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72 条记录 (耗时 0.025 秒)

    Glucopyranosyloxypyrazole derivatives and use thereof in medicines
    31.
    发明申请
    Glucopyranosyloxypyrazole derivatives and use thereof in medicines 有权
    吡喃葡萄糖氧吡唑衍生物及其在药物中的应用

    公开(公告)号：US20060025352A1

    公开(公告)日：2006-02-02

    申请号：US11247216

    申请日：2005-10-12

    申请人： Hideki Fujikura ,  Nobuhiko Fushimi ,  Toshihiro Nishimura ,  Takeshi Nakabayashi ,  Masayuki Isaji

    发明人： Hideki Fujikura ,  Nobuhiko Fushimi ,  Toshihiro Nishimura ,  Takeshi Nakabayashi ,  Masayuki Isaji

    IPC分类号： A61K31/7052 ,  C07H17/02

    CPC分类号： A61K45/06 ,  A61K31/7056 ,  C07H17/02 ,  A61K2300/00

    摘要： The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug;.one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.

    摘要翻译： 本发明提供由以下通式表示的吡喃葡萄糖氧吡唑衍生物：其中R表示氢原子，低级烷基或形成前药的基团; Q和T表示由以下通式表示的基团：（其中P表示 氢原子或形成前药的基团），而另一个表示低级烷基或卤代（低级烷基）基团; R 2表示氢原子，低级烷基，低级烷氧基，低级烷硫基，卤代（低级烷基）或卤素原子; 并且条件是当R表示氢原子或低级烷基时，P不表示氢原子，或其药学上可接受的盐，其在人SGLT2中具有抑制活性并具有改善的口服吸收，因此可用作 用于预防或治疗与高血糖相关的疾病如糖尿病，糖尿病并发症或肥胖症的药剂及其药学上可接受的盐及其药学用途。

    Nitrogenous heterocyclic derivative, medicinal composition containing the same, medical use thereof, and intermediate therefor
    34.
    发明申请
    Nitrogenous heterocyclic derivative, medicinal composition containing the same, medical use thereof, and intermediate therefor 失效
    含氮杂环衍生物，含有它们的药物组合物，其医疗用途及其中间体

    公开(公告)号：US20050049203A1

    公开(公告)日：2005-03-03

    申请号：US10481013

    申请日：2002-06-17

    申请人： Toshihiro Nishimura ,  Hideki Fujikura ,  Nobuhiko Fushimi ,  Kazuya Tatani ,  Kenji Katsuno ,  Masayuki Isaji

    发明人： Toshihiro Nishimura ,  Hideki Fujikura ,  Nobuhiko Fushimi ,  Kazuya Tatani ,  Kenji Katsuno ,  Masayuki Isaji

    IPC分类号： A61P3/04 ,  A61P3/10 ,  A61P43/00 ,  C07H17/02 ,  A61K31/7052

    CPC分类号： C07H17/02 ,  Y02P20/55 ,  Y10S514/866 ,  Y10S514/909

    摘要： The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula: wherein X1 and X3 independently represent N or CH; X2 represents N or CR2; X4 represents N or CR3; and with the proviso that one or two of X1, X2, X3 and X4 represent N; R1 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkoxy-substituted (lower alkyl) group, a lower alkoxy-substituted(lower alkoxy) group, a lower alkoxy(lower alkoxy) -substituted (lower alkyl) group, a cyclic lower alkyl group, a halo(lower alkyl) group or a group represented by the general formula: HO-A—wherein A represents a lower alkylene group, a lower alkyleneoxy group or a lower alkylenethio group; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a cyclic lower alkyl group, a lower alkoxy group, an amino group, a (lower acyl)amino group, a mono(lower alkyl)amino group or a di(lower alkyl)amino group; and R3 represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, or prodrugs thereof which are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutical compositions comprising the same, and pharmaceutical uses and production intermediates thereof.

    摘要翻译： 本发明提供由以下通式表示的含氮杂环衍生物：其中X 1和X 3独立地表示N或CH; X 2表示N或CR 2; X 4表示N或CR 3; 并且条件是X 1，X 2，X 3和X 4中的一个或两个表示N; R 1表示氢原子，卤素原子，低级烷基，低级烷氧基，低级烷硫基，低级烷氧基取代的（低级烷基），低级烷氧基取代的（低级烷氧基） 低级烷氧基（低级烷氧基） - 取代（低级烷基）基团，环状低级烷基，卤代（低级烷基）基团或由通式HO-A表示的基团：其中A表示低级亚烷基， 低级亚烷基氧基或低级亚烷基硫基; R 2表示氢原子，卤素原子，低级烷基，环状低级烷基，低级烷氧基，氨基，（低级酰基）氨基，单（低级烷基）氨基或 二（低级烷基）氨基; R 3表示可用作预防或治疗与糖尿病，糖尿病并发症或肥胖症等高血糖症相关疾病的药剂的氢原子或低级烷基或其药学上可接受的盐或其前体药物，药物 含有它们的组合物，及其制药用途和生产中间体。

    Pictorial communication apparatus
    35.
    发明授权
    Pictorial communication apparatus 失效
    图形通讯设备

