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    VARIABLE STIFFNESS WIRE GUIDE
    1.
    发明申请
    VARIABLE STIFFNESS WIRE GUIDE 有权
    可变硬线指南

    公开(公告)号：US20090082851A1

    公开(公告)日：2009-03-26

    申请号：US11860837

    申请日：2007-09-25

    申请人： John A. Brumleve ,  Brian L. Bates

    发明人： John A. Brumleve ,  Brian L. Bates

    IPC分类号： A61F2/06

    CPC分类号： A61M25/09025 ,  A61M2025/0915

    摘要： The present invention provides a wire guide having a variable stiffness region that may be selectively adjusted to vary the stiffness along a portion of the wire guide. The wire guide generally comprises an outer core member and an inner core member, wherein the inner core member is disposed for longitudinal movement with respect to the outer core member. The outer core member is attached to a proximal end of a coiled member, while the inner core member is attached to the coiled member at an attachment region between proximal and distal ends of the coiled member. In operation, distal advancement of the outer core member with respect to the inner core member causes the coiled member to compress at a location between the proximal end of the coiled member and the attachment region, thereby selectively increasing the stiffness along a portion of the length of the wire guide.

    摘要翻译： 本发明提供了具有可变刚度区域的导线器，其可以被选择性地调节以沿着导线器的一部分改变刚度。 线导向器通常包括外芯部件和内芯部件，其中内芯部件设置成相对于外芯部件纵向移动。 外芯构件附接到线圈构件的近端，而内芯构件在线圈构件的近端和远端之间的附接区附接到线圈构件。 在操作中，外芯构件相对于内芯构件的远端前进使得线圈构件在线圈构件的近端和附接区域之间的位置处被压缩，从而沿着长度的一部分选择性地增加刚度 的导线。

    Biofilm-inhibiting medical products
    5.
    发明授权
    Biofilm-inhibiting medical products 有权
    生物膜抑制医疗产品

    公开(公告)号：US08343536B2

    公开(公告)日：2013-01-01

    申请号：US12019477

    申请日：2008-01-24

    申请人： Brian L. Bates ,  Michael C. Hiles ,  Chad E. Johnson

    发明人： Brian L. Bates ,  Michael C. Hiles ,  Chad E. Johnson

    IPC分类号： A61L15/00 ,  A61K35/12 ,  C12N15/00

    CPC分类号： A61L15/40 ,  A61L15/44 ,  A61L2300/102 ,  A61L2300/404

    摘要： A biofilm-inhibiting medical product includes a carrier formed from a natural, bioremodelable material, whereby the carrier includes a biocidal bismuth thiol agent and/or one or more other biofilm-inhibiting or wound healing agents. A method for using the biofilm-inhibiting medical product to treat a wound or tissue defect in a patient's body is described.

    摘要翻译： 生物膜抑制医疗产品包括由天然的生物可重塑材料形成的载体，由此所述载体包含杀生物铋硫醇试剂和/或一种或多种其它生物膜抑制或伤口愈合剂。 描述了使用生物膜抑制医疗产品来治疗患者体内的伤口或组织缺陷的方法。

    HERNIA PATCH WITH REMOVABLE RESILIENT ELEMENT
    6.
    发明申请
    HERNIA PATCH WITH REMOVABLE RESILIENT ELEMENT 审中-公开
    具有可拆卸弹性元件的HERNIA配件

    公开(公告)号：US20110152897A1

    公开(公告)日：2011-06-23

    申请号：US13029347

    申请日：2011-02-17

    申请人： Brian L. Bates

    发明人： Brian L. Bates

    IPC分类号： A61B17/00

    CPC分类号： A61F2/0063 ,  A61B17/00234 ,  A61F2002/0072

    摘要： The invention provides, in certain aspects, grafting devices deliverable into the body for repairing defects in bodily structure walls. One such grafting device comprises a compliant sheet-form material, and a removable resilient element that is retained in association with the sheet-form material. In some forms, the resilient element is adapted for delivery in its entirety into the body, and thereafter, can be disassociated from the sheet-form material for removal from the body. The sheet-form material may be formed with one or more of a variety of biocompatible materials including some that are naturally derived and some that are non-naturally derived. Illustratively, the sheet-form material may be comprised of a remodelable, angiogenic material, for example, a remodelable extracellular matrix (ECM) material. In additional embodiments, the invention provides methods and apparatuses for delivering these and other inventive grafting device into the body.

    摘要翻译： 本发明在某些方面提供可递送到身体中的修补器件结构壁中的缺陷的移植装置。 一种这样的接枝装置包括顺应性片状材料和与片状材料相关联地保持的可移除的弹性元件。 在一些形式中，弹性元件适于将其全部输送到本体中，此后可以与片状材料分离，以从身体移除。 片状材料可以由各种生物相容性材料中的一种或多种形成，包括天然衍生的一些生物相容性材料，一些是非天然衍生的。 示例性地，片状材料可以由可重塑的血管生成材料，例如可重塑的细胞外基质（ECM）材料组成。 在另外的实施例中，本发明提供了用于将这些和其它创新的移植装置递送到体内的方法和装置。

    COATED IMPLANTABLE MEDICAL DEVICE
    7.
    发明申请
    COATED IMPLANTABLE MEDICAL DEVICE 失效
    涂层可植入医疗器械

    公开(公告)号：US20110046723A1

    公开(公告)日：2011-02-24

    申请号：US12902788

    申请日：2010-10-12

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III

    IPC分类号： A61F2/82

    CPC分类号： A61L33/022 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/06 ,  A61F2/24 ,  A61F2/82 ,  A61F2/91 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

    Coated implantable medical device method
    8.
    发明授权
    Coated implantable medical device method 有权
    涂层可植入医疗器械方法

    公开(公告)号：US07867275B2

    公开(公告)日：2011-01-11

    申请号：US11515395

    申请日：2006-09-01

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  William D. Voorhees, III ,  Thomas G. Kozma

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  William D. Voorhees, III ,  Thomas G. Kozma

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/24 ,  A61F2/82 ,  A61F2/885 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

    Coated implantable medical device
    9.
    发明授权
    Coated implantable medical device 有权
    涂层可植入医疗器械

    公开(公告)号：US07862605B2

    公开(公告)日：2011-01-04

    申请号：US11604539

    申请日：2006-11-27

    申请人： Anthony O. Ragheb ,  Brian L. Bates ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III

    发明人： Anthony O. Ragheb ,  Brian L. Bates ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III

    IPC分类号： A61F2/06

    CPC分类号： A61K51/1282 ,  A61F2/24 ,  A61F2/82 ,  A61F2250/0068 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of a bioactive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of bioactive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of bioactive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a stent graft. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12，以及至少一个位于结构的至少一个表面上的生物活性剂层18 任选地，装置10可以包括位于生物活性剂层18上方的至少一个多孔的，优选的聚合物层20，并且还可以包括至少一个被涂覆在结构12的一个表面上的涂层16， 至少一层生物活性剂层依次放置在涂层16的至少一部分上。多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。结构12是 优选构造为支架移植物。 多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。 特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。