摘要:
Novel 1-substituted benzodiazepine derivatives and salt thereof having the formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a lower alkoxy group or a trifluoromethyl group; R.sub.2 is a pyridyl group or a group of the formula ##STR2## wherein R.sub.5 and R.sub.6 represent individually a hydrogen atom, a halogen atom, a lower alkyl group or a trifluoromethyl group); R.sub.3 is a hydrogen atom or a lower alkyl group; R.sub.4 is a lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl group; m is 1 or 2; and n is an integer of 1 to 4, and a process for preparation thereof and pharmaceutical use of the same.
摘要:
Benzodiazepine derivatives of the formula, ##SPC1##Wherein R.sub.1 is a C.sub.2-4 alkenyl group, R.sub.2 is a halogen atom and R.sub.3 is a hydrogen or halogen atom, which are useful as minor tranquilizer and anticonvulsant. These compounds are prepared by reacting a compound of the formula, ##SPC2##Wherein R.sub.1, R.sub.2, and R.sub.3 are as defined above, with a compound of the formula, ##EQU1## wherein X is an oxygen or sulfur atom.
摘要翻译:下式的苯并二氮杂衍生物,其中R 1为C 2-4链烯基,R 2为卤素原子,R 3为氢或卤素原子,其可用作较小的镇静剂和抗惊厥药。 这些化合物通过使下式的化合物,即WHEREIN R 1,R 2和R 3如上所定义的化合物与下式化合物O CH 2 -CONGOR | X NH-C ANGLE O反应而制备,其中X是氧或硫 原子。
摘要:
Fused quinazolinone derivatives of the formula, ##SPC1##Wherein R.sub.1 and R.sub.2 are individually hydrogen, C.sub.1.sub.-4 alkyl, C.sub.1.sub.-4 alkoxy, nitro, C.sub.1.sub.-4 alkylsulfonyl or halogen; R.sub.3 is pyridyl, thienyl or a group of the formula ##SPC2##Wherein R.sub. 4 is hydrogen or halogen; R is hydrogen, C.sub.1.sub.-4 alkyl, C.sub.2.sub.-5 alkenyl, aralkyl, (C.sub.3.sub.-6 cycloalkyl)C.sub.1.sub.-4 alkyl, (C.sub.1.sub.-4 alkoxy)C.sub.1.sub.-4 alkyl, (C.sub.1.sub.-4 alkylthio)C.sub.1.sub.-4 alkyl, hydroxy-C.sub.1.sub.-4 alkyl or C.sub.2.sub.-5 alkanoyloxy-C.sub.1.sub.-4 alkyl; Y is oxygen, or a group of the formula N - R.sub.5, wherein R.sub.5 is hydrogen or C.sub.1.sub.-4 alkyl; and Z is C.sub.2.sub.-5 alkylene or alkenylene, are prepared by reacting a trihaloacetamidophenyl ketone derivative of the formula, ##SPC3##Wherein R.sub.1, R.sub.2, R.sub. 3 and R are as defined above; and X.sub.1, X.sub.2 and X.sub.3 are halogen, with an amine of the formula, HY - Z - NH.sub.2, wherein Y and Z are as defined above, or a salt thereof, in the presence of a solvent or a mixture thereof. They have remarkable pharmacological properties such as anti-inflammatory, analgesic and/or uricosuric activities.