    公开(公告)号：US5412418A

    公开(公告)日：1995-05-02

    申请号：US276619

    申请日：1994-07-18

    申请人： Toshihiro Nishimura ,  Toshio Hayashi ,  Hirotaka Kawano ,  Hideshi Fujiki

    发明人： Toshihiro Nishimura ,  Toshio Hayashi ,  Hirotaka Kawano ,  Hideshi Fujiki

    IPC分类号： H04N7/14

    CPC分类号： H04N7/147

    摘要： A first pictorial communication apparatus for transmitting and receiving a pictorial signal and a sound signal through a first channel and a control message through a second channel, having a line interface for communicating with ISDN, a video codec portion for coding and decoding of the pictorial signal, a key input portion and a camera, further comprises a character storing portion for storing character codes in corporation with the key input portion, a data conversion portion for converting character data train read from the character storing portion into a character video signal. On arrival of a call in an automatic answering mode, the character data train is read and transmitted through the first channel in place of a video signal from the camera after the conversion. The second apparatus has similar structure. A called second apparatus transmits the character code data train included in the control message through the second channel in the automatic answering mode on the arrival of call without the conversion. The called apparatus detects the character code data train from the control message and indicates the character code data train as an answering message after conversion by the data conversion portion.

    摘要翻译： 第一图形通信装置，用于通过具有用于与ISDN通信的线路接口的第二信道通过第一信道和控制消息发送和接收图形信号和声音信号，用于编码和解码图形信号的视频编解码器部分 键输入部分和相机，还包括用于与键输入部分一起存储字符代码的字符存储部分，用于将从字符存储部分读取的字符数据串转换成字符视频信号的数据转换部分。 在呼叫到达自动应答模式时，字符数据串被读取并通过第一信道发送，代替来自摄像机的视频信号。 第二装置具有相似的结构。 所谓的第二装置在没有转换的情况下，在自动应答模式下通过第二信道通过第二信道发送包括在控制消息中的字符码数据串。 被叫设备从控制消息中检测字符代码数据串，并且在由数据转换部转换之后，将字符代码数据串指示为应答消息。

    Silica-based antimony containing film-forming composition
    37.
    发明授权
    Silica-based antimony containing film-forming composition 失效
    含二氧化硅的含锑成膜组合物

    公开(公告)号：US4793862A

    公开(公告)日：1988-12-27

    申请号：US92510

    申请日：1987-09-03

    申请人： Tsutomu Ishikawa ,  Muneo Nakayama ,  Akira Hashimoto ,  Toshihiro Nishimura

    发明人： Tsutomu Ishikawa ,  Muneo Nakayama ,  Akira Hashimoto ,  Toshihiro Nishimura

    IPC分类号： H01L21/22 ,  H01L21/225 ,  C09K3/00

    CPC分类号： H01L21/2255 ,  H01L21/2225

    摘要： An improved silica-based film-forming composition for diffusion of antimony in the doping works of semiconductors is proposed which comprises an organic solvent, a partial hydrolysis product of an alkoxy silane compound and an antimony compound dissolved in the organic solvent. The antimony compound in the inventive composition is an alkoxy antimony or aryloxy antimony compound so that the problem of corrosion of the coating apparatus can be entirely avoided without decreasing the dopant concentration in the semiconductor substrate, as well as to provide a film-forming composition which is advantageously stable in storage.

    摘要翻译： 提出了一种改进的二氧化硅基成膜组合物，用于在半导体的掺杂工艺中扩散锑，其包括有机溶剂，烷氧基硅烷化合物的部分水解产物和溶解在有机溶剂中的锑化合物。 本发明组合物中的锑化合物是烷氧基锑或芳氧基锑化合物，从而可以在不降低半导体衬底中的掺杂剂浓度的情况下完全避免涂覆装置的腐蚀问题，以及提供一种成膜组合物， 有利地在储存中稳定。

    Glucopyranosyloxypyrazole derivatives and use thereof in medicines
    40.
    发明授权
    Glucopyranosyloxypyrazole derivatives and use thereof in medicines 有权
    吡喃葡萄糖氧吡唑衍生物及其在药物中的应用

    公开(公告)号：US07989424B2

    公开(公告)日：2011-08-02

    申请号：US12169882

    申请日：2008-07-09

    申请人： Hideki Fujikura ,  Nobuhiko Fushimi ,  Toshihiro Nishimura ,  Takeshi Nakabayashi ,  Masayuki Isaji

    发明人： Hideki Fujikura ,  Nobuhiko Fushimi ,  Toshihiro Nishimura ,  Takeshi Nakabayashi ,  Masayuki Isaji

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： A61K45/06 ,  A61K31/7056 ,  C07H17/02 ,  A61K2300/00

    摘要： The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.

    摘要翻译： 本发明提供由以下通式表示的吡喃葡萄糖氧吡唑衍生物：其中R表示氢原子，低级烷基或形成前药的基团; Q和T之一表示由通式表示的基团：（其中P表示氢原子或形成前药的基团），而另一个表示低级烷基或卤代（低级烷基）基团; R2表示氢原子，低级烷基，低级烷氧基，低级烷硫基，卤代（低级烷基）或卤素原子; 并且条件是当R表示氢原子或低级烷基时，P不表示氢原子，或其药学上可接受的盐，其在人SGLT2中具有抑制活性并具有改善的口服吸收，因此可用作 用于预防或治疗与高血糖相关的疾病如糖尿病，糖尿病并发症或肥胖症的药剂及其药学上可接受的盐及其药学用途。