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31.发明申请公开(公告)号：US20070044811A1
公开(公告)日：2007-03-01
申请号：US11506232
申请日：2006-08-17
申请人： Mark Deem , Hanson Gifford , William Malecki , Kenneth Horne
发明人： Mark Deem , Hanson Gifford , William Malecki , Kenneth Horne
CPC分类号： A61B18/1492 , A61B2017/00575 , A61B2017/00867 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00619 , A61B2018/0063 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2018/1472 , A61B2090/3614 , C08L2201/12
摘要： Methods and apparatus for treatment of patent foramen ovale (PFO) generally involve use of a catheter having at least one closure device at its distal end. In some embodiments, the catheter also includes one or more energy transmission members for delivering energy to the closure device(s) and to the tissue adjacent the PFO to induce closure of the PFO. Closure devices may comprise, for example, a bioresorbable matrix or a non-resorbable matrix. In some embodiments, the closure device contains particles dispersed within the closure device to increase conductance and/or to reduce resistance and/or impedance. An exemplary method involves advancing a catheter to position its distal end into the tunnel of the PFO and fixing the closure device within the tunnel of the patent foramen PFO.
摘要翻译： 专利卵泡（PFO）的治疗方法和装置通常涉及使用在其远端具有至少一个闭合装置的导管。 在一些实施例中，导管还包括一个或多个能量传递构件，用于将能量传递到闭合装置和邻近PFO的组织以引起PFO的闭合。 闭合装置可以包括例如生物可再吸收的基质或不可再吸收的基质。 在一些实施例中，闭合装置包含分散在闭合装置内的颗粒，以增加电导和/或降低电阻和/或阻抗。 示例性方法包括推进导管以将其远端定位到PFO的隧道中并将闭合装置固定在专利孔PFO的隧道内。
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公开(公告)号：US20070078485A1
公开(公告)日：2007-04-05
申请号：US11464746
申请日：2006-08-15
申请人： MARK DEEM , Hanson Gifford , William Malecki , Kenneth Horne
发明人： MARK DEEM , Hanson Gifford , William Malecki , Kenneth Horne
IPC分类号： A61B17/08
CPC分类号： A61B18/1492 , A61B2017/00575 , A61B2017/00867 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00619 , A61B2018/0063 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2018/1472 , A61B2090/3614 , C08L2201/12
摘要： Methods and apparatus for treatment of patent foramen ovale (PFO) generally involve use of a catheter having at least one closure device at its distal end. In some embodiments, the catheter also includes one or more energy transmission members for delivering energy to the closure device(s) and to the tissue adjacent the PFO to induce closure of the PFO. Closure devices may comprise, for example, a bioresorbable matrix or a non-resorbable matrix. In some embodiments, the closure device contains particles dispersed within the closure device to increase conductance and/or to reduce resistance and/or impedance. An exemplary method involves advancing a catheter to position its distal end into the tunnel of the PFO and fixing the closure device within the tunnel of the patent foramen PFO.
摘要翻译： 专利卵泡（PFO）的治疗方法和装置通常涉及使用在其远端具有至少一个闭合装置的导管。 在一些实施例中，导管还包括一个或多个能量传递构件，用于将能量传递到闭合装置和邻近PFO的组织以引起PFO的闭合。 闭合装置可以包括例如生物可再吸收的基质或不可再吸收的基质。 在一些实施例中，闭合装置包含分散在闭合装置内的颗粒，以增加电导和/或降低电阻和/或阻抗。 示例性方法包括推进导管以将其远端定位到PFO的隧道中并将闭合装置固定在专利孔PFO的隧道内。
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公开(公告)号：US20050034735A1
公开(公告)日：2005-02-17
申请号：US10665974
申请日：2003-09-18
申请人： Mark Deem , Hanson Gifford , William Malecki , Kenneth Horne
发明人： Mark Deem , Hanson Gifford , William Malecki , Kenneth Horne
CPC分类号： A61B18/1492 , A61B2017/00575 , A61B2017/00867 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00619 , A61B2018/0063 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2018/1472 , A61B2090/3614 , C08L2201/12
摘要： Methods and apparatus for treatment of patent foramen ovale (PFO) generally involve use of a catheter having at least one closure device at its distal end. In some embodiments, the catheter also includes one or more energy transmission members for delivering energy to the closure device(s) and to the tissue adjacent the PFO to induce closure of the PFO. Closure devices may comprise, for example, a bioresorbable matrix or a non-resorbable matrix. In some embodiments, the closure device contains particles dispersed within the closure device to increase conductance and/or to reduce resistance and/or impedance. An exemplary method involves advancing a catheter to position its distal end into the tunnel of the PFO and fixing the closure device within the tunnel of the patent foramen PFO.
