公开(公告)号：US20060140858A1

公开(公告)日：2006-06-29

申请号：US10514632

申请日：2003-05-16

申请人： David Goldenberg ,  Hans Hansen ,  Shui-on Leung ,  William McBride ,  Zhengxing Gu

发明人： David Goldenberg ,  Hans Hansen ,  Shui-on Leung ,  William McBride ,  Zhengxing Gu

IPC分类号： A61K49/14 ,  A61K51/00 ,  C07K7/06

CPC分类号： A61K51/1048 ,  A61K47/665 ,  A61K47/6879 ,  A61K51/1063 ,  A61K2039/505 ,  B82Y5/00 ,  C07K5/0215 ,  C07K5/1016 ,  C07K5/1019 ,  C07K7/06 ,  C07K16/18 ,  C07K16/3007 ,  C07K16/3046 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/12 ,  C07K2317/13 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2319/00

摘要： The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds the targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the targetable constructs and bi-specific antibodies or antibody fragments, as well as methods for using them.

摘要翻译： 本发明涉及可靶向的构建体，其可以由具有特异性结合靶组织的至少一个臂的双特异性抗体或抗体片段和至少一个特异性结合可靶向构建体的其它臂结合。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生可靶向构建体和双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。

公开(公告)号：US20050100543A1

公开(公告)日：2005-05-12

申请号：US10882151

申请日：2004-07-01

申请人： Hans Hansen ,  William McBride ,  Zhengxing Qu

发明人： Hans Hansen ,  William McBride ,  Zhengxing Qu

IPC分类号： A61K20060101 ,  A61K39/395 ,  A61K47/48 ,  A61K51/08 ,  A61K51/10 ,  C07K16/28 ,  C07K16/30 ,  C07K16/44 ,  C12N9/00

CPC分类号： C07K16/2887 ,  A61K47/6897 ,  A61K51/1027 ,  A61K51/1048 ,  A61K51/109 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/3007 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/01

摘要： Provided herein are targetable constructs that are multivalent carriers of bi-specific antibodies, i.e., each molecule of a targetable construct can serve as a carrier of two or more bi-specific antibodies. Also provided are targetable complexes formed by the association of a targetable construct with two or more bi-specific antibodies. The targetable constructs and targetable complexes of the invention are incorporated into biosensors, kits and pharmaceutical compositions, and are used in a variety of therapeutic and other methods.

摘要翻译： 本文提供作为双特异性抗体的多价载体的可靶向构建体，即可靶向构建体的每个分子可以用作两种或更多种双特异性抗体的载体。 还提供了通过可靶向构建体与两种或更多种双特异性抗体缔合形成的可靶向复合物。 将本发明的可靶向构建体和可靶向复合物掺入生物传感器，试剂盒和药物组合物中，并且以多种治疗和其它方法使用。

公开(公告)号：US20050003403A1

公开(公告)日：2005-01-06

申请号：US10829388

申请日：2004-04-22

申请人： Edmund Rossi ,  Chien Chang ,  William McBride

发明人： Edmund Rossi ,  Chien Chang ,  William McBride

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K14/475 ,  C07K14/52 ,  C07K16/00 ,  C07K16/30 ,  C07K16/44 ,  C07K16/46 ,  C12N20060101 ,  C12N15/00 ,  C12P21/04 ,  C12Q1/68

CPC分类号： C07K16/44 ,  A61K2039/505 ,  C07K16/3007 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/626 ,  C07K2318/20 ,  C07K2319/00

摘要： The invention provides for a polyvalent protein complex (PPC) comprising two polypeptide chains generally arranged laterally to one another. Each polypeptide chain typically comprises 3 or 4 “v-regions”, which comprise amino acid sequences capable of forming an antigen binding site when matched with a corresponding v-region on the opposite polypeptide chain. Up to about 6 “v-regions” can be used on each polypeptide chain. The v-regions of each polypeptide chain are connected linearly to one another and may be connected by interspersed linking regions. When arranged in the form of the PPC, the v-regions on each polypeptide chain form individual antigen binding sites.

