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    Apparatus and methods for coating medical devices
    31.
    发明授权
    Apparatus and methods for coating medical devices 有权

    公开(公告)号：US10507309B2

    公开(公告)日：2019-12-17

    申请号：US16160425

    申请日：2018-10-15

    Applicant: Surmodics, Inc.

    Inventor： Ralph A. Chappa ,  Andrew G. Bach ,  Mark MacGregor

    IPC: B05B13/04 ,  A61M25/10

    Abstract: Embodiments herein include apparatus and methods for coating medical devices. In an embodiment, a coating apparatus is included having a coating application unit including a movement restriction structure, a fluid applicator having a lengthwise major axis, a fluid distribution bar having a body angled with respect to the major lengthwise axis of the fluid applicator between 0 and 20 degrees, a rotation mechanism and an axial motion mechanism. The axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.

    APPARATUS AND METHODS FOR COATING MEDICAL DEVICES
    32.
    发明申请
    APPARATUS AND METHODS FOR COATING MEDICAL DEVICES 审中-公开

    公开(公告)号：US20190151629A1

    公开(公告)日：2019-05-23

    申请号：US16160425

    申请日：2018-10-15

    Applicant: Surmodics, Inc.

    Inventor： Ralph A. Chappa ,  Andrew G. Bach ,  Mark MacGregor

    IPC: A61M25/10 ,  B05B13/04

    CPC classification number: A61M25/1029 ,  A61M2025/1031 ,  B05B13/0442

    Abstract: Embodiments herein include apparatus and methods for coating medical devices. In an embodiment, a coating apparatus is included having a coating application unit including a movement restriction structure, a fluid applicator having a lengthwise major axis, a fluid distribution bar having a body angled with respect to the major lengthwise axis of the fluid applicator between 0 and 20 degrees, a rotation mechanism and an axial motion mechanism. The axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.

    COATINGS WITH CRYSTALLIZED ACTIVE AGENT(S) AND METHODS
    36.
    发明申请
    COATINGS WITH CRYSTALLIZED ACTIVE AGENT(S) AND METHODS 有权
    具有结晶活性剂（S）和方法的涂料

    公开(公告)号：US20170007745A1

    公开(公告)日：2017-01-12

    申请号：US15211833

    申请日：2016-07-15

    Applicant: Surmodics, Inc.

    Inventor： Ralph A. Chappa ,  Kimberly K. M. Lindsoe

    IPC: A61L31/16 ,  A61L31/10

    CPC classification number: A61L31/16 ,  A61K6/0017 ,  A61K31/56 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/06

    Abstract: The present invention relates to coatings with crystallized active agent(s) and related methods. In an embodiment, the invention includes a method for coating a medical device including selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. In an embodiment, the invention includes an elution control coating disposed on a medical device, the elution control coating including a polymer, and an active agent, wherein the active agent is at least about 80% crystallized within one week of being disposed on the medical device. In an embodiment, the invention includes a method for enhancing the formation of active agent crystals within a coating layer including forming a coating solution and adjusting the concentration of the active agent in the coating solution to reach some percentage of the active agent saturation point. In an embodiment, the invention includes a method of enhancing crystallization of an active agent, the method including forming a coating solution comprising a polymer, an active agent, and a solvent; applying the coating solution to a substrate; and increasing the rate of active agent nucleation within the coating.

    Abstract translation: 本发明涉及具有结晶活性剂的涂层和相关方法。 在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括选择溶剂和聚合物，选择至少一定量饱和度的活性剂的浓度，形成具有选定浓度的活性剂的涂料组合物 ，并将所述涂料组合物施用于所述医疗装置。 在一个实施方案中，本发明包括设置在医疗装置上的洗脱控制涂层，洗脱控制涂层包括聚合物和活性剂，其中活性剂在被放置在医疗上的一周内至少约80％结晶 设备。 在一个实施方案中，本发明包括一种用于增强涂层内活性剂晶体形成的方法，包括形成涂层溶液并调节涂层溶液中活性剂的浓度达到活性剂饱和点的一定百分比。 在一个实施方案中，本发明包括增强活性剂结晶的方法，所述方法包括形成包含聚合物，活性剂和溶剂的包衣溶液; 将涂布溶液涂布到基材上; 并增加涂层内活性剂成核的速率。

    Coating apparatus and methods
    37.
    发明授权
    Coating apparatus and methods 有权
    涂装设备及方法

    公开(公告)号：US09283350B2

    公开(公告)日：2016-03-15

    申请号：US14063124

    申请日：2013-10-25

    Applicant: SurModics, Inc.

    Inventor： Ralph A. Chappa ,  Timothy M. Kloke

    IPC: B05C1/06 ,  B05C13/02 ,  A61M25/00 ,  A61M25/10 ,  B05C1/00

    CPC classification number: A61M25/0009 ,  A61M25/1029 ,  A61M2025/1031 ,  B05C1/00 ,  B05C1/06 ,  B05C13/02 ,  Y10S901/43

    Abstract: Embodiments of the invention include coating apparatuses and related methods. In an embodiment, the invention includes a coating apparatus. The coating apparatus can include a motor, a rotating contact member, a fluid applicator, a fluid pump, and a base member. The fluid applicator can include an orifice. The rotating contact member can be configured to rotate around a device to be coated that does not rotate. The rotating contact member can be configured to move along the lengthwise axis of a device to be coated. In an embodiment, the invention includes a method of coating a medical device. The method of coating a medical device can include a rotating a contact member around the outer diameter of a non-rotating medical device, applying a coating solution to the outer diameter of the non-rotating medical device at a position adjacent to the contact member, and moving at least one of the contact member and the non-rotating medical device with respect to one another so that the contact member moves with respect to the lengthwise axis of the non-rotating medical device. Other embodiments are also included herein.

    Abstract translation: 本发明的实施例包括涂覆装置和相关方法。 在一个实施例中，本发明包括涂覆装置。 涂布装置可以包括马达，旋转接触构件，流体施加器，流体泵和基座构件。 流体施加器可以包括孔口。 旋转接触构件可以构造成围绕不旋转的待涂覆装置旋转。 旋转接触构件可以构造成沿待涂覆的装置的纵向轴线移动。 在一个实施例中，本发明包括涂覆医疗装置的方法。 医疗装置的涂敷方法可以包括使非旋转医疗装置的外径附近的接触部件旋转，在与所述接触部件相邻的位置向所述非旋转医疗装置的外径施加涂布溶液， 并且相对于彼此移动所述接触构件和所述非旋转医疗装置中的至少一个，使得所述接触构件相对于所述非旋转医疗装置的纵向轴线移动。 本文还包括其它实施例。

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