公开(公告)号：US07162308B2

公开(公告)日：2007-01-09

申请号：US10719632

申请日：2003-11-21

申请人： Robert C. O'Brien ,  Christine Frysz

发明人： Robert C. O'Brien ,  Christine Frysz

IPC分类号： A61N1/00

CPC分类号： B21C37/00 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/056 ,  A61N1/08 ,  A61N1/36017 ,  A61N1/3605 ,  B82Y30/00

摘要： Coatings for implantable electrodes consisting of single- or multi-walled nanotubes, nanotube ropes, carbon whiskers, and a combination of these are described. The nanotubes can be carbon or other conductive nanotube-forming materials such as a carbon-doped boron nitride. The nanotube coatings are grown “in situ” on a catalytic substrate surface from thermal decomposition, or they are bonded to the substrate using a metal or conductive metal oxide thin film binder deposited by means of a metal compound precursor in liquid form. In the latter case, the precursor/nanotube coating is then converted to a pure metal or conductive metal oxide, resulting in the desired surface coating with imbedded nanotubes.

摘要翻译： 描述了由单壁或多壁纳米管，纳米管绳索，碳晶须及其组合组成的可植入电极的涂层。 纳米管可以是碳或其它导电纳米管形成材料，例如碳掺杂的氮化硼。 纳米管涂层在热分解的催化底物表面上“原地”生长，或者使用通过液体形式的金属化合物前体沉积的金属或导电金属氧化物薄膜粘合剂将其结合到基底上。 在后一种情况下，将前体/纳米管涂层转化为纯金属或导电金属氧化物，从而形成嵌入的纳米管所需的表面涂层。

公开(公告)号：US20050085884A1

公开(公告)日：2005-04-21

申请号：US10968310

申请日：2004-10-19

申请人： Robert O'Brien ,  Robert Naugler ,  Warren Dabney ,  Christine Frysz ,  Andrew Fisk

发明人： Robert O'Brien ,  Robert Naugler ,  Warren Dabney ,  Christine Frysz ,  Andrew Fisk

IPC分类号： A61N1/05

CPC分类号： H01R4/5033 ,  A61N1/05 ,  A61N1/0553 ,  A61N1/056 ,  H01R4/183 ,  H01R13/5224

摘要： High reliability electrical connections between a helical strand and flat electrodes, such as strip electrodes found in implantable neurostimulator systems, are described. The connection consists of a crimp joint in which an inside diameter mandrel is used to provided the coil with sufficient radial rigidity to ensure structural integrity of the crimp. The mandrel is made of a relatively soft biocompatible material that deforms rather than damages the fine wires of the helical strand during crimping. The crimp is accomplished by radial deformation of an annular or semi-annular crimping member that receives the helical strand/mandrel assembly.

摘要翻译： 描述了在可植入的神经刺激器系统中发现的螺旋线和扁平电极之间的高可靠性电连接，例如条形电极。 连接件包括一个卷边接头，其中使用内径心轴来使线圈具有足够的径向刚度，以确保卷曲的结构完整性。 心轴由相对柔软的生物相容性材料制成，其在卷曲期间变形而不损坏螺旋股线的细线。 卷曲是通过接收螺旋股/心轴组件的环形或半环形压接构件的径向变形实现的。

公开(公告)号：US20110208030A1

公开(公告)日：2011-08-25

申请号：US13074186

申请日：2011-03-29

申请人： Robert A. Stevenson ,  Warren S. Dabney ,  Christine Frysz ,  Richard L. Brendel

发明人： Robert A. Stevenson ,  Warren S. Dabney ,  Christine Frysz ,  Richard L. Brendel

IPC分类号： A61N1/05 ,  A61N1/36 ,  A61B5/04

CPC分类号： A61N1/08 ,  A61B18/1492 ,  A61B2018/00839 ,  A61B2090/374 ,  A61N1/05 ,  A61N1/086 ,  A61N1/37 ,  A61N1/3718 ,  G01R33/285 ,  G01R33/287 ,  G01R33/288 ,  H03H1/0007 ,  H03H7/1766 ,  H03H2007/013 ,  Y10T29/49169