摘要翻译： 本发明提供了包含两条多肽链的多价蛋白质复合物（PPC），其通常彼此横向排列。 每个多肽链通常包含3或4个“v区”，其包含当与相对的多肽链上的相应v-区域匹配时能够形成抗原结合位点的氨基酸序列。 每个多肽链可以使用多达约6个“v区”。 每个多肽链的v-区域彼此线性连接并且可以通过散在的连接区域连接。 当以PPC的形式排列时，每个多肽链上的v-区域形成单独的抗原结合位点。

公开(公告)号：USD285028S

公开(公告)日：1986-08-12

申请号：US573977

申请日：1984-01-25

申请人： William McBride

设计人： William McBride

公开(公告)号：US3998676A

公开(公告)日：1976-12-21

申请号：US492637

申请日：1974-07-29

申请人： Richard A. Plauson, deceased ,  by Mary E. Plauson, legal representative ,  William McBride

发明人： Richard A. Plauson, deceased ,  by Mary E. Plauson, legal representative ,  William McBride

IPC分类号： C06B21/00 ,  C06B45/32 ,  C06B45/34 ,  C06B27/00 ,  C06B33/00 ,  C06B45/30

CPC分类号： C06B21/0083 ,  C06B45/32

摘要： Aluminum particles are coated with a composition containing 84 .+-. 3 wei percent desensitizing wax, 2 .+-. 0.5 weight percent lecithin and 14 .+-. 1 weight percent nitrocellulose prior to being mixed with other ingredients of an explosive composition in a bomb manufacturing process in order to eliminate the possibility of dust explosions occurring during the bomb manufacturing process.

摘要翻译： 在与炸药制造中的爆炸性组合物的其他成分混合之前，将含有84 +/- 3重量％脱敏蜡，2 +/- 0.5重量百分比卵磷脂和14 +/- 1重量％硝化纤维素的组合物涂覆在铝颗粒上 以消除炸弹制造过程中发生粉尘爆炸的可能性。

公开(公告)号：US20070142296A1

公开(公告)日：2007-06-21

申请号：US11640557

申请日：2006-12-18

申请人： William McBride ,  David Goldenberg

发明人： William McBride ,  David Goldenberg

IPC分类号： A61K38/08 ,  C07K7/06 ,  A61K31/7048 ,  A61K31/704

CPC分类号： C07K5/0815 ,  A61K38/00 ,  A61K47/6897 ,  A61K49/0002 ,  A61K51/109 ,  B82Y5/00 ,  C07K5/1008 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1021 ,  C07K7/06 ,  Y02A50/411

摘要： The present invention provides compounds of the formula X—R1-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)—R3(Y)—NR4R5; or R1(X)-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)—R3(Y)—NR4R5, in which X is a hard acid cation chelator, a soft acid cation chelator or Ac—, R1, R2 and R3 are independently selected from a covalent bond or one or more D-amino acids that can be the same or different, Y is a hard acid cation chelator, a soft acid cation chelator or absent, Z is a hard acid cation chelator, a soft acid cation chelator or absent, and A and B are haptens or hard acid cation chelators and can be the same or different, and R4 and R5 are independently selected from the group consisting of hard acid cation chelators, soft acid cation chelators, enzymes, therapeutic agents, diagnostic agents and H. The present invention also provides methods of using these compounds and kits containing the compounds.

摘要翻译： 本发明提供式XR 1 -D- [Dpr，Orn或Lys]（A）-R 2（Z）-D- [Dpr，Orn 或Lys]（B）-R 3（Y）-NR 4 R 5; （X）-D- [Dpr，Orn或Lys]（A）-R 2（Z）-D- [Dpr，Orn或Lys]（ B）-R 3（Y）-NR 4 R 5，其中X是硬酸阳离子螯合剂，软酸阳离子螯合剂 或Ac-，R 1，R 2和R 3独立地选自共价键或一个或多个D氨基酸，其可以 Y是硬酸阳离子螯合剂，软酸阳离子螯合剂或不存在，Z是硬酸阳离子螯合剂，软酸阳离子螯合剂或不存在，A和B是半抗原或硬酸阳离子螯合剂， R 4和R 5可以相同或不同，R 4和R 5独立地选自硬酸阳离子螯合剂，软酸阳离子螯合剂，酶，治疗剂， 诊断剂和H.本发明还提供使用这些化合物和含有化合物的试剂盒的方法。

公开(公告)号：US20060228300A1

公开(公告)日：2006-10-12

申请号：US11391584

申请日：2006-03-28

申请人： Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

发明人： Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

IPC分类号： A61K51/00 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K39/395 ,  A61K47/65 ,  A61K47/6853 ,  A61K51/088 ,  A61K51/1048 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  C07K16/283 ,  C07K16/3007 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2319/00 ,  C07K2319/70

摘要： The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization and docking domain attached to a first precursor, and a second monomer comprising an anchoring domain attached to a second precursor. The first and second precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. The disclosed methods and compositions provide a simple, easy to purify way to obtain any binary compound attached to any monomeric compound, or any trinary compound.

