公开(公告)号：US20060035852A1

公开(公告)日：2006-02-16

申请号：US10537002

申请日：2003-11-21

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

IPC分类号： A61K48/00

CPC分类号： C07K16/3076 ,  A61K47/48569 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K2317/30 ,  C07K2317/34 ,  G01N33/57484

摘要： The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for said products. Said invention also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for said polypeptides, peptides and proteins.

摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定和用于编码所述产物的核酸。 所述发明还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码所述多肽，肽和蛋白质的核酸 。

公开(公告)号：US08840902B2

公开(公告)日：2014-09-23

申请号：US13634696

申请日：2011-03-09

申请人： Thorsten Klamp ,  Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Thomas Hiller ,  Jens Schumacher

发明人： Thorsten Klamp ,  Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Thomas Hiller ,  Jens Schumacher

IPC分类号： A61K39/00 ,  A61P35/00

CPC分类号： C07K14/4748 ,  A61K39/0011 ,  A61K2039/5156 ,  A61K2039/523 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/57 ,  A61K2039/575 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/40 ,  C12N7/00 ,  C12N2730/10123 ,  C12N2730/10134 ,  C12N2730/10143 ,  C12N2730/10171

摘要： The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

摘要翻译： 本发明涉及使用包含全部或部分乙型肝炎病毒核心抗原蛋白的嵌合蛋白和包含衍生自肿瘤相关抗原的细胞外部分的表位的氨基酸序列的肿瘤免疫治疗，特别是肿瘤免疫治疗。 特别地，本发明提供了包含所述嵌合蛋白的病毒样颗粒，其可用于在受试者内针对肿瘤相关抗原，特别是针对在其表面上携带所述肿瘤相关抗原的细胞引起体液免疫应答，其中 肿瘤相关抗原是所述受试者的自身蛋白质。

公开(公告)号：US20140186338A1

公开(公告)日：2014-07-03

申请号：US14043109

申请日：2013-10-01

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

IPC分类号： C07K16/30 ,  A61K47/48

CPC分类号： C07K16/3076 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K2317/30 ,  C07K2317/34 ,  G01N33/57484

摘要： The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.

摘要翻译： 本技术涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本技术的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸 ，肽和蛋白质。

公开(公告)号：US20140017254A1

公开(公告)日：2014-01-16

申请号：US13946302

申请日：2013-07-19

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Dirk Usener

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Dirk Usener

IPC分类号： C07K14/47

CPC分类号： A61K39/0011 ,  A61K45/06 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/57 ,  A61K2039/572 ,  C07K14/4748 ,  C07K16/2803 ,  C07K16/30 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/574

摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.

摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。

公开(公告)号：US08586047B2

公开(公告)日：2013-11-19

申请号：US12423153

申请日：2009-04-14

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C12P21/08

CPC分类号： C07K16/3076 ,  A61K47/48569 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K2317/30 ,  C07K2317/34 ,  G01N33/57484

摘要： The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.

摘要翻译： 本技术涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本技术的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸 ，肽和蛋白质。

公开(公告)号：US20130183305A1

公开(公告)日：2013-07-18

申请号：US13808423

申请日：2011-07-04

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Korden Walter ,  Maria Kreuzberg ,  Sylvia Luxen

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Korden Walter ,  Maria Kreuzberg ,  Sylvia Luxen

IPC分类号： C07K16/30

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

摘要： The invention relates to the treatment and/or prevention of tumor diseases associated with cells expressing CLD-N6, in particular cancer and cancer metastasis using antibodies which bind to CLDN6. The present application demonstrates that the binding of antibodies to CLDN6 on the surface of tumor cells is sufficient to inhibit growth of the tumor and to prolong survival and extend the lifespan of tumor patients. Furthermore, binding of antibodies to CLDN6 is efficient in inhibiting growth of CLDN6 positive germ cell tumors such as teratocarcinomas or embryonal carcinomas, in particular germ cell tumors of the testis.

