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56 条记录 (耗时 0.041 秒)

    Method for inhibiting the binding of low density lipoprotein to blood vessel matrix
    36.
    发明授权
    Method for inhibiting the binding of low density lipoprotein to blood vessel matrix 失效
    抑制低密度脂蛋白与血管基质结合的方法

    公开(公告)号：US6156315A

    公开(公告)日：2000-12-05

    申请号：US966296

    申请日：1997-11-07

    申请人： Ira J. Goldberg ,  Sivaram Pillarisetti

    发明人： Ira J. Goldberg ,  Sivaram Pillarisetti

    IPC分类号： A61K38/00 ,  A61K38/17 ,  C07K14/775 ,  C07K16/18 ,  A61K39/395

    CPC分类号： C07K16/18 ,  A61K38/1709 ,  C07K14/775 ,  C12N2799/022

    摘要： This invention also provides a method of treating atherosclerosis in a subject, comprising administering to the subject an effective amount of a substance capable of binding to the amino-terminal region of apolipoprotein B, thereby treating the atherosclerosis. This invention also provides a method for inhibiting the binding of low density lipoprotein to blood vessel matrix in a subject, comprising administering to the subject an effective amount of a substance capable of competing with the amino-terminal region of apolipoprotein B for binding to blood vessel matrix, thereby inhibiting the binding of low density lipoprotein to blood vessel matrix. This invention also provides a method for identifying a compound capable of ameliorating atherosclerosis. Additionally, this invention provides a kit for inhibiting the binding of low density lipoprotein to blood vessel matrix, wherein the kit comprises a substance capable of binding to the amino-terminal region of apolipoprotein B.

    摘要翻译： 本发明还提供一种治疗受试者的动脉粥样硬化的方法，其包括向受试者施用有效量的能够结合载脂蛋白B的氨基末端区域的物质，从​​而治疗动脉粥样硬化。 本发明还提供一种抑制受试者中低密度脂蛋白与血管基质的结合的方法，其包括向受试者施用有效量的与载脂蛋白B的氨基末端区域竞争结合血管的物质 从而抑制低密度脂蛋白与血管基质的结合。 本发明还提供了鉴定能够改善动脉粥样硬化的化合物的方法。 此外，本发明提供了一种用于抑制低密度脂蛋白与血管基质结合的试剂盒，其中该试剂盒包含能够结合载脂蛋白B的氨基末端区域的物质。

    Small-molecule modulators of hepatocyte growth factor/scatter factor activities
    39.
    发明申请
    Small-molecule modulators of hepatocyte growth factor/scatter factor activities 审中-公开
    肝细胞生长因子/分散因子活性的小分子调节剂

    公开(公告)号：US20050096372A1

    公开(公告)日：2005-05-05

    申请号：US11007333

    申请日：2004-12-08

    申请人： Sivaram Pillarisetti ,  Itzhak Goldberg

    发明人： Sivaram Pillarisetti ,  Itzhak Goldberg

    IPC分类号： A61K31/415 ,  A61K31/42

    CPC分类号： A61K31/42 ,  A61K31/415

    摘要： The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

    摘要翻译： 本发明涉及具有模拟或激动肝细胞生长因子/分散因子（HGF / SF）活性或抑制或拮抗HGF / SF活性的能力的小有机分子，前者可用于促进例如组织的血管形成或 用于促进伤口或组织愈合的器官，或增加或恢复心肌梗死后心脏缺血组织的血流量。 抑制细胞生长或增殖在治疗例如炎性关节和皮肤疾病等炎性疾病以及诸如癌症的增生性增生性疾病中是有益的。

    Small-molecule modulators of hepatocyte growth factor/scatter factor activities
    40.
    发明授权
    Small-molecule modulators of hepatocyte growth factor/scatter factor activities 失效
    肝细胞生长因子/分散因子活性的小分子调节剂

    公开(公告)号：US06589997B2

    公开(公告)日：2003-07-08

    申请号：US09896832

    申请日：2001-06-29

    申请人： Sivaram Pillarisetti ,  Itzhak D. Goldberg

    发明人： Sivaram Pillarisetti ,  Itzhak D. Goldberg

    IPC分类号： A01N3500

    CPC分类号： A61K31/42 ,  A61K31/415

    摘要： The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

    摘要翻译： 本发明涉及具有模拟或激动肝细胞生长因子/分散因子（HGF / SF）活性或抑制或拮抗HGF / SF活性的能力的小有机分子，前者可用于促进例如组织的血管形成或 用于促进伤口或组织愈合的器官，或增加或恢复心肌梗死后心脏缺血组织的血流量。 抑制细胞生长或增殖在治疗例如炎性关节和皮肤疾病等炎性疾病以及诸如癌症的增生性增生性疾病中是有益的。