摘要翻译:下式的稠合喹唑啉酮衍生物WHEREIN R1和R2分别为氢,C1-4烷基,C1-4烷氧基,硝基,C1-4烷基磺酰基或卤素; R 3是吡啶基,噻吩基或式WHEREIN R 4是氢或卤素的基团; R为氢,C 1-4烷基,C 2-5烯基,芳烷基,(C 3-6环烷基)C 1-4烷基,(C 1-4烷氧基)C 1-4烷基,(C 1-4烷硫基)C 1-4烷基,羟基 C 1-4烷基或C 2-5烷酰氧基-C 1-4烷基; Y为氧,或式为N-R5的基团,其中R5为氢或C1-4烷基; Z是C2-5亚烷基或亚烯基,是通过下式的三卤代乙酰胺基苯基酮衍生物WHEREIN R1,R2,R3和R如上所定义而制备的; 并且X 1,X 2和X 3是卤素,在溶剂或其混合物的存在下,与下式的胺HY-Z-NH 2(其中Y和Z如上定义)或其盐。 它们具有显着的药理学性质,如抗炎,镇痛和/或尿酸活性。
摘要:
A bulky, water-disintegratable cleaning article is formed of water-disintegratable paper impregnated with 100% to 500% by weight of an aqueous agent. The water-disintegratable paper is a substantially water dispersible fibrous sheet containing a water soluble or swellable binder. The water-disintegratable paper has a great number of protrusions and depressions formed by embossing and has a basis weight of 30 to 150 g/m2. The bulky, water-disintegratable cleaning article has a thickness T1 of 1.0 to 3.0 mm under a load of 0.3 kPa and a thickness T2 of at least 0.9 mm under a load of 1.0 kPa.
摘要:
A component installing device comprises: a tray component supply section (8) having a plurality of conjointly provided tray component supply mechanisms (7) for moving selected trays (4) from a storage position (5) to a component supply position (6), according to need, thereby providing the components (2) accommodated therein for use; and a cassette component supply section (13) having a plurality of mutually aligned component supply cassettes (12) for carrying components in a tape cassette or a bulk cassette, and transporting said components to a component supply position (11), one at a time, thereby providing said components for use. Components (2) accommodated in the respective trays (4) located at the component supply positions (6) of the respective tray component supply mechanisms (7) in the tray component supply section (8), and components (2) transported to the component supply positions (11) of the respective component supply cassettes (12) in the cassette component supply section (13), are variously handled and installed at prescribed positions on a circuit board (1) by means of an installing head (21).
摘要:
A slide-type solvent transfer unit is used, and a plurality of nozzles at a head part which suck and hold components are moved down simultaneously to transfer flux to electronic components. In comparison with an electronic component mounting method including a transfer operation whereby nozzles are lowered one by one by a conventional electronic component mounting apparatus equipped with a rotary type solvent transfer unit, the time required for moving the nozzles up and down is shortened and a total cycle time is reduced, so that production efficiency is improved.
摘要:
For determination of the expiration of the life of a cutting tool on the basis of a resistance signal from sensor lines, a true signal component indicative of the abrasion of the sensor lines should be extracted from the resistance signal. In a signal processing method according to the present invention, an output of an abrasion sensor is sampled in a predetermined sampling cycle (Step S1), and then the sampled data is passed through a median filter for elimination of a noise therefrom (Step S2). Further, the noise-free data is passed through a separation filter (Step S3). By the separation filter, reduction data having a time-serially reduced in value is separated and eliminated from the noise-free data. As a result, true data indicative of a change in the resistance of the sensor is obtained. The true data is subjected to a counter function process (Step S4) thereby to determine how many sensor lines have been cut off by the abrasion. The expiration of the life of the cutting tool is detected when the number of the cut-off sensor lines reaches a predetermined number (Step S5).
摘要:
A solvent transfer unit is made a slide type and a plurality of nozzles at a head part which suck and hold components are moved down simultaneously to transfer the flux to electronic components. In comparison with an electronic component mounting method including a transfer operation whereby nozzles are lowered one by one by a conventional electronic component mounting apparatus equipped with a rotary type solvent transfer unit, a time for moving the nozzles up, down is shortened and a total cycle time is reduced, so that production efficiency is improved.
摘要:
A cleaning article comprising a detergent-retaining layer containing a hydrophobic material and detergent gradual-releasing layers having a higher density than the detergent-retaining layer, and the detergent-retaining layer is sandwiched between the detergent gradual-releasing layers.
摘要:
A disk cartridge has a case including a first planar portion and a second planar portion which are disposed opposite to each other with a given spacing therebetween, and a plurality of walls which join the first planar portion and the second planar portion together. The case contains an information carrying disk in a rotatable manner and has an opening formed in one of the walls through which the disk can be inserted or removed. The disk cartridge has a lid mounted on the case for opening or closing the opening. The lid is formed so that an outer surface of the lid is located inside an outer surface of the wall in which the opening is formed.