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    Reconstruction for cone-beam computed tomography imaging with off-center flat panel detector
    31.
    发明授权
    Reconstruction for cone-beam computed tomography imaging with off-center flat panel detector 有权
    用偏心平板检测器进行锥束计算机断层扫描成像的重建

    公开(公告)号：US09087404B2

    公开(公告)日：2015-07-21

    申请号：US13697445

    申请日：2011-04-25

    申请人： Eberhard S. Hansis ,  Dirk Schaefer ,  Michael Grass

    发明人： Eberhard S. Hansis ,  Dirk Schaefer ,  Michael Grass

    IPC分类号： G01N23/04 ,  G06T1/00 ,  G06T11/00

    CPC分类号： G06T11/008 ,  G06T11/006 ,  G06T2211/432

    摘要： Computed tomography (CT) reconstruction includes reconstructing an axially extended reconstructed image from a measured cone beam x-ray projection data set (Pm), optionally having an off-center geometry. The reconstructing is performed for an extended volume (eFOV) comprising a reconstructable volume (rFOV) of the measured cone beam x ray data set that is extended along the axial direction. The projection data set may be weighted in the volume domain. Iterative reconstruction may be used, including initializing a constant volume and performing one or more iterations employing a first iterative update followed by one or more iterations employing a second, different iterative update. Alternatively, backprojection filtration (BPF) reconstruction may be used, including transforming the projection data set to a new geometry including finite differences between neighboring projection views and performing BPF using Hilbert filtering along a plurality of different directions and averaging the resultant reconstructed images to generate the final reconstructed image.

    摘要翻译： 计算机断层摄影（CT）重建包括从测量的锥形束X射线投影数据集（Pm）重建轴向延伸的重建图像，可选地具有偏心几何。 对包括沿轴向延伸的测量的锥形束x射线数据集的可重建体积（rFOV）的扩展体积（eFOV）进行重建。 投影数据集可以在体积域中加权。 可以使用迭代重建，包括初始化恒定体积并且使用第一迭代更新执行一个或多个迭代，随后使用第二，不同迭代更新的一个或多个迭代。 或者，可以使用反投影过滤（BPF）重建，包括将投影数据集变换为包括相邻投影视图之间的有限差异的新几何，并且使用沿着多个不同方向的希尔伯特滤波来执行BPF，并平均所得到的重建图像以产生 最终重建图像。

    Image data registration for dynamic perfusion CT
    32.
    发明授权
    Image data registration for dynamic perfusion CT 有权
    用于动态灌注CT的图像数据注册

    公开(公告)号：US09002089B2

    公开(公告)日：2015-04-07

    申请号：US13643167

    申请日：2011-04-12

    申请人： Michael Grass ,  Alfonso Agatino Isola

    发明人： Michael Grass ,  Alfonso Agatino Isola

    IPC分类号： G06K9/00 ,  G06T7/00 ,  A61B6/00

    CPC分类号： G06T7/0026 ,  A61B6/507 ,  G06T7/32 ,  G06T2207/10076 ,  G06T2207/30104

    摘要： A method of registering a 4D contrast enhanced image data set, wherein the 4D contrast enhanced image data set includes image data of the same volume of interest acquired at different timeframes with changing contrast enhancement, the volume of interest includes moving structure, and the different timeframes correspond to a predetermined motion phase of interest in different motion cycles of the moving structure, the method, comprising: registering image data corresponding to a plurality of the different timeframes with reference image from one of the timeframes.

    摘要翻译： 一种注册4D对比度增强图像数据集的方法，其中所述4D对比度增强图像数据集包括在改变对比度增强的不同时间帧处获取的相同感兴趣体积的图像数据，所述感兴趣的体积包括移动结构和不同的时间帧 对应于移动结构的不同运动周期中的感兴趣的预定运动相位，该方法包括：将与多个不同时间帧对应的图像数据与来自其中一个时间帧的参考图像进行对应。

    Method for continuous catalytic hydrogenation
    36.
    发明授权
    Method for continuous catalytic hydrogenation 有权
    连续催化氢化方法