摘要： A TANK filter is provided for a lead wire of an active medical device (AMD). The TANK filter includes a capacitor in parallel with an inductor. The parallel capacitor and inductor are placed in series with the lead wire of the AMD, wherein values of capacitance and inductance are selected such that the TANK filter is resonant at a selected frequency. The Q of the inductor may be relatively maximized and the Q of the capacitor may be relatively minimized to reduce the overall Q of the TANK filter to attenuate current flow through the lead wire along a range of selected frequencies. In a preferred form, the TANK filter is integrated into a TIP and/or RING electrode for an active implantable medical device.

公开(公告)号：US07569452B2

公开(公告)日：2009-08-04

申请号：US11470018

申请日：2006-09-05

申请人： Richard Fu ,  Christine Frysz ,  Mingguang Zhu ,  Kenneth Billings

发明人： Richard Fu ,  Christine Frysz ,  Mingguang Zhu ,  Kenneth Billings

IPC分类号： H01L21/8242

CPC分类号： H01G4/35 ,  H01G4/232 ,  H01G4/236

摘要： A filter capacitor comprising a pre-sintered substrate supporting alternating active and ground electrode layers segregated by a dielectric layer is described. The substrate is of a ceramic material that maintains its shape and structure dimensions even after undergoing numerous sintering steps. Consequently, relatively thin active and ground electrode layers along with the intermediate dielectric layer can be laid down or deposited by a screen-printing technique. Using a relatively thin over-glaze in comparison to a thick upper dielectric layer finishes the capacitor. Consequently, a significant amount of space is saved in comparison to a comparably rated capacitor or, a capacitor of a higher rating can be provided in the same size as a conventional prior art capacitor. The pre-sintered ceramic substrate is used instead of conventional tape cast technology for the base dielectric.

摘要翻译： 描述了一种滤波电容器，其包括支撑由电介质层分离的交替的有源和接地电极层的预烧结基板。 该基材是陶瓷材料，即使在经历许多烧结步骤之后也保持其形状和结构尺寸。 因此，可以通过丝网印刷技术布置或沉积相对薄的有源和接地电极层以及中间介电层。 与较厚的上电介质层相比，使用相对较薄的上釉整理电容器。 因此，与等效电容器相比，节省了大量的空间，或者可以提供与常规现有技术电容器相同尺寸的较高额定电容器。 使用预烧结陶瓷基板代替用于基底电介质的传统的带式铸造技术。

公开(公告)号：US07113387B2

公开(公告)日：2006-09-26

申请号：US11136843

申请日：2005-05-24

申请人： Robert A. Stevenson ,  Richard L. Brendel ,  John Roberts ,  Christine Frysz

发明人： Robert A. Stevenson ,  Richard L. Brendel ,  John Roberts ,  Christine Frysz

IPC分类号： H01G4/35 ,  H01G4/236 ,  H01G4/228

CPC分类号： A61N1/3754 ,  A61N1/3752 ,  H01G4/35

摘要： An EMI filter capacitor assembly utilizes biocompatible and non-migratable materials to adapt electronic components for direct body fluid exposure. The assembly includes a capacitor having first and second sets of electrode plates which are constructed of non-migratable biocompatible material. A conductive hermetic terminal of non-migratable and biocompatible material adjacent to the capacitor is conductively coupled to the second set of electrode plates. One or more conductive terminal pins having at least an outer surface of non-migratable and biocompatible material are conductively coupled to the first set of electrode plates, while extending through the hermetic terminal in non-conductive relation. The terminal pins may be in direct contact with the first set of electrode plates, or in contact with a termination surface of conductive connection material. The termination surface is also constructed of non-migratable and biocompatible materials. Layers of glass may be disposed over surfaces of the assembly, including the capacitor.