摘要翻译： 专利卵泡（PFO）的治疗方法和装置通常涉及使用在其远端具有至少一个闭合装置的导管。 在一些实施例中，导管还包括一个或多个能量传递构件，用于将能量传递到闭合装置和邻近PFO的组织以引起PFO的闭合。 闭合装置可以包括例如生物可再吸收的基质或不可再吸收的基质。 在一些实施例中，闭合装置包含分散在闭合装置内的颗粒，以增加电导和/或降低电阻和/或阻抗。 示例性方法包括推进导管以将其远端定位到PFO的隧道中并将闭合装置固定在专利孔PFO的隧道内。
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34.发明申请公开(公告)号：US20080004658A1
公开(公告)日：2008-01-03
申请号：US11855787
申请日：2007-09-14
申请人： William Malecki , Dan Francis , Kenneth Home , Mark Deem , Hanson Gifford , Jose Alejandro
发明人： William Malecki , Dan Francis , Kenneth Home , Mark Deem , Hanson Gifford , Jose Alejandro
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/3439 , A61B18/1445 , A61B18/1492 , A61B2017/00575 , A61B2017/00867 , A61B2017/306 , A61B2017/3445 , A61B2018/00214 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00619 , A61B2018/0063 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2018/00898 , A61B2018/1472 , A61B2090/3614 , C08L2201/12
摘要： Methods and apparatus for treatment of anatomic defects in human tissues, such as patent foramen ovale (PFO), atrial or ventricular septal defects, left atrial appendage, patent ductus arteriosis, blood vessel wall defects and certain electrophysiological defects, involve positioning a distal end of an elongate catheter device at the site of the anatomic defect, engaging tissues at the site of the anatomic defect to bring the tissues together, and applying energy to the tissues with the catheter device to substantially close the anatomic defect acutely. Apparatus generally includes an elongate catheter having a proximal end and a distal end, a vacuum application member coupled with the distal end for engaging tissues at the site of the anatomic defect and applying vacuum to the tissues to bring them together, and at least one energy transmission member coupled with the vacuum application member for applying energy to tissues at the site of the anatomic defect to substantially close the defect acutely.
摘要翻译： 用于治疗人体组织中解剖缺陷的方法和装置，例如卵圆孔（PFO），心房或室间隔缺损，左心耳，动脉导管未闭，血管壁缺陷和某些电生理缺陷，涉及定位远端 在解剖缺损部位处的细长导管装置，将解剖缺损部位的组织接合在一起，并将组织用导管装置施加能量以急剧地闭合解剖缺损。 装置通常包括具有近端和远端的细长导管，与远端连接的真空施加构件，用于接合解剖缺损部位处的组织，并向组织施加真空以将它们组合在一起，以及至少一种能量 传输构件与真空施加构件联接，用于向解剖缺陷位置处的组织施加能量以急剧地闭合缺陷。
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35.发明申请公开(公告)号：US20050131401A1
公开(公告)日：2005-06-16
申请号：US11049791
申请日：2005-02-02
申请人： William Malecki , Dan Francis , Kenneth Home , Mark Deem , Hanson Gifford , Jose Alejandro
发明人： William Malecki , Dan Francis , Kenneth Home , Mark Deem , Hanson Gifford , Jose Alejandro
CPC分类号： A61B17/0057 , A61B17/3439 , A61B18/1445 , A61B18/1492 , A61B2017/00575 , A61B2017/00867 , A61B2017/306 , A61B2017/3445 , A61B2018/00214 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00619 , A61B2018/0063 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2018/00898 , A61B2018/1472 , A61B2090/3614 , C08L2201/12
摘要： Methods and apparatus for treatment of anatomic defects in human tissues, such as patent foramen ovale (PFO), atrial or ventricular septal defects, left atrial appendage, patent ductus arteriosus, blood vessel wall defects and certain electrophysiological defects, involve positioning a distal end of an elongate catheter device at the site of the anatomic defect, engaging tissues at the site of the anatomic defect to bring the tissues together, and applying energy to the tissues with the catheter device to substantially close the anatomic defect acutely. Apparatus generally includes an elongate catheter having a proximal end and a distal end, a vacuum application member coupled with the distal end for engaging tissues at the site of the anatomic defect and applying vacuum to the tissues to bring them together, and at least one energy transmission member coupled with the vacuum application member for applying energy to tissues at the site of the anatomic defect to substantially close the defect acutely.
