公开(公告)号：US20060128729A1

公开(公告)日：2006-06-15

申请号：US11285982

申请日：2005-11-23

申请人： Manojit Pal ,  Yeleswarapu Rao ,  Ish Khanna ,  Nalivela Swamy ,  Venkataraman Subramanian ,  Venkateswara Batchu ,  Javed Iqbal ,  Sivaram Pillarisetti

发明人： Manojit Pal ,  Yeleswarapu Rao ,  Ish Khanna ,  Nalivela Swamy ,  Venkataraman Subramanian ,  Venkateswara Batchu ,  Javed Iqbal ,  Sivaram Pillarisetti

IPC分类号： A61K31/519 ,  C07D487/02

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.

摘要翻译： 本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗与例如细胞相关的多种病症和疾病状态的方法 增殖，炎症，糖苷酶表达或Perlecan的低表达。

公开(公告)号：US20060084645A1

公开(公告)日：2006-04-20

申请号：US11234695

申请日：2005-09-23

申请人： Manojit Pal ,  Srinivas Kalleda ,  Srinivas Padakanti ,  Nalivela Swamy ,  Koteswar Yeleswarapu ,  Christopher Alexander ,  Ish Khanna ,  Javed Iqbal ,  Sivaram Pillarisetti ,  Deepak Barange

发明人： Manojit Pal ,  Srinivas Kalleda ,  Srinivas Padakanti ,  Nalivela Swamy ,  Koteswar Yeleswarapu ,  Christopher Alexander ,  Ish Khanna ,  Javed Iqbal ,  Sivaram Pillarisetti ,  Deepak Barange

IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/506 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

CPC分类号： C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

摘要翻译： 本发明提供新的杂环化合物，特别是取代的嘧啶，用于制备和使用这些杂环化合物的方法和组合物，以及用于治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或疾病 由Perlecan低表达介导的状态。

公开(公告)号：US07820654B2

公开(公告)日：2010-10-26

申请号：US11234695

申请日：2005-09-23

申请人： Manojit Pal ,  Srinivas Kalleda ,  Srinivas Padakanti ,  Nalivela Kumara Swamy ,  Koteswar Rao Yeleswarapu ,  Christopher W. Alexander ,  Ish Khanna ,  Javed Iqbal ,  Sivaram Pillarisetti ,  Deepak Barange

发明人： Manojit Pal ,  Srinivas Kalleda ,  Srinivas Padakanti ,  Nalivela Kumara Swamy ,  Koteswar Rao Yeleswarapu ,  Christopher W. Alexander ,  Ish Khanna ,  Javed Iqbal ,  Sivaram Pillarisetti ,  Deepak Barange

IPC分类号： A61K31/54 ,  A61K31/535 ,  A61K31/497 ,  A61K31/505 ,  C07D417/00 ,  C07D413/00 ,  C07D403/00 ,  C07D239/02

CPC分类号： C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention is directed to a compounds, methods and compositions for making the compounds and methods of treating a variety of diseases and disease states including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan, comprising the administration of new heterocyclic compounds, particularly substituted pyrimidines. The present invention is directed to novel compounds represented by the general formula:

摘要翻译： 本发明涉及用于制备化合物的化合物，方法和组合物以及治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或由Perlecan低表达介导的疾病 包括施用新的杂环化合物，特别是取代的嘧啶。 本发明涉及由以下通式表示的新化合物：

公开(公告)号：US20060128702A1

公开(公告)日：2006-06-15

申请号：US11286006

申请日：2005-11-23

申请人： Manojit Pal ,  Ish Khanna ,  Venkataraman Subramanian ,  Srinivas Padakanti ,  Sivaram Pillarisetti

发明人： Manojit Pal ,  Ish Khanna ,  Venkataraman Subramanian ,  Srinivas Padakanti ,  Sivaram Pillarisetti

IPC分类号： A61K31/5377 ,  A61K31/4709 ,  A61K31/4706 ,  C07D413/02 ,  C07D401/02 ,  C07D215/38

CPC分类号： C07D215/38 ,  C07D215/44 ,  C07D401/02 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D413/02

摘要： The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.

摘要翻译： 本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗与例如细胞相关的多种病症和疾病状态的方法 增殖，炎症，糖苷酶表达或Perlecan的低表达。

公开(公告)号：US20060172984A1

公开(公告)日：2006-08-03

申请号：US11284757

申请日：2005-11-22

申请人： Richard Timmer ,  Christopher Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Yeleswarapu Rao ,  Manojit Pal ,  Jangalgar Reddy ,  Velagala Venkata Rama Reddy ,  Sesha Alluri ,  Potlapally Kumar ,  Gaddam Reddy

发明人： Richard Timmer ,  Christopher Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Yeleswarapu Rao ,  Manojit Pal ,  Jangalgar Reddy ,  Velagala Venkata Rama Reddy ,  Sesha Alluri ,  Potlapally Kumar ,  Gaddam Reddy

IPC分类号： A61K31/53 ,  C07D403/14

CPC分类号： A61K31/53 ,  C04B35/632 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

摘要翻译： 本发明涉及包含治疗由炎性反应引起的病理生理状况的化合物的方法和组合物。 特别地，本发明涉及抑制或阻断糖基化蛋白质产生内皮细胞中信号传导相关炎症反应诱导的化合物。 本发明涉及抑制平滑肌增殖的化合物。 特别地，本发明涉及通过调节HSPG例如Perlecan抑制平滑肌细胞增殖的化合物。 本发明还涉及化合物用于治疗以平滑肌增生为特征的血管闭塞症状，例如再狭窄和动脉粥样硬化。