公开(公告)号：US20060200231A1

公开(公告)日：2006-09-07

申请号：US11307226

申请日：2006-01-27

申请人： Robert O'Brien ,  Christine Frysz

发明人： Robert O'Brien ,  Christine Frysz

IPC分类号： A61F2/06

CPC分类号： A61L31/084 ,  A61F2/91 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/108 ,  Y10T29/49885

摘要： A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.

摘要翻译： 描述了一种包含多孔溅射柱状金属的药物洗脱外层的血管支架，每个柱用生物相容性含碳材料封盖。 这通过将支架放置在紧密的心轴上并将组件旋转在溅射通量中来完成。 其结果是均匀地分布在支架的金属丝网的向外侧上的涂层，同时防止溅射的柱状涂层到达需要光滑的血液相容表面的内侧。 然后将支架从心轴移除，暴露所有表面，并最终涂覆有碳层如无定形碳或类金刚石碳。 碳质涂层增强生物相容性，而不阻止在柱状结构之间形成的孔隙中提供的治疗药物的淘析。 其结果是适应于其血管环境的血液动力学和免疫应答要求的支架。

公开(公告)号：US06768629B1

公开(公告)日：2004-07-27

申请号：US10452704

申请日：2003-06-02

申请人： Kevin M. Allen ,  Thomas W. Shipman ,  Christine Frysz

发明人： Kevin M. Allen ,  Thomas W. Shipman ,  Christine Frysz

IPC分类号： H01G435

CPC分类号： H01G4/35 ,  A61N1/3754 ,  Y10T29/435

摘要： A filtered feedthrough including a ferrule surrounding an insulator supporting one or more lead wires and at least one ground pin is described. The insulator defines a channel cutout extending from a first insulator side to a channel cutout bottom part way through the thickness of the insulator and in communication with the ferrule. An attached filter capacitor shunts electromagnetic interference from the lead wire to the ground pin, and the ground pin is in electrical communication with the ferrule by way of a ferrule-ground pin braze joint formed in the channel cutout.

摘要翻译： 描述了包括围绕支撑一个或多个引线和至少一个接地引脚的绝缘体的套圈的滤波馈通。 绝缘体限定了从第一绝缘体侧延伸到通道切口底部的沟槽切口，穿过绝缘体的厚度并与套圈连通。 附加的滤波电容器将引线的电磁干扰分流到接地引脚，并且接地引脚通过形成在通道开口中的套圈 - 接地引脚钎焊接头与套圈电连通。

公开(公告)号：US20110213233A1

公开(公告)日：2011-09-01

申请号：US13081314

申请日：2011-04-06

申请人： Robert A. Stevenson ,  Warren S. Dabney ,  Christine Frysz ,  Richard L. Brendel

发明人： Robert A. Stevenson ,  Warren S. Dabney ,  Christine Frysz ,  Richard L. Brendel

IPC分类号： A61B5/04 ,  A61N1/36 ,  A61N1/362

CPC分类号： A61N1/05 ,  A61B5/04 ,  A61B5/0428 ,  A61B5/7203 ,  A61B2562/18 ,  A61M5/14276 ,  A61M5/172 ,  A61N1/086 ,  A61N1/37 ,  A61N1/3754

摘要： A TANK filter is provided for a lead wire of an active medical device (AMD). The TANK filter includes a capacitor in parallel with an inductor. The parallel capacitor and inductor are placed in series with the lead wire of the AMD, wherein values of capacitance and inductance are selected such that the TANK filter is resonant at a selected frequency. The Q of the inductor may be relatively maximized and the Q of the capacitor may be relatively minimized to reduce the overall Q of the TANK filter to attenuate current flow through the lead wire along a range of selected frequencies. In a preferred form, the TANK filter is integrated into a TIP and/or RING electrode for an active implantable medical device.

