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84 条记录 (耗时 0.051 秒)

    Adaptive anti-tachycardia therapy apparatus and method
    35.
    发明授权
    Adaptive anti-tachycardia therapy apparatus and method 有权
    适应性抗心动过速治疗仪及方法

    公开(公告)号：US07729762B2

    公开(公告)日：2010-06-01

    申请号：US11267071

    申请日：2005-11-03

    申请人： Weimin Sun ,  Bruce H. KenKnight ,  Martin Tze ,  Yatheendhar Manicka

    发明人： Weimin Sun ,  Bruce H. KenKnight ,  Martin Tze ,  Yatheendhar Manicka

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3962

    摘要： A method and apparatus for delivering anti-tachycardia pacing in an adaptive manner is disclosed. A cardiac rhythm management device, such as an implantable pacemaker, having anti-tachycardia pacing capability delivers anti-tachycardia pacing therapy in accordance with a selected pacing protocol upon detection of a terminable arrhythmia. The protocol is selected from a library of available protocols. A record of the successes and failures of each available protocol in converting tachyarrhythmias is maintained in a result table for use in selecting the protocol.

    摘要翻译： 公开了以自适应方式递送抗心动过速起搏的方法和装置。 具有抗心动过速起搏能力的心脏节律管理装置，例如可植入心脏起搏器，在检测到可终止的心律失常时，根据选定的起搏方案提供抗心动过速起搏治疗。 协议从可用协议库中选择。 在用于选择协议的结果表中保留了每种可用协议在转换快速性心律失常方面的成功和失败的记录。

    Self-calibrating rate-adaptive pacemaker
    36.
    发明授权
    Self-calibrating rate-adaptive pacemaker 失效
    自校准速率自适应起搏器

    公开(公告)号：US07567839B2

    公开(公告)日：2009-07-28

    申请号：US11457382

    申请日：2006-07-13

    申请人： Weimin Sun ,  Bruce R. Jones ,  Douglas J. Lang ,  Donald Hopper

    发明人： Weimin Sun ,  Bruce R. Jones ,  Douglas J. Lang ,  Donald Hopper

    IPC分类号： A61N1/18

    CPC分类号： A61N1/365 ,  A61N1/36585

    摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

    摘要翻译： 一种用于自动调整速率适应性心脏起搏器的操作参数的系统和方法。 按照该方法，以周期性的间隔测量患者获得的最大功耗水平并存储。 然后可以使用存储的最大消耗水平来更新长期最大消耗水平，并且调整速率 - 响应曲线的斜率以将更新的长期最大消耗水平映射到最大允许起搏速率。 存储的最大消耗电平也可用于更新用于调整速率响应曲线的斜率的传感器目标速率。

    RATE-ADAPTIVE THERAPY WITH SENSOR CROSS-CHECKING
    37.
    发明申请
    RATE-ADAPTIVE THERAPY WITH SENSOR CROSS-CHECKING 有权
    具有传感器交叉检查的速率自适应治疗

    公开(公告)号：US20060265019A1

    公开(公告)日：2006-11-23

    申请号：US11461632

    申请日：2006-08-01

    申请人： Weimin Sun ,  Bruce Jones ,  Douglas Lang

    发明人： Weimin Sun ,  Bruce Jones ,  Douglas Lang

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36585

    摘要： A method and system for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker in which maximum exertion levels attained by the patient are measured at periodic intervals and stored in order to compute or update a maximum exercise capacity. The slope of the rate-response curve is then adjusted to map an exertion level corresponding to the updated maximum exercise capacity to a maximum allowable pacing rate. In accordance with the invention, a maximum exercise capacity is determined by cross-checking periodic maximum exertion level sensor values with a motion-level sensor value.

    摘要翻译： 一种用于自动调整速率自适应心脏起搏器的操作参数的方法和系统，其中以周期性间隔测量由患者获得的最大消耗水平并存储以便计算或更新最大运动能力。 然后调整速率 - 响应曲线的斜率以将对应于更新的最大运动能力的运动水平映射到最大允许起搏速率。 根据本发明，通过用运动水平传感器值交叉检查周期性最大消耗水平传感器值来确定最大运动能力。

    Rate-adaptive therapy with sensor cross-checking
    38.
    发明授权
    Rate-adaptive therapy with sensor cross-checking 有权

    公开(公告)号：US07092758B2

    公开(公告)日：2006-08-15

    申请号：US10364129

    申请日：2003-02-10

    申请人： Weimin Sun ,  Bruce R. Jones ,  Douglas J. Lang

    发明人： Weimin Sun ,  Bruce R. Jones ,  Douglas J. Lang

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36585

    摘要： A method and system for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker in which maximum exertion levels attained by the patient are measured at periodic intervals and stored in order to compute or update a maximum exercise capacity. The slope of the rate-response curve is then adjusted to map an exertion level corresponding to the updated maximum exercise capacity to a maximum allowable pacing rate. In accordance with the invention, a maximum exercise capacity is determined by cross-checking periodic maximum exertion level sensor values with a motion-level sensor value.

    Methods and compositions for the detection of mucolipidosis IV mutations
    40.
    发明申请
    Methods and compositions for the detection of mucolipidosis IV mutations 审中-公开
    检测粘液脂肪病IV突变的方法和组成

    公开(公告)号：US20050153300A1

    公开(公告)日：2005-07-14

    申请号：US10754446

    申请日：2004-01-09

    申请人： Weimin Sun ,  Feras Hantash

    发明人： Weimin Sun ,  Feras Hantash

    IPC分类号： C07H21/04 ,  C12Q1/68

    CPC分类号： C07H21/04 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16

    摘要： The present invention provides a simple high-throughput assay for detecting Mucolipidosis IV mutant sequences (IVS3-2A>G, and/or the del6.4 kb) and optionally wildtype sequences in the same assay using probes with labeled with detectable labels, amplification with a DNA polymerase and acquisition of fluorescence in real time. The assay is automated, high throughput and cost effective, since two mutations and a wildtype sequence can be detected in a single reaction, as opposed to separate reactions.

    摘要翻译： 本发明提供了一种用于在使用具有可检测标记的标记的探针的相同测定中检测粘液状脂血症IV突变体序列（IVS3-2A> G和/或del6.4kb）和任选的野生型序列的简单高通量测定， DNA聚合酶和实时荧光获取。 该测定是自动化，高通量和成本有效的，因为在单独的反应中可以检测到两个突变和野生型序列，而不是单独的反应。