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    Implantable drug delivery devices for genitourinary sites
    1.
    发明授权
    Implantable drug delivery devices for genitourinary sites 有权
    用于泌尿生殖部位的植入式药物输送装置

    公开(公告)号：US09283361B2

    公开(公告)日：2016-03-15

    申请号：US13813745

    申请日：2011-08-03

    申请人： Paul DiCesare ,  Jeffrey Radziunas ,  Andrew Barnes ,  Eric Britschock ,  David Sutton

    发明人： Paul DiCesare ,  Jeffrey Radziunas ,  Andrew Barnes ,  Eric Britschock ,  David Sutton

    IPC分类号： A61M31/00

    CPC分类号： A61M31/002

    摘要： Implantable drug delivery devices are provided lo have a deployment shape for implantation in the body and a retention shape for retention in the body. The device may have one or more elongated drug reservoirs containing a drug, mid the drug reservoir may be formed from a deformable material. In one case, a first filament is attached to the first end of the drug reservoir and second filament is attached to the second end of the drug reservoir, wherein a fastener is positioned about the first and second filaments to permit shortening and prevent lengthening of the filaments with reference to the ends of the daig reservoir, as a means for transforming the device from the implantation shape to the retention shape.

    摘要翻译： 可植入药物递送装置具有用于植入体内的展开形状和用于保持在体内的保持形状。 该装置可以具有包含药物的一个或多个细长的药物储存器，药物储存器的中部可以由可变形材料形成。 在一种情况下，第一丝被附着到药物储存器的第一端并且第二丝连接到药物储存器的第二端，其中紧固件围绕第一和第二长丝定位以允许缩短和防止延长 参考daig储存器的端部的细丝作为将装置从植入形状转换成保持形状的手段。

    Cam-actuated medical puncturing device and method
    2.
    发明授权
    Cam-actuated medical puncturing device and method 有权
    凸轮式医疗穿刺装置及方法

    公开(公告)号：US08998941B2

    公开(公告)日：2015-04-07

    申请号：US11568634

    申请日：2005-05-05

    申请人： Paul Dicesare ,  Jeffrey Radziunas ,  Christopher A. Battles

    发明人： Paul Dicesare ,  Jeffrey Radziunas ,  Christopher A. Battles

    IPC分类号： A61B17/32 ,  A61B5/15 ,  A61B5/151

    CPC分类号： A61B5/1411 ,  A61B5/150022 ,  A61B5/150259 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150503 ,  A61B5/150564 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/150832 ,  A61B5/150885 ,  A61B5/15111 ,  A61B5/15117 ,  A61B5/1513 ,  A61B5/15142 ,  A61B5/15144 ,  A61B5/15186

    摘要： The medical puncturing device includes a housing (12), a shield (13), and a skin puncturing assembly disposed within the housing. The shield is axially movable in the housing. The skin puncturing assembly includes a movable carrier and a skin puncturing element mounted to the carrier. A distal end of the skin puncturing element is adapted for puncturing the skin of a patient. The carrier is movable from a retracted position wherein the skin puncturing element is disposed within the shield to a puncturing position wherein the distal end of the skin puncturing element is exposed. The carrier is maintained in the retracted position by engagement of flexure members or a retaining tab with the carrier. A drive spring is provided to move the carrier from the retracted position to the puncturing position. A retraction spring is provided to return the carrier and skin puncturing element into the housing.

    摘要翻译： 医疗穿刺装置包括壳体（12），护罩（13）和设置在壳体内的皮肤穿刺组件。 屏蔽件可在壳体中轴向移动。 皮肤穿刺组件包括可移动的载体和安装到载体的皮肤穿刺元件。 皮肤穿刺元件的远端适于穿刺患者的皮肤。 承载件可以从缩回位置移动，其中，皮肤穿刺元件设置在护罩内，到穿刺位置，其中皮肤穿刺元件的远端被暴露。 承载件通过弯曲构件或保持翼片与载体的接合而保持在缩回位置。 提供驱动弹簧以将托架从缩回位置移动到穿刺位置。 提供缩回弹簧以将托架和皮肤穿刺元件返回到壳体中。

    ROTARY-ACTUATED MEDICAL PUNCTURING DEVICE
    6.
    发明申请
    ROTARY-ACTUATED MEDICAL PUNCTURING DEVICE 有权
    旋转式医疗器械

    公开(公告)号：US20090118753A1

    公开(公告)日：2009-05-07

    申请号：US11568619

    申请日：2005-05-04

    申请人： Paul Dicesare ,  Christopher Battles ,  Jeffrey Radziunas

    发明人： Paul Dicesare ,  Christopher Battles ,  Jeffrey Radziunas

    IPC分类号： A61B17/32 ,  B23P11/00

    CPC分类号： A61B5/150832 ,  A61B5/150022 ,  A61B5/150259 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150503 ,  A61B5/150564 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/150885 ,  A61B5/15111 ,  A61B5/15117 ,  A61B5/1513 ,  A61B5/15144 ,  Y10T29/49826

