. The graft material also comprises an ECM disposed in the holes of the polymeric sheet. The polymeric sheet of the graft material could be a textile or a porous polymer.

    摘要翻译： 本发明涉及用于植入，移植，替换或修复患者的一部分的移植材料以及制备移植材料的方法。 本发明还涉及由移植材料形成的支架移植物和腔内假体。 更具体地说，本发明是一种移植材料，其包括包含孔的聚合物片。 接枝材料还包括设置在聚合物片的孔中的ECM。 接枝材料的聚合物片材可以是织物或多孔聚合物。

    Method for filtering blood in a blood vessel of a patient
    39.
    发明授权
    Method for filtering blood in a blood vessel of a patient 失效
    用于过滤患者血管中的血液的方法

    公开(公告)号：US5329942A

    公开(公告)日：1994-07-19

    申请号：US856114

    申请日：1992-03-20

    申请人： Rolf Gunther ,  Brian L. Bates

    发明人： Rolf Gunther ,  Brian L. Bates

    IPC分类号： A61B17/00 ,  A61F2/01

    CPC分类号： A61F2/01 ,  A61F2002/011 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0071 ,  A61F2230/0093

    摘要： A method of filtering blood in a blood vessel of a patient wherein a catheter is initially introduced into the blood vessel and then advanced to a desired location within the blood vessel. Subsequently, a portion of a positioning assembly having a filter distally attached thereto is guided through the catheter. The filter is then positioned at a location beyond the distal end of the catheter within the blood vessel with the positioning assembly. The positioning assembly is then locked to the catheter. The catheter is then anchored to an object located outside of the blood vessel. Thereafter, an amount of blood is filtered within the blood vessel with the filter. The filter can be readily repositioned by unlocking the positioning assembly from the catheter, repositioning the filter within the blood vessel with the positioning assembly and then relocking the positioning assembly to the catheter.

    摘要翻译： 一种过滤患者血管中的血液的方法，其中导管最初被引入血管中，然后前进到血管内的所需位置。 随后，具有向其远端附接的过滤器的定位组件的一部分被引导通过导管。 然后使用定位组件将过滤器定位在血管内超过导管远端的位置处。 然后将定位组件锁定到导管。 然后将导管锚固到位于血管外部的物体。 此后，用过滤器在血管内过滤血量。 可以通过从导管解锁定位组件来重新定位过滤器，通过定位组件将过滤器重新定位在血管内，然后将定位组件重新锁定到导管上。