摘要翻译： 用于治疗人体组织中解剖缺陷的方法和装置，例如卵圆孔（PFO），心房或室间隔缺损，左心耳，动脉导管未闭，血管壁缺陷和某些电生理缺陷，涉及定位远端 在解剖缺损部位处的细长导管装置，将解剖缺损部位的组织接合在一起，并将组织用导管装置施加能量以急剧地闭合解剖缺损。 装置通常包括具有近端和远端的细长导管，与远端连接的真空施加构件，用于接合解剖缺损部位处的组织，并向组织施加真空以将它们组合在一起，以及至少一种能量 传输构件与真空施加构件联接，用于向解剖缺陷位置处的组织施加能量以急剧地闭合缺陷。
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公开(公告)号：US09511210B2
公开(公告)日：2016-12-06
申请号：US11750967
申请日：2007-05-18
申请人： Mark E. Deem , Hanson Gifford , Steven Kim , Alexey Salamini
发明人： Mark E. Deem , Hanson Gifford , Steven Kim , Alexey Salamini
IPC分类号： A61M31/00 , A61K38/48 , A61M25/10 , A61M35/00 , A61N1/05 , A61N1/32 , A61M29/00 , A61M29/02 , A61K9/00 , A61B18/14 , A61B18/18 , A61B17/00 , A61M25/00 , A61N7/00 , A61N7/02
CPC分类号： A61M31/00 , A61B18/1492 , A61B18/18 , A61B2017/00765 , A61K9/0043 , A61K38/4886 , A61K38/4893 , A61M25/007 , A61M25/0084 , A61M25/10 , A61M29/00 , A61M29/02 , A61M35/00 , A61M2025/0008 , A61M2025/0057 , A61M2025/0096 , A61M2025/105 , A61M2210/0618 , A61N1/05 , A61N1/0546 , A61N1/0568 , A61N1/327 , A61N7/00 , A61N7/022 , C12Y304/24069 , Y02A50/471
摘要： Apparatus for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.
摘要翻译： 将毒素和毒素片段输送到患者鼻腔的装置提供毒素的释放和能量的释放，所述能量选择性地对靶细胞进行培养以增强毒素的摄取。 使用能量介导的递送对于缺乏细胞结合能力的轻链片段毒素是特别有利的。
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公开(公告)号：US07655243B2
公开(公告)日：2010-02-02
申请号：US11750963
申请日：2007-05-18
申请人： Mark E. Deem , Hanson Gifford
发明人： Mark E. Deem , Hanson Gifford
CPC分类号： A61M31/00 , A61B18/1492 , A61B18/18 , A61B2017/00765 , A61K9/0043 , A61K38/4886 , A61K38/4893 , A61M25/007 , A61M25/0084 , A61M25/10 , A61M29/00 , A61M29/02 , A61M35/00 , A61M2025/0008 , A61M2025/0057 , A61M2025/0096 , A61M2025/105 , A61M2210/0618 , A61N1/05 , A61N1/0546 , A61N1/0568 , A61N1/327 , A61N7/00 , A61N7/022 , C12Y304/24069 , Y02A50/471
摘要： Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.
