公开(公告)号：US20060068493A1

公开(公告)日：2006-03-30

申请号：US11247066

申请日：2005-10-11

申请人： Jay Short ,  Barry Marrs ,  Jeffrey Stein

发明人： Jay Short ,  Barry Marrs ,  Jeffrey Stein

IPC分类号： C40B40/10 ,  C40B30/02 ,  C12N9/00 ,  C12N1/12 ,  C12N1/14 ,  C12N1/18

CPC分类号： C12N15/1086 ,  C12N15/1034 ,  C12N15/1079 ,  C12N15/1093 ,  C12N15/52 ,  C12Q1/00

摘要： Disclosed is a process of screening clones having DNA from an uncultivated microorganism for a specified protein, e.g. enzyme, activity by screening for a specified protein, e.g. enzyme, activity in a library of clones prepared by (i) recovering DNA from a DNA population derived from at least one uncultivated microorganism; and (ii) transforming a host with recovered DNA to produce a library of clones which is screened for the specified protein, e.g. enzyme, activity.

公开(公告)号：US20050187190A1

公开(公告)日：2005-08-25

申请号：US11040679

申请日：2005-01-21

申请人： Sanjay Vasu ,  Jeffrey Stein

发明人： Sanjay Vasu ,  Jeffrey Stein

IPC分类号： A61K31/381 ,  A61K31/665 ,  A61K31/69

CPC分类号： A61K31/381 ,  A61K31/665 ,  A61K31/69

摘要： The present method relates to modulating the mammalian inflammatory response using the bacterial autoinducer-2 and analogs and agonists thereof. In particular, the invention provides for ameliorating or reducing inflammation in inflammatory diseases and conditions associated with production of IL-1 and IL-6.

摘要翻译： 本方法涉及使用细菌自体诱导剂-2及其类似物和激动剂调节哺乳动物炎症反应。 特别地，本发明提供改善或减少炎性疾病和与产生IL-1和IL-6相关的病症的炎症。

公开(公告)号：US20050096675A1

公开(公告)日：2005-05-05

申请号：US10998779

申请日：2004-11-29

申请人： Hanson Gifford ,  Lee Bolduc ,  Jeffrey Stein ,  Paul DiCesare ,  Peter Costa ,  William Holmes

发明人： Hanson Gifford ,  Lee Bolduc ,  Jeffrey Stein ,  Paul DiCesare ,  Peter Costa ,  William Holmes

IPC分类号： A61B17/00 ,  A61B17/064 ,  A61B17/11 ,  A61B17/115 ,  A61B17/12 ,  A61F2/00 ,  A61B17/08

CPC分类号： A61B17/12109 ,  A61B17/064 ,  A61B17/0643 ,  A61B17/11 ,  A61B17/115 ,  A61B17/12036 ,  A61B17/12045 ,  A61B17/12136 ,  A61B2017/00243 ,  A61B2017/0641 ,  A61B2017/1135 ,  A61B2017/12127 ,  A61F2002/30092 ,  A61F2210/0014

摘要： A system for performing an end-to-side vascular anastomosis, including an anastomosis device, an application instrument and methods for performing a vascular anastomosis. The system is applicable for performing an anastomosis between a vascular graft and the ascending aorta in coronary artery bypass surgery, particularly in port-access CABG surgery. A first aspect of the invention includes a vascular anastomosis staple. A first configuration has two parts: an anchor member, forming the attachment with the target vessel wall and a coupling member, forming the attachment with the bypass graft vessel. The anastonosis is completed by inserting the coupling member, with the graft vessel attached, into the anchor member. A second configuration combines the functions of the anchor member and the coupling member into a one-piece anastomosis staple. A second aspect of the invention includes an anastomotic fitting, having an inner flange over which the graft vessel is everted and an outer flange which contacts the exterior surface of the target vessel. A tailored amount of compression applied by the inner and outer flanges grips the target vessel wall and creates a leak-proof seal between the graft vessel and the target vessel. A third aspect of the invention has a flange to which the graft vessel attaches, by everting the graft vessel over the flange, and a plurality of staple-like members which attach the flange and the everted end of the graft vessel to the wall of the target vessel to form the anastomosis

摘要翻译： 一种用于执行端对侧血管吻合的系统，包括吻合装置，应用仪器和用于进行血管吻合的方法。 该系统适用于在冠状动脉旁路手术中进行血管移植物和升主动脉之间的吻合，特别是在进入CABG手术中。 本发明的第一方面包括血管吻合缝合物。 第一构造具有两部分：锚定构件，与目标血管壁形成附件和联接构件，与旁路移植血管形成附件。 通过将连接构件插入移植物血管插入锚定构件来完成吻合。 第二种结构将锚定构件和联接构件的功能结合成一体式吻合钉。 本发明的第二方面包括一种吻合装置，其具有内部凸缘，移植物容器在其上延伸，外部凸缘接触目标血管的外表面。 由内外法兰施加的定制的压缩量夹住目标血管壁，并在移植血管和靶血管之间产生防漏密封。 本发明的第三方面具有凸缘，移植管通过使移植物容器穿过凸缘而附接到该凸缘上，以及多个钉状构件，其将该移植物容器的凸缘和脱出端附接到 靶血管形成吻合