摘要翻译： 为主动医疗装置（AMD）的引线提供TANK滤波器。 TANK滤波器包括与电感并联的电容器。 并联电容器和电感器与AMD的引线串联放置，其中选择电容和电感值，使得TANK滤波器以选定的频率谐振。 电感器的Q可以相对最大化，并且电容器的Q可以相对最小化，以减小TANK滤波器的总体Q，以衰减沿着选定频率的范围通过引线的电流。 在优选形式中，TANK滤波器被集成到用于有源可植入医疗装置的TIP和/或RING电极中。

公开(公告)号：US20070149048A1

公开(公告)日：2007-06-28

申请号：US11682400

申请日：2007-03-06

申请人： Robert O'Brien ,  Robert Naugler ,  Warren Dabney ,  Christine Frysz ,  Andrew Fisk

发明人： Robert O'Brien ,  Robert Naugler ,  Warren Dabney ,  Christine Frysz ,  Andrew Fisk

IPC分类号： H01R9/05

CPC分类号： H01R4/5033 ,  A61N1/05 ,  A61N1/0553 ,  A61N1/056 ,  H01R4/183 ,  H01R13/5224

摘要： High reliability electrical connections between a helical strand and flat electrodes, such us strip electrodes found in implantable neurostimulator system, are described. The connection consists of a crimp joint in which an inside diameter mandrel is used to provided the coil with sufficient radial rigidity to ensure structural integrity of the crimp. The mandrel is made of a relatively soft biocompatible material that deforms rather than damages the fine wires of the helical strand during crimping. The crimping is acomplished by radial deformation of an annular or semi-annular crimping member that receives the helical strand/mandrel assembly.

摘要翻译： 描述了螺旋线和扁平电极之间的高可靠性电连接，例如我们在可植入神经刺激器系统中发现的带状电极。 连接件包括一个卷边接头，其中使用内径心轴来使线圈具有足够的径向刚度，以确保卷曲的结构完整性。 心轴由相对柔软的生物相容性材料制成，其在卷曲期间变形而不损坏螺旋股线的细线。 卷边由接收螺旋股/心轴组件的环形或半环形压接构件的径向变形而形成。

公开(公告)号：US20070053137A1

公开(公告)日：2007-03-08

申请号：US11470018

申请日：2006-09-05

申请人： Richard Fu ,  Christine Frysz ,  Mingguang Zhu ,  Kenneth Billings

发明人： Richard Fu ,  Christine Frysz ,  Mingguang Zhu ,  Kenneth Billings

IPC分类号： H01G4/35

CPC分类号： H01G4/35 ,  H01G4/232 ,  H01G4/236

摘要： A filter capacitor comprising a pre-sintered substrate supporting alternating active and ground electrode layers segregated by a dielectric layer is described. The substrate is of a ceramic material that maintains its shape and structure dimensions even after undergoing numerous sintering steps. Consequently, relatively thin active and ground electrode layers along with the intermediate dielectric layer can be laid down or deposited by a screen-printing technique. Using a relatively thin over-glaze in comparison to a thick upper dielectric layer finishes the capacitor. Consequently, a significant amount of space is saved in comparison to a comparably rated capacitor or, a capacitor of a higher rating can be provided in the same size as a conventional prior art capacitor. The pre-sintered ceramic substrate is used instead of conventional tape cast technology for the base dielectric.

摘要翻译： 描述了一种滤波电容器，其包括支撑由电介质层分离的交替的有源和接地电极层的预烧结基片。 该基材是陶瓷材料，即使在经历许多烧结步骤之后也保持其形状和结构尺寸。 因此，可以通过丝网印刷技术布置或沉积相对薄的有源和接地电极层以及中间介电层。 与较厚的上电介质层相比，使用相对较薄的上釉整理电容器。 因此，与等效电容器相比，节省了大量的空间，或者可以提供与常规现有技术电容器相同尺寸的较高额定电容器。 使用预烧结陶瓷基板代替用于基底电介质的传统的带式铸造技术。