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公开(公告)号：US20130163071A1
公开(公告)日：2013-06-27
申请号：US13693896
申请日：2012-12-04
Applicant: The Regents of the University of California
Inventor： Daniel R. Solli , Bahram Jalali , Claus Ropers
IPC: G02F1/35
CPC classification number: G02F1/353 , G02F1/365 , G02F2001/3528
Abstract: Methods and systems are provided for generation and detection of rogue waves, including hydrodynamic rogue waves and optical rogue waves. A method for generating an optical rogue wave comprises the steps of generating an input pulse into a nonlinear optical medium, and perturbing the input pulse by directing a narrow-band seed radiation into the input pulse. The seed radiation has a frequency and timing to generate broadband radiation within the nonlinear optical medium.
Abstract translation: 提供了用于产生和检测流氓波的方法和系统，包括流体动力学流氓波和光学流氓波。 一种用于产生光流氓波的方法包括以下步骤：将输入脉冲产生到非线性光学介质中，并通过将窄带种子辐射引入输入脉冲来扰乱输入脉冲。 种子辐射具有在非线性光学介质内产生宽带辐射的频率和时间。
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公开(公告)号：US20230280259A1
公开(公告)日：2023-09-07
申请号：US18117708
申请日：2023-03-06
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Bahram Jalali , Eric D. Diebold , Brandon Buckley
IPC: G01N15/14 , G01N33/537 , G01N21/64
CPC classification number: G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/64 , G01N33/537 , G01N2015/1006
Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.
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公开(公告)号：US11630053B2
公开(公告)日：2023-04-18
申请号：US17666841
申请日：2022-02-08
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Bahram Jalali , Eric D. Diebold , Brandon Buckley
IPC: G01N15/14 , G01N33/537 , G01N21/64 , G01N15/10
Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.
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34.发明申请公开(公告)号：US20230052995A1
公开(公告)日：2023-02-16
申请号：US17745206
申请日：2022-05-16
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Eric D. Diebold , Bahram Jalali , Brandon Buckley
Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.
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35.发明授权公开(公告)号：US11371937B2
公开(公告)日：2022-06-28
申请号：US16528463
申请日：2019-07-31
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Eric D. Diebold , Bahram Jalali , Brandon Buckley
Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.
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Patent Agency Ranking
36.发明授权公开(公告)号：US11327016B2
公开(公告)日：2022-05-10
申请号：US16528436
申请日：2019-07-31
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Eric D. Diebold , Bahram Jalali , Brandon Buckley
Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.
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公开(公告)号：US20200311532A1
公开(公告)日：2020-10-01
申请号：US16835993
申请日：2020-03-31
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Bahram Jalali , Tingyi Zhou , Cejo Konuparamban Lonappan
Abstract: A Lambda reservoir computing system that can readily handle shifts in the distribution of input and output data. Data is modulated onto the spectrum of a broadband optical pulse which is subjected to nonlinear optical effects transforming the data to a higher optical dimensional space. The optical information is converted to electronic signals for processing by an electronic machine learning stage which then generates an output based on the data processed by the learning stage.
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公开(公告)号：US10746630B2
公开(公告)日：2020-08-18
申请号：US16225144
申请日：2018-12-19
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Bahram Jalali , Cejo Lonappan , Asad Madni
IPC: G01M11/00 , H04B10/073 , G06K9/36 , G06K9/00 , G06K9/20
Abstract: Apparatus and/or method for performing single-shot network analysis of electrical, electronic and electro-optical elements (e.g., components, circuits, modules, sub-systems and/or systems) on a device, or devices, under test (DUT). A pulsed optical source is directed through a first dispersion element to an modulator, while a delayed version of the pulsed optical source is directed to the DUT (pulsed optical source converted to electrical signal if DUT has electrical input), whose electrical output is fed to the modulator whose modulated optical pulse output is stretched through a second optical dispersion element, then converted to an electrical signal and processed to provide analysis and/or display of DUT response.
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39.发明授权公开(公告)号：US10593039B2
公开(公告)日：2020-03-17
申请号：US15928992
申请日：2018-03-22
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Bahram Jalali , Ata Mahjoubfar , Lifan Chen
Abstract: A method and apparatus for using deep learning in label-free cell classification and machine vision extraction of particles. A time stretch quantitative phase imaging (TS-QPI) system is described which provides high-throughput quantitative imaging, and utilizing photonic time stretching. In at least one embodiment, TS-QPI is integrated with deep learning to achieve record high accuracies in label-free cell classification. The system captures quantitative optical phase and intensity images and extracts multiple biophysical features of individual cells. These biophysical measurements form a hyperdimensional feature space in which supervised learning is performed for cell classification. The system is particularly well suited for data-driven phenotypic diagnosis and improved understanding of heterogeneous gene expression in cells.
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公开(公告)号：US20190279369A1
公开(公告)日：2019-09-12
申请号：US16358565
申请日：2019-03-19
Applicant: The Regents of the University of California
Inventor： Bahram Jalali , Mohammadhossein Asghari
Abstract: Object and shape detection in digital images utilizing edge detection is described. In a first edge detection approach, phase transformation is utilized in the frequency domain, such as in response to Fourier transform, followed by use of a frequency-domain phase kernel and inverse-Fourier transform. Edge detection is also provided using a phase transform in the spatial domain utilizing a convolution approach. In a second edge detection approach, phase stretching is utilized, such as in combination with phase histogramming along with thresholding and morphological operations. Numerous example images are provided illustrating benefits of the disclosed technology with different applications and under different conditions.
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