公开(公告)号：US5486196A

公开(公告)日：1996-01-23

申请号：US55413

申请日：1993-05-03

申请人： Bernard Hirshowitz ,  Amnon Levy ,  Alexander R. Gilat ,  Eitan Rogel ,  Jeffrey Stein ,  Julian Borgia

发明人： Bernard Hirshowitz ,  Amnon Levy ,  Alexander R. Gilat ,  Eitan Rogel ,  Jeffrey Stein ,  Julian Borgia

IPC分类号： A61B17/06 ,  A61B17/08 ,  A61B19/00 ,  A61B17/00

CPC分类号： A61B17/08 ,  A61B17/06066 ,  A61B2017/081 ,  A61B2090/032 ,  A61B2090/0801 ,  A61B90/02

摘要： An apparatus for closing wide skin defects may be used with two long interdermal needles configured for insertion underneath skin close to margins of a skin defect. The skin closing apparatus may include two U-shaped retaining members configured as a flange connecting two legs and forming a U-shaped profile. Each of the legs may include a sharp hook at the end of the leg adapted for piercing the skin and engaging one of the long interdermal needles. Each retaining member may include a pivoting platform that pivots up to 20.degree. from an initial position indicated by a detent mechanism. A contracting mechanism such as a screw may connect the retaining members and approximate the interdermal needles, while bringing the skin margins together until final closure of the skin defect results. The skin closing apparatus may also include a clutch mechanism configured to disengage the screw from a knob or handle, when a predetermined force is met or exceeded. A visual or auditory element may also be provided to indicate the amount of force applied to the skin. A retractor may be packaged with the skin closing apparatus and long interdermal needles in a presterilized kit. The retractor may exhibit atraumatic ends having curved edges. The retractor may also exhibit english and metric measuring scales to aid in placing the skin closing apparatus and long interdermal needles about the skin defect. The device may be configured as a single use device utilized with gamma sterilization. In the event the device is configured for multiple uses, any conventional sterilization method may be utilized.

摘要翻译： 可以使用用于闭合宽皮肤缺陷的装置，其中两个长的腹膜针被配置用于插入皮肤缺陷边缘附近的皮肤下面。 皮肤关闭装置可以包括两个U形保持构件，其构造成连接两个腿并形成U形轮廓的凸缘。 每个腿部可以包括在腿部末端处的尖锐的钩子，其适于刺穿皮肤并且接合长的经皮针中的一个。 每个保持构件可以包括枢转平台，其从由止动机构指示的初始位置枢转高达20°。 诸如螺钉的收缩机构可以将保持构件连接并且近似于透皮针，同时使皮肤边缘在一起，直到皮肤缺陷的最终闭合。 皮肤关闭装置还可以包括离合器机构，其被配置为当达到或超过预定力时使螺钉与旋钮或手柄脱离。 还可以提供视觉或听觉元件以指示施加到皮肤的力的量。 收缩器可以与皮肤闭合装置和长的经皮针包装在预先灭活的试剂盒中。 牵开器可能表现为具有弯曲边缘的无创伤端。 牵开器还可以展示英制和公制测量秤，以帮助将皮肤关闭装置和长的皮肤针放置在皮肤缺陷周围。 该装置可以被配置为与伽马灭菌一起使用的单一使用装置。 在设备被配置为多用途的情况下，可以使用任何常规的灭菌方法。

公开(公告)号：US5117978A

公开(公告)日：1992-06-02

申请号：US680412

申请日：1991-04-04

申请人： Arthur Blumenfeld ,  Bert D. Heinzelman ,  Jeffrey Stein

发明人： Arthur Blumenfeld ,  Bert D. Heinzelman ,  Jeffrey Stein

IPC分类号： A61B5/0492

CPC分类号： A61B5/0492

摘要： A monopolar needle assembly comprises a disposable insulated needle having an uninsulated tip projecting from a needle stem and a sheath for covering the needle. The protective sheath is preferably plastic and injection molded. The needle is disposed within a protective sheath until the needle is inserted into the patient, thereby preventing contamination of the needle. As embodied herein, the exterior and interior surfaces of the protective sheath are tapered to conform essentially to the elongated configuration of the needle. The portion of the sheath proximate the needle stem includes flanges projecting from the exterior of the sheath to prevent the monopolar needle assembly of the present invention from rolling if it is dropped.

摘要翻译： 单极针组件包括一次性绝缘针，其具有从针杆突出的未绝缘尖端和用于覆盖针的护套。 保护套优选为塑料并注射成型。 将针放置在保护套内，直到针插入患者体内，从而防止针的污染。 如本文所体现的，保护套的外表面和内表面是锥形的，以基本上符合针的细长结构。 靠近针杆的鞘的部分包括从护套的外部突出的凸缘，以防止本发明的单极针组件在下落时滚动。