公开(公告)号：US20060084644A1

公开(公告)日：2006-04-20

申请号：US11234257

申请日：2005-09-23

申请人： Manojit Pal ,  Christopher Alexander ,  Ish Khanna ,  Javed Iqbal ,  Ram Pillarisetti ,  Santanu Maitra ,  Gayla Roberts ,  Lavanya Sagi ,  Chintakunta Krishna ,  Jennepalli Sreenu

发明人： Manojit Pal ,  Christopher Alexander ,  Ish Khanna ,  Javed Iqbal ,  Ram Pillarisetti ,  Santanu Maitra ,  Gayla Roberts ,  Lavanya Sagi ,  Chintakunta Krishna ,  Jennepalli Sreenu

IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/44 ,  C07D417/02 ,  C07D403/02 ,  C07D413/02 ,  C07D401/02

CPC分类号： C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

摘要翻译： 本发明提供新的杂环化合物，特别是取代的吡啶，制备和使用这些杂环化合物的方法和组合物，以及用于治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或疾病 由Perlecan低表达介导的状态。

公开(公告)号：US07622486B2

公开(公告)日：2009-11-24

申请号：US11234257

申请日：2005-09-23

申请人： Manojit Pal ,  Christopher W. Alexander ,  Ish Khanna ,  Javed Iqbal ,  Ram Pillarisetti ,  Santanu Maitra ,  Gayla W. Roberts ,  Lavanya Sagi ,  Chintakunta Vamsee Krishna ,  Jennepalli Sreenu

发明人： Manojit Pal ,  Christopher W. Alexander ,  Ish Khanna ,  Javed Iqbal ,  Ram Pillarisetti ,  Santanu Maitra ,  Gayla W. Roberts ,  Lavanya Sagi ,  Chintakunta Vamsee Krishna ,  Jennepalli Sreenu

IPC分类号： A61K31/445 ,  A61K31/44 ,  C07D401/02

CPC分类号： C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

摘要翻译： 本发明提供新的杂环化合物，特别是取代的吡啶，制备和使用这些杂环化合物的方法和组合物，以及用于治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或疾病 由Perlecan低表达介导的状态。

公开(公告)号：US07335656B2

公开(公告)日：2008-02-26

申请号：US11512863

申请日：2006-08-30

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Sridevi Alluri ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Sridevi Alluri ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

IPC分类号： A61M31/00 ,  A61F2/86 ,  C07D251/70 ,  C07D251/52 ,  C07D251/30 ,  A61P35/00

CPC分类号： A61K31/53 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods, compounds, and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses, and is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention also relates to compounds that inhibit smooth muscle proliferation, for example, by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis. This invention also relates to medical devices, such as a stent, comprising a compound or composition of this invention disposed on or within the medical device.

摘要翻译： 本发明涉及包含治疗由炎性反应引起的病理生理状况的化合物的方法，化合物和组合物，并且涉及抑制或阻断糖基化蛋白质产生内皮细胞中信号传导相关炎症反应诱导的化合物。 本发明还涉及抑制平滑肌增殖的化合物，例如通过调节HSPG如Perlecan。 本发明还涉及化合物用于治疗以平滑肌增生为特征的血管闭塞症状，例如再狭窄和动脉粥样硬化。 本发明还涉及包括设置在医疗装置上或内部的本发明的化合物或组合物的医疗装置，例如支架。

公开(公告)号：US07112587B2

公开(公告)日：2006-09-26

申请号：US10400134

申请日：2003-03-26

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Bhatlapenumarthy Sesha Sridevi ,  Potlapally Rajendar Kumar ,  Gaddam Om Reddy

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Bhatlapenumarthy Sesha Sridevi ,  Potlapally Rajendar Kumar ,  Gaddam Om Reddy

IPC分类号： C07D251/30 ,  C07D251/46 ,  C07D251/48 ,  A61K31/53 ,  A61P35/00

CPC分类号： A61K31/53 ,  C04B35/632 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

公开(公告)号：US20050227983A1

公开(公告)日：2005-10-13

申请号：US10808210

申请日：2004-03-24

申请人： Richard Timmer ,  Christopher Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Alluri ,  Velagala Venkata Krishna Reddy ,  Manojit Pal ,  Jangalgar Reddy ,  Koteswar Yeleswarapu ,  Gaddam Reddy ,  Potlapally Kumar

发明人： Richard Timmer ,  Christopher Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Alluri ,  Velagala Venkata Krishna Reddy ,  Manojit Pal ,  Jangalgar Reddy ,  Koteswar Yeleswarapu ,  Gaddam Reddy ,  Potlapally Kumar

IPC分类号： A61K31/53 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  C07D251/46 ,  C07D251/52 ,  C12M1/34 ,  C07D43/02

CPC分类号： C07D251/46

摘要： The present invention relates to triazine compounds and their analogs and derivatives, and methods and compositions comprising these compounds. The compounds and compositions of this invention are useful for, among other things, treating pathophysiological conditions arising from inflammatory responses, inhibiting or blocking glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells, inhibiting smooth muscle proliferation, treating vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis, and the like.

摘要翻译： 本发明涉及三嗪化合物及其类似物和衍生物，以及包含这些化合物的方法和组合物。 本发明的化合物和组合物尤其可用于治疗由炎症反应引起的病理生理学病症，抑制或阻断糖基化蛋白产生内皮细胞中信号传导相关炎症反应的诱导，抑制平滑肌增生，治疗血管闭塞症状 其特征在于平滑肌增生如再狭窄和动脉粥样硬化等。