摘要翻译： 本发明涉及使用结合CLDN6的抗体治疗和/或预防与表达CLD-N6的细胞，特别是癌症和癌症转移相关的肿瘤疾病。 本申请表明抗体对CLDN6在肿瘤细胞表面的结合足以抑制肿瘤的生长并延长存活并延长肿瘤患者的寿命。 此外，抗体与CLDN6的结合在抑制CLDN6阳性生殖细胞肿瘤如畸胎癌或胚胎性癌，特别是睾丸生殖细胞肿瘤的生长中是有效的。

公开(公告)号：US20130052217A1

公开(公告)日：2013-02-28

申请号：US13634696

申请日：2011-03-09

申请人： Thorsten Klamp ,  Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Thomas Hiller ,  Jens Schumacher

发明人： Thorsten Klamp ,  Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Thomas Hiller ,  Jens Schumacher

IPC分类号： C07K19/00 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  A61P35/00 ,  C12N5/10 ,  A61K39/29 ,  A61K31/7088 ,  A61P37/04 ,  C12N15/62 ,  C12N1/00

CPC分类号： C07K14/4748 ,  A61K39/0011 ,  A61K2039/5156 ,  A61K2039/523 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/57 ,  A61K2039/575 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/40 ,  C12N7/00 ,  C12N2730/10123 ,  C12N2730/10134 ,  C12N2730/10143 ,  C12N2730/10171

摘要： The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

公开(公告)号：US20100111975A1

公开(公告)日：2010-05-06

申请号：US12531267

申请日：2008-03-14

申请人： Ugur Sahin ,  Michael Koslowski ,  Ozlem Tureci

发明人： Ugur Sahin ,  Michael Koslowski ,  Ozlem Tureci

IPC分类号： A61K39/395 ,  C12N5/16 ,  C07K16/00 ,  A61P35/00

CPC分类号： C07K16/30 ,  C07K16/18 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.

摘要翻译： 本发明提供了可用作治疗和/或预防与表达GT468的细胞相关疾病（包括肿瘤相关疾病如乳腺癌，肺癌，胃癌，卵巢癌和肝细胞癌）的治疗剂的抗体。

公开(公告)号：US20090252714A1

公开(公告)日：2009-10-08

申请号：US12420627

申请日：2009-04-08

申请人： Ugur Sahin ,  Ozlem Tureci ,  Alexander Zaigler

发明人： Ugur Sahin ,  Ozlem Tureci ,  Alexander Zaigler

IPC分类号： A61K48/00 ,  G01N33/566 ,  A61K38/17 ,  A61K31/711 ,  A61P25/00 ,  A61P25/28

CPC分类号： G01N33/564 ,  G01N33/56972 ,  G01N2800/285

摘要： According to the invention, autoantibodies, the appearance of which is characteristic of neurological autoimmune diseases, especially multiple sclerosis, are detected and the respective autoantigens identified. It can further be shown that many of these autoantigens are expressed specifically in the brain. The identification of the autoantigens and autoantibodies is useful for diagnosis and treatment. A brain-specific expression of the autoantigens further emphasizes an important role of the antigens and antibodies in the origin and development of neurological autoimmune diseases.

摘要翻译： 根据本发明，检测其外观是神经性自身免疫性疾病，特别是多发性硬化症的特征的自身抗体，并鉴定出相应的自身抗原。 可以进一步表明，许多这些自身抗原在脑中特异性表达。 自身抗体和自身抗体的鉴定对于诊断和治疗是有用的。 自身抗原的脑特异性表达进一步强调了抗原和抗体在神经性自身免疫性疾病的起源和发展中的重要作用。

公开(公告)号：US20080166350A1

公开(公告)日：2008-07-10

申请号：US11596649

申请日：2005-05-18

申请人： Ozlem Tureci ,  Ugur Sahin ,  Michael Koslowski

发明人： Ozlem Tureci ,  Ugur Sahin ,  Michael Koslowski

IPC分类号： A61K39/395 ,  C07H21/04 ,  A61K39/00 ,  C12Q1/68 ,  C12N5/00 ,  C07K14/435 ,  C07K17/00 ,  C07K2/00 ,  C12N15/00 ,  A61P35/04 ,  C07K16/00

CPC分类号： A61K6/00 ,  A61K47/6851 ,  A61K49/00 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K16/303 ,  C07K16/3046 ,  C07K16/3076 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/75 ,  C12N9/88 ,  C12Y406/01002 ,  G01N33/57496

摘要： According to the invention, gene products expressed in a tumor-associated manner and the nucleic acids coding therefor were identified. The invention relates to the therapy and diagnosis of diseases wherein said gene products expressed in a tumor-associated manner are aberrantly expressed. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumor associated manner and to nucleic acids coding therefor.

摘要翻译： 根据本发明，鉴定了以肿瘤相关方式表达的基因产物和其编码的核酸。 本发明涉及疾病的治疗和诊断，其中以肿瘤相关方式表达的所述基因产物被异常表达。 本发明还涉及以肿瘤相关方式表达的蛋白质，多肽和肽以及编码它们的核酸。