公开(公告)号：US07801608B2

公开(公告)日：2010-09-21

申请号：US11422101

申请日：2006-06-05

申请人： Dan Li ,  Cheng Zhang

发明人： Dan Li ,  Cheng Zhang

IPC分类号： A61N1/08

CPC分类号： A61N1/3622 ,  A61N1/3712

摘要： A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and a hemodynamic sensor that senses a hemodynamic signal. The implantable medical device includes a hemodynamic sensor-controlled closed-loop ATP system that uses the hemodynamic signal for ATP capture verification. When ATP pulses are delivered according to a selected ATP protocol to terminate a tachyarrhythmia episode, the implantable medical device performs the ATP capture verification by detecting an effective cardiac contraction from the hemodynamic signal. The ATP protocol is adjusted using an outcome of the ATP capture verification.

摘要翻译： 心律管理（CRM）系统包括可植入的医疗装置，其传递抗心律失常疗法，包括抗心动过速起搏（ATP）和感测血液动力学信号的血液动力学传感器。 可植入医疗装置包括血液动力学传感器控制的闭环ATP系统，其使用血流动力学信号进行ATP捕获验证。 当根据选定的ATP方案递送ATP脉冲以终止快速性心律失常发作时，可植入医疗装置通过从血液动力学信号检测有效的心脏收缩来执行ATP捕获验证。 使用ATP捕获验证的结果调整ATP方案。

公开(公告)号：US20100153540A1

公开(公告)日：2010-06-17

申请号：US12336163

申请日：2008-12-16

申请人： Dan Li ,  Chuanxiong Guo ,  Yunxin Liu ,  Yongguang Zhang

发明人： Dan Li ,  Chuanxiong Guo ,  Yunxin Liu ,  Yongguang Zhang

IPC分类号： G06F15/173

CPC分类号： H04W4/02 ,  H04L41/12 ,  H04L67/18

摘要： A geographic location of a network device is determined using response delay times from internet servers used as landmarks. A coordination server provides to a client a list of area landmark servers (ALS) with known geographic locations. The client probes ALSs, measures response delays, and provides results to the coordination server. The coordination server then provides to the client a list of additional city landmark servers (CLS) within the area. The client probes the CLSs and provides results to the coordination server which then determines the geographic location of the client.

摘要翻译： 使用来自用作地标的互联网服务器的响应延迟时间来确定网络设备的地理位置。 协调服务器向客户端提供具有已知地理位置的区域地标服务器（ALS）的列表。 客户端探测ALS，测量响应延迟，并向协调服务器提供结果。 然后，协调服务器向客户端提供该区域内的附加城市地标服务器（CLS）的列表。 客户端探测CLS并向协调服务器提供结果，然后协调服务器确定客户端的地理位置。

公开(公告)号：US20100023082A1

公开(公告)日：2010-01-28

申请号：US12507436

申请日：2009-07-22

申请人： Yanting Dong ,  M. Jason Brooke ,  Dan Li ,  Kevin J. Stalsberg

发明人： Yanting Dong ,  M. Jason Brooke ,  Dan Li ,  Kevin J. Stalsberg

IPC分类号： A61N1/365 ,  A61B5/00

CPC分类号： A61B5/0452 ,  A61B5/0002 ,  A61B5/04525 ,  A61N1/365 ,  A61N1/3702

摘要： An apparatus comprises an implantable sensor, which provides a plurality of physiologic sensor signals of a subject, and a processor. The processor includes a feature module and a detection module. The feature module is configured to identify a feature in the sensor signals and to determine a measure of quality of the feature in the sensor signals. The detection module is configured to perform a morphology analysis of a subsequent portion of at least one of the sensor signals using the feature when the measure of quality of the feature satisfies a quality measure threshold.

摘要翻译： 一种装置包括可植入传感器，其提供对象的多个生理传感器信号和处理器。 处理器包括特征模块和检测模块。 特征模块被配置为识别传感器信号中的特征并且确定传感器信号中的特征的质量的度量。 所述检测模块被配置为当所述特征的质量度量满足质量测量阈值时，使用所述特征来对所述传感器信号中的至少一个的后续部分进行形态分析。

公开(公告)号：US20090264716A1

公开(公告)日：2009-10-22

申请号：US12425193

申请日：2009-04-16

申请人： Allan C. Shuros ,  Dan Li

发明人： Allan C. Shuros ,  Dan Li

IPC分类号： A61N1/365 ,  A61B5/0205 ,  A61B5/00 ,  A61N1/39

CPC分类号： A61N1/36585 ,  A61B5/02028 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/3962

摘要： This document discusses, among other things, an apparatus comprising an implantable hemodynamic sensor circuit that provides a hemodynamic signal representative of mechanical function of a cardiovascular system of a subject and a controller circuit communicatively coupled to the hemodynamic sensor circuit. The controller circuit includes a detection module configured to detect an onset of tachyarrhythmia, a signal analyzer module configured to determine a measure of morphological variability of the hemodynamic signal during the episode of tachyarrhythmia, and a rhythm discrimination module configured to deem whether the tachyarrhythmia episode is indicative of ventricular tachycardia (VT) according to the measure of morphological variability.