摘要翻译： 将毒素和毒素片段输送到患者的鼻腔的方法和系统提供毒素的释放和能量的释放，所述能量选择性地对靶细胞进行培养以增强毒素的摄取。 使用能量介导的递送对于缺乏细胞结合能力的轻链片段毒素是特别有利的。
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公开(公告)号：US07608275B2
公开(公告)日：2009-10-27
申请号：US11459090
申请日：2006-07-21
申请人： Mark E. Deem , Hanson Gifford
发明人： Mark E. Deem , Hanson Gifford
CPC分类号： A61M37/00 , A61B18/1492 , A61B18/1815 , A61B2018/0016 , A61B2018/00214 , A61B2018/00434 , A61B2018/1861 , A61K9/0021 , A61K9/0078 , A61K38/164 , A61K38/168 , A61K38/4893 , A61K41/00 , A61K41/0028 , A61K41/0047 , A61M37/0092 , A61M2210/1035 , A61N1/08 , A61N1/303 , A61N1/327 , A61N5/10 , A61N7/00 , A61N2007/003 , C12Y304/24069 , Y02A50/471 , A61K2300/00
摘要： Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
摘要翻译： 提供了用于施用神经毒素片段的方法和装置，例如肉毒杆菌毒素（BoNT）的活性轻链（LC），如血清型A，B，C，D，E，F或G肉毒毒素之一 通过靶向细胞膜的透化以使肉毒杆菌神经毒素轻链（BoNT-LC）分子穿过目标细胞膜转移到在哺乳动物系统中产生治疗反应的细胞溶质中。 所述方法和装置包括使用基于导管的递送系统，非侵入性递送系统和透皮递送系统。
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公开(公告)号：US08636684B2
公开(公告)日：2014-01-28
申请号：US13328203
申请日：2011-12-16
申请人： Mark E. Deem , Hanson Gifford
发明人： Mark E. Deem , Hanson Gifford
CPC分类号： A61M31/00 , A61B18/1492 , A61B18/18 , A61B2017/00765 , A61K9/0043 , A61K38/4886 , A61K38/4893 , A61M25/007 , A61M25/0084 , A61M25/10 , A61M29/00 , A61M29/02 , A61M35/00 , A61M2025/0008 , A61M2025/0057 , A61M2025/0096 , A61M2025/105 , A61M2210/0618 , A61N1/05 , A61N1/0546 , A61N1/0568 , A61N1/327 , A61N7/00 , A61N7/022 , C12Y304/24069 , Y02A50/471
摘要： Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.
摘要翻译： 将毒素和毒素片段输送到患者的鼻腔的方法和系统提供毒素的释放和能量的释放，所述能量选择性地对靶细胞进行培养以增强毒素的摄取。 使用能量介导的递送对于缺乏细胞结合能力的轻链片段毒素是特别有利的。
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公开(公告)号：US20120089078A1
公开(公告)日：2012-04-12
申请号：US13328203
申请日：2011-12-16
申请人： Mark E. Deem , Hanson Gifford
发明人： Mark E. Deem , Hanson Gifford
IPC分类号： A61M37/00
CPC分类号： A61M31/00 , A61B18/1492 , A61B18/18 , A61B2017/00765 , A61K9/0043 , A61K38/4886 , A61K38/4893 , A61M25/007 , A61M25/0084 , A61M25/10 , A61M29/00 , A61M29/02 , A61M35/00 , A61M2025/0008 , A61M2025/0057 , A61M2025/0096 , A61M2025/105 , A61M2210/0618 , A61N1/05 , A61N1/0546 , A61N1/0568 , A61N1/327 , A61N7/00 , A61N7/022 , C12Y304/24069 , Y02A50/471
摘要： Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.
摘要翻译： 将毒素和毒素片段输送到患者的鼻腔的方法和系统提供毒素的释放和能量的释放，所述能量选择性地对靶细胞进行培养以增强毒素的摄取。 使用能量介导的递送对于缺乏细胞结合能力的轻链片段毒素是特别有利的。
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