    公开(公告)号：US08586784B2

    公开(公告)日：2013-11-19

    申请号：US11320409

    申请日：2005-12-29

    申请人： Michael Grass ,  Burkhard Reeken ,  Axel Tuchlenski ,  Alfred Kaizik

    发明人： Michael Grass ,  Burkhard Reeken ,  Axel Tuchlenski ,  Alfred Kaizik

    IPC分类号： C07C61/00

    CPC分类号： C07C67/303 ,  Y02P20/582 ,  C07C69/75

    摘要： The invention relates to the preparation of alicyclic carboxylic acids or their derivatives by selective hydrogenation of the corresponding aromatic carboxylic acid (derivatives) in at least two series-connected reactors, at least one reactor being operated in loop operating mode. The catalyst volumes in the method are set in such a manner that the catalyst volume required, based on the conversion rate, is as low as possible.

    摘要翻译： 本发明涉及通过在至少两个串联连接的反应器中选择性氢化相应的芳族羧酸（衍生物）来制备脂环族羧酸或其衍生物，至少一个反应器以循环操作模式操作。 该方法中的催化剂体积设定为使得基于转化率所需的催化剂体积尽可能低。

    COMPUTED TOMOGRAPHY SYSTEM AND METHOD FOR TRACKING A BOLUS
    37.
    发明申请
    COMPUTED TOMOGRAPHY SYSTEM AND METHOD FOR TRACKING A BOLUS 有权
    计算机图像系统和追踪玻璃的方法

    公开(公告)号：US20130279783A1

    公开(公告)日：2013-10-24

    申请号：US13977042

    申请日：2012-01-04

    申请人： Holger Schmitt ,  Michael Grass

    发明人： Holger Schmitt ,  Michael Grass

    IPC分类号： G06T11/00

    CPC分类号： G06T11/008 ,  A61B6/032 ,  A61B6/469 ,  A61B6/481 ,  A61B6/488 ,  A61B6/504

    摘要： The present invention relates to a computed tomography system (10) and a corresponding method which enable tracking of a contrast material bolus and which involve a reduced radiation dose. The proposed computed tomography system (10) comprises an acquisition unit including an X-ray source (18) and an X-ray detector (30) for acquiring projection data sets (42, 44, 46), a reconstruction unit (41) for reconstructing a planning image (48) from a first projection data set (42), an identification unit (52) for identifying a region of interest (40) in the planning image (48), a selection unit (54) for selecting a projection angle (60) through the region of interest (40), a calculator (62) for calculating a target projection value (64) for a projection of said region of interest (40) with the selected projection angle (60), a control unit (32) for controlling said acquisition unit to acquire a second, reduced projection data set (44) including projection data from projections of said region of interest (40) with the selected projection angle (60), and a comparator (68) for comparing projection values of the second projection data set (44) with the target projection value (64), wherein the control unit (32) is adapted to control the acquisition unit to initiate the acquisition of a third projection data set (46) based on the comparison result (70) and to reconstruct a diagnostic image (50) from the third projection data set (46).

    摘要翻译： 本发明涉及计算机断层摄影系统（10）和相应的方法，其能够跟踪造影剂推注并涉及降低的辐射剂量。 所提出的计算机断层摄影系统（10）包括：采集单元，包括用于获取投影数据组（42,44,46）的X射线源（18）和X射线检测器（30）;重建单元（41），用于 从第一投影数据集（42）重建规划图像（48）;识别单元（52），用于识别所述规划图像（48）中的感兴趣区域（40）;选择单元（54），用于选择投影 通过感兴趣区域（40）的角度（60）;计算器（62），用于计算用于所选择的投影角度（60）的所述感兴趣区域（40）的投影的目标投影值（64）;控制单元 （32），用于控制所述获取单元以选择的投影角度（60）获取包括来自所述感兴趣区域（40）的投影的投影数据的第二缩小投影数据集（44），以及比较器 第二投影数据集（44）的投影值与目标投影值（64），w 这里，控制单元（32）适于控制采集单元基于比较结果（70）开始获取第三投影数据集（46），并且从第三投影数据集重建诊断图像（50） （46）。

    Apparatus for generating an image of moving object
    39.
    发明授权
    Apparatus for generating an image of moving object 有权
    用于产生移动物体的图像的装置

