Method of localizing fluorescent markers
    32.
    发明申请
    Method of localizing fluorescent markers 有权
    定位荧光标记物的方法

    公开(公告)号:US20060098188A1

    公开(公告)日:2006-05-11

    申请号:US11268975

    申请日:2005-11-08

    IPC分类号: G01J3/30 G01N21/64

    摘要: The invention describes a method of determining the position of fluorescent markers in a sample (4), with a high spatial resolution. To this end, the sample (4) is illuminated with an exciting light beam (11), while the sample (4) is simultaneously scanned by a particle beam (3). During scanning, markers will be impinged upon by the particle beam (3) and will be damaged, in such a manner that the marker impinged upon will no longer emit fluorescence radiation. This leads to a reduction of the flux of fluorescence radiation. This reduction is detected. Seeing as the position of the particle beam (3) w.r.t. the sample is known at the moment that the marker is damaged, the position of the marker in the sample is, accordingly, also known.

    摘要翻译: 本发明描述了以高空间分辨率确定样品(4)中的荧光标记物的位置的方法。 为此,样品(4)被激发光束(11)照射,而样品(4)被粒子束(3)同时扫描。 在扫描期间,标记物将被粒子束(3)撞击并且将被损坏,使得撞击的标记将不再发射荧光辐射。 这导致荧光辐射通量的减少。 检测到这种减少。 看到粒子束(3)的位置w.r.t. 在标记被损坏的时刻,样品是已知的,因此,标记物在样品中的位置也是已知的。

    Optical information record medium
    33.
    发明申请
    Optical information record medium 审中-公开
    光信息记录介质

    公开(公告)号:US20060075418A1

    公开(公告)日:2006-04-06

    申请号:US10537879

    申请日:2003-11-12

    IPC分类号: G11B7/24 G11B23/03

    摘要: An optical information record medium (1) has at least one information layer (100) comprising a transparent substrate wherein nano-elements (101), for example nanotubes, having a symmetry axis are embedded. Information can be recorded by orienting the axes of the nano-elements within selected regions (110,120) in the same direction. Information can be read from the medium by means of a radiation beam having a polarization direction (p1, p2) corresponding to the said direction of the nano-elements, thereby creating absorptive information areas (110,120). In this way high information density can be achieved.

    摘要翻译: 光学信息记录介质(1)具有至少一个信息层(100),该信息层(100)包括透明基板,其中嵌有具有对称轴的纳米元件(101),例如纳米管。 可以通过将纳米元件的轴在相同方向上定向在选定区域(110,120)内来记录信息。 可以通过具有对应于纳米元件的所述方向的偏振方向(p 1,p 2)的辐射束从介质读取信息,从而产生吸收信息区域(110,120)。 这样可以实现高信息密度。