    摘要： The medical puncturing device includes an actuator, a shield, and a skin puncturing assembly. The actuator and shield are movable relative to one another. The skin puncturing assembly includes a carrier and a skin puncturing element. A distal end of the skin puncturing element is adapted for puncturing the skin of a patient. The carrier is movable from a retracted position wherein the distal end of the skin puncturing element is disposed within the shield to a puncturing position wherein the distal end of the skin puncturing element is exposed to puncture the skin of a patient. The carrier is maintained in the retracted position by interference engagement between the carrier and shield. A drive spring is provided to move the carrier from the retracted to puncturing positions. A retraction spring is provided to return the carrier to a position wherein the shield encompasses the skin puncturing element.

    摘要翻译： 医疗穿刺装置包括致动器，护罩和皮肤穿刺组件。 致动器和屏蔽件可相对于彼此移动。 皮肤穿刺组件包括载体和皮肤穿刺元件。 皮肤穿刺元件的远端适于穿刺患者的皮肤。 承载件可以从缩回位置移动，其中，皮肤穿刺元件的远端设置在护罩内到穿刺位置，其中皮肤穿刺元件的远端暴露以刺穿患者的皮肤。 载体通过载体和屏蔽之间的干涉接合而保持在缩回位置。 提供驱动弹簧以将托架从缩回位置移动到穿刺位置。 提供缩回弹簧以将托架返回到其中护罩包围皮肤穿刺元件的位置。

    Devices and methods for performing a vascular anastomosis
    8.
    发明申请
    Devices and methods for performing a vascular anastomosis 审中-公开
    用于进行血管吻合的装置和方法

    公开(公告)号：US20050149077A1

    公开(公告)日：2005-07-07

    申请号：US11059169

    申请日：2005-02-16

    申请人： Hanson Gifford ,  Lee Bolduc ,  Jeffrey Stein ,  Paul DiCesare ,  Peter Costa ,  William Holmes

    发明人： Hanson Gifford ,  Lee Bolduc ,  Jeffrey Stein ,  Paul DiCesare ,  Peter Costa ,  William Holmes

    IPC分类号： A61B17/00 ,  A61B17/064 ,  A61B17/11 ,  A61B17/115 ,  A61B17/12 ,  A61F2/00 ,  A61B17/08

    CPC分类号： A61B17/12109 ,  A61B17/064 ,  A61B17/0643 ,  A61B17/11 ,  A61B17/115 ,  A61B17/12036 ,  A61B17/12045 ,  A61B17/12136 ,  A61B2017/00243 ,  A61B2017/0641 ,  A61B2017/1135 ,  A61B2017/12127 ,  A61F2002/30092 ,  A61F2210/0014

    摘要： A system for performing an end-to-side vascular anastomosis including an anastomosis device, an application instrument and methods for performing a vascular anastomosis. The system is applicable for performing an anastomosis between a vascular graft and the ascending aorta in coronary artery bypass surgery, particularly in port-access CABG surgery. A first aspect of the invention includes a vascular anastomosis staple. A first configuration has two parts: an anchor member, forming the attachment with the target vessel wall and a coupling member, forming the attachment with the bypass graft vessel. The anastomosis is completed by inserting the coupling member, with the graft vessel attached, into the anchor member. A second configuration combines the functions of the anchor member and the coupling member into a one-piece anastomosis staple. A second aspect of the invention includes an anastomotic fitting, having an inner flange over which the graft vessel is everted and an outer flange which contacts the exterior surface of the target vessel. A tailored amount of compression applied by the inner and outer flanges grips the target vessel wall and creates a leak-proof seal between the graft vessel and the target vessel. A third aspect of the invention has a flange to which the graft vessel attaches, by everting the graft vessel over the flange, and a plurality of staple-like members which attach the flange and the everted end of the graft vessel to the wall of the target vessel to form the anastomosis

    摘要翻译： 一种用于执行端对侧血管吻合的系统，包括吻合装置，应用仪器和用于进行血管吻合的方法。 该系统适用于在冠状动脉旁路手术中进行血管移植物和升主动脉之间的吻合，特别是在进入CABG手术中。 本发明的第一方面包括血管吻合缝。 第一构造具有两部分：锚定构件，与目标血管壁形成附件和联接构件，与旁路移植血管形成附件。 通过将连接构件插入到锚定构件中来完成吻合。 第二种结构将锚定构件和联接构件的功能结合成一体式吻合钉。 本发明的第二方面包括一种吻合装置，其具有内部凸缘，移植物容器在其上延伸，外部凸缘接触靶容器的外表面。 由内外法兰施加的定制的压缩量夹住目标血管壁，并在移植血管和靶血管之间产生防漏密封。 本发明的第三方面具有凸缘，移植管通过使移植物容器穿过凸缘而附接到该凸缘上，以及多个钉状构件，其将该移植物容器的凸缘和脱出端附接到 靶血管形成吻合