    公开(公告)号：US08478014B2

    公开(公告)日：2013-07-02

    申请号：US12990817

    申请日：2009-05-05

    申请人： Uwe Jandt ,  Dirk Schaefer ,  Michael Grass

    发明人： Uwe Jandt ,  Dirk Schaefer ,  Michael Grass

    IPC分类号： G06K9/00

    CPC分类号： G06T11/005 ,  G06T7/564 ,  G06T2211/412

    摘要： The present invention relates to an apparatus for generating an image of a moving object, wherein a movement of the object comprises a multiple of moving phases. The apparatus comprises a measured detection data providing unit (20) for providing measured detection data of the moving object, which have been detected by using a detection process and which are assigned to the moving phases. The apparatus comprises further a reconstruction unit (13) for reconstructing an image object of the object from the provided measured detection data and an adaptation unit (18) for adapting the image object for different moving phases such that simulated detection data are adapted to the measured detection data of the respective moving phase, wherein the simulated detection data are determined by simulating the detection process, which has been used for detecting the measured detection data assigned to the respective moving phase, with the image object.

    摘要翻译： 本发明涉及一种用于生成移动物体的图像的装置，其中物体的移动包括多个移动相位。 该装置包括测量检测数据提供单元（20），用于提供已经通过使用检测处理检测并被分配给运动相位的移动物体的测量检测数据。 所述设备还包括用于根据所提供的测量的检测数据重建对象的图像对象的重建单元（13）和用于使图像对象适应不同的移动阶段的适配单元（18），使得模拟的检测数据适应于所测量的 检测数据，其中通过模拟已经用于检测分配给各个运动相位的测量检测数据的检测过程与图像对象来确定模拟检测数据。

    3D-ORIGINATED CARDIAC ROADMAPPING
    40.
    发明申请
    3D-ORIGINATED CARDIAC ROADMAPPING 有权
    3D原版CARDIAC ROADMAPPING

    公开(公告)号：US20130116551A1

    公开(公告)日：2013-05-09

    申请号：US13810292

    申请日：2011-07-15

    申请人： Raoul Florent ,  Vincent Auvray ,  Michael Grass ,  Dirk Schaefer ,  Gert Schoonenberg

    发明人： Raoul Florent ,  Vincent Auvray ,  Michael Grass ,  Dirk Schaefer ,  Gert Schoonenberg

    IPC分类号： A61B6/02

    CPC分类号： A61B6/022 ,  A61B6/12 ,  A61B6/4441 ,  A61B6/463 ,  A61B6/487 ,  A61B6/504 ,  A61B6/5223 ,  A61B6/5235 ,  A61B2090/364 ,  A61B2090/367

    摘要： The present invention relates to 3D-originated cardiac roadmapping. In order to improve the accuracy of the information provided to the user as navigation information, without any additional burden to the patient such as additional X-ray dose, a method is described comprising the steps of a) providing 3D+t image data of a vascular structure of an object; b) acquiring two-dimensional image data of the object, which object comprises the vascular structure, the 2D image data comprising at least one 2D image; c) projecting the vascular structure, thereby generating a plurality of mask images on the basis of a 3D+t image data; d) registering the at least one 2D image with one of the plurality of the mask images, wherein the registration comprises finding the maximum of a similarity factor between the mask images and the at least one 2D image; e) generating a combination of the at least one 2D image and a projection of the vascular structure on the basis of the 3D+t image data according to the registration; and f) displaying the combination as a guiding vessel tree projection. Thus improved cardiac roadmapping in form of a topographical roadmapping is provided since the roadmapping is based on three-dimensional data.

    摘要翻译： 本发明涉及3D起源的心脏路线图。 为了提高作为导航信息提供给用户的信息的准确性，对病人没有任何额外的负担，例如额外的X射线剂量，描述了一种方法，其包括以下步骤：a）提供一个 物体的血管结构; b）获取所述对象的二维图像数据，所述对象包括所述血管结构，所述2D图像数据包括至少一个2D图像; c）投影血管结构，从而基于3D + t图像数据生成多个掩模图像; d）使用所述多个掩模图像之一登记所述至少一个2D图像，其中所述注册包括找到所述掩模图像与所述至少一个2D图像之间的相似性因子的最大值; e）根据所述注册，基于所述3D + t图像数据生成所述至少一个2D图像和所述血管结构的投影的组合; 以及f）将组合显示为引导血管树投影。 因此，由于路线图基于三维数据，所以提供了形成路面图的形式的改进的心脏路线图。