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    Use of compounds capable of inhibiting the proteolytic processing of semaphorins for prevention, treatment, diagnosis and prognosis of an invasive disease
    1.
    发明申请
    Use of compounds capable of inhibiting the proteolytic processing of semaphorins for prevention, treatment, diagnosis and prognosis of an invasive disease 审中-公开
    使用能够抑制信号素的蛋白水解加工的化合物用于预防，治疗，诊断和预后的侵袭性疾病

    公开(公告)号：US20070010433A1

    公开(公告)日：2007-01-11

    申请号：US10520741

    申请日：2003-07-10

    申请人： Morten Albrechtsen ,  Claus Christensen ,  Eugene Lukanidin ,  Ole Olsen

    发明人： Morten Albrechtsen ,  Claus Christensen ,  Eugene Lukanidin ,  Ole Olsen

    IPC分类号： A61K38/17

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  C07K16/18 ,  G01N33/57484 ,  G01N33/57488 ,  G01N2333/4704

    摘要： The present invention relates to use of compounds directed to inhibiting expression and/or proteolytic processing semaphorins SEMA3E and/or sema3E and/or activation of a receptor by a proteolytic product of said semaphorins for the manufacture of a medicament for prevention, treatment diagnosis and/or prognosis of an invasive disease. The invention features the compounds selected from the group comprising antisense compounds derived from the sequence of SEMA3E and/or sema3E, peptide compounds derived from the sequence of said semaphorins, anti-bodies against said semaphorins, and peptide compounds derived from the sequence of Plexin A receptor. Furthermore, the invention provides methods for prognosis and/diagnosis of malignancy of cancer based of estimation of the levels of expression and proteolytic processing of said semaphorins in a sample of a tissue or body fluid. The invention also concerns a method for producing an attractant polypeptide by establishing a cleavage product of SEMA3E. and/or sema3E.

    摘要翻译： 本发明涉及用于抑制表达和/或蛋白水解处理信号素SEMA3E和/或sema3E和/或通过所述信号素的蛋白水解产物激活受体的化合物在制备用于预防，治疗诊断和/ 或侵入性疾病的预后。 本发明的特征在于选自衍生自SEMA3E和/或sema3E序列的反义化合物的组合物，衍生自所述信号素序列的肽化合物，针对所述信号素的抗体，以及衍生自Plexin A序列的肽化合物 受体。 此外，本发明基于对组织或体液样品中所述信号素的表达水平和蛋白水解加工的估计，提供了对癌症恶性程度的预后和/诊断方法。 本发明还涉及通过建立SEMA3E的切割产物来产生引诱多肽的方法。 和/或sema3E。

    Energy saving brewing method
    2.
    发明授权
    Energy saving brewing method 有权
    节能酿造方法

    公开(公告)号：US09587210B2

    公开(公告)日：2017-03-07

    申请号：US13701604

    申请日：2011-05-31

    申请人： Søren Knudsen ,  Preben Riis ,  Birgitte Skadhauge ,  Lene Mølskov Bech ,  Ole Olsen

    发明人： Søren Knudsen ,  Preben Riis ,  Birgitte Skadhauge ,  Lene Mølskov Bech ,  Ole Olsen

    IPC分类号： C12C1/00 ,  C12C7/00 ,  A01H5/00 ,  C12C1/073 ,  C12C7/20 ,  C12C1/18 ,  C12C7/22

    CPC分类号： C12C7/22 ,  C12C1/073 ,  C12C1/18 ,  C12C7/20

    摘要： Barley based beverages are produced in large quantities, employing highly energy consuming methods, for example in the malting and brewhouse facilities for kiln drying and wort boiling operations, respectively. The present invention relates to energy saving methods for preparing barley based beverages, as well as to barley plants useful in such methods. In particular, the invention describes barley plants with combined traits of null-lipoxygenase-1 (null-LOX-1), null-lipoxygenase-2 (null-LOX-2) and null-S-adenosylmethionine:methionine S-methyltransferase in one plant, which is particularly useful for energy saving methods to prepare barley based beverages, such as beer.

    摘要翻译： 大麦生产的大麦饮料分别采用高耗能的方法，例如用于窑干和麦汁煮沸操作的麦芽酿造设施。 本发明涉及制备大麦饮料的节能方法以及用于这种方法的大麦植物。 特别地，本发明描述了一种具有零脂肪氧合酶-1（无效LOX-1），无效脂氧合酶-2（无效LOX-2）和无效S-腺苷甲硫氨酸：甲硫氨酸S-甲基转移酶的组合性状的大​​麦植物 植物，其对于制备基于大麦的饮料（例如啤酒）的节能方法特别有用。

    Barley with reduced lipoxygenase activity and beverage prepared therefrom
    3.
    发明授权
    Barley with reduced lipoxygenase activity and beverage prepared therefrom 有权
    具有降低的脂氧合酶活性的大麦和由其制备的饮料

    公开(公告)号：US09363959B2

    公开(公告)日：2016-06-14

    申请号：US13141579

    申请日：2009-12-28

    申请人： Birgitte Skadhauge ,  Finn Lok ,  Klaus Breddam ,  Ole Olsen ,  Lette Mølskov Bech ,  Søren Knudsen

    发明人： Birgitte Skadhauge ,  Finn Lok ,  Klaus Breddam ,  Ole Olsen ,  Lette Mølskov Bech ,  Søren Knudsen

    IPC分类号： A01H5/10 ,  C12C1/18 ,  C12C12/00

    CPC分类号： A01H5/10 ,  C12C1/18 ,  C12C12/00 ,  C12C2200/01

    摘要： According to the invention, there is provided barley with total loss of functional lipoxygenase (LOX)-1 and LOX-2 enzymes, and plant products produced thereof, such as malt manufactured by using barley kernels defective in the synthesis of the fatty acid-dioxygenating enzymes LOX-1 and LOX-2. Said enzymes account for the principal activities related to dioxygenation of linoleic acid into 9- and 13-hydroperoxy octadecadienoic acid, respectively. 9-Hydroperoxy octadecadienoic acid represents a LOX pathway metabolite, which—through further enzymatic or spontaneous reactions—may lead to the appearance of trans-2-nonenal (T2N). The invention enables brewers to produce a beer having insignificant levels of stale, T2N-specific off-flavors, even after prolonged storage of the beverage.

    摘要翻译： 根据本发明，提供了具有功能性脂氧合酶（LOX）-1和LOX-2酶的总损失的大麦及其生产的植物产品，例如通过使用在合成脂肪酸 - 双氧合中缺陷的大麦仁制备的麦芽 酶LOX-1和LOX-2。 所述酶分别涉及与亚油酸双加氧相关的9-和13-氢过氧十八碳二烯酸的主要活性。 9-氢过氧十八碳二烯酸代表LOX途径代谢物，通过进一步的酶促或自发反应，可能导致反式-2-壬醛（T2N）的出现。 本发明使酿造商能够生产具有不明显水平的陈年T2N特异性异味的啤酒，即使在饮料长期储存之后。