摘要翻译： 本文件尤其涉及一种包括可植入血液动力学传感器电路的装置，其提供表示受试者的心血管系统的机械功能的血液动力学信号和通信地耦合到血液动力学传感器电路的控制器电路。 所述控制器电路包括检测模块，所述检测模块被配置为检测快速性心律失常的发作，信号分析器模块被配置为确定在快速性心律失常发作期间的血液动力学信号的形态变异性的度量;以及节律辨别模块，其被配置为认为是否发生快速性心律失常发作 根据形态变异性的测量指示室性心动过速（VT）。

公开(公告)号：US20090228078A1

公开(公告)日：2009-09-10

申请号：US12327601

申请日：2008-12-03

申请人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

发明人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

IPC分类号： A61N1/36

CPC分类号： A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

摘要翻译： 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地植入神经刺激器，电源和至少一个电极在肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

公开(公告)号：US07575707B2

公开(公告)日：2009-08-18

申请号：US11097975

申请日：2005-03-29

申请人： Younan Xia ,  Dan Li

发明人： Younan Xia ,  Dan Li

IPC分类号： D01D5/08 ,  D01D5/24 ,  D01D5/34 ,  D01F9/08 ,  H05B7/00

CPC分类号： D01D5/0069 ,  B82Y30/00 ,  C04B35/62259 ,  C04B35/624 ,  C04B35/6264 ,  C04B35/62675 ,  C04B35/62849 ,  C04B35/62876 ,  C04B35/62892 ,  C04B35/63404 ,  C04B35/63408 ,  C04B35/63432 ,  C04B35/63444 ,  C04B2235/3272 ,  C04B2235/3289 ,  C04B2235/3293 ,  C04B2235/408 ,  C04B2235/441 ,  C04B2235/483 ,  C04B2235/5284 ,  D01D5/24 ,  D01D5/34 ,  D01F1/10

摘要： A method for electrospinning nanofibers having a core-sheath, tubular, or composite structure is disclosed. The process uses a spinneret having first and second capillaries that channel first and second fluids in the spinneret, the second capillary surrounding the first. A high voltage is applied between the spinneret and a spaced conductive collector. In one embodiment, the first fluid is a mineral oil and the second fluid is a polymeric solution that may include a polymer, a catalyst, a solvent, and a sol-gel precursor. The as-spun nanofiber includes an oil core and a composite sheath. The oil may be removed to produce a composite tubular fiber or the polymer and oil may be removed by calcination to produce a ceramic tubular fiber. In other embodiments, miscible fluids are used to produce porous nanofibers, selected additives functionalize the surfaces of the nanofibers and/or conjugated polymers are used.

摘要翻译： 公开了一种具有芯鞘，管状或复合结构的电纺丝纳米纤维的方法。 该方法使用具有第一和第二毛细管的喷丝头，其在喷丝头中引导第一和第二流体，第二毛细管围绕第一毛细管。 在喷丝头和间隔的导电收集器之间施加高电压。 在一个实施方案中，第一流体是矿物油，第二流体是可以包括聚合物，催化剂，溶剂和溶胶 - 凝胶前体的聚合物溶液。 原纺丝纳米纤维包括油芯和复合护套。 可以除去油以产生复合管状纤维，或者可以通过煅烧除去聚合物和油，以产生陶瓷管状纤维。 在其它实施方案中，可混溶的流体用于生产多孔纳米纤维，所选择的添加剂使纳米纤维和/或共轭聚合物的表面功能化。

公开(公告)号：US20090043355A1

公开(公告)日：2009-02-12

申请号：US11835812

申请日：2007-08-08

申请人： Shelley M. Cazares ,  Haresh G. Sachanandani ,  Benjamin Ettori ,  Dan Li ,  Yanting Dong

发明人： Shelley M. Cazares ,  Haresh G. Sachanandani ,  Benjamin Ettori ,  Dan Li ,  Yanting Dong

IPC分类号： A61N1/02

CPC分类号： A61N1/37282 ,  A61B5/0031 ,  A61N1/3627 ,  A61N1/36585 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/63

摘要： A system evaluates the performance of an implantable medical device, such as by using a remote external server and a user interface and stored historical physiological data of a population of congestive heart failure (CHF) patients. A processor is coupled to a patient data storage device to apply multiple algorithm variations against the same implantable physiological data from the patient to produce corresponding resulting CHF indicators. The user interface includes a display that is configured to display to a user information allowing comparison between the resulting CHF indicators from the multiple algorithm variations. The display also includes a population data selector to permit the user to select physiological data from a population that includes a different set of one or more patients or physiological data collected over a period of time from the patient. This permits optimization of an algorithm parameter or selection of a best performing algorithm.

摘要翻译： 系统评估可植入医疗装置的性能，例如通过使用远程外部服务器和用户界面以及存储充血性心力衰竭（CHF）患者群体的历史生理数据。 处理器耦合到患者数据存储装置，以对来自患者的相同的可植入生理数据应用多个算法变化，以产生相应的所得CHF指示符。 用户界面包括被配置为向用户显示信息的显示器，允许根据多个算法变化比较所得到的CHF指示符。 显示器还包括种群数据选择器，以允许用户从包括不同组的一个或多个患者或在患者的一段时间内收集的生理数据的群体中选择生理数据。 这允许优化算法参数或选择最佳执行算法。

公开(公告)号：US20090005826A1

公开(公告)日：2009-01-01

申请号：US12206198

申请日：2008-09-08

申请人： Dan Li

发明人： Dan Li

IPC分类号： A61N1/39

CPC分类号： A61B5/0464 ,  A61B5/04525 ,  A61B5/7264

摘要： An implantable cardioverter/defibrillator (ICD) includes a tachyarrhythmia detection and classification system that classifies tachyarrhythmias based on a morphological analysis of arrhythmic waveforms and a template waveform. Correlation coefficients each computed between morphological features of an arrhythmic waveform and morphological features of the template waveform provide for the basis for classifying the tachyarrhythmia. In one embodiment, a correlation analysis takes into account the uncertainty associated with the production of the template waveform by using a template band that includes confidence intervals.

摘要翻译： 植入式心律转复除颤器（ICD）包括快速心律失常检测和分类系统，其根据心律失常波形和模板波形的形态学分析对快速性心律失常进行分类。 在心律失常波形的形态特征与模板波形的形态特征之间计算的相关系数为分类快速性心律失常提供依据。 在一个实施例中，相关分析通过使用包括置信区间的模板带来考虑与模板波形的产生有关的不确定性。

公开(公告)号：US20080262558A1

公开(公告)日：2008-10-23

申请号：US11736286

申请日：2007-04-17

申请人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

发明人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

IPC分类号： A61N1/365

CPC分类号： A61N1/3621

摘要： A system including at least one implantable sensor circuit adapted to produce an electrical sensor signal related to one or more physiologic cardiovascular events of a subject, a therapy circuit configured to provide anti-tachycardia pacing (ATP) therapy, and a controller. The controller includes a tachyarrhythmia detection circuit and an efficacy circuit. The tachyarrhythmia detection circuit is configured to detect a tachyarrhythmia episode in the subject using the electrical sensor signal, and to determine whether the tachyarrhythmia episode is of a type that is treatable with ATP. The efficacy circuit is configured to estimate an efficacy of a currently configured ATP therapy for the subject, and the controller is configured to alter a delivery regimen of the currently configured ATP therapy when the estimated ATP therapy efficacy is deemed insufficient. Other systems and methods are described.

摘要翻译： 一种系统，包括适于产生与受试者的一个或多个生理性心血管事件相关的电传感器信号的至少一个可植入传感器电路，被配置为提供抗心动过速起搏（ATP）治疗的治疗电路和控制器。 控制器包括快速性心律失常检测电路和功效电路。 快速心律失常检测电路被配置为使用电传感器信号检测受试者的快速性心律失常发作，并且确定快速性心律失常发作是否是可用ATP治疗的类型。 功效电路被配置为估计当前配置的ATP治疗对受试者的功效，并且当估计的ATP治疗功效被认为不足时，控制器被配置为改变当前配置的ATP治疗的递送方案。 描述了其他系统和方法。

公开(公告)号：US20080183228A1

公开(公告)日：2008-07-31

申请号：US11668627

申请日：2007-01-30

申请人： Jaeho Kim ,  Joseph M. Bocek ,  Dan Li

发明人： Jaeho Kim ,  Joseph M. Bocek ,  Dan Li

IPC分类号： A61N1/39

CPC分类号： A61N1/3962 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/0464 ,  A61B5/7264 ,  A61N1/3925

摘要： An implantable cardioverter/defibrillator (ICD) delivers atrial pacing under several scenarios during a tachyarrhythmia episode that is detected using a ventricular rate. In various embodiments, the atrial pacing terminates the detected tachyarrhythmia and/or enhances the classification of the detected tachyarrhythmia, thus avoiding ineffective and/or unnecessary delivery of a ventricular anti-tachyarrhythmia therapy when the detected tachyarrhythmia has a supraventricular origin.

摘要翻译： 植入式心律转复除颤器（ICD）在使用心室率检测到的快速性心律失常发作期间在几种情况下提供心房起搏。 在各种实施方案中，心房起搏终止所检测到的快速性心律失常和/或增强检测到的快速性心律失常的分类，从而避免了当检测到的快速性心律失常具有室上性起源时，无效和/或不必要地输送室性抗快速性心律失常治疗。