公开(公告)号：US20060034759A1

公开(公告)日：2006-02-16

申请号：US11198846

申请日：2005-08-08

申请人： David Goldenberg ,  Hans Hansen ,  Shui-on Leung ,  William McBride ,  Zhengxing Qu

发明人： David Goldenberg ,  Hans Hansen ,  Shui-on Leung ,  William McBride ,  Zhengxing Qu

IPC分类号： A61K51/00 ,  C07K7/06 ,  C07K16/46

CPC分类号： A61K51/1048 ,  A61K47/665 ,  A61K47/6879 ,  A61K51/1063 ,  A61K2039/505 ,  B82Y5/00 ,  C07K5/0215 ,  C07K5/1016 ,  C07K5/1019 ,  C07K7/06 ,  C07K16/18 ,  C07K16/3007 ,  C07K16/3046 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/12 ,  C07K2317/13 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2319/00

摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.

公开(公告)号：US20050025709A1

公开(公告)日：2005-02-03

申请号：US10866180

申请日：2004-06-14

申请人： William McBride ,  David Goldenberg

发明人： William McBride ,  David Goldenberg

IPC分类号： A61K38/00 ,  A61K49/00 ,  C07K5/10 ,  A61K38/16 ,  A61K38/43 ,  C12N9/00 ,  C07F5/00

CPC分类号： C07K5/0815 ,  A61K38/00 ,  A61K47/6897 ,  A61K49/0002 ,  A61K51/109 ,  B82Y5/00 ,  C07K5/1008 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1021 ,  C07K7/06 ,  Y02A50/411

摘要： The present invention provides compounds of the formula X—R1-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)—R3(Y)—NR4R5; or R1(X)-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)—R3(Y)—NR4R5, in which X is a hard acid cation chelator, a soft acid cation chelator or Ac—, R1, R2 and R3 are independently selected from a covalent bond or one or more D-amino acids that can be the same or different, Y is a hard acid cation chelator, a soft acid cation chelator or absent, Z is a hard acid cation chelator, a soft acid cation chelator or absent, and A and B are haptens or hard acid cation chelators and can be the same or different, and R4 and R5 are independently selected from the group consisting of hard acid cation chelators, soft acid cation chelators, enzymes, therapeutic agents, diagnostic agents and H. The present invention also provides methods of using these compounds and kits containing the compounds.

摘要翻译： 本发明提供式XR 1 -D- [Dpr，Orn或Lys]（A）-R 2（Z）-D- [Dpr，Orn或Lys]（B）-R 3的化合物 >（Y）-NR 4 R 5; 或者R 1（X）-D- [Dpr，Orn或Lys]（A）-R 2（Z）-D- [Dpr，Orn或Lys]（B）-R 3（Y） -NR 4 R 5，其中X是硬酸阳离子螯合剂，软酸阳离子螯合剂或Ac-，R 1，R 2和R 3独立地选自共价键 或一个或多个可以相同或不同的D-氨基酸，Y是硬酸阳离子螯合剂，软酸阳离子螯合剂或不存在，Z是硬酸阳离子螯合剂，软酸阳离子螯合剂或不存在，A B是半抗原或硬酸阳离子螯合剂，可以相同或不同，R 4和R 5独立地选自硬酸阳离子螯合剂，软酸阳离子螯合剂，酶，治疗剂， 诊断剂和H.本发明还提供使用这些化合物和含有化合物的试剂盒的方法。

公开(公告)号：US20050002945A1

公开(公告)日：2005-01-06

申请号：US10776470

申请日：2004-02-11

申请人： William McBride ,  David Goldenberg ,  Carl Noren ,  Hans Hansen

发明人： William McBride ,  David Goldenberg ,  Carl Noren ,  Hans Hansen

IPC分类号： A61K47/48 ,  A61K51/04 ,  A61K51/08 ,  A61K51/10 ,  C07K7/06 ,  C07K16/18 ,  C07K16/30 ,  C07K16/44 ,  C07K16/46 ,  A61K39/00

CPC分类号： A61K51/0497 ,  A61K47/665 ,  A61K51/04 ,  A61K51/0455 ,  A61K51/048 ,  A61K51/1048 ,  A61K51/1063 ,  A61K2039/505 ,  B82Y5/00 ,  C07K5/06078 ,  C07K5/1013 ,  C07K5/1016 ,  C07K5/1019 ,  C07K7/06 ,  C07K16/18 ,  C07K16/3007 ,  C07K16/3046 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/12 ,  C07K2317/13 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2319/00

摘要： Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.

摘要翻译： 公开了包含两个或多个通过间隔物或载体缀合的半抗原的化合物。 半抗原可以包括二亚乙基三胺五乙酸（DTPA），组氨酰胺 - 琥珀酰 - 谷氨酰胺（HSG）或DTPA和HSG的组合。 化合物还包括效应分子，其可以与一个或多个半抗原，间隔物/载体或两者结合。 效应分子可以通过多个键连接，包括酯键，亚氨基键，氨基键，硫键，硫代缩氨基脲键，缩氨基脲键，肟键，醚键或这些键的组合。 还公开了合成化合物的化合物和/或前体的方法。