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59 条记录 (耗时 0.06 秒)

    Use of compounds capable of inhibiting the proteolytic processing of semaphorins for prevention, treatment, diagnosis and prognosis of an invasive disease
    33.
    发明申请
    Use of compounds capable of inhibiting the proteolytic processing of semaphorins for prevention, treatment, diagnosis and prognosis of an invasive disease 审中-公开
    使用能够抑制信号素的蛋白水解加工的化合物用于预防，治疗，诊断和预后的侵袭性疾病

    公开(公告)号：US20070010433A1

    公开(公告)日：2007-01-11

    申请号：US10520741

    申请日：2003-07-10

    申请人： Morten Albrechtsen ,  Claus Christensen ,  Eugene Lukanidin ,  Ole Olsen

    发明人： Morten Albrechtsen ,  Claus Christensen ,  Eugene Lukanidin ,  Ole Olsen

    IPC分类号： A61K38/17

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  C07K16/18 ,  G01N33/57484 ,  G01N33/57488 ,  G01N2333/4704

    摘要： The present invention relates to use of compounds directed to inhibiting expression and/or proteolytic processing semaphorins SEMA3E and/or sema3E and/or activation of a receptor by a proteolytic product of said semaphorins for the manufacture of a medicament for prevention, treatment diagnosis and/or prognosis of an invasive disease. The invention features the compounds selected from the group comprising antisense compounds derived from the sequence of SEMA3E and/or sema3E, peptide compounds derived from the sequence of said semaphorins, anti-bodies against said semaphorins, and peptide compounds derived from the sequence of Plexin A receptor. Furthermore, the invention provides methods for prognosis and/diagnosis of malignancy of cancer based of estimation of the levels of expression and proteolytic processing of said semaphorins in a sample of a tissue or body fluid. The invention also concerns a method for producing an attractant polypeptide by establishing a cleavage product of SEMA3E. and/or sema3E.

    摘要翻译： 本发明涉及用于抑制表达和/或蛋白水解处理信号素SEMA3E和/或sema3E和/或通过所述信号素的蛋白水解产物激活受体的化合物在制备用于预防，治疗诊断和/ 或侵入性疾病的预后。 本发明的特征在于选自衍生自SEMA3E和/或sema3E序列的反义化合物的组合物，衍生自所述信号素序列的肽化合物，针对所述信号素的抗体，以及衍生自Plexin A序列的肽化合物 受体。 此外，本发明基于对组织或体液样品中所述信号素的表达水平和蛋白水解加工的估计，提供了对癌症恶性程度的预后和/诊断方法。 本发明还涉及通过建立SEMA3E的切割产物来产生引诱多肽的方法。 和/或sema3E。

    Human coagulation Factor VII variants
    34.
    发明申请
    Human coagulation Factor VII variants 失效
    人凝血因子VII变体

    公开(公告)号：US20060252129A1

    公开(公告)日：2006-11-09

    申请号：US11486586

    申请日：2006-07-14

    申请人： Egon Persson ,  Ole Olsen

    发明人： Egon Persson ,  Ole Olsen

    IPC分类号： C07K14/745 ,  C07H21/04 ,  C12P21/04

    CPC分类号： C12N9/647 ,  A61K38/00 ,  C12N9/6437 ,  C12Y304/21021

    摘要： The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as nucleic acid constructs encoding such variants, vectors and host cells comprising and expressing the nucleic acid, pharmaceutical compositions, uses and methods of treatment.

    摘要翻译： 本发明涉及具有凝血活性的新型人凝血因子VIIa变体以及编码这样的变体，载体和宿主细胞的核酸构建体，其包含并表达核酸，药物组合物，用途和治疗方法。

    Device for vibratory stimulation on the human body
    35.
    发明授权
    Device for vibratory stimulation on the human body 失效
    用于人体振动刺激的装置

    公开(公告)号：US06923773B2

    公开(公告)日：2005-08-02

    申请号：US10465392

    申请日：2003-06-20

    申请人： Gunnar Leivseth ,  Ole Olsen

    发明人： Gunnar Leivseth ,  Ole Olsen

    IPC分类号： A61H1/00 ,  A61H23/02

    CPC分类号： A61H1/005 ,  A61H1/001 ,  A61H1/006 ,  A61H23/0263 ,  A61H2203/0406

    摘要： A device for vibratory stimulation on the human body comprises a support platform, a panel supported by the platform and forming a standing surface for a person using the device, and a vibrator for imparting to the panel a vibratory movement. Two standards are mounted to the platform at opposite sides of the panel, forming handles for the person standing on the standing surface between the standards to hold on. A sensor is provided for sensing the load on the panel or on the standards exerted by the person standing on the standing surface. A control unit is connected with the sensor and the vibrator for controlling the operation of the vibrator in dependence on the load sensed by the sensor.

    摘要翻译： 用于在人体上进行振动刺激的装置包括支撑平台，由平台支撑的面板，并且使用该装置形成人的站立面，以及用于向面板施加振动运动的振动器。 两个标准安装在面板对面的平台上，形成了站在站立表面上的人员握持标准之间的手柄。 提供传感器用于感测面板上的负载或者站在站立面上的人施加的标准。 控制单元与传感器和振动器连接，用于根据传感器感测到的负载来控制振动器的操作。

    Method for diagnosing and testing/training pelvic floor musculature
    36.
    发明授权
    Method for diagnosing and testing/training pelvic floor musculature 失效
    诊断和测试/训练盆底肌肉组织的方法

    公开(公告)号：US6059740A

    公开(公告)日：2000-05-09

    申请号：US78106

    申请日：1998-05-13

    申请人： Gunnar Leivseth ,  Ole Olsen

    发明人： Gunnar Leivseth ,  Ole Olsen

    IPC分类号： A61B5/22 ,  A63B23/20 ,  A63B24/00 ,  A61B5/103

    CPC分类号： A63B23/20 ,  A61B5/227 ,  A63B2220/51

    摘要： A measurement and training apparatus to be inserted in the vagina or rectum for diagnostic and pelvic musculature training purposes, comprises, two axially split halves of a substantially cylindrical body, kept at an adjustable distance from each other. A strain gauge measures a force perpendicular to the axis of the apparatus. The measurement is executed in a flexural mode where a forward end of one of the halves is bent toward the other half with a small deflection.

    摘要翻译： 插入阴道或直肠以进行诊断和骨盆肌肉训练目的的测量和训练装置包括保持彼此可调节距离的基本圆柱形主体的两个轴向分开的两半。 应变计测量垂直于设备轴线的力。 测量以弯曲模式执行，其中一个半部的前端以小的偏转向另一半弯曲。