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公开(公告)号:US6160109A
公开(公告)日:2000-12-12
申请号:US109215
申请日:1998-06-30
申请人: George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang , Muthiah Manoharan
发明人: George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang , Muthiah Manoharan
IPC分类号: C07H21/04 , B01J31/02 , C07F9/141 , C07F9/6584 , C07H9/04 , C07H9/06 , C07H19/10 , C07H21/00 , C12N15/09 , C12Q1/68
CPC分类号: C07H21/00 , C07F9/1411 , C07F9/65846 , C07H9/04 , C07H9/06 , C07H19/10
摘要: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate and boranophosphate linkages are disclosed.
摘要翻译: 公开了用于制备含有非对映体富集的硫代磷酸酯和硼磷酸酯键的低聚物的方法和中间体。
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公开(公告)号:US5945521A
公开(公告)日:1999-08-31
申请号:US948152
申请日:1997-10-09
申请人: George Just , Zhili Xin , Eric Marsault , Yi Jin
发明人: George Just , Zhili Xin , Eric Marsault , Yi Jin
IPC分类号: C07H21/04 , B01J31/02 , C07F9/141 , C07F9/6584 , C07H9/04 , C07H9/06 , C07H19/10 , C07H21/00 , C12N15/09 , C12Q1/68 , C07H1/02
CPC分类号: C07H9/04 , C07F9/1411 , C07F9/65846 , C07H19/10 , C07H21/00 , C07H9/06
摘要: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
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公开(公告)号:US08293752B2
公开(公告)日:2012-10-23
申请号:US12164762
申请日:2008-06-30
申请人: Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人: Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号: A61K31/535 , A61K31/52 , C07D239/42 , C07D413/14 , C07D401/14
CPC分类号: C07D417/14 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07F9/65583
摘要: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译: 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物,以及Raf介导的疾病的治疗方法。
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公开(公告)号:US20090036419A1
公开(公告)日:2009-02-05
申请号:US12164762
申请日:2008-06-30
申请人: Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人: Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号: A61K31/397 , C07D239/24 , A61K31/505 , C07D295/00 , C07D473/00 , C12N9/99 , A61P9/00 , A61P37/02 , A61P31/12 , A61P19/08 , A61P29/00 , A61P25/00 , A61P35/00 , A61K31/52 , A61K31/5377 , A61K31/496 , A61K31/502
CPC分类号: C07D417/14 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07F9/65583
摘要: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译: 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物,以及Raf介导的疾病的治疗方法。
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公开(公告)号:US20090005359A1
公开(公告)日:2009-01-01
申请号:US12164905
申请日:2008-06-30
申请人: Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人: Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号: A61K31/55 , C07D487/04 , A61K31/551 , A61K31/5377 , A61K31/519
CPC分类号: C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译: 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物,以及Raf介导的疾病的治疗方法。
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公开(公告)号:US06476216B1
公开(公告)日:2002-11-05
申请号:US09051610
申请日:1998-12-03
申请人: George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang
发明人: George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang
IPC分类号: C07H2100
CPC分类号: C07H9/04 , C07F9/1411 , C07F9/65846 , C07H9/06 , C07H19/10 , C07H21/00
摘要: The present invention is directed to methods for solid phase nucleotide synthesis utilizing substituted imidazole catalysts.
摘要翻译: 本发明涉及使用取代的咪唑催化剂的固相核苷酸合成方法。
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公开(公告)号:US5734041A
公开(公告)日:1998-03-31
申请号:US546198
申请日:1995-10-20
申请人: George Just , Zhili Xin , Eric Marsault , Yi Jin
发明人: George Just , Zhili Xin , Eric Marsault , Yi Jin
IPC分类号: C07H21/04 , B01J31/02 , C07F9/141 , C07F9/6584 , C07H9/04 , C07H9/06 , C07H19/10 , C07H21/00 , C12N15/09 , C12Q1/68 , C07H1/02
CPC分类号: C07H9/04 , C07F9/1411 , C07F9/65846 , C07H19/10 , C07H21/00 , C07H9/06
摘要: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
摘要翻译: 公开了制备含有非对映体富集的硫代磷酸酯键的低聚物